Glycyrrhizic acid ammonium ntsev, tseem hu ua Monoammonium glycyrrhizinate , yog ib qho chaw muab tau los ntawm cov hauv paus hniav ntawm cov nroj tsuag licorice (Glycyrrhiza glabra ). Nws tus lej CAS yog 53956-04-0, thiab nws muaj cov qauv molecular ntawm C42H65NO16 nrog qhov hnyav molecular ntawm kwv yees li 839.96-856.99 nyob ntawm lub xeev hydration.
Cov tshuaj no muaj ntau yam tshuaj ua haujlwm, suav nrog tshuaj tiv thaiv- mob, tiv thaiv- ua xua, tiv thaiv- plab hnyuv, thiab tiv thaiv- kab mob siab. Cov kev tshawb fawb tshawb fawb tau pom tias nws muaj peev xwm tswj hwm lub cev tiv thaiv kab mob los ntawm kev txo qis kev tsim cov cytokines xws li TNF- thiab IL-1 , thiab modulating nuclear factor-kappa B (NF-κB) taw qhia txoj hauv kev.
Lub cev, nws zoo nkaus li cov hmoov dawb crystalline nrog qhov ntom ntawm 1.43g / cm³ thiab lub ntsiab lus melting nyob ib ncig ntawm 209ºC. Nws cov ntsiab lus kub yog 971.4ºC ntawm 760mmHg, thiab lub teeb nyem yog 288.1ºC. Nws yog me ntsis soluble hauv dej, me ntsis soluble hauv anhydrous ethanol, thiab xyaum insoluble hauv acetone, tab sis nws dissolves nyob rau hauv dilute daws ntawm acids thiab alkali hydroxides.
Qhov sib xyaw ua ke ruaj khov nyob rau hauv qhov kub thiab txias thiab yuav tsum tau muab ntim rau ntawm 2-8ºC kom pom kev khaws cia. Nws yog dav siv hauv kev lag luam kws kho mob rau kev kho mob ntawm kev ua pa, kab mob siab, thiab raws li kev noj qab haus huv ntxiv vim nws cov txiaj ntsig kho ntau yam.
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| Tshuaj Formula | C30H49NO4 |
| Exact Mass | 487.37 |
| Molecular Luj | 487.73 |
| m/z | 487.37 (100.0%), 488.37 (32.4%), 489.37 (2.7%), 489.37 (2.4%) |
| Elemental Analysis | C, 73.88; H, 10.13; N, 2.87; O, 13.12 |
Cov teebmeem Hepatoprotective
- Kev kho mob siab: Nws yog feem ntau siv rau hauv kev kho mob ntawm ntau lub siab mob xws li mob siab migratory kab mob siab, mob siab ua haujlwm siab, mob siab rau lub siab, thiab cov theem pib ntawm cirrhosis. Nws nthuav tawm los tiv thaiv- mob thiab tiv thaiv- cov teebmeem hepatotoxic, pab txo lub siab puas tsuaj thiab txhawb lub siab cell rov tsim dua tshiab.
- Txo qis Alanine Aminotransferase (ALT) qib: Nws tau pom tias txo qis ALT, qhov taw qhia ntawm daim siab raug mob, los ntawm kev rov ua kom lub siab ua haujlwm ntawm tes thiab tiv thaiv cov rog degeneration.
Antiviral thiab Antitoxin Properties
- Antiviral Activity: Nws nthuav tawm cov khoom siv tshuaj tua kab mob, ua kom muaj txiaj ntsig zoo hauv kev sib ntaus sib tua kab mob.
- Detoxification: Nws muaj zog detoxifying los tiv thaiv ntau yam co toxins, xws li diphtheria toxin, tetanus toxin, nab venom, thiab pufferfish lom.
Cov kab mob ua pa
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Antiviral nyhuv
Ammonium glycyrrhizinate muaj cov tshuaj tiv thaiv kab mob thiab tuaj yeem tiv thaiv kab mob sib kis thiab kis tau tus kab mob. Nws tuaj yeem txo tus kab mob rov ua dua los ntawm inhibiting cov haujlwm ntawm cov kab mob sib kis enzymes, thaiv cov synthesis ntawm tus kab mob RNA.
Hauv kev xyaum kho mob, ammonium glycyrrhizinate tau siv los kho cov kab mob kis xws li mob khaub thuas thiab tau ua tiav qee yam kev kho mob. -
Kev tiv thaiv kab mob kev tiv thaiv
Ammonium glycyrrhizinate muaj kev tswj hwm ntawm lub cev tiv thaiv kab mob, uas tuaj yeem txhim kho lub cev tiv thaiv kab mob thiab txhim kho kev tiv thaiv. Nws tuaj yeem ua rau kom muaj kev ua haujlwm ntawm lymphocytes, txhim kho lub cev cellular thiab humoral tiv thaiv kab mob, yog li tiv thaiv kab mob thiab kab mob.
Lwm yam kev siv kho mob
- Nws tau raug siv los kho cov kab mob digestive, kab mob hauv qhov ncauj, thiab kab mob plab vim nws cov tshuaj tiv thaiv - mob thiab rwj - kho cov khoom.
- Nws nthuav tawm cov teebmeem zoo sib xws rau adrenal corticosteroids, ua rau nws muaj txiaj ntsig zoo hauv qee yam tshuaj hormonal.
lwm daim ntawv thov
Glycyrrhizic acid ammonium ntsev, dhau ntawm nws txoj kev tsim siv hauv kev siv tshuaj, ua kom pom cov ntawv cog lus hauv kev tshawb fawb thiab kev tsim kho, tshuaj pleev ib ce, thiab muaj peev xwm hauv kev lag luam zaub mov. Nws cov khoom siv lom neeg tshwj xeeb thiab kev siv ntau yam txuas ntxiv mus nyiam cov kws tshawb fawb thiab cov kws tshawb fawb, uas nquag tshawb nrhiav txoj hauv kev tshiab rau nws siv. Nrog rau kev tshawb fawb thiab kev loj hlob tsis tu ncua, lub neej yav tom ntej zoo li ci ntsa iab rau qhov sib xyaw ua ke ntau yam.
- Kev txiav txim siab thiab kev txheeb xyuas cov ntsiab lus:Nws yog siv hauv kev tshawb fawb tshawb fawb rau kev txiav txim siab cov ntsiab lus thiab kev txheeb xyuas lub hom phiaj. Nws ua hauj lwm raws li ib tug siv compound rau analytical txoj kev, tso cai rau cov neeg soj ntsuam kom meej quantity thiab characterize nws nyob rau hauv ntau yam qauv.
- Pharmacological kev sim:Hauv kev tshawb fawb pharmacological, qhov sib xyaw no ua lub luag haujlwm tseem ceeb hauv kev tshawb xyuas nws cov haujlwm lom neeg thiab cov txheej txheem ntawm kev ua. Cov kws tshawb fawb siv nws los kawm txog nws cov tshuaj tiv thaiv - mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob, thiab lwm yam.
- Cov khoom siv tawv nqaij: Nws tau pom nws txoj hauv kev rau cov tshuaj pleev ib ce vim nws cov tshuaj tiv thaiv zoo heev - mob, antioxidant, thiab tawv nqaij - cov khoom ua kom txias. Nws yog siv nyob rau hauv ntau yam khoom tu tawv nqaij xws li toners, serums, thiab cream los pab soothe tawv nqaij khaus, txo qhov liab, thiab txhawb kev noj qab haus huv ntawm daim tawv nqaij.
- Kev nyab xeeb thiab kev cai: Nws siv nyob rau hauv cov tshuaj pleev ib ce yog tswj los ntawm ntau yam tub ceev xwm, nrog rau kev pom zoo concentrations feem ntau khaws cia kom tsis txhob muaj kev ruaj ntseg. Piv txwv li, Tebchaws Asmeskas Cov Khoom Siv Tshuaj Txhuam Hniav (CIR) tau pom tias nws muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce ntawm ntau txog 0.1%.
- Flavour Enhancer: Txawm hais tias tsis muaj ntau npaum li nws cov kev siv tshuaj, nws tau tshawb nrhiav los ua lub ntuj tsw qab hauv qee cov khoom noj vim nws qhov qab zib heev. Txawm li cas los xij, nws qhov kev siv tseem ceeb hauv cov zaub mov tseem txwv vim yog tus nqi thiab kev tswj hwm kev txiav txim siab.
- Drug Delivery Systems: Nrog nws cov xwm txheej amphiphilic, nws tau pom cov lus cog tseg raws li cov khoom siv rau kev xa tshuaj. Nws tuaj yeem txhim kho cov solubility thiab bioavailability ntawm cov tshuaj hydrophobic, muaj peev xwm txhim kho lawv cov txiaj ntsig kho mob.
- Lwm thaj chaw kho mob: Kev tshawb fawb txuas ntxiv tseem tab tom tshawb nrhiav lub peev xwm ntawm nws hauv lwm qhov chaw kho mob, xws li neuroprotection, immunomodulation, thiab kev kho mob ntawm cov kab mob metabolic.
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txheej txheem synthesis
Lub synthesis ntawmglycyrrhizic acid ammonium ntsevNws suav nrog ntau cov kauj ruam tseem ceeb, suav nrog kev npaj cov khoom siv raw, kev tsim cov ntsev ammonium los ntawm kev nruab nrab thiab nag lossis daus, purification los ntawm kev pom, ntxuav, thiab recrystallization, thiab thaum kawg, ziab thiab khaws cov khoom kawg. Cov txheej txheem no ua kom muaj cov ntshiab ammonium ntsev ntawm glycyrrhizic acid haum rau siv ntau yam kev siv, tshwj xeeb tshaj yog nyob rau hauv kev lag luam tshuaj.
Glycyrrhizic Acid Extraction: Cov khoom pib, glycyrrhizic acid, feem ntau yog muab rho tawm los ntawm cov hauv paus hniav thiab rhizomes ntawm licorice nroj tsuag (Glycyrrhiza uralensis Fisch.), uas yog nplua nuj nyob rau hauv no compound. Cov txheej txheem rho tawm yuav suav nrog kev siv dej lossis ethanol ua cov kuab tshuaj, ua raws li cov txheej txheem kev ua kom huv thiab ua kom huv.
Acidification thiab Extraction:
Cov crude glycyrrhizic acid feem ntau raug rau acidification nrog hydrochloric acid los yog sulfuric acid, uas pab txhawb nws cov extraction rau hauv cov organic hnyav xws li ethanol. Cov kauj ruam no yuav pab tshem tawm impurities thiab mloog zoo rau glycyrrhizic acid.
Neutralization thiab nag lossis daus:
Lub acidic extract yog ces neutralized los ntawm kev ntxiv ntawm ammonia los yog ammonium hydroxide. Qhov no neutralization tshwm sim nyob rau hauv tsim ntawm ammonium ntsev ntawm glycyrrhizic acid, uas precipitates tawm ntawm kev daws. Cov pH raug hloov mus rau ib ncig ntawm 7.2-7.5 kom ua tiav cov nag lossis daus.
Lim thiab ntxuav:
Cov ntsev ammonium precipitated yog lim thiab ntxuav nrog cov kuab tshuaj uas tsim nyog, xws li ethanol lossis dej khov -txias acetic acid, kom tshem tawm cov khoom seem uas seem. Cov kauj ruam no txhim kho qhov purity ntawm cov khoom.
Recrystalization:
Kev lim dej ntxiv tuaj yeem suav nrog recrystallization los ntawm cov kuab tshuaj tsim nyog, xws li 75% ethanol nrog cov pa roj carbon activated rau decolorization. Cov txheej txheem no yields ntshiab heevglycyrrhizic acid ammonium ntsevnyob rau hauv daim ntawv ntawm dawb crystals.
Kev ziab thiab khaws cia: Cov ntsev ammonium purified yog qhuav kom tshem tawm cov kuab tshuaj ntxiv thiab khaws cia rau hauv qhov chaw txias, qhuav kom nws ruaj khov.
Kho eczema thiab dermatitis
Kev soj ntsuam kev ua tau zoo ntawm kev sib xyaw ammonium glycyrrhizinate hauv kev kho mob eczema thiab dermatitis
Eczema dermatitis belongs rau hom kev ua xua qeeb, yog li cov tshuaj tiv thaiv kab mob feem ntau siv hauv kev kho mob. Ntawm lawv, mizolastine yog ib qho uas nquag siv H1 receptor antagonist nrog siab tiv thaiv kev ua xua, tab sis muaj qhov pom tseeb tsis zoo. Kev siv lub sij hawm ntev kuj tuaj yeem ua rau muaj kev cuam tshuam loj heev xws li txo qis neutrophil suav. Nyob rau hauv xyoo tas los no, cov ntaub ntawv tshawb fawb txog kev sib xyaw ammonium glycyrrhizinate tau tshaj tawm tag nrho cov txiaj ntsig zoo ntawm ntau dua 80.00% hauv kev kho eczema thiab dermatitis. Yog li, qhov kev tshawb fawb no tau tshawb xyuas qhov ua tau zoo ntawm cov tshuaj ammonium glycyrrhizinate. Cov txiaj ntsig tau pom tias tag nrho cov txiaj ntsig zoo ntawm cov tshuaj ammonium glycyrrhizinate yog siab li 90.48%, raws li cov ntaub ntawv qhia, thiab cov txiaj ntsig tau zoo dua li ntawm mizolastine. Nws tuaj yeem xaus lus tias compound ammonium oxalate zoo dua hauv kev kho eczema thiab dermatitis.
Cov tshuaj ammonium oxalate feem ntau yog siv los tiv thaiv kev tsis haum tshuaj nrog adrenal cortex zoo li cov teebmeem. Nws tsis tsuas yog muaj kev tswj hwm kev tiv thaiv kab mob zoo xwb, tab sis kuj tuaj yeem cuam tshuam qhov kev tso tawm ntawm cov kab mob inflammatory induced los ntawm qeeb hom hypersensitivity tshwm sim, yog li exerting muaj zog tiv thaiv - inflammatory thiab tiv thaiv kev tsis haum tshuaj. Nyob rau hauv xyoo tas los no, kev tshawb fawb soj ntsuam ntawm compound ammonium oxalate tau pom tias nws tuaj yeem kho eczema thiab dermatitis tag nrho, nrog tus nqi qis dua thiab muaj kev nyab xeeb ntawm cov tshuaj. Hauv txoj kev tshawb no, nws kuj tau pom tias qhov rov tshwm sim dua thiab qhov tshwm sim ntawm qhov tsis zoo tshwm sim yog qhov qis dua tom qab kev kho mob nrog cov tshuaj ammonium oxalate, qhia tias kev kho cov nyhuv ntawm compound ammonium oxalate yog ntseeg tau.
Kev kho mob herpes zoster hauv cov neeg laus
Kev sib xyaw ua ke ntawm famciclovir thiab compound ammonium glycyrrhizinate rau kev kho mob ntawm cov laus herpes zoster
Nyob rau hauv cov ntsiab lus, kev kho mob ntawm eczema thiab dermatitis nrog compound ammonium glycyrrhizinate yog txhim khu kev qha, nrog tsawg recurrence tus nqi, siab kev ruaj ntseg, thiab siab daim ntawv thov nqi. Herpes zoster yog tshwm sim los ntawm varicella zoster virus (VZV). Nws muaj cov yam ntxwv ntawm kev ua neurotropic thiab cov tawv nqaij tus phooj ywg, ua rau mob los yog necrosis ntawm invaded ganglion, ua rau mob neuropathic, ua raws li los ntawm hlwv, npaj raws li ib co peripheral paj tis, feem ntau tsis tshaj midline. Cov neeg laus raug kev txom nyem los ntawm physiological poob. Lub cev tsis muaj zog thiab cov lus teb qeeb ntawm lub cev ua rau cov tsos mob ntawm tus kab mob herpes zoster atypical, uas tuaj yeem yooj yim ncua tus mob thiab ua rau lub sijhawm ntev ntawm tus kab mob, feem ntau ua rau mob neuropathic tsis tu ncua txog li 30% mus rau 50% ntawm cov neeg mob. Cov neeg laus cov neeg mob feem ntau ua rau muaj qhov siab ntawm cov tshuaj tiv thaiv VZV, uas cuam tshuam ncaj qha rau qib thiab lub sijhawm ntawm qhov mob.
Acyclovir ib txwm raug suav hais tias muaj kev cuam tshuam zoo rau tus kab mob herpes thiab cov txiaj ntsig kho mob ntawm herpes zoster. Tab sis nws cov bioavailability tsawg, ib nrab - lub neej luv luv, cov tshuaj nquag muaj siab, cov neeg laus muaj kev ua tsis zoo, thiab cov tshuaj tua kab mob ib txwm muaj tsis muaj kev kho mob rau cov mob neuropathic. Tseem muaj kev sib cav txog kev kho mob ntawm corticosteroids. Qee tus neeg tawm tswv yim tias kev tswj hwm ntxov ntawm prednisone rau cov neeg mob laus tuaj yeem txo qhov mob, tiv thaiv kev mob toxicity thiab kev puas tsuaj rau ganglia thiab paj hlwb, thiab txo qis postherpetic neuralgia. Tab sis qee tus neeg kuj ntseeg tias kev siv cov tshuaj corticosteroids thaum lub sijhawm mob hnyav tuaj yeem kis tus kab mob thiab ua rau lub sijhawm ntev.
FAQ
1. Dab tsi yog ammonium glycyrrhizinate?
Ammonium glycyrrhizinate yog ntsev daim ntawv tau los ntawm kev kho glycyrrhizic acid muab rho tawm los ntawm licorice nrog dej ammonia. Nws yog cov dej ntau dua -soluble thiab ruaj khov active ingredient, thiab yog dav siv nyob rau hauv cov tshuaj, tshuaj pleev ib ce thiab zaub mov industries.
2. Lub hom phiaj tseem ceeb yog dab tsi?
Feem ntau ua raws li kev tiv thaiv- mob, tiv thaiv- ua xua, lub siab- tiv thaiv thiab tiv thaiv kab mob- tswj tus neeg sawv cev, feem ntau pom muaj nyob rau hauv cov tshuaj tiv thaiv kab mob siab hauv qhov ncauj, tshuaj pleev xim rau ntawm daim tawv nqaij (xws li eczema), siab - cov khoom tu tawv nqaij kawg (rau kev kho mob thiab kev kho mob).
3. Dab tsi yuav tsum tau sau tseg thaum siv nws?
Raws li cov khoom siv raw, nws tsis tuaj yeem siv ncaj qha. Nws yuav tsum tau formulated rau hauv daim ntawv teev ntau npaum thiab concentration los ntawm ib tug kws manufacturers. Ntev- siv sijhawm ntev lossis siv ntau dhau tuaj yeem ua rau pseudo-aldosteronism (xws li ntshav siab, edema, thiab ntshav tsis muaj poov tshuaj), thiab nws yuav tsum tau siv raws li cov cai raws li kev qhia ntawm kws kho mob lossis kws tshaj lij.
Cim npe nrov: glycyrrhizic acid ammonium ntsev cas 53956-04-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom