1,1'-carbonyldiimidazole, Alias N.n'- Carbonyl diimidazole, 1,1'- carbonyl diimidazole, tsis muaj tshuab molec4o, incessoluble hauv dej, soluble hauv dej cawv thiab ether. CarbonyL diimidazole yog ib hom ntawm compound nrog muaj zog reactivity. Nws tuaj yeem muaj kev cuam tshuam nrog-Cooh,-Nh2,-Auj thiab lwm pab pawg ua haujlwm los ua ke ntau cov ketones, esters, ureas thiab lwm cov tebchaw uas nyuaj rau tau los ntawm cov txheej txheem sib xws. Piv txwv li, cov tshuaj tiv thaiv nrog Amine tuaj yeem suav ua ke imidazole tshuaj tua kab, thaum zam kev siv cov tshuaj lom neeg lom zem uas tsis yooj yim rau khw thiab thauj. Mas siv rau cov tshuaj synthic, tshuaj tua kab thiab tshuaj siv tshuaj.
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Tshuaj Cov Qauv |
C7H6N4O |
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Muaj pes tsawg leej |
162 |
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Molecular hnyav |
162 |
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m/z |
162 (100.0%), 163 (7.6%), 163 (1.5%) |
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Kev Ntsuam Xyuas |
C, 51.85; H, 3.73; N, 34.55; O, 9.87 |
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Raws li ib tug heev nquag carbonylation reagent,1,1'-carbonyldiimidazole(CDI) tau pom muaj kev thov dav dav hauv cov khoom siv hauv cov organic, biochemistry, cov ntaub ntawv kev tshawb fawb thiab tshuaj vim nws cov qauv tshuaj thiab cov tshuaj tiv thaiv.
Cov CDI molecule muaj ob lub iMidazole Rings bridged los ntawm pab pawg carbonyL. Nws pab pawg carbonyl yog qhib los ntawm cov nyhuv hluav taws xob-rho tawm cov nyhuv ntawm imidazole ntiv nplhaib los ua cov pa roj carbon ntau. Cov qauv no pab kom nws rov qab cuam tshuam nrog cov pab pawg ua haujlwm muaj cov hydrogen ntau (xws li acylm imidazole, carbamoy los yog ester imidazole. Cov intermediales no tuaj yeem hnov mob ntxiv nrog nucleophiles (xws li cov roj hmab, roj cawv, Thiols) los tsim cov khoom lag luam xws li kev saib xyuas, cov tshuaj esas, thiab cov zaub ntsuab. Nws cov yam ntxwv ntawm cov yam ntxwv muaj xws li:
Kev xaiv siab: Nyob rau hauv thawj amine \/ aline sib xyaw ua ke, thiab ob pab pawg ua haujlwm tau ua tiav los ntawm kev tswj hwm cov kev cai.
Cov tshuaj tiv thaiv me me: Tsis muaj cov muaj zog acid, muaj zog hauv paus lossis qhov kub muaj zog, thiab cov tshuaj tiv thaiv tuaj yeem ua tiav ntawm chav tsev kub txog 60 degree.
Intermediate Stability: Cov inylated acyl imidazole intermediate tuaj yeem muaj cov kuab tshuaj organic rau ob peb teev, uas yooj yim rau kev ua haujlwm ib ruam dhau ib kauj ruam.
Cov kev xaiv tsis muaj tshuaj lom: nws tuaj yeem hloov cov kuab lom heev (cocl₂) rau cov synthesis ntawm isocyanates thiab urea compounds.
1. High-effecticiency Tus Neeg Sawv Cev Rau Peptide Nyiaj Txiag
CDI yog qhov tseem ceeb reagent hauv theem theem peptide artthesis thiab kua theem peptide synthesis, thiab nws cov tshuab ntawm kev nqis tes ua suav nrog:
Kev ua kom ncaj qha ntawm carboxylic acid: reacts nrog cov pab pawg carboxyl ntawm amino acids los tsim cov amino pab pawg ntawm lwm cov amino acid los ua peptide daim ntawv cog lus. Piv txwv li, nyob rau hauv synthesis ntawm antimicrobial peptide peptide peptide peptide peptide} {} {% piv nrog cov txheej txheem dCC \/ hobt txoj kev sib tw, thaum txo cov kev sib tw.
Txoj kev tiv thaiv kev xaiv hauv cheeb tsam: los ntawm kev kho cov tshuaj tiv thaiv kab mob, xaiv kev tiv thaiv N-Terminus lossis C-Terminus tuaj yeem ua tiav. Piv txwv li, thaum synthesizing cyclicizing peptides, CDI tuaj yeem ua kom qhib cov pawg ntawm cov khoom ua ntej lub ntsiab peptide.
Kev hloov kho peptide thiab ceg: siv cov pawg carboxyl activated los ntawm CDI, cov fluorescent glycol (pawm) lossis dendrimer hloov kho tau tuaj yeem qhia tau. Piv txwv li, fluorescein isothiocyanate (Fitc) yog txuas mus rau Lysine sab saw ntawm CDI kom pom kev tshuaj pom.
2. Protein hla kev sib txuas thiab immobilization
CDI-FOLDIALIAL Cross-sib txuas lus tuaj yeem tsim cov khoom xoom-ntev amide kev sib tw lossis ib leeg-carbon spaced carbamate sib tw ntawm protein molecules:
Enzyme immobilization: qab zib oxidase (gox) yog immobilized ntawm lub npoo ntawm cov nanoparticle nanoparticles los ntawm activating cov carboxyl pawg los ntawm CDI. Qhov kev ua rov qab tus nqi rov qab ntawm cov enzyme immobized mus txog 92%, thiab nws tuaj yeem siv tau siv ntau dua 10 zaug.
Kev npaj tiv thaiv kab mob antibody-antigen complexes: nyob rau hauv lub synthesis ntawm immunose cov ntaub ntawv, CDI tuaj yeem tsim cov txheej txheem hydroxylated (CDI muaj ib qho kev ua kom muaj txiaj ntsig zoo tshaj plaws rau kev ua kom muaj zog ntawm Igg hauv ntshav.
1. Khoom cua ntawm cov ketones, ester thiab urea compounds
Synthesis ntawm Ketones: CDI reacts nrog ocegompic reagents (xws li grampard reagents) kom ua tau zoo cattering pob txha pob txha. Piv txwv li, nyob rau hauv synthesis ntawm acetophenone, CDI qauv nce ntxiv los ntawm cov kab lis kev cai ib txwm muaj thiab zam lub cim ntawm hydrogen chloride.
Synthesis of Ester: CDI accordates carboxylic acids thiab condenses lawv nrog dej cawv rau cov ntawv esters. Cov qauv no muaj txiaj ntsig zoo hauv kev sib txuas ntawm cov chiral esters. Piv txwv li, nyob rau hauv kev npaj ntawm cov tshuaj intermediatiatiatiatiatiatiatiatiatianyes antelmivir, CDI txujci tau tuaj yeem tswj tau qhov enantiomer ntau dhau (EE) rau ntau dua 99%.
Urea compounds: CDI reacts nrog amines los ua cov carbamoyl imidazole intermediates, uas yog ntxiv rau lwm lub amine los tsim urea. Txoj kev no luv luv ntawm cov tshuaj tiv thaiv 2 kauj ruam piv nrog cov qauv phosgene thaum synthiaizing cov tshuaj ntsuab fluroxypyr, thiab nce cov atomic siv los ntawm 30%.
2. Tsis-phosgene synthesis ntawm ownocyanates
CDI reacts nrog amines los ua cov ntawv isocyanates, zam kev siv cov tshuaj lom tau zoo heev. Piv txwv li, thaum synthesizing polyurethane raw khoom Toluene raw deedce lub sijhawm los ntawm 8 teev mus rau 2 teev, thiab cov khoom purity ncav 99.5%.
3. Kev tsim kho ntawm Heterocyclic Tebchaw
CDI tuaj yeem siv los ua tus pub zaub mov carbonyl los koom nrog Heterocyclic Synthesis:
Imidazolopyridines: Los ntawm kev sib cav sib ceg ntawm CDI thiab 2- A] A IMIDGY Cov Tub Rog nrog cov haujlwm antitumor ua tau zoo tuaj yeem tsim tau zoo.
-Txhua kab mob tshuaj kho mob Intermediates: CDI reacts nrog potassium voov ntsev rau synthesium acid los txhawb 18% piv nrog cov qauv tshuaj lom neeg.
1. Polymer ua haujlwm
1,1'-carbonyldiimidazoletuaj yeem qhia txog kev ua haujlwm molecules rau hauv polymer qhov chaw los ntawm kev sib tsooalent:
Biocompatibility hloov kho: nyob rau saum npoo ntawm polylactic acid-co-glycolic acid (pyethylene glycolicity ntawm cov khoom siv thiab txhawb nqa tes adhesion.
Kev hloov kho polymer polymer: nyob rau saum npoo ntawm polypyrrole (ppy), CDI tuaj yeem tsim cov piam thaj hauv qab zib kom tsis txhob muaj qhov tsis muaj kev txwv tsis pub muaj qhov tsawg li}}}. 1μm.
2. Nanomaterial Dege Engineering
CDI tuaj yeem ua tiav cov haujlwm ua haujlwm ntawm nanoparticles:
Quantum dot Hloov kho: CDI yog siv rau ob peb lub tshuaj tua kab mob rau kev tsim cov qog nqaij daim tawv funcher ca125 nrog qhov rhiab ntawm {1}}. 1ng \/ ml.
Kev ua haujlwm ntawm kev sib nqus Nanoparticles: nyob rau saum npoo ntawm Fe₃o₄, CDI tuaj yeem ua tiav cov lus pom zoo ntawm cov qog nqaij hlav.
1. Khoom cua ntawm cov tshuaj tua kab mob cuam tshuam
CDI yog Irreplaceable nyob rau hauv synthesis ntawm -Lactam tshuaj tua kab mob:
Cepharosporin C SAT SAMPICATION: CDI accordates tus carboxyl pawg
Ceg
2. Qhov tseem ceeb intermediates ntawm Tshuaj Tiv Thaiv Antiviral
Thaum synthesizing lub anti-HIV tshuaj EFAVIRENTY tau tsim kho cov kauj ruam urea, thiab tag nrho cov txiaj ntsig tau nce los ntawm 45% mus rau 68%.
3. Kev hloov kho cov tshuaj tsis zoo
CDI tuaj yeem siv rau kev hloov kho pgylation ntawm paclitaxel tshuaj, xws li coupling mpeg {0}} Lub neej ntawm cov tshuaj (los ntawm 2.8 teev) thiab txo immunogenicity.
Kev ua txuj ci thiab kev lag luam cuam tshuam
Ntsuab chemistry coj tus cwj pwm:
CDI cov tshuaj tiv thaiv kev zam kev siv cov tshuaj lom neeg lom (xws li phosgene thiab cyanide), thiab muaj cov qauv Atom) Green Officistrial Txuj Ci ntawm E<10.
Muaj qhov ua tau:
CDI txoj kev tau ua tiav TUJ-qib kev tsim khoom. Piv txwv li, hauv synthesis ntawm ceftriaxone sodium intermediates, txhua xyoo tau ntau lawm tus nqi yog 35% qis dua txoj kev ib txwm muaj.
InterdiscInments Kev sib koom ua ke:
CDI Technology txhawb kev hla dhau txoj kev ua txuj ci hauv cov organic synthesis, biochemistry thiab cov khoom siv science. Piv txwv li, hauv cov ntaub so ntswg tsim, CDI-hloov kho cov ntaub ntawv scaffold tuaj yeem ua tiav cov kev txhawb nqa tshuab thiab ntsuas hluav taws xob transdal.
Synthesis ntawm1,1'-carbonyldiimidazole:
Lub imidazole yog requeed nrog phosgene yaj nyob rau hauv benzene, lub imidazole hydrothloride nyob rau hauv cov reactant nyob rau hauv cov reactant yog featant, thiab cov carbonyldiimidazole nrog ib tug tawm los ntawm 91%.
Ncuav 2 {0 {13}} ml ntawm anhydrous benzene mus rau hauv 500 mL conical funnel thiab hnyav nws nrog nres. Tshem lub khob ntsaws thiab nruab ib lub roj inlet yeeb nkab nrog cov xuab zeb core lim ntawm lub funnel. Nyob rau hauv kev tiv thaiv ntawm chav sov thiab ziab yas, txog 20g phosgene tau qhia txog li {{4} ml). Plug lub funnel thiab hnyav nws tam sim ntawd. Qhov hnyav tiag tiag ntawm phosgene yog 16.55 g (0.167 mole). Yog li ntawd, qhov yuav tsum tau ntawm iMidazole yog suav raws li cov piv txwv ntawm phosgene los imidazole ntawm 1: 4. Tom qab ntawd, nruab lub funnel ntawm peb caj dab firask muaj 45.60g (0.669Mol) imidazole thiab 500ml anhydrous tetrahydrofuran. Tawg taws thiab electromagnetic stiring, poob lub daws benzene ntawm phosgene ntawm {16}} feeb. Txuas ntxiv sib xyaw rau 15 feeb, thiab cia sawv ntsug ntawm chav tsev kub rau 1 teev. Nyob rau hauv ib qho cua qhuav, tshem tawm imidazole hydrochloride nrog cov xuab zeb core funnel. Qhov filtrate yog concertrated rau dryness
Ceev faj! Phosgene yog tshuaj lom, thiab txoj haujlwm no yuav tsum tau nqa tawm hauv lub suab zoo hood.
Cim npe nrov: 1,1'-carbonyldiimidAnidAnidAmitAzole Next {3}}, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag