Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab lwm tus neeg ntawm 1-bromo-5 -97-6 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale loj siab zoo 1-bromo-5-fluoropentan Cas 407-97-6 Kev Muag Khoom ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pib cov ntaub ntawv rau MDM yog 1-bromo-5-Chojentane,1-bromo-5-fluoropentane, thiab 1h - indazole - 3-carboxylic acid mthyl ester. Molecular mis c5h10brf, cas 407-97-6. Kev lag luam muaj cov tshuaj lom neeg hauv tsev lossis kev lag luam uas tuaj yeem siv rau kev sib txuas ntawm MDM yuav muaj tshuaj lom. Kev siv cov khoom lag luam xws li reagents lossis cov kuab tshuaj yuav ua rau muaj cov tshuaj lom loj yog cov khoom tsis zoo. Cov khoom siv tshuaj ntsuab cog uas siv los ua kev haus luam yeeb uas tuaj yeem muaj cov tshuaj sib xyaw ua ke ntawm cov khoom siv los ntawm cov nroj tsuag tshiab thiab cov kuab tshuaj uas muaj peev xwm ua tau rau qee cov tshuaj tshwj xeeb. Nws kuj yog siv nyob rau hauv kev npaj cov pob txha nqus inibitors, tiv thaiv cov neeg sawv cev rau tib neeg AN1A adrenal recenors thiab lwm yam tshuaj hauv tshuaj txiag hluav taws xob. Ib qho ntxiv, raws li kev xaiv tshwj xeeb, 1-bromo-5-chloropentane tuaj yeem siv los ntxuav pyruvic acid.
Chratographic tej yam kev mob Chromatographic kem yog ib qho elastic quartz capillary sab uas tau txhaj 0.25x50mx0.3um; Cov kua ua kua nyob ruaj ruaj yog FFAP; Kab kub: 60℃c (3min), 10℃C / min, 200℃C (5min); Vaporization chamber kub yog 250℃c, ntes kub yog 250℃c; Tom qab cov cab kuj nkag mus (n2) nkag mus rau hauv kem, tus nqi txaus yog 0.6m / min, tus nqi ntws ntawm huab cua yog 300ML / min; Kev txhaj tshuaj ntim yog 0.1u1, thiab kev sib cais sib cais yog 60: 1.
|
Tshuaj Cov Qauv |
C5H10BRF |
|
Muaj pes tsawg leej |
168 |
|
Molecular hnyav |
169 |
|
m/z |
168 (100.0%), 170 (97.3%), 169 (5.4%), 171 (5.3%) |
|
Kev Ntsuam Xyuas |
C, 35,53; H, 5.96; Br, 47.27; F, 11.24 |
|
|
|
|
Ceev |
1.360 |
|
Kub taw tes |
162 Qib |
|
Rtecs tsis muaj. |
RZ9810000 |
|
Refronction Index |
1.4406 |
|
Kev Cia |
Kaw Hauv Qhuav, Chav Chav |
|
Puab |
Kua |
|
xim |
Tsis muaj kob |
|
Dej solubility |
Me ntsis soluble hauv dej. |
|
Cov lus qhia ua ntej |
P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
|
Cov khoom lag luam txaus ntshai tsis muaj. |
1993 |
|
Kev Nyab Xeeb Chav |
3 |
|
Ntim qeb |
I |
1-bromo-5-fluoropentane(CAS naj npawb: 407-97-6) yog ib txoj kev ncaj halogenated hydrocarbon uas muaj bromine thiab fluorine thiab fluorine thiab fluorine thiab zoo li cov kua tsis muaj kob.
Nyob rau hauv cov qauv molecular ntawm 1-bromo-5-Chroopentane, lub bromine atom thiab fluorine atom yog nyob ntawm ob qho kawg ntawm cov pa roj carbon saw (txoj hauj lwm 1 thiab txoj hauj lwm 5), feem. Qhov kev sib txawv no ua rau nws muaj kev cuam tshuam loj sib deev. Nws cov kev cuam tshuam yog qhov tseem ceeb ntawm cov hauv qab no:
1. Nucleophilic hloov cov kev tawm tsam
Bromine atoms, raws li cov pab pawg tsis muaj peev xwm ua rau lub ntsej muag nucleophilic xws li cov neeg siv roj ntsha xws li cov tshuaj tua kab mob fluorinary lossis fluorinated pentanol derivatives. Piv txwv li, cov fluoropentanamine tuaj yeem ua tau zoo los ntawm kev rov ua haujlwm ammonia, uas yog cov tshuaj tiv thaiv ua ntej rau cov tshuaj tiv thaiv yeeb tshuaj fluoxetine (prozac).
2. Coupling cov tshuaj tiv thaiv
Nyob rau hauv palladium catalysis, 1 - Bromo-5-ChroopiTane-comping Cylbborane acid, tsim CC Bonds thiab tsim cov fluoro-1-arylomentane-1-arylomentane-1-arylomentance. Hom khoom no muaj daim ntawv thov tus nqi hauv thaj teb ua kua crystal cov ntaub ntawv, thiab tuaj yeem ua kom zoo ua kom haum txoj haujlwm fluorine atoms.
3. Fluorine hloov cov nyhuv
Lub zog electronegativity ntawm fluorine atoms (3.98) muaj feem cuam tshuam nrog cov kev faib tawm hauv hluav taws xob (PKA}} 30) Cov xeeb ceem no yog qhov tshwj xeeb tshaj yog nyob rau hauv cov synthesis ntawm fluorine {}}} muaj lactones.
Nws yog tsuas yog siv los ua pob txha pob txha hauv cov tshuaj squthesis, thiab nws cov ntaub ntawv thov suav nrog:
1. Khoom cua ntawm cov tshuaj tiv thaiv kab mob
Pib txij 1-bromo-5-Chroopentaniturile yog tsim los ntawm Cyanide cov tshuaj tiv thaiv, thiab tom qab ntawd hydrolyzed kom tau 5-fluorovaleric acid. Tom qab txuas nrog aminothiazole, cov kua qaub no tuaj yeem siv los ua ke los synthesize nucleoside analog ua ntej rau kev txhim kho cov tshuaj tiv thaiv kabmob anti. Kev sim cov ntaub ntawv qhia tau tias cov lus qhia ntawm fluorinated ntu ua kom muaj cov tshuaj tiv thaiv cov tshuaj ntawm transcriptase los ntawm 2.3 zaug.
2. Intermedite ntawm anti - cov qog nqaij
Nyob rau hauv synthesis ntawm platinum raws anticancer siv tshuaj derivatives, thaum kawg fluorine ua haujlwm nrog lub peev xwm ntawm kev ua kom muaj peev xwm ntawm hydrogen. Kev sim ntawm tes tau pom tias hom derivative no txo cov IC50 tus nqi ntawm A549 Mob Kab Mob ntawm 40% piv rau Cisplatin.
3. Chiral Yeeb Tshuaj Synthesis
Los ntawm kev siv lub suab paj nruag ua rau cov tshuaj fluorine atoms, kev tsim cov chaw chairules tuaj yeem ua rau. Piv txwv li, los ntawm sharpless asymmetric epoxmidation kev tawm tsam, nws hloov pauv mus rau hauv chairal epoxides ntxiv rau kev kho mob ntawm Parkinson tus kab mob.
1. Cov khoom siv lead ua
Cov tshuaj fluorinated ntawm nws tuaj yeem txo cov rog sib xyaw thiab txhim kho cov lus teb ceev ntawm cov kua muaju. Qhia nws mus rau hauv Biphenyl ua kua Crystal Molecules tuaj yeem nce cov ntsiab lus kub ntawm 85 qib mus rau 102℃thaum ua kev tswj hwm nematic stability.
2. Kev ua haujlwm ntawm polymers
Raws li ib tug comonomer, nws tuaj yeem dhau mus Aom Hloov Hloov Radical Polymerization (ATRP) nrog STRYRENE los tsim fluorinated polystyrene. Lub zog saum npoo ntawm cov khoom no yog tsawg li 22 mn / m, uas tuaj yeem siv rau kev npaj ntawm tus kheej-}}}}}}}}}}}}}}}}}}} tu cov txheej txheej.
3. Ionic kua hloov ua kua
Los ntawm Quermization cov tshuaj tiv thaiv, nws tau hloov mus rau hauv cov tshuaj fluorinated imidazole kua. Hom ionic ionic no muaj kev tshaj tawm ntawm 15 ms / cm (25 degree) thiab tseem muaj kua ntawm {degree, ua rau nws haum rau tsawg-kub roj cell electrolytes.
Tshuaj tua kab thiab cov tshuaj tshwj xeeb
1. Fluorinated Tshuaj Tshuaj Nrog
1 - Bromo-5-Chroopentane tuaj yeem siv los ua ke Foolrones, thiab nws cov tshuab kev ua yog ua rau inhibit kab gamma aminobutyric ac receptors. Cov kev sim teb tau pom tias fluorine uas muaj cov fluorine nce lub tuag tuag ntawm cov tshuaj tua kab ntawm 78% mus rau 92%.
2. Surfactant
Cov tshuaj fluorinated segments xaus surfactants nrog hydrophobicity thiab oleophlicity. Cov tshuaj fluorocarbon surfactant synthesized nrog 1-bromo-5-m, uas tuaj yeem nce cov khoom siv hluav taws xob kom ntau tau los ntawm 30% thaum siv hluav taws ua npuas neeg sawv cev.
3. Cov kuab tshuaj tshwj xeeb
Nws cov viscosity qis (0.85 CP, 25 degree) thiab High boiling point (162 degree) ua 1-bromo-5-chomo-5-Chrooypentane tus neeg siv cov kuab tshuaj rau hauv hluav taws xob. Cov kev sim tau pom tias nws cov kev ua kom muaj zog rau silicon li 15% siab dua yog isopropanol, thiab cov seem yog tsawg dua 0.1 PPM.
1. Cov kev xaiv cheeb tsam
Hauv SN ₂ kev tawm tsam, lub tshuab hluav taws xob rho tawm ntawm cov fluorine atoms ua rau muaj kev them ib nrab, ua rau bromine atoms ntau dua kev tawm tsam los ntawm nucleophiles. Los ntawm kev kho cov kuab polarity (xws li hloov pauv ntawm methanol mus rau DMF), Regioselectivity tuaj yeem nce ntawm 65% mus rau 89%.
2. Catalytic cev kev txhim kho
Hauv kev sib txuas ua ke, lub PP (Pph α) ₄ / K α ₄ PO ₄ system tuaj yeem ua tiav cov txiaj ntsig sib txuas ntawm 92% ntawm 1-bromo-5-phenypobonic acid. Ntxiv 10 Mol% CUI ua catalalt tuaj yeem txuas ntxiv cov tshuaj tiv thaiv lub sijhawm rau 4 teev.
3. Tus Txheej Txheem Kev Nyab Xeeb
Txhim kho kev hloov pauv ntws rov qab los ua ke1-bromo-5-fluoropentaneNyob rau hauv teb rau qhov muaj txiaj ntsig zoo ntawm bromides. Los ntawm microchanannel tsim, kev nqus tau zoo ntawm hydrogen bromide tau nce mus rau 98%, thiab qhov tso pa tawm tau txo los ntawm 70% piv rau cov khoom sib xyaw ua ke.
5-fluoroamyl bromide, tseem hu ua 1-bromo-5-chroopentane, yog ib qho organic ntau yam uas tuaj yeem npaj los ntawm ntau cov kev sib txawv synthesis. Ntawm no yog ob txoj kev synthesis:
Txoj Kev 1: Haloalanane hloov cov tshuaj tiv thaiv catalyzed los ntawm alkali
Tshuaj Muaj Tshuaj:
Ch3(Ch2)3F + ch3(Ch2)3Br +2 naoh → Ch3(Ch2)3Br + ch3(Ch2)3F +2 h2o {{2} af
1. Npaj ib lub raj tshuaj tiv thaiv huv thiab ua kom ntseeg tau tias nws qhuav tag nrho. Ntxiv 5-fluoropentane thiab 1,5-dibromopentane hauv kev sib piv ntawm kev sib piv rau cov tshuaj tiv thaiv flask. Feem ntau, siv ntau dhau ntawm 1,5-dibromopentane tuaj yeem xaiv raws li cov reactant.
2. Ntxiv cov nyiaj tsim nyog ntawm alkali catalyst, xws li sodium hydroxide (Naoh) lossis potassium carbonate (k2Co las3), rau cov tshuaj tiv thaiv flask. Tus nqi ntawm catalyst tuaj yeem hloov kho raws li cov kev piv txwv ntawm cov reactants thiab cov tshuaj tiv thaiv.
3. Foob cov tshuaj tiv thaiv lub raj mis thiab ua kom sov rau qhov ntsuas kub. The reaction temperature is generally between 70-90 degrees Celsius, depending on the properties of the reactant and the catalyst used.
4. Lub sij hawm cov tshuaj tiv thaiv lub sijhawm nyob ntawm cov kev mob tshwj xeeb, thiab feem ntau yuav tsum muaj kev txuas ntxiv ntawm ob peb teev.
5. Tom qab cov tshuaj tiv thaiv tiav, txias lub raj mis tawm mus rau chav sov.
6. Cais thiab rho tawm cov tshuaj tiv thaiv sib xyaw. Feem ntau, organic volvents xws li dichhloromethane (Ch2Kwj Cl2) lossis ether (li2O) tuaj yeem siv los rho tawm cov khoom lag luam.
7. Tshem tawm cov dej thiab qhuav cov organic txheej, xws li siv anhydrous sodium chloride (NACL) rau noo noo nqus thiab lim kom tshem tawm cov khoom impurities.
8. Siv cov hau kev uas tsim nyog (xws li distillation, crystallization, thiab lwm yam) los ntxuav cov organic txheej thiab tau txais 1-bromo-5-Chomo-5-Chojentane.
Txoj Kev 2: Los ntawm reacting haloalkanes nrog lanthanum fluoride
Tshuaj Muaj Tshuaj:
Ch3(Ch2)3Br + leaf3Ch3(Ch2)3F + Labr3
1. Npaj ib lub raj tshuaj tiv thaiv huv thiab ua kom ntseeg tau tias nws qhuav tag nrho. Ntxiv 5-bromopentane thiab lilthhanum fluoride hauv cov nyiaj hniav hawb pob rau cov tshuaj tiv thaiv flask. Nquag, lanthanum fluoride nrog me ntsis siab dua cov piv zoo dua li theoretical cov kev sib piv tau tuaj yeem xaiv raws li cov reactant.
2. Foob cov tshuaj tiv thaiv lub raj mis thiab ua kom sov rau qhov ntsuas kub. Cov tshuaj tiv thaiv kub feem ntau yog nruab nrab ntawm 150-200 degrees Celsius, thiab cov lus kub tshwj xeeb yog nyob ntawm cov yam ntxwv ntawm cov reactant thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv thiab xaiv cov tshuaj tiv thaiv.
3. Lub sijhawm tshuaj tiv thaiv lub sijhawm nyob ntawm cov kev sim ua ntej, thiab feem ntau yuav tsum tau ua tas li ntawm ob peb teev.
4. Tom qab cov tshuaj tiv thaiv tiav, txias lub raj mis tawm mus rau chav sov.
5. Cais thiab rho tawm cov tshuaj tiv thaiv sib xyaw. Feem ntau, organic volvents xws li dichhloromethane (Ch2Kwj Cl2) lossis ether (li2O) tuaj yeem siv los rho tawm cov khoom lag luam.
6. Tshem tawm cov dej thiab qhuav cov organic txheej, xws li siv anhydrous sodium chloride (NACL) rau noo noo nqus thiab lim kom tshem tawm cov khoom impurities.
7. Thov kom cov txheej txheem organic siv cov hau kev tsim nyog xws li distillation, crystallization, thiab lwm yam kom tau txais 1-bromo-5-Chojentane.
Qhov no tsuas yog qhia luv luv rau ob txoj kev kuaj kab ke ntawm1-bromo-5-fluoropentaneCov. Yog xav paub cov ntaub ntawv ntxaws ntxaws lossis lwm cov qauv hluavtaws, thov tham sab laj cov kws tshaj lij lossis cov phau ntawv, lossis xa email rau peb. Peb yuav muaj cov kws ntsuam xyuas kev kuaj kab ke teb koj cov lus nug.
Cim npe nrov: 1-Bromo-5-Fluoropentan Cas 407-97-6, Cov chaw muag khoom, chaw tsim khoom, Hoobkas, yuav, nqe, loj, rau muag