2,5 {- dimethoxy - beta-nitrostyyreneyog ib qho uas muaj ntxhiab nitroalkene sib xyaw nrog cov tshuaj muaj kev cuam tshuam zoo thiab cov khoom siv lub cev tshwj xeeb. Nws cov qauv molecular nyob ib puag ncig ntawm lub nplhaib Benzene, nrog rau cov khoom me me, muab cov khoom siv hluav taws xob muaj zog, muab cov khoom siv hluav taws xob muaj zog, muab cov khoom siv hluav taws xob muaj zog, muab cov nyiaj siv hluav taws xob} Ib txhij, Nitro Group ({{{}} tsis muaj ib sab sib xyaw ua ke {}}} thim electrophilic ua haujlwm ua haujlwm pab pawg. Qhov no "thawb {{{{}}} rub tawm" cov khoom siv hluav taws xob uas tseem ceeb (xws li cov kab ke tseem ceeb rau kev tsim cov txiaj ntsig zoo ntawm cov khoom siv hauv nruab nrab (xws li cov khoom tseem ceeb ntawm kev tsim kho cov nitrogen {}}}}} muaj cov molecules (xws li Indoles, tetrahydroquinines, thiab lwm yam) thiab ua haujlwm phenethylamine derivatives. Qhov no sib xyaw no feem ntau yog nthuav tawm ua daj rau cov txiv kab ntxwv muaju lossis cov xim hmoov, thiab cov xim muaj zog, thiab cov khoom siv hluav taws xob muaj zog (ICT) kev hloov pauv. Ntxiv rau nws cov tub ntxhais lub luag haujlwm hauv cov cuab yeej ua haujlwm hauv cov yeeb tshuaj thiab cov kev ua haujlwm ntawm cov qauv tshuaj thiab cov kev ua haujlwm ntawm kev ua haujlwm thiab cov kev ua haujlwm tau zoo thiab xav tau ua raws li kev ceev faj thaum lub sijhawm ua haujlwm.
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Tshuaj Cov Qauv |
C10H11No4 |
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Muaj pes tsawg leej |
209.07 |
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Molecular hnyav |
209.20 |
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m/z |
209.07 (100.0%), 210.07 (10.8%) |
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Kev Ntsuam Xyuas |
C, 57.41; H, 5.30; N, 6.70; O, 30.59 |
Triazole Synthesis
Cov compound tau tshaj tawm tias yuav siv nyob rau hauv synthesis ntawm triazole - Raws bioactive molecules. Cov lwg me me no feem ntau ua cov haujlwm muaj roj ntsha xws li cov tshuaj tiv thaiv kab mob antimalrobial, antifungal, lossis anticancer lub zog.
Triazoles yog chav kawm ntawm tsib - Muab tswv yim heterocyclic cov xeeb ceem los ntawm lub xub ntiag ntawm peb nitrogen atoms hauv lawv lub nplhaib qauv. Cov tebchaw no tau txais cov xim tseem ceeb hauv ntau thaj teb vim lawv cov khoom siv muaj kuab lom thiab cov khoom siv roj lom.
Chemically, triazoles yog paub rau lawv cov kev ruaj khov thiab reactivity, uas ua rau lawv muaj txiaj ntsig hauv synthic synthesis. Lawv tuaj yeem ua tau zoo los ntawm Cyclodition cov kev cuam tshuam, xws li lub Hisonen 1,3 Dipolar Cycloditition (Feem ntau paub tias "Nyem Chemistry"), koom nrog Azides thiab Alkynes. Hom no tau ua tau zoo heev thiab regioselective, tso cai rau kev sib koom tes ntawm triazole mozieties rau hauv molecules.
Kev ua haujlwm biologically, triazoles ua rau muaj ntau yam kev ua si, suav nrog cov kev ua si, suav nrog cov antimicrobial, antifungal, thiab anticancer cov khoom. Ntau triazole - Raws cov tebchaw tau tsim ua cov tshuaj los kho kab mob thiab kab mob. Piv txwv li, qee cov triazoles yog siv los ua cov tshuaj antifungal hauv ob qho tib neeg thiab cov kws kho tsiaj, thaum lwm cov lus cog tseg ua tshuaj tiv thaiv kab mob celling tshwj xeeb.
Ntxiv rau lawv cov kev siv roj ntsha, triazoles kuj tau siv hauv cov ntaub ntawv kev tshawb fawb thiab agnemicals. Lawv lub peev xwm los ua cov hydrogen bonds thiab sib cuam tshuam nrog ntau substrates ua rau lawv pab tau nyob rau hauv kev tsim cov ntaub ntawv tshiab thiab tshuaj tua kab. Zuag qhia tag nrho, triazoles sawv cev rau cov chav kawm ntau yam ntawm cov tebchaw nrog cov peev xwm tseem ceeb hauv ntau thaj tsam tshawb fawb thiab kev txhim kho.
Triazoles tuaj yeem ua tau zoo los ntawm ntau txoj kev, nrog cyclodition cov kev coj ua yog ib qho ntawm feem ntau cov thiab ua tau zoo. Cov kev cuam tshuam no feem ntau koom nrog kev siv Azides thiab alkynes lossis nitriles, ua rau kev tsim ntawm 1,2,3-triazole rings.
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Cyclodition kev tawm tsam
Nyem Chemistry
Lub HUCUCKGAR 1,3-Dipolar Cycloditition, feem ntau yog hu ua "Nyem Chemistry," yog ib txoj kev muaj zog rau kev sib txuas triazesizes. Qhov tshuaj tiv thaiv no cuam tshuam nrog cyclodition ntawm ib azide, feem ntau catchalyzed los ntawm tooj liab (i) ntsev, los ua 1,2,3-triazole.
Cov tshuaj tiv thaiv me ntsis
- Cov tshuaj tiv thaiv tau los ntawm kev hais kwv txhiaj [{3+2] cycloaddition mechanism, qhov twg} dipole (1,3 {}
- Tus tooj liab (i) catalyst plays lub luag haujlwm tseem ceeb hauv kev ua kom nrawm dua ntawm 1,4-distigstituted 1,2,3-triazole cov khoom loj.
Kev ua tau zoo thiab xaiv
- Nyem Chemistry yog tus cwj pwm los ntawm nws cov kev ua tau zoo, feem ntau ua tiav kom tiav nyob rau hauv kev mob me me nrog kev phiv tshuaj me me.
- Cov tshuaj tiv thaiv yog regioselective heev, kom ntseeg tau tias cov khoom triazole yog tsim nrog ib qho tshwj xeeb regiochemistry, uas yog qhov tseem ceeb rau kev twv xyuas thiab tswj hwm cov khoom ntawm lub txiaj ntsig ntawm cov txiaj ntsig ntawm cov txiaj ntsig.
Versatility
- Humicen 1,3 {{- dipolar cyclodord tuaj yeem siv rau ntau yam kev sib tw thiab Alkynes, tso cai rau cov khoom siv sib txawv ntawm ntau haiv neeg.
- Cov versatility no ua rau nws muaj cov cuab yeej muaj txiaj ntsig hauv cov khoom siv hluav taws xob hauv nruab nrog cev, ua kom muaj kev sib txuam ntawm triazole maneties rau hauv cov txheej txheem molecular.
Cov Ntawv Thov
- Triazoles synthesized ntawm nias Chemistry Nrhiav cov ntawv thov hauv ntau daim teb hauv ntau thaj teb, suav nrog cov tshuaj, agnaphys, thiab cov ntaub ntawv science.
- Lawv raug siv los ua cov qauv siv tshuaj nolecules, cov khoom siv tshuaj yeeb, thiab cov ntaub ntawv ua haujlwm vim yog lawv cov khoom siv ua haujlwm ruaj khov, thiab muaj peev xwm los tsim cov ntawv hydrogen.
Azide {{0} ecyne cyclodate (CUAAC)
Lub CuaaC cov tshuaj tiv thaiv tau zoo heev thiab regioselective, ua rau nws ib txoj kev nyiam rau triazole synthesis. Nws tau nyhav nyob rau hauv cov mob me thiab tiv thaiv ntau pawg ua haujlwm, tso cai rau kev sib txuam ntawm triazole molecules.
Siab efficiency
Lub CUAC cov tshuaj tiv thaiv feem ntau coj tau sai thiab kom ua tiav, txawm tias ntawm cov tshuaj ntsuab tsawg ntawm reactants. Qhov kev ua tau zoo no yog ntaus nqi rau lub luag hauj lwm catalytic (i)
Regioselectivity
Cov tshuaj tiv thaiv yog cov regiosTawm heev, feem ntau yielding 1,4 -}}} dis dis dis dis dis omomzole isomer. Qhov no regioselectivity yog qhov tseem ceeb rau kev twv xyuas thiab tswj tau cov khoom ntawm qhov tshwm sim triazules, ua kom muaj txiaj ntsig, ua kom muaj txiaj ntsig zoo hauv cov txiaj ntsig zoo.
Cov tshuaj tiv thaiv me me
Cov tshuaj tiv thaiv ntawm CUAAC tuaj yeem nqa tawm hauv qab cov mob me, feem ntau nyob rau hauv chav sov thiab muaj cov kuab tshuaj aqueous lossis organic cov kuab tshuaj nrog cov tshuaj lom tsawg. Cov mob me me ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev tsis txaus siab thiab kev tsis txaus siab ntawm cov pab pawg ua haujlwm rhiab, ua rau cov tshuaj tiv thaiv haum rau ntau yam ntawm cov substrates.
Ua haum pab pawg pab pawg
Ib qho ntawm qhov tseem ceeb tshaj plaws ntawm cov kev tshuaj tiv thaiv kab mob cua ci yog nws kev ua siab ntev rau ntau haiv neeg ua haujlwm. Qhov kev tiv thaiv no tso cai rau kev sib koom tes ntawm triazole moziole uas tsis muaj kev tiv thaiv cov txheej txheem hluavtaws thiab nce nws cov versatility.
2,5 {- dimethoxy - beta-nitrostyyrene, nrog nws cov kev sib tw ua ke, tuaj yeem koom nrog Cyclodition cov kev cuam tshuam nrog tsim triazole objole {}}} muaj cov lwg me. Lub tshuab hluav taws xob - tshem tawm cov pab pawg nitro txuas nrog nws cov kev sib koom tes ua ke, ua rau nws tus khub tsim nyog hauv cov kev tiv thaiv no.
Kev sib koom tes
Kev ua hauj lwm
Ob daim ntawv cog lus ob zaug hauv2,5 {- dimethoxy - beta-nitrostyyrenetuaj yeem ua haujlwm los ntawm cyclodition cov kev cai nrog Azides, ua rau kev tsim ntawm triazole rings. Qhov no tso cai rau kev qhia ntawm Triazole Mozeries rau hauv cov lwg me me, muaj feem hloov nws lub cev thiab tshuaj siv tshuaj.
Ntau haiv neeg nyob rau hauv triazole synthesis
Los ntawm kev sib txawv ntawm Azide lossis Alkyne tus khub hauv cyclodition cov kev tshuaj tiv thaiv, ntau ntau yam ntawm triazole ntau ntawm triazole ntau ntawm triazole ntau {} muaj cov lwg me me tuaj yeem ua ke. Qhov kev sib txawv no yog qhov tseem ceeb rau kev tshawb nrhiav tus qauv-}} Cov lus sib txuas lus thiab txheeb xyuas cov kev txhim kho tshiab lossis kev txhim kho kev muaj tswv yim.
Cov synthesis ntawm triazoles los ntawm cyclodition cov kev cai, koom nrog Azides thiab alkynes lossis nitriles, yog ib txoj kev muaj zog thiab ntau yam hauv cov organic.2,5 {- dimethoxy - beta-nitrostyyrene, nrog nws cov kev sib tw sib xyaw, tuaj yeem ua lub luag haujlwm tseem ceeb hauv cov synthesis, tso cai rau kev sib koom tes ntawm triazole molecules. Lub resulting triazole -} muaj cov kev siv hauv cov tshuaj, agnchemicals, ua rau lawv muaj kev tshawb fawb tseem ceeb ntawm kev tshawb fawb thiab kev txhim kho.
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Kev tshawb nrhiav cov reagent
Lub zog tshwj xeeb ua rau nws muaj txiaj ntsig kev ntsuas kev ntsuas hauv tshuaj ntsuam xyuas. Nws cov kev cuam tshuam, UV {{{- Kev ua kom muaj kev nqus, thiab cov yam ntxwv solubility cia nws siv nyob rau hauv ntau cov txheej txheem kev xaiv, txhim kho ntawm cov hau kev no. Xws li, nws ua lub luag haujlwm tseem ceeb hauv kev txheeb xyuas qhov tseeb thiab kev pom tseeb ntawm cov tebchaw thiab kev siv khoom lag luam.
Tshuaj lom neeg muaj feem rau kev siv tshuaj ntsuam
Kev xav tau
Lub compound ob daim ntawv cog lus, cuam tshuam los ntawm hluav taws xob -}} tshem tawm cov pab pawg nitro, kev ua kom pom kev zoo siab. Qhov kev cuam tshuam no tso cai rau nws koom nrog ntau yam tshuaj lom neeg uas tuaj yeem siv tau rau cov hom phiaj ntsuas.
UV {-} vis kev nqus
Tej zaum nws yuav muaj tus yam ntxwv UV -}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} ill tsim nyog rau kev tsom xam spectrophotometric.
So
Nws solubility nyob rau hauv ntau cov kuab tshuaj tuaj yeem ua tau zoo rau cov kev sib txawv ntawm cov kev daws teeb meem thiab tuav hauv chav kuaj.
Kev Ntsuam Xyuas Cov Ntxhi
Spectrophotometry
Qhov sib xyaw ua UV {-}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} other react or້ນ react or lossis lwm qhov sib txuas uas muaj kev hloov pauv nrog nws, ua rau kev hloov pauv ntawm kev nqus tau.
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Osromroography
Hauv kem chromatography los yog nyias - txheej txheem chromatography, nws tuaj yeem siv los ua tus neeg sawv cev ntawm tes los yog ua tus neeg sawv cev ntawm kev sib cais thiab nrhiav kom kuaj xyuas.
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Cov tshuaj tiv thaiv -} raws tshuaj ntsuam
Vim nws cov kev cuam tshuam, nws tuaj yeem siv rau hauv cov tshuaj tiv thaiv - raws cov hau kev ntsuas. Piv txwv li, nws yuav raug siv rau hauv cov xim fluorimetric lossis fluorimetric lossis fluorimetric uas muaj kev hloov hauv cov xim lossis fluorescence qhia muaj lossis concentration ntawm ib qho kev sib txuas tshwj xeeb.
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Ua dab tsi tsom xam |
Cov compound tuaj yeem ua ke nrog lwm cov txuj ci ntsuas xws li kev xaiv fluorroscopy los muab kev xaiv ua kom zoo dua thiab cov kev ntsuas ntawm kev tsom xam cov qauv.
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Cov txiaj ntsig zoo hauv kev ntsuas analytical
RabELLIALS
Cov tshuaj lom tshwj xeeb tuaj yeem txhim kho kev xaiv ntawm cov txheej txheem kev txheeb xyuas cov hau kev, tso cai rau kev txheeb xyuas raug thiab ntau qhov sib txuas lus sib txuas lus hauv kev cuam tshuam nrog lwm yam kev cuam tshuam.
Kev hnov tau
Qhov sib xyaw ua ke; UV {{-}}}}}}}}}}}}}}}}}}}}} }မalyalyTICAL TSWV YIM, ua rau cov tshuaj ntsuam qis ntawm cov analytes.
Versatility
Nws siv nyob rau hauv ntau hom kev qhia tawm tsam ua rau nws muaj ntau yam reagent hauv kev tsom ntsuas tshuaj lom neeg.
Qhov sib xyaw rau cov versatility txuas rau nws cov ntawv thov hauv ntau yam kev lag luam. Nws yog siv ntau yam tshuaj lom neeg siv tshuaj yeeb, tshuaj, dyes thiab pigments, plastics / polymers, thiab cov nplaum sib xyaw / cov tshuaj nplaum. Nyob rau hauv cov chaw ua hauj lwm kws tshuaj, nws tau qhia cov lus cog tseg uas ua tau zoo nyob rau hauv synthesis ntawm tyrosine-}}}}}}}}}}} }ase {}}}}}}}}} aidase {}}}}}}}}} aidase {}}}}}}}} aidase {}}}}}}}} ishase inibitors thiab AIDS cov tshuaj tua kab.
Kev Tshawb Fawb Ntxiv mus txuas ntxiv mus tshawb cov txheej txheem tshiab thiab cov ntawv thov rau2,5 {- dimethoxy - beta-nitrostyyreneCov. Nws cov siab reactivity thiab muaj peev xwm rau cov kev hloov tsheb ntau yam ua rau nws muaj txiaj ntsig zoo hauv cov organic. Raws li kev tshawb fawb loj zuj zus, nws yog qhov yuav zoo li cov ntawv thov tshiab thiab cov tswv yim hluavtaws yuav raug nrhiav pom, txuas ntxiv nthuav nws cov nqi hluav taws xob hauv ntau thaj teb.
Cim npe nrov: 2,5 {- dimethoxy- beta-nitrostyerure Cas 40276-11-7, Chaw tsim khoom, chaw tsim khoom, yuav khoom, loj, rau muag