Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov khoom lag luam ntawm 2-cyclohexen-1-ib qho 930-68-7 hauv Suav teb. Txais tos rau kev lag luam wholesale ntau yam zoo 2-cyclohexen-1-ib qho 1330-68-7 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
2-cyclohexen-1-ibyog cov organic sib xyaw nrog cov tshuaj noj C₆h₈o, cais raws li ib, {-}}}}}}}}}}} Tsis muaj Cyclic Ketone. Kev Tsim qauv, nws nta rau - Muab tswv yim cyclohexene nplhaib nrog Ketone ua haujlwm nrog Ketone ua haujlwm thiab ib tus khub thib ob (C}} C) thiab thib peb carbons. Cov conjugation no cuam tshuam cov kev cuam tshuam tshwj xeeb, ua rau nws muaj feem cuam tshuam ntau hauv cov xwm txheej organic.
Lub cev, nws zoo li tsis muaj xim rau cov kua daj daj nrog cov yam ntxwv tsw phem. Nws yog ib nrab soluble hauv dej tab sis ntau soluble hauv cov kuab tshuaj yeeb zoo ib yam li ethanol lossis ether. Qhov sib xyaw ua ke yog nkag siab txog huab cua thiab lub teeb, tsim nyog ua tib zoo khaws cia hauv qab cov kev mob kom tiv thaiv kev ua tsis taus kev ua kom tsis txhob muaj kev txwv tsis pub muaj kev cuam tshuam.
Chemically, nws reasive ob pab pawg thiab carbon Cov khoom no ua rau nws muaj txiaj ntsig zoo hauv synthesizing kws tshuaj, agnchemicals, thiab cov ntxhiab. Piv txwv li, nws ua haujlwm ua ntej ua ntej hauv kev tsim cov carvone, terpene siv nyob rau hauv fliaings thiab naj hoom.
Thaum tsis siv dav siv los ua ib qho khoom siv sib cais, nws ua lub tuam txhab kev tsim kho lossis cov txheej txheem kev cuam tshuam thiab cov versatility.
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Tshuaj Cov Qauv |
C6H8O |
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Muaj pes tsawg leej |
96.06 |
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Molecular hnyav |
96.13 |
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m/z |
96.06 (100.0%), 97.06 (6.5%) |
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Kev Ntsuam Xyuas |
C, 74.97; H, 8.39; O, 16.64 |
Kws Tshuaj Kho Mob
2-cyclohexen-1-ibUa hauj lwm ua qhov tseem ceeb hauv nruab nrab nyob rau hauv synthesis ntawm steroid compounds. Cov tshuaj steroids yog siv dav hauv lawv cov tshuaj rau lawv anti-} pahunpressive, thiab lwm yam kev kho mob.
Steroids yog chav kawm ntawm cov organic cov xeeb ntxwv uas muaj los ntawm cov kab mob carbon monoxenton muaj plaub lub nplhaib (peb rau {{{{1} {{tus thawj nplhaib). Lawv siv dav hauv lawv cov tshuaj rau lawv anti -} pa, thiab lwm yam cuam tshuam kho mob. Cov synthesis ntawm cov tshuaj steroids feem ntau koom nrog cov kev tsim kho no lub system nplhaib, thiab nws ua lub luag haujlwm tseem ceeb hauv cov txheej txheem no.
Pib Cov Khoom Siv: Ua raws li kev pib cov khoom pib rau cov synthesis ntawm cov tshuaj steroids. Nws, {-}} Cov pab pawg carbonyL tuaj yeem hloov kho cov pab pawg ua haujlwm tau yooj yim los qhia txog cov khoom siv hluav taws xob tsim nyog los qhia txog cov pob txha steroidon.
Lub nplhaib siv: Ib qho ntawm cov kauj ruam tseem ceeb hauv steroid synthesis yog kev tsim ntawm fused nplhaib system. Nws tuaj yeem siv los ua tus - paim nplhaib ntawm cov tshuaj steroids los ntawm cov kev sib tw, suav nrog kev sib deev thiab kev sib tw. Piv txwv li, nws tuaj yeem yauv ua diels - cov khoom siv dienophile, uas tuaj yeem hloov kho hauv plab me me los ua cov steroid skeleton.
Ua haujlwm pab pawg qhia: Cov pab pawg carbonyL tuaj yeem txo mus rau ib qho dej cawv, oxidized rau carboxylic acid, lossis hloov mus rau lwm pab pawg xws li amines lossis ntau. Cov kev hloov pauv no yog qhov tseem ceeb rau kev sib txuas ntawm cov tshuaj steroids tshwj xeeb nrog cov khoom siv roj ntsha.
Synthesis ntawm progesterone: Progesterone yog lub ntuj steroid tshuaj nrog lub zog tseem ceeb ntawm lub cev. Nws tuaj yeem ua ke los ntawm ntau -}}}}}}}}}}}}}}}}}}}}}}} ring function functionမ introductionမ introduction groupမ်းက function group Proup Taw Qhia, Thiab Saleocontrol. Kev siv tso cai rau kev tsim kho kom zoo ntawm lub cev muaj zog ntawm cov pob txha uas muaj tseeb nrog cov kev ua haujlwm raug.
Synthesis ntawm corticosteroids: Corticosteroids yog chav kawm ntawm cov tshuaj steroids nrog anti {{o {o {otion} kev cuam tshuam thiab immunosuppressive cuam tshuam. Lawv tau siv dav hauv cov tshuaj los saib ntau yam mob xws li hawb pob, mob caj dab, thiab cov kab mob tawv nqaij. Cov synthesis ntawm corticosteroids feem ntau koom nrog qhov tseem ceeb hauv nruab nrab los tsim lub pob txha taub hau thiab qhia cov haujlwm tsim nyog rau kev ua haujlwm lom neeg.
Nws yog siv nyob rau hauv kev tsim cov tshuaj, suav nrog anti - Cov sawv cev zoo li cov carprofen. Qhov sib xyaw ua ke reassonity, tshwj xeeb yog nws, {{{{}}}}}} Txoj kev hloov pauv carborations uas tsis muaj kev sib hloov hauv cov tshuaj.
Cov ntawv thov tshuaj
- Anti {-} Cov neeg sawv cev: Ua raws li qhov tseem ceeb hauv nruab nrab hauv cov synthesis ntawm anti - pa cov tshuaj xws li carprofen. Carprofen yog qhov tsis- steroidal anti {}}} qhov mob thiab mob hauv cov tsiaj, tshwj xeeb dev.
- Ntau yam Nruab Nrab: Qhov sib xyaw ua ke, {-} Txoj cai carborony tsis tau lees paub, suav nrog Michael ntxiv, thiab diels {1} {alder kev tshua. Cov kev tawm tsam no yog qhov tseem ceeb rau cov khoom siv hluav taws xob ntawm cov yeeb tshuaj molecules nrog cov kev ua ub no.
Tshuaj lom neeg cov khoom lag luam thiab ua kom muaj zog
- , {-}} cov qauv carboryl: Cov qauv tshwj xeeb no cuam tshuam rau nws, ua rau tus neeg sib tw zoo tshaj plaws rau ntau yam hluavtaws hluavtaws zoo. Lub tshuab hluav taws xob - txom nyem carbon-} Cov pab pawg carbon
- So: Nws yog soluble nyob rau hauv ntau cov kuab tshuaj organic, suav nrog kev haus dej caw, yog neeg muaj kev nyab xeeb, Esters, thiab Haloalkanes. Cov solubility no txhim kho nws cov versatility hauv cov khoom siv tawm tswv yim thiab tshuaj siv tshuaj yeeb.
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Organic Synthesis
Michael ntxiv cov tshuaj tiv thaiv
Raws li ib tug raug, -} Tsis muaj carbonyl compound, nws undergoes Michael ntxiv nrog ntau nucleophiles. Qhov kev cuam tshuam no tau siv nyob rau hauv cov synthesis ntawm cov organic molecules.
Diels -} Txoj Kev Sib
Nws tuaj yeem ua raws li Dienophile hauv Diels - Cov khoom siv muaj zog rau kev tsim kho ntawm rau- Cov nplhaib tswv cuab hauv cov synthic synthesis.
Lwm yam kev tawm tsam
Qhov compound carbonyl thiab alkene ua haujlwm ua kom nws koom nrog ntau yam ntawm lwm cov olieticase, xws li 1,2- thiab 1,4-ntxiv, txo, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations, thiab oxidations.
Mechanism ntawm Michael ntxiv
Nucleophilic nres
Michael ntxiv cov kev cuam tshuam nrog lub nucleophilic nres ntawm lub nucleophile (xws li lub ntsej muag ci ntsa iab, cais ionbon ntawm lub, {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Cov carbonyyl system. Qhov kev tawm tsam no ua rau kev tsim cov carbon monoxide tshiab {}}} daim carbon bond.
Kev Hloov Chaw
Ua raws li Nucleophilic nres, qhov kev hloov proton muaj tshwm sim, ua rau muaj kev tsim cov ruaj khov sib cav. Qhov nruab nrab no tuaj yeem ua rau protonated rau cov zaub mov zoo kawg nkaus ntxiv.
2-cyclohexen-1-ib li dienophile
Tus qauv thiab kev siv ua
Nws, {-}} Cov qauv carboryl ua rau nws lub tshuab hluav taws xob ua rau nws lub tshuab hluav taws xob, uas yog reashly in diess- kev tawm tsam. CarboryL pab pawg tsis tsuas yog nce cov hluav taws xob tsis txaus ntawm tus alkene tab sis kuj muab ib lub vev xaib rau kev ua haujlwm ntxiv tom qab cyclodord.
Regioselectivity thiab kev ua yeeb yam
Cov tshuaj tiv thaiv nrog txoj kev diene tuaj yeem txuas nrog siab regioselectivity thiab seroselectivity, ua rau kev tsim ntawm ib qho khoom lag luam loj lossis kev sib xyaw ua ntej ntawm isomers. Qhov kev xaiv no yog qhov tseem ceeb nyob rau hauv synthesis ntawm cov qauv molecules nrog cov kev pab txhawb kev tshwj xeeb.
Kev Tsim Ntau Lawm
Lub catalytic oxidation ntawm cyclohexene los tsim nws cuam tshuam nrog kev siv cov oxidant, feem ntau hydrogen peroxide, nyob rau hauv muaj ntawm catalyst. Vanadium {{1 {}}} Raws li cov tebchaw, xws li vanadium pentoxide (v₂o₅), yog feem ntau siv los ua kev muaj peev xwm los pab txhawb cov tshuaj tiv thaiv oxidation raws li cov mob me.
◆ Cov kev tshawb fawb thiab kev txhim kho keeb kwm2-cyclohexen-1-ibyog rooted nyob rau hauv nws qhov tseem ceeb raws li ib tug organic synthesis nruab nrab. Nws kev tsim khoom lag luam feem ntau cuam tshuam nrog catalytic oxidation ntawm cyclohexene, tshwj xeeb siv Vanadium catalysts nrog hydrogen peroxide. Cov txheej txheem no hais txog qhov sib xyaw ua haujlwm hauv cov loj-} teev tshuaj ntsuam.
◆ Hauv chav kuaj, nws tuaj yeem suav ua ke los ntawm ntau txoj kev. Ib txoj hauv kev cuam tshuam txog cov hydrolysis ntawm 3-pawg neeg-2-cyclohexen-1-ol, uas tau muab los ntawm cyclohexanedione, enol ether kev tsim, thiab txo qis. Lwm txoj hauv kev pib los ntawm kev ua haujlwm, tab begch txo ua raws li los ntawm Isomerization. Cov kev hluavtaws no underscore cov compound cov nqi hluav taws xob hauv kev tshawb fawb thiab kev kawm txuj ci.
Reacturity yog tus cwj pwm los ntawm nws lub tshuab hluav taws xob {{}}} cov tub rog tsis zoo, -}}} Cov carbonyl compound. Nws tuaj yeem yauv ntau yam kev tawm tsam, suav nrog kev sib ntxiv nrog cov organic tooj liab nucleophiles, Michael ntxiv nrog enol seepes, thiab phosphonium silylation. Cov kev tawm tsam no ua rau pom cov versatility rau hauv cov khoom siv tawm tswv yim, qhov twg nws ua haujlwm ua lub tsev thaiv kev ua kom lwg metending.
◆ Cov ntawv tso cai sib xyaw ua ke txuas ntxiv tshaj cov xwm txheej hauv nruab hnub. Nws yog siv nyob rau hauv kev tsim cov nylon, raws li cov tshuaj tiv thaiv hluavtaws me me, thiab raws li cov kuab tshuaj. Nws cov kev cuam tshuam thiab cov khoom siv ua kom haum rau nws haum rau cov haujlwm ntau haiv neeg no.
Xyoo dhau los, kev tshawb fawb txog 2-cyclohexen-1-ib qho tau tsom rau kev txhim kho nws cov kev hloov pauv hluavtaws, thiab nthuav nws cov ntawv thov hauv ntau yam kev lag luam. Qhov kev sib xyaw ua ke tseem ceeb hauv cov synthic thiab nws lub peev xwm rau kev txhim kho ntxiv mus txuas ntxiv tsav cov kev tshawb fawb.
Cov Ntaub Ntawv Siv Khoom Siv
Synthesis ntawm steroids thiab cov tshuaj hormones
2-cyclohexen-1-ib ua haujlwm ua ntu zus tseem ceeb hauv kev tsim cov corticosteroids thiab poj niam txiv neej tshuaj hormones. Piv txwv li:
Cortisone synthesis: lub enone undergoes diels - cov kev txwv tsw zoo} Ib qho kev kawm 2023 los ntawm Pfizer pom tias siv 2-cyclohexen-1-ib cov khoom siv hluav taws xob los ntawm 30% piv rau cov qauv ib txwm muaj.
Progesterone derivatives: Michael ntxiv ntawm nucleophiles (piv txwv li, amines) rau} roj av ntawm 2-cields}
Anticancer Cov Neeg Sawv Cev
Derivatives ntawm 2-cyclohexen-1-ib qho khoom tso tawm cov kev ua kom muaj zog tiv thaiv kev ua haujlwm. Piv txwv li:
Cov neeg sau se hauv nruab nrab: Lub enone yog alkylated los tsim cov tseem ceeb ua ntej hauv synthesis ntawm paclita ®), tshuaj siv tshuaj se. Ib qho 2024 patent (US20240156789A1) Cov lus qhia txog kev siv pallalytic txoj kev siv palladium nanoparticles los txhim kho cov paib.
Sab saum toj-eeperase Internoisomerors: 3-bromo-2-cyclohexen-1-ib qho derivatives cuam tshuam DNA ua tus mob qog nqaij hlav cancer. Kev sim khomob (Ntu II, 2023) tau qhia txog 45% tus nqi teb nyob rau hauv cov neeg mob rau zes qe menyuam.
Antiepileptic thiab Neerological Yeeb Tshuaj
Amine derivatives ntawm 2-cyclohexen-1-ib, xws li 3-amino-2-cyclohexen-1-ib, ua li Gaba receptor modulators. Piv txwv li:
Levetiracacetam analogues: synthesized los ntawm reductive amination ntawm cov enone, cov tebchaw txo cov qauv tshuaj (cov neeg siv tshuaj kho mob tshuaj, 2023).
Parkinson tus kab mob: Nitro derivatives (piv txwv li, 4 {{{5-cyclohexen-1-cyclohexen-1-cyclohexen-1-cyclohexen-1-cyclohexen-1-cyclohexen-1-cyclohexen-1-cyclohexen-1-codro-}
Cim npe nrov: 2-Cyclohexen-1-Ib Li Ib Li 930-68-7, cov neeg muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, loj, rau muag