2-Amino-6-bromopyridine CAS 19798-81-3

2-Amino-6-bromopyridineQhia txog tus nqi tshwj xeeb tshaj li cov organic synthesis: lub intramolecular N-H...N hydrogen daim ntawv cog lus ua ib tug pseudo-rau- lub nplhaib sib koom ua ke, ua rau muaj kev cuam tshuam rau kev faib tawm thiab kev vibration spectrum ntawm cov molecule, uas ua rau muaj kev hloov pauv hauv lub xeev tshwj xeeb. Qhov no ua rau nws yog ib qho qauv sib xyaw rau kev kawm intramolecular hydrogen bond dynamics. Hauv kev sib koom ua ke chemistry, cov molecule no yog atypical "claw- zoo li" precursor, qhov twg cov amino pawg thiab bromine atom tuaj yeem koom tes nrog lub chaw hlau los tsim cov chelate distorted. Cov complexes nthuav tawm unconventional regioselectivity nyob rau hauv catalyzing C-X daim ntawv cog lus ua kom. Nyob rau hauv xyoo tas los no, nws tau siv rau hauv cov ntaub ntawv tshawb fawb los tsim cov fluorescent pawg nrog kev zoo siab -lub xeev intramolecular proton hloov cov teebmeem. Lub bromine atom tso cai rau kev tswj hwm ntawm cov luminescence zog los ntawm kev sib txuas lus, thaum cov amino pawg muab qhov chaw rau kev tsim hydrogen -bonded organic moj khaum, tsim cov ntaub ntawv crystalline nrog anisotropic proton conduction muaj peev xwm. Tsis tas li ntawd, nyob rau hauv thaj tsam ntawm nonlinear optics, nws cov molecular asymmetry thiab polarity ua rau nws muaj peev xwm ua lub tsev thaiv rau kev npaj cov organic thib ob- xaj cov khoom siv kho qhov muag uas tsis yog linear. Los ntawm kev ua haujlwm ntawm bromine atom, supermolecular polarization tuaj yeem ua tiav. Cov tshuaj no kuj tseem siv tau los ua ob qho -labeling carrier nyob rau hauv isotope labeling kev tshawb fawb, siv bromine atom thiab amino pawg los qhia cov xov tooj cua lossis cov isotopes ruaj khov raws li kev taug qab txoj hauv kev lom zem hloov pauv. Cov ntawv thov tsis zoo no qhia txog nws lub peev xwm ua ntau lub platform, deb tshaj nws cov kev nkag siab ib txwm ua raws li cov khoom sib txuas nruab nrab.

2-Amino-6-bromopyridine, tseem hu ua Aminobromopyridine los yog 6-bromo-2-pyridinamine, yog ib qho tshuaj tseem ceeb hauv cov pyridine derivatives, tus cwj pwm los ntawm nws cov mis molecular C5H6BrN2 thiab molecular hnyav ntawm 174.018. Cov tshuaj no muaj nyob rau hauv qhov ntiav ntiav daj rau lub teeb xim av hmoov nyob rau hauv chav tsev kub thiab siab, muaj ib tug melting point ntawm 88-93 degree.

Hauv thaj chaw ntawm kev siv tshuaj sib txuas, nws tau pom cov ntaub ntawv siv tau, tshwj xeeb tshaj yog nyob rau hauv kev sib xyaw ntawm cov tshuaj tiv thaiv -HIV. Nws ua hauj lwm ua ib qho tseem ceeb nruab nrab ntawm cov organic thiab tshuaj chemistry, ua kom muaj kev tsim cov khoom tawg yooj yim tseem ceeb rau cov tshuaj tiv thaiv kab mob. Ib qho piv txwv tseem ceeb yog nws lub luag haujlwm hauv kev sib txuas ntawm 7-azaindole, ib ntu uas muaj nyob hauv cov tshuaj tiv thaiv HIV. Qhov kev pab cuam no qhia txog nws qhov tseem ceeb hauv kev txhim kho kev kho mob txhawm rau tiv thaiv HIV.

Ntxiv mus, nws nthuav tawm cov solubility nyob rau hauv polar organic solvents xws li N, N-dimethylformamide tab sis qhia tsis zoo solubility nyob rau hauv non{1}}polar solvents xws li chloroform thiab dichloromethane, thiab yog insoluble nyob rau hauv dej. Cov khoom no pab txhawb nws txoj kev siv hauv cov txheej txheem hluavtaws tshwj xeeb uas tswj kev solubility yog qhov tseem ceeb.

Kev koom ua ke ntawm2-Amino-6-bromopyridinehauv kev tiv thaiv -HIV tshuaj synthesis tsis yog tsuas yog nthuav dav ntau yam ntawm cov kev xaiv kho mob tab sis kuj tseem qhia txog qhov muaj ntau yam ntawm pyridine derivatives hauv tshuaj chemistry. Los ntawm kev ua kom muaj cov tshuaj tiv thaiv kab mob muaj zog, qhov sib xyaw no ua rau muaj kev nce qib hauv kev kho mob HIV, muab kev cia siab rau cov neeg mob thoob ntiaj teb. Hauv cov ntsiab lus, nws qhov kev siv tau zoo hauv kev sib txuas cov tshuaj tiv thaiv -HIV qhia txog nws lub luag haujlwm tseem ceeb hauv kev lag luam tshuaj, ua kom pom nws tus nqi hauv kev daws teeb meem kev noj qab haus huv tseem ceeb.

 

 

Chemical Properties thiab Potential Hazards

2-amino-6-bromopyridineyog nitrogen-muaj cov tshuaj heterocyclic nrog cov mis molecular C₅H₅BrN₂ thiab molecular hnyav ntawm 174.018. Nyob rau hauv chav tsev kub, nws yog ib lub teeb daj rau lub teeb xim av hmoov nrog lub melting point ntawm 88 -91℃thiab ib tug boiling point ntawm 273 degree. Cov amino pawg (-NH₂) thiab bromine atom (-Br) nyob rau hauv nws cov qauv tshuaj endowed nrog reactivity, thiab nws yuav koom nyob rau hauv oxidation, txo los yog hloov cov tshuaj tiv thaiv. Cov khoom no ua rau muaj kev phom sij me ntsis rau lub cev dej. Nws raug txwv nruj kom tso nws mus rau hauv ib puag ncig yam tsis tau tso cai. Cov khib nyiab yuav tsum tau kho raws li cov txheej txheem rau cov tshuaj phem.

Environmental Risk Assessment

 

Kev phom sij ntawm cov dej

Cov tshuaj no muaj tshuaj lom me ntsis rau cov kab mob hauv dej thiab tuaj yeem cuam tshuam kev sib npaug ntawm cov dej hauv lub cev. Yog tias tso tawm yam tsis muaj kev kho mob, nws tuaj yeem ua paug rau cov dej ntws, pas dej lossis dej hauv av.

Av muaj kuab paug

Cov dej ntws los yog kev pov tseg tsis raug yuav ua rau cov khoom seem hauv av, cuam tshuam rau kev ua haujlwm microbial lossis kev loj hlob ntawm cov nroj tsuag. Nws yuav tsum tau kho raws li cov qauv rau cov pov tseg phom sij thiab yuav tsum tsis txhob muab pov tseg los yog muab pov tseg ntawm qhov xav tau.

Ecotoxicity

Tsis muaj cov ntaub ntawv ntxaws ntxaws ecotoxicity, tab sis raws li cov organic synthesis nruab nrab, nws siv thiab tso tawm yuav tsum tau tswj nruj me ntsis kom tsis txhob muaj kev sib txuam los ntawm cov khoom noj khoom haus.

 

 

Kev Tswj Xyuas Kev Cia thiab Khib Nyiab

Cia tej yam kev mob

Khaws rau hauv ib lub thawv ntim rau hauv qhov chaw txias thiab qhuav, kom deb ntawm qhov chaw ntub dej kom tiv thaiv kom tsis txhob ya raws thiab nqus.

Qhov ntsuas kub tau pom zoo yog chav tsev kub (20-25 degree), thiab nws yuav tsum tau ceev kom deb ntawm cov kua qaub, muaj zog alkalis lossis oxidants.

Cov thawv ntim khoom yuav tsum tau cim nrog lub npe ntawm cov tshuaj, CAS naj npawb (19798-81-3) thiab kev qhia txog kev phom sij.

Kev pov tseg pov tseg

Nws yog txwv tsis pub tso tawm ncaj qha rau hauv cov kav dej lossis cov khib nyiab zoo tib yam. Nws yuav tsum tau kho raws li cov qauv rau cov tshuaj phem.

Hu rau cov koom haum kev tiv thaiv ib puag ncig lossis ua raws li cov cai hauv zos rau kev pov tseg los ntawm kev kub siab -kev kub hnyiab lossis tshuaj lom neeg tsis zoo, thiab khaws cov ntaub ntawv kho mob.

2-Amino-6-bromopyridineyog nitrogen-muaj heterocyclic compound. Nws cov tshuaj stability yog cuam tshuam los ntawm ntau yam. Cov hauv qab no txheeb xyuas nws qhov kev ruaj ntseg los ntawm ntau qhov kev xav:

2-Amino-6-bromopyridine yog lub teeb daj mus rau daj ntseg xim av hmoov nyob rau hauv chav tsev kub thiab lub siab ib txwm. Nws cov ntsiab lus melting yog 88-91 degree, nws qhov kub kub yog 273℃(760 mmHg), thiab nws qhov taw tes flash yog 118.9 degree. Qhov no qhia tau hais tias cov khoom muaj thermal stability ntawm chav tsev kub, tab sis nws yuav decompose los yog volatilize nyob rau hauv high-temperature tej yam kev mob. Yog li ntawd, thaum khaws cia, kev sib cuag ncaj qha nrog cov nplaim taws qhib lossis qhov chaw kub siab yuav tsum raug zam kom tsis txhob muaj kev sib tsoo lossis tawg.

2-Amino-6-bromopyridine tuaj yeem khaws cia rau lub sijhawm ntev hauv qhov chaw kaw, txias thiab qhuav. Nws qhov ruaj khov ruaj khov yog cuam tshuam los ntawm cov hauv qab no:

Hygroscopicity:Cov tshuaj no tuaj yeem nqus cov dej noo thiab tsim cov pob, uas tuaj yeem cuam tshuam rau nws cov purity thiab kev ua haujlwm. Yog li ntawd, nws yuav tsum tau muab cia rau hauv ib lub thawv airtight kom tsis txhob muaj kev sib cuag nrog huab cua.

Tshuaj compatibility:Nws yuav tsum raug zam los ntawm kev sib cuag nrog cov oxidants muaj zog, muaj zog acids, los yog cov hauv paus muaj zog los tiv thaiv exothermic cov tshuaj tiv thaiv los yog tiam ntawm cov pa phem. Piv txwv li, kev sib xyaw nrog cov oxidants muaj zog tuaj yeem ua rau muaj kev kub ntxhov, txawm tias tawg.

Lub teeb cuam tshuam:Ntev - lub sij hawm raug rau lub teeb yuav ua rau lub decomposition ntawm cov khoom. Yog li ntawd, nws raug pom zoo kom khaws cia rau hauv qhov chaw tsaus.

Cov amino pawg (-NH₂) thiab bromine atom (-Br) nyob rau hauv 2-amino-6-bromopyridine molecule muab nws siab reactivity, uas tej zaum yuav koom nyob rau hauv ntau yam tshuaj tiv thaiv:

Cov tshuaj tiv thaiv oxidation:Thaum muaj cov oxidants muaj zog, cov tshuaj tiv thaiv oxidation yuav tshwm sim, tsim cov tshuaj lom xws li nitrogen oxides lossis bromides.

Hloov cov tshuaj tiv thaiv:Lub bromine atom tej zaum yuav raug hloov los ntawm lwm pab pawg, uas ua rau tsim cov tebchaw tshiab.

Acid- cov tshuaj tiv thaiv hauv paus: Cov amino pawg muaj cov yam ntxwv tseem ceeb thiab tuaj yeem raug cuam tshuam nrog cov kua qaub, tsim cov ntsev.

Txhawm rau txhim kho cov tshuaj lom neeg ruaj khov ntawm 2-amino-6-bromopyridine, cov kev ntsuas hauv qab no tuaj yeem siv:

Optimize cia tej yam kev mob:Khaws cia rau hauv ib qho chaw kaw rau hauv qhov chaw txias, qhuav, thiab tsaus ntuj, tsis txhob muaj oxidants, acids, thiab bases.

Tswj qhov chaw ua haujlwm:Ua haujlwm hauv lub fume hood lossis cov khoom siv hauv zos kom txo cov plua plav dispersion. Thaum lub sijhawm ua haujlwm, tsis txhob siv lub siab - cua ntws los yog lub zog sib zog kom tiv thaiv kev tsim cov aerosols.

Siv cov stabilizers:Hauv cov ntawv thov tshwj xeeb, ntxiv cov stabilizers los tiv thaiv qhov tshwm sim ntawm cov kev cuam tshuam sab thiab txuas ntxiv lub neej kev pab cuam ntawm cov khoom.

1. 2-amino-6-bromopyridine yog dab tsi?
Nws yog ib qho tseem ceeb organic synthetic intermediate nrog cov tshuaj formula C₅H₅BrN₂. Nws cov qauv nta ib pawg amino (-NH₂) ntawm 2- txoj hauj lwm thiab bromine atom (-Br) ntawm 6-txoj hauj lwm ntawm lub nplhaib pyridine.
2. Cov ntawv thov tseem ceeb yog dab tsi?
Nws yog tsuas yog siv rau kev sib txuas ntawm cov tshuaj thiab tshuaj tua kab molecules, xws li cov khoom tseem ceeb rau kev tsim cov tshuaj heterocyclic; Nws kuj yog siv rau hauv ligand synthesis, cov ntaub ntawv science, thiab coupling tshua (xws li cov tshuaj tiv thaiv Suzuki).
3. Dab tsi yuav tsum tau sau tseg thaum siv nws?
Nws yuav tsum muab khaws cia rau hauv qhov chaw kaw, lub teeb - pov thawj, thiab ib puag ncig qhuav; Thaum lub sijhawm ua haujlwm, cov cuab yeej tiv thaiv (cov hnab looj tes, tsom iav) yuav tsum hnav kom tsis txhob nqus cov plua plav lossis nkag mus rau ntawm daim tawv nqaij; nws yog khaus, yog li nws yuav tsum tau ua haujlwm hauv lub fume hood thiab cov pov tseg yuav tsum tau muab pov tseg raws li cov kev cai rau cov tshuaj phem.

Cim npe nrov: 2-amino-6-bromopyridine cas 19798-81-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom