Triethylsilane CAS TSIS TAU: 617-86-7

Triethylsilaneyog ib qho xim tsis muaj xim thiab pob tshab organosilicon nruab nrab. Ib qho yooj yim hydrolysis, tso tawm ethanol, tsim cov khoom sib xws. Nws tuaj yeem npaj tau los ntawm kev ua haujlwm ntawm silicon hmoov nrog ethanol nyob rau hauv lub xub ntiag ntawm tooj liab catalyst. Nws yog siv los ua ke organosilicon intermediates thiab ntau yam silane coupling agents. Nws tseem tuaj yeem siv los npaj cov roj purity silane los ntawm cov tshuaj tiv thaiv tsis sib xws, lossis npaj cov khoom siv organic-inorganic hybrid. Nws yog tshuaj lom thiab yuav tsum tau tiv thaiv los ntawm noo noo thaum khaws cia.

Siv 1. Siv cov organic synthesis thiab tshuaj intermediates.

Siv 2. Nyob rau hauv qhov kev txiav txim ntawm cov dej alkaline, Si-H daim ntawv cog lus nyob rau hauv lub molecule yog tawg, hydrogen gas tawm, thiab triethylsilanol yog generated. Cov tshuaj tiv thaiv nrog alkyllithium, hydrogen atom hauv Si-H daim ntawv cog lus yog hloov los ntawm pawg alkyl. React nrog lithium alkoxide los tsim triethylalkoxysilane. Nyob rau hauv lub xub ntiag ntawm txhuas trichloride, nws reacts nrog hydrogen chloride tsim triethylchlorosilane. Nyob rau hauv qhov kev txiav txim ntawm platinum catalyst, nws tuaj yeem cuam tshuam ntxiv cov tshuaj tiv thaiv nrog alkenes. Nws tuaj yeem npaj los ntawm kev txo qis triethylchlorosilane nrog lithium hydride lossis lithium tetrahydrogen, thiab nws tuaj yeem siv los ua ke cov organosilicon tebchaw.

Siv 3. Ethylsilane, abbreviated li Et3SiH, yog ib qho kev txo tus neeg sawv cev, feem ntau yog siv rau hauv cov synthesis ntawm cov organic silicon. Feem ntau, qhov txo qis cov tshuaj tiv thaiv yog nqa tawm hauv ib puag ncig alkaline.Triethylsilanetuaj yeem siv los ua tus neeg sawv cev txo qis hauv ib puag ncig acidic xws li TFA Siv yog nws qhov zoo tshaj plaws. Nws tuaj yeem siv rau kev txo qis ntawm acetals, lossis tshem tawm cov pawg alkoxy ntawm cov suab thaj, thiab lwm yam. Tsis tas li ntawd, nws tuaj yeem siv nrog kev hloov pauv hlau catalysts los ua hydrosilylation scission ntxiv.

Siv 4. Multifunctional txo tus neeg sawv cev; siv rau kev tshawb fawb ntawm 2-chromanol txo cov tshuaj tiv thaiv; siv rau kev sib txuas ntawm trialkylsilane trialkylsilane los ntawm hydrosilation cov tshuaj tiv thaiv ntawm alkenes, thiab cov cis-xaiv tau tuaj yeem pom nrog TES ; Synthesis ntawm Nav1.7 spiro-oxindole blocker rau kev kho mob; rau redox-induced cationic polymerization; rau Beckmann rearrangement ntawm cyclododecanone oxime; rau allene thiab Regioselective reductive coupling cov tshuaj tiv thaiv ntawm enones.

Siv 5. Nws yog siv los ua reactivation catalyst tom qab catalytic polymerization ntawm styrene; Nws yog siv rau kev tshawb fawb txog kev kwv yees lub teeb nyem ntawm cov organic silicon.

Synthetic method oftriethylsilane:

1. Nws tuaj yeem npaj tau los ntawm kev txo qis triethylchlorosilane nrog lithium hydride lossis lithium tetrahydrogen txhuas.

2. Nruab lub tshuab ua kom muaj txiaj ntsig zoo, lub qhov tso tawm, thiab lub raj xa dej loj rau ntawm 5-liter peb-caj dab. Lub tom kawg yog nruab nrog lub tshuab txias txias nrog cov dej khov qhuav thiab acetone. Siv lub raj mis no los ua cov tshuaj ethylmagnesium bromide (12.6 moles) hauv ether. 406.5 g (30 moles) ntawm trichlorosilane yaj nyob rau hauv 1200 ml ntawm anhydrous ether tov yog ntxiv dropwise thereto nyob rau hauv txias thiab muaj zog stirring. Qhov ntxiv yuav siv li 6 teev. Cov tshuaj tiv thaiv sib xyaw yog nplawm ntawm chav tsev kub rau 8 teev, tom qab ntawd rhaub kom reflux rau 1 teev. Cov ether tau distilled los ntawm kev siv 20-kab tais thiab cov seem tau muab tso rau hauv chav da dej rau 10 teev. Ntxiv 180 ml dej thiab do kom nws hydrolyzed, ces ntxiv 372 ml ntawm concentrated hydrochloric acid, cais cov aqueous txheej, thiab extract nrog ob 500 ml ntawm ether. Cov ether extract tau ua ke nrog cov khoom, ntxuav nrog dej, ces qhuav ntawm 150 g ntawm anhydrous poov tshuaj carbonate rau 2 teev, thiab raug rau fractional distillation ntawm ib tug 4- tais kem kom tau 27.03 g (77.5 feem pua) ntawm nws. .

3. Siv ethyl bromide thiab chlorosilane raws li cov ntaub ntawv pib, cov synthesis ntawm nws yog nqa tawm los ntawm Grignard thiab condensation tshua, thiab cov khoom yog tau los ntawm concentration, rectification thiab rov qab. Hauv cov txheej txheem tsim khoom, trimethylbenzene, cov kuab tshuaj kub kub kub, yog siv los hloov cov nplaim taws thiab tawg ether lossis tetrahydrofuran hnyav rau cov tshuaj tiv thaiv, thiab cov khoom siv tshuaj tiv thaiv yog purified kom tau covtriethylsilane. Txoj kev no kov yeej cov kev tsis txaus ntawm cov txheej txheem ib txwm muaj, xws li qhov xav tau kub hnyav thiab cov kuab tshuaj rov qab tsis zoo, thiab ua rau kev ua kom zoo dua qub thiab muaj kev nyab xeeb, thiab qhov hnyav rov qab mus txog ntau dua 85 feem pua.

Piv nrog rau peb txoj kev saum toj no, cov nqi tsim khoom thiab qhov zoo ntawm peb txoj kev muaj kev sib tw ntau dua hauv kev ua lag luam. Peb lub tuam txhab txais cov txheej txheem thib peb ntawm kev tsim khoom rau ntau lub sijhawm ntawm kev tsim khoom loj. Tam sim no, cov txheej txheem ntau lawm yog mature thiab cov khoom zoo yog ruaj khov. Nws yog cov txheej txheem tsim khoom tshiab uas tau txais ethyl bromide kom dhau Grignard thiab condensation cov tshuaj tiv thaiv, ua kom zoo, centrifuge, thiab qhuav.triethylsilanemus rau synthesize nws. Nws muaj kev tsim kho tshiab hauv kev xaiv cov kev tawm tsam, rov ua dua tshiab ntawm cov tshuaj tiv thaiv cov kuab tshuaj, thiab cov txheej txheem distillation. Nyob rau hauv cov nqe lus ntawm zoo, muaj tshiab breakthroughs nyob rau hauv kev txhim kho cov khoom zoo. Kev txhim kho cov khoom zoo thiab ruaj khov ntawm nws yuav cuam tshuam ncaj qha rau qhov zoo ntawm cov tshuaj tiv thaiv kab mob khaub thuas oseltamivir. Nyob rau tib lub sijhawm, kev ua kom zoo ntawm cov txheej txheem synthesis thiab kev tsim khoom muaj txiaj ntsig zoo ntawm kev txo qis ib puag ncig thiab cov nqi tsim khoom, thiab tseem cuam tshuam rau tus nqi ntawm cov tshuaj tiav oseltamivir rau qee yam.

Nws yog tsuas yog siv nyob rau hauv lub synthesis ntawm organosilicon thiab raws li ib tug intermediate rau kev kho mob ntawm noog mob khaub thuas tshuaj oseltamivir (lub npe lag luam Tamiflu). Nrog rau kev nthuav dav ntawm daim ntawv thov ntau yam, cov khoom no yog siv technology-intensive, siab ntxiv tus nqi, thiab kev ua haujlwm thiab siv cov khoom siv tshuaj zoo kawg nkaus. Txoj kev loj hlob ntawm H1N1 thoob ntiaj teb cov kab mob ua npaws avian kab mob kis tau zoo heev tau ua rau tsoomfwv Suav thiab cov lag luam nce qib khaws cia thiab tsim cov tshuaj tiv thaiv kab mob khaub thuas. Nws kuj tseem muaj kev cia siab ntau thiab qhov chaw ua ib qho ntawm nws cov khoom siv raw.

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