3-hydroxytetrahydrofofroid CAS 453-20-3

3-hydroxytetrahydrofuran(3 {{- htf) belongs rau cov qauv molecular, uas muaj qhov hnyav molecular 18.1051, ntom / cm3, thiab voos. Raws li chairality, nws tuaj yeem faib ua (s) -3-htf thiab (r) -3-htf. Ntawm lawv, (s) -3-htf yog ib hom 3-HTF ntawm kev ua lag luam. Raws li ib qho tseem ceeb kws tshuaj nruab nrab, nws yog dav siv nyob rau hauv cov synthesis ntawm anticancer tshuaj, mob ntshav tshuaj, anti pab thiab lwm yam tshuaj. Raws li lub tsev pheeb suab hauv nruab nrab, nws tuaj yeem siv nyob rau hauv cov synthesis ntawm alfatinib (ob sab kev tshuaj ntsuab (obsab) cov tshuaj kho mob. Tsis tas li ntawd, 3-htf kuj tseem siv tau los ua hluavtaws tshuaj tua kab, uas tuaj yeem txhim kho cov kev ua kom zoo nkauj thiab xaiv cov tshuaj ntsuab ether etbicides.

3-hydroxytetrahydrofuran(3-HTF) yog cov organic sib xyaw nrog ntau cov ntawv thov.

1. Yeeb tshuaj synthesis:

3-HTF tuaj yeem siv ua qhov nruab nrab hauv cov hluavtaws ntawm ntau cov tshuaj. Piv txwv li, nws tuaj yeem siv los ua hluavtaws tiv thaiv anti anti anti anti antietic tshuaj thiab lwm yam kev siv hlwb hauv nruab nrab ntsig txog cov tshuaj.

2. Kev ua kom muaj zog thiab cov roj:

3-HTF tuaj yeem siv los ua cov khoom siv raw rau kev siv hluav taws xob txuas ntxiv thiab cov roj txuas ntxiv. Los ntawm hydrogen hydrolysis kev tawm tsam, 3-HTF tuaj yeem hloov mus rau hauv hydrogen thiab ethylene glycol, uas tuaj yeem siv rau roj hlwb thiab lwm yam kev siv hluav taws xob.

3. Hnyav:

Vim nws cov solubility zoo thiab cov tshuaj lom tsawg, 3-htf tuaj yeem siv los ua cov kuab tshuaj. Nws tuaj yeem siv tau kom yaj qee cov kab ke organic, tsho xim, thiab resins. Ib qho ntxiv, vim nws qhov tsis muaj hluav taws xob qis, 3-HTF tuaj yeem siv los hloov chaw nyob rau qee cov ntawv thov tshwj xeeb.

4. Cov ntaub ntawv Polymer:

3-HTF tuaj yeem siv ua monomer rau synthesis. Nws tuaj yeem cog lus polymerization nrog lwm cov Monomers los ua cov ntaub ntawv polymer nrog cov haujlwm tshwj xeeb thiab cov khoom. Cov ntaub ntawv no tuaj yeem siv rau hauv cov plastics, txheej, cov plaub hau, thiab cov nplaum.

5. Ua liaj ua teb ua liaj ua teb:

3-HTF tuaj yeem siv tau los ua cov tshuaj lom neeg ua liaj ua teb xws li cov tshuaj tua kab thiab cov tshuaj tua kab. Cov tshuaj no pab tiv thaiv cov qoob loo los ntawm cov kab tsuag thiab kab mob, thiab txhim kho cov qoob loo tawm thiab zoo.

6. Tsau:

3-HTF tuaj yeem siv ua cov khoom siv raw rau surfactants. Nws tuaj yeem siv nrog lwm cov tebchaw los ua surfactants nrog zoo emulsifying, dispersing, thiab stetilizing tej yam. Cov surfactants yog siv dav hauv cov liaj teb xws li cov tshuaj ntsiav tshuaj, tshuaj pleev ib ce, tshuaj ntxuav tshuaj, thiab cov khoom tu tus kheej.

7. Kev Ntsuam Xyuas Tshuaj:

3-HTF tuaj yeem siv ua cov qauv sab hauv rau cov roj checkography. Nws tuaj yeem siv rau kev txheeb xyuas kom muaj tseeb los pab txiav txim siab thiab tshawb pom qhov muaj thiab concentration ntawm lwm cov tebchaw.

8. Lwm cov ntawv thov:

3-HTF tseem siv tau rau synthesizing kua siv lead ua kua, cov tshuaj txuag, cov txuj lom hauv cov txuj lom, thiab khoom noj ntxiv. Ib qho ntxiv, nws tseem siv nyob rau qee thaj teb tshwj xeeb, xws li cov ntaub ntawv kho qhov muag, khoom siv hluav taws xob, thiab biomedical centerering.

Cov hydrolysis synthesis txoj kev ntawm3-hydroxytetrahydrofuranNrog epoxy acetone yog raws li hauv qab no:

Kauj ruam:

Epoxy Acetone + H2O → C4H8O2

1. Npaj epoxy acetone thiab aqueous daws.

2. DRISCE EPETONY ACETONE RAU ​​HAUV QHOV TSIM NYOG (xws li Eethanol lossis dimethylformamide) los npaj kev daws ntawm kwv yees li 0.1-0.5 M.

3. Maj mam ntxiv dej rau epoxy acetone tov, feem ntau ua kom cov dropwise. Nplawm yuav tsum tau tswj xyuas thaum cov txheej txheem kev tshwm sim.

4. Txuas ntxiv nplawm cov tshuaj tiv thaiv sib xyaw ntawm chav tsev kub rau ib lub sijhawm (feem ntau ntau teev rau ob peb hnub) mus rau hydrolyze epoxy acetone tsim.

5

3 {- hydle - cov txheej txheem txo cov khoom siv hydroxyl

- hydroxyl ketone + txo tus neeg sawv cev → c4h8o2

Kauj ruam:

1. Npaj {- hydroxyl ketone thiab txo tus neeg sawv cev ntawm tus neeg sawv cev.

2. Ntxiv - hydroxy ketones yog yaj nyob rau hauv cov kuab tshuaj uas tsim nyog, xws li kev daws teeb meem ntawm kev tsim nyog.

3. Rau {-}} Ntxiv rau cov tshuaj tiv thaiv zoo rau cov neeg sawv cev hydroxyl, thiab tus nqi yuav tsum tau hloov kho raws li cov kev sib piv zoo ntawm cov tshuaj tua kab.

4. Cov tshuaj tiv thaiv feem ntau yuav tsum muaj lub sijhawm ntev ntev. Rov qab los ntawm chav sov thiab txuas ntxiv nplawm li ob peb teev mus rau ob peb hnub los xyuas kom meej cov tshuaj txaus.

Tom qab cov tshuaj tiv thaiv tau ua tiav, cov khoom lag luam xav tau yuav ua kom huv los ntawm cov tshuaj tiv thaiv, rho tawm, lossis lwm txoj kev tsim nyog.

Lub ethyl acetate hydrolysis txoj kev rau nws yog raws li hauv qab no:

C4H8O2+H2O → C4H8O2+C2H4O2

Kauj ruam:

1. Npaj ethyl acetate thiab aqueous daws.

2. Dutival ethyl acetate nyob rau hauv ib tug tsim nyog hnyav, xws li ethanol lossis dimethylformamide, thiab npaj kev daws ntawm kwv yees li 0.1-0.5 M.

3. Maj mam ntxiv dej rau cov tshuaj ethyl acetate daws, feem ntau ua rau kev ua yeeb yam. Nplawm yuav tsum tau tswj xyuas thaum cov txheej txheem kev tshwm sim.

4. Txuas ntxiv nplawm cov tshuaj tiv thaiv sib xyaw ntawm chav tsev kub rau ib lub sijhawm (feem ntau ntau teev rau ob peb hnub) mus rau ntau hnub) kom tiav hydrolyze attyl acetate los tsim.

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Isoamyl haus cawv cov qauv Esterification txoj kev ntawm nws yog raws li hauv qab no:

C4h8o 2+ C5h12o → C5H8o2 Isoamyl Ester + H2O

Kauj ruam:

1. Npaj a3-hydroxytetrahydrofuranthiab isoamyl cawv tov.

2. Daws 3-HTF nyob rau hauv ib qho kev tsim nyog hnyav, xws li dimethylformamide lossis tetrahydrofuran, thiab npaj kev daws teeb meem ntawm kev tsim nyog.

3. Ntxiv cov nyiaj tsim nyog ntawm catalyst, feem ntau siv los ua cov acidic catalyst, xws li sulfuric acid lossis p} toluesulfonic acid, mus rau 3-HTF kev daws teeb meem. Qhov nyiaj ntxiv yuav tsum tau hloov kho raws li qhov tshwj xeeb cov kev sib piv ntawm cov reactants.

4. Ntxiv isoamyl cawv rau cov tshuaj tiv thaiv sib xyaw. Isoamyl Cawv yog dej cawv ntawm cov tshuaj esterification, thiab nws cov tshuaj ntxiv yuav tsum ua rau cov qauv hniav nyiaj hniav nyiaj ntawm 3-htf.

5. Cov tshuaj tiv thaiv kab sib xyaw feem ntau yuav tsum tau ua kom tawg nyob rau hauv chav tsev kub rau ob peb hnub los xyuas kom muaj kev tshua zoo.

Tom qab cov tshuaj tiv thaiv tiav, qhov xav tau 3-htf Esterification cov khoom lag luam tuaj yeem ua kom huv ntawm cov tshuaj tiv thaiv, rho tawm, lossis lwm txoj hauv kev tsim nyog.

3-hydroxytetrahydrofofuran yog ib qho tseem ceeb organic sib xyaw ua ke nrog cov kev siv tshuaj dav hauv ntau yam tshuaj synthesis, thiab tshuaj ntsuab kev lag luam. Hauv tshuaj lom neeg hluavtaws, nws feem ntau koom ua ib qho nrab hauv kev tsim kho ntawm ntau yam kev ua tiav olecules; Hauv kev thaj teb cov tshuaj muaj cov tshuaj lwg 3-hydroxytetrahyDrofuran hauv lawv cov qauv, uas ua lub luag haujlwm tseem ceeb hauv kev kho mob ntawm cov kab mob; Hauv kev lag luam txuj lom, nws tuaj yeem siv los ua cov khoom siv hluav taws xob nrog cov cim aromas. Txawm li cas los xij, zoo li ntau cov tshuaj lom neeg, 3-hydroxytetrahydrofuran kuj tseem tuaj yeem ua rau qee qhov kev tsis zoo thaum siv tab sis kuj ua rau muaj kev phom sij rau ib puag ncig.

Cim npe nrov: 3-HydroxytetrahyDrofofofuran Cas 453-20-3, cov neeg tsim khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag