4-Amino-3,5-dichloroacetophenoneyog ib qho organic compound nrog cov mis mos molecular tshwj xeeb thiab qhov hnyav molecular (C8H7Cl2NO, molecular hnyav 204.05), uas feem ntau nthuav tawm beige lossis yellowish crystals. Nws cov ntsiab lus melting yog li ntawm 158{14}}166 degree, kub taw tes yog li 351.5℃(ntawm 760 mmHg siab), thiab nws qhov ceev yog li 1.4 ± 0.1 g / cm³. Tsis tas li ntawd, nws yog insoluble nyob rau hauv dej txias, tab sis me ntsis soluble nyob rau hauv dej kub, thiab soluble nyob rau hauv organic solvents xws li ethanol, ether, benzene thiab hais txog . 4-Amino-3,5-dihloroacetophenone yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm hnoos-relieving thiab asth. Nws tuaj yeem siv los ua tshuaj intermediates thiab tsiaj pub additives. Tsis tas li ntawd, 4-Amino-3,5-dihloroacetophenone kuj tseem tuaj yeem siv rau hauv kev sib txuas ntawm lwm cov tshuaj zoo, xws li dyes thiab txuj lom.
|
|
|
|
|
|
| Tshuaj Formula | C8H7Cl2 Nr |
| Molecular Luj | 204.05 |
| Exact Mass | 202.99 |
| m/z | 202.99 (100.0%), 204.99 (63.9%), 206.98 (10.2%), 203.99 (8.7%), 205.99 (5.5%) |
| Elemental Analysis | C, 47,09; H, 3,46; lus, 34,75; N, 6,86; ib 7,84 |
| Melting point | 162-166℃(lit.) |
| Boiling point | 351.5 ± 42.0℃(Tshaj tawm) |
| Qhov ntom | 1.2748 (zeeg) |
| Refractive Index | 1.5500 (kwv yees) |
| Cia tej yam kev mob | Khaws nyob rau hauv qhov chaw tsaus, inert cua, chav tsev kub |
| Solubility | DMSO (me ntsis), Methanol (me ntsis) |
| Daim ntawv | Khoom |
| Acidity Coefficient (pKa) | -1.72 ± 0.10 (Kev kwv yees) |
| Xim | Lub teeb Tan rau Brown |
Peb yog cov chaw tsim khoom4-Amino-3,5-Dichloroacetophenone.
Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog peb lub koom haum ntawm peb.
Cov hauv qab no yog cov kauj ruam ntxaws ntxaws thiab sib npaug ntawm cov tshuaj sib npaug kom tau txais 3,5-dichloro-4-aminoacetophenone los ntawm chlorinating p-aminoacetophenone:
Cov tshuaj tiv thaiv p-aminoacetophenone nrog hydrochloric acid: C6H4CH2CH2N++HCl → C6H4CH2CH2NH2+ HCl
Kev npaj p-aminoacetophenone hydrochloride: C6H4CH2CH2OH + HCl → C6H4CH2CH2Cl + H2O
Kev npaj ntawm imine raws tebchaw: C6H4CH2CH2Cl + CH3OH → C6H4CH (CH3) CH UA2OH + HCl
Kev npaj ntawm pyridine nplhaib compounds: C6H4CH (CH3) CH UA2OH + O2 → C6H4CH (CH3) COOH + H2O
Hydrolysis cov tshuaj tiv thaiv: C6H4CH (CH3) COOH + H2O → C6H4CH (CH3)COO(-)+H(+)+HCOOH
Ntxuav thiab ziab: C6H4CH (CH3)COO(-) + anhydrous ethanol → C6H4CH(CH)3COOH+(CH3) 2CHOH
Kev sim cov kauj ruam
Muab para aminoacetophenone (AR) thiab anhydrous hydrochloric acid (AR) cais nyob rau hauv qhuav thiab huv beakers rau siv tom qab.
Kev npaj cov tshuaj hydrochloric acid: Ntxiv ib qho tsim nyog ntawm cov concentrated hydrochloric acid rau hauv lub lauj kaub uas muaj dej me me, do zoo, thiab txias rau chav tsev kub.
Kev npaj p-aminoacetophenone hydrochloride: Maj mam ntxiv p-aminoacetophenone rau saum cov tshuaj hydrochloric acid, do thaum ntxiv kom txog thaum yaj tag. Tom qab ntawd cia cov tshuaj sawv ntsug rau ib lub sij hawm kom tag nrho cais cov precipitate.
Kev npaj ntawm imine raws li cov tebchaw: Tom qab lim tawm cov tshuaj insoluble ntawm p-aminoacetophenone hydrochloride tau nyob rau hauv cov kauj ruam dhau los, ntxiv ib qho tsim nyog cov kuab tshuaj xws li methanol los yog ethanol dropwise los hloov nws mus rau hauv imine raws tebchaw. Ua tib zoo saib xyuas kev tswj cov dej acceleration kom tsis txhob muaj oxidation ntau dhau ua rau cov khoom tsim los ntawm - khoom.
Kev npaj ntawm pyridine nplhaib tebchaw: Maj mam ntxiv cov imine compound tau nyob rau hauv cov kauj ruam dhau los mus rau ib qho hnyav uas muaj pyridine (xws li pyridine, pyridine, thiab lwm yam) nyob rau hauv stirring, thiab tswj qhov kub tsis tshaj 60 degree. Tom qab lub dripping tiav lawm, txuas ntxiv stirring rau ib lub sij hawm ntawm lub sij hawm kom tiav cov tshuaj tiv thaiv.
Hydrolysis cov tshuaj tiv thaiv: Hydrolyze cov pyridine nplhaib compound tau nyob rau hauv cov kauj ruam dhau los mus rau hauv ib tug sib tov ntawm pyridine nplhaib tebchaw thiab pyridine ketones. Kev ua haujlwm tshwj xeeb yog ntxiv cov sib tov rau cov dej uas tsim nyog, ua kom sov li ntawm 80 degree, thiab ua kom nplawm rau qee lub sijhawm kom txog thaum tag nrho cov pyridine ketones hloov mus rau hauv pyridine.
Ntxuav thiab ziab: Lim tawm cov dej ntau dhau los ntawm cov khoom tau txais hauv cov kauj ruam dhau los, ntxuav nws ib zaug nrog anhydrous ethanol, thiab tom qab ntawd muab tso rau hauv qhov chaw muaj cua zoo kom cua qhuav kom tau cov khoom lag luam 3,5-dichloro-4-aminoacetophenone.
4-Amino-3,5-Dichloroacetophenone(CAS naj npawb: 37148-48-4) yog ib qho tseem ceeb ntawm cov tshuaj nruab nrab nrog cov kev siv dav hauv kev lag luam tshuaj. Cov hauv qab no yog ib qho kev tshawb fawb ntxaws txog nws txoj kev siv hauv kev lag luam tshuaj, txhawm rau txhawm rau txheeb xyuas nws qhov tseem ceeb thiab muaj txiaj ntsig zoo.
Raws li qhov nruab nrab ntawm hnoos thiab hawb pob suppressant ketoconazole
Qhov zoo tshaj plaws -paub siv yog ib qho nruab nrab ntawm kev sib txuas ntawm hnoos thiab mob hawb pob, xws li Quechuanxin (tseem hu ua Chuankening, Chuanshu ntsiav tshuaj, thiab lwm yam). Ketamine yog ib yam tshuaj tshiab uas siv tau los kho cov kab mob ua pa xws li tracheitis thiab hawb pob, tshwj xeeb tshaj yog rau cov mob hawb pob thiab cov neeg laus mob hawb pob.
(1) Pharmacological teebmeem ntawm ketoconazole
Ketamine feem ntau alleviates cov tsos mob hawb pob los ntawm inhibiting contraction ntawm bronchial du nqaij, dilating lub bronchi. Nws kuj tseem tuaj yeem txo cov hlab ntsws reactivity, txo qhov kev tso tawm ntawm cov neeg kho mob inflammatory, thiab yog li txo cov hlab ntsws o thiab edema. Tsis tas li ntawd, ketoconazole kuj muaj cov tshuaj tiv thaiv kev ua xua, uas tuaj yeem cuam tshuam kev tso tawm ntawm cov tshuaj tsis haum tshuaj thiab txo qhov tshwm sim ntawm kev tsis haum tshuaj.
(2) Lub luag haujlwm hauv kev sib txuas ntawm clenbuterol
Raws li qhov tseem ceeb nruab nrab, nws koom nrog ntau cov tshuaj tiv thaiv hauv cov txheej txheem synthesis ntawm chlortetracycline. Cov tshuaj tiv thaiv no suav nrog kev hloov pauv, ntxiv, condensation, thiab lwm yam, thaum kawg ua rau kev tsim cov tshuaj chlortetracycline, uas ua rau hnoos thiab mob hawb pob. Yog li ntawd, nws qhov zoo thiab purity muaj feem cuam tshuam rau kev sib txuas thiab kev ua tau zoo ntawm chlortetracycline.
Kev siv lwm yam tshuaj intermediates
Ntxiv nrog rau kev ua haujlwm ua tus nruab nrab rau clenbuterol, nws kuj tuaj yeem siv los ua ke rau lwm cov tshuaj intermediates uas ua lub luag haujlwm tseem ceeb hauv cov txheej txheem kev tsim tshuaj.
(1) Synthesize lwm yam hnoos thiab mob hawb pob
Ntxiv nrog rau ketoconazole, nws kuj tuaj yeem siv los ua cov tshuaj hnoos thiab mob hawb pob. Cov tshuaj no muaj cov tshuaj pharmacological zoo ib yam li clenbuterol, tab sis nrog cov qauv tshuaj sib txawv thiab cov txheej txheem ntawm kev ua. Los ntawm kev qhia nws, hnoos ntau dua thiab mob hawb pob tuaj yeem tsim kho nrog cov teebmeem tshwj xeeb thiab cov kev mob tshwm sim qis dua tuaj yeem tsim.
(2) Synthesize lwm hom tshuaj
Nws kuj tseem tuaj yeem siv los ua ke rau lwm hom tshuaj, xws li tshuaj tiv thaiv -cov tshuaj tiv thaiv, tshuaj tiv thaiv- qog nqaij hlav, thiab lwm yam. Nyob rau hauv cov txheej txheem synthesis ntawm cov tshuaj no, raws li cov intermediates tseem ceeb, lawv koom nrog cov tshuaj tiv thaiv thiab thaum kawg tsim cov tshuaj molecules nrog cov tshuaj pharmacological tshwj xeeb.
Daim ntawv thov hauv kev tsim tshuaj
Nws kuj tseem muaj peev xwm siv tus nqi hauv kev tsim tshuaj. Nws cov qauv tshuaj tshwj xeeb thiab cov khoom ua rau nws yog ib qho ntawm cov neeg sib tw tseem ceeb hauv kev tsim tshuaj.
(1) Raws li qhov pib ntawm kev tsim tshuaj tshiab
Nws tuaj yeem ua qhov chaw pib rau kev tsim tshuaj tshiab, thiab los ntawm kev hloov kho tshuaj thiab kev hloov kho, cov tshuaj tshiab nrog cov tshuaj pharmacological tshiab thiab cov kev mob tshwm sim tsawg tuaj yeem tsim. Cov tshuaj tshiab no yuav muaj ntau yam kev kho mob thiab ua tau zoo dua.
(2) Ua ib qho qauv sib xyaw rau kev tshuaj xyuas tshuaj
Nws tseem tuaj yeem ua tus qauv sib xyaw rau kev tshuaj xyuas tshuaj. Los ntawm kev khi rau lub hom phiaj proteins lossis receptors, lawv cov txiaj ntsig thiab kev sib raug zoo tuaj yeem raug soj ntsuam, muab kev txhawb zog rau kev txhim kho tshuaj tshiab.
Lwm daim ntawv thov hauv kev kho mob
Ntxiv nrog rau cov ntawv thov saum toj no, nws kuj tseem muaj lwm yam txiaj ntsig ntawm daim ntawv thov hauv thaj chaw tshuaj.
(1) Raws li kev tshuaj ntsuam reagent
Nws tuaj yeem siv los ua cov tshuaj analytical reagent rau tshuaj ntsuam xyuas thiab kuaj pom. Nws cov khoom siv tshuaj tshwj xeeb ua rau nws yog ib qho tseem ceeb reagent hauv qee cov tshuaj tiv thaiv, pab cov kws tshawb fawb kom nkag siab ntau dua thiab txheeb xyuas cov khoom ntawm cov khoom.
(2) Raws li kev tshawb fawb hauv cov tshuaj metabolism
Nws kuj tseem siv tau los ua cov khoom tshawb fawb rau cov tshuaj metabolism. Los ntawm kev kawm nws cov txheej txheem metabolic hauv lub cev, peb tuaj yeem nkag siab txog kev nqus, kev faib tawm, cov metabolism, thiab tshem tawm cov tshuaj hauv lub cev, muab kev txhawb zog rau kev txhim kho tshuaj tshiab.
Nws muaj ntau daim ntawv thov tus nqi hauv kev kho mob. Raws li ib qho tseem ceeb nruab nrab ntawm hnoos thiab mob hawb pob suppressant ketoconazole, nws kuj ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj tshiab, kev tshawb fawb tshuaj metabolism, thiab lwm yam. Nyob rau hauv lub neej yav tom ntej, nrog kev nce qib ntawm kev siv tshuaj thev naus laus zis thiab kev sib sib zog nqus ntawm kev tshawb fawb thiab kev tsim tshuaj tshiab, kev siv4-Amino-3,5-Dichloroacetophenonenyob rau hauv kev lag luam teb yuav dav dua. Nyob rau tib lub sijhawm, nws tseem yuav tsum tau ua kom muaj kev tiv thaiv ib puag ncig thiab kev tiv thaiv kev nyab xeeb kom muaj kev nyab xeeb thiab ruaj khov thaum tsim khoom thiab siv.
3,5-dichloro-4-aminoacetophenone (CAS naj npawb: 37148-48-4), raws li ib qho tseem ceeb aromatic ketone compound, muaj kev tshawb fawb thiab kev loj hlob keeb kwm yos rov qab mus rau nruab nrab-20th caug xyoo. Nws tau dhau los ntawm theem tseem ceeb los ntawm kev tshawb fawb txog kev sib xyaw ua ke mus rau cov ntawv thov kev lag luam, maj mam dhau los ua ib qho tseem ceeb hauv kev lag luam xws li tshuaj, tshuaj tua kab, thiab cov ntaub ntawv tshawb fawb.
Lub synthesis pib los ntawm kev tshawb fawb thov rau chlorinated aromatic ketone tebchaw. Cov txheej txheem synthesis thaum ntxov tau ua raws li kev hloov pauv ntawm electrophilic, los ntawm kev qhia cov tshuaj chlorine atoms thiab cov amino pawg ntawm lub nplhaib benzene, ua raws li kev qhia ntawm acetyl pawg. Piv txwv li, nyob rau xyoo 1950, cov kws tshawb fawb tau siv 4-aminoacetophenone ua cov khoom siv raw thiab qhia cov roj chlorine rau hauv cov kua dej glacial acetic acid rau cov tshuaj chlorination. Los ntawm kev tswj cov tshuaj tiv thaiv kab mob (xws li kub thiab tshuaj chlorine gas txhaj tshuaj), 3,5-dichloro-4-aminoacetophenone tau ua tiav tiav. Cov txiaj ntsig ntawm txoj kev no yog kwv yees li 50%, txawm hais tias qhov ua tau zoo yog qhov tsawg, nws tso lub hauv paus rau kev tshawb fawb tom ntej.
Nyob rau xyoo 1970, nrog rau kev nce qib ntawm cov khoom siv hluav taws xob sib xyaw ua ke, cov kws tshawb fawb tau pib tshawb nrhiav cov txheej txheem synthesis zoo dua. Piv txwv li, pib los ntawm 2,6-dichloroaniline, qhia cov pab pawg acetyl los ntawm cov tshuaj tiv thaiv acylation, thiab tom qab ntawd purifying los ntawm recrystallization, high-purity khoom yuav tau. Txoj kev no tsis tsuas yog ua kom yooj yim rau kev ua haujlwm, tab sis kuj tseem txhim kho cov txiaj ntsig zoo (txog 80% lossis ntau dua), ua ib qho tseem ceeb siv rau kev tsim khoom.
Nyob rau xyoo 1980, nrog kev xav tau ntau ntxiv rau cov tshuaj no hauv kev lag luam xws li tshuaj thiab tshuaj tua kab, nws cov khoom lag luam tau dhau los ua kev tshawb fawb tsom. Cov tuam txhab tshuaj hauv tsev, xws li Zhongshan Dixin Chemical Co., Ltd. thiab Jiangsu Pulesi Biotechnology Co., Ltd., tau ua tiav loj - nplai ntau lawm los ntawm kev ua kom zoo dua cov tshuaj tiv thaiv thiab txhim kho cov khoom tsim. Piv txwv li, los ntawm kev siv cov khoom siv tshuaj tiv thaiv chlorination tas mus li, cov roj chlorine tau nthuav tawm tuaj yeem raug tswj xyuas kom txo tau cov tiam los ntawm - khoom; Los ntawm kev siv cov kuab tshuaj rov qab, cov nqi tsim khoom tuaj yeem txo qis thiab ib puag ncig muaj kuab paug tuaj yeem txo qis.
Tib lub sijhawm, cov kws tshawb fawb kuj tau tsim cov txheej txheem ntsuab synthesis. Piv txwv li, siv tooj liab bromide es tsis txhob ua kua bromine raws li bromination reagent zam kev siv cov tshuaj lom bromine thiab txhim kho cov tshuaj tiv thaiv kev nyab xeeb; Los ntawm kev hloov cov tshuaj tiv thaiv ib txwm muaj nrog catalytic hydrogenation txo, cov pov tseg emissions tau txo. Cov kev tsim kho tshiab no ua rau lawv cov khoom tsim tau zoo ib puag ncig thiab txhawb kev txhim kho kev lag luam.
Nkag mus rau xyoo pua 21st, daim ntawv thov teb tau nthuav dav tas li. Nyob rau hauv cov tshuaj, raws li ib tug tseem ceeb intermediate rau lub synthesis ntawm hnoos thiab hawb pob suppressant ketoconazole, nws qhov kev thov tseem loj hlob. Piv txwv li, 4-amino-3,5-dichloro-alpha-bromoacetophenone npaj los ntawm cov tshuaj tiv thaiv bromination tuaj yeem txuas ntxiv cov isotope ruaj khov sau npe clenbuterol cov tshuaj rau kev tshawb fawb txog tshuaj metabolism.
Hauv kev tshawb fawb ntawm cov ntaub ntawv tshawb fawb, nws cov qauv ketone aromatic ua rau nws yog ib qho tseem ceeb monomer rau kev npaj cov khoom siv polymer. Piv txwv li, nws cov derivatives tuaj yeem siv los tsim cov khoom siv photoluminescent, kua siv lead ua cov ntaub ntawv, thiab lwm yam, thiab muaj peev xwm siv tau cov txiaj ntsig hauv cov cuab yeej tso saib, kho qhov muag pom, thiab lwm yam.
Cim npe nrov: 4-Amino-3,5-Dichloroacetophenone CAS 37148-48-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom