Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm n {}}}} Txais tos rau kev lag luam wholesale mis zoo n-ethaigycarbonyl-1,2-lidhiquinibine CAS 16357-59-8 Kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
N {- Ete} Ete} Ey} Ethe ethoxy-1,2-diydroquinium(EEDQ) yog cov organic sib xyaw nrog cov molecular cov mis c14h17No3 thiab CAS 169-8, muaj rau quinoline derivatives. Feem ntau yog dawb lossis me ntsis daj ua kom khov. Organic Intermediate, Coupling Tus Neeg Sawv Cev hauv Peptide synthesis, classic sib xyaw cov qauv peptide peptide, me thiab ua tau zoo. Tsis pub lwm tus sawv cev, peptide synthesis condensation tus neeg sawv cev, feem ntau siv rau amino thiab carboxyl pawg tsim hws. Cov tsos no ua rau nws yooj yim los txheeb xyuas thiab paub qhov txawv hauv chav kuaj. Nws muaj qee qhov solubility hauv cov ethanoform, xws li chloroform, ethohanol, etc. Qhov no tso cai rau nws los ua synthesized thiab sib cais los ntawm kev daws teeb meem. Qhov kev xaiv ntawm cov kuab tshuaj muaj qhov cuam tshuam tseem ceeb ntawm nws solubility. Cov kuab tshuaj sib txawv yuav ua rau cov kev hloov pauv tseem ceeb hauv lawv solubility, yog li cuam tshuam lawv cov haujlwm thiab kev thov hauv kev sim. Nws muaj cov ntawv thov tseem ceeb hauv kev ua liaj ua teb xws li chemistry, tshuaj, thiab cov ntaub ntawv kawm txuj ci. Raws li ib tug organic compound nrog cov qauv tshuaj lom neeg muaj kev cog lus, nws tau qhia txog kev npaj ua tshuaj, cov ntaub ntawv kev tshawb fawb, kev ua haujlwm txheeb thiab cim npe, thiab kev tshawb fawb txog kev kawm. Nrog rau kev tshawb nrhiav hauv qhov ntsuas thiab cov ntawv thov, nws ntseeg tias nws yuav muaj ntau yam tshiab tshawb pom thiab thov yav tom ntej.
|
Tshuaj Cov Qauv |
C14h17no3 |
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Muaj pes tsawg leej |
247 |
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Molecular hnyav |
247 |
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m/z |
C, 68.00; H, 6.93; N, 5.66; O, 19.41 |
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Kev Ntsuam Xyuas |
H, 2.79; La, 32.08; N, 9.70; O, 55.42 |
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Melting taw tes 62-67 Degree C (Lit.), npau meem (0.1 hli), muaj acid Hmoov, Xim Dawb Rau Beige, Dej Soluble insoluble, rhiab
N {- Ete} Ete} Ey} Ethe ethoxy-1,2-diydroquinium(EEDQ), raws li ib qho tseem ceeb organic sib xyaw ua ke, tau pom nws cov ntawv thov dav hauv ntau daim teb.
Hauv thaj teb ntawm peptide synthesis, EEDQ tau dav siv ua ib pawg neeg pom zoo hauv cov kev cuam tshuam ntawm amino thiab carboxyl. Nws cov nyhuv catalytic ua rau cov txheej txheem synthesis ntawm peptides ntau dua thiab tswj tau.
Daim Ntawv Thov Piv Txwv:
Synthesis ntawm cov peptex: nyob rau hauv cov synthesis ntawm cov peptes xws li peptoChod acid (GCA), yog npaj peptide tshuaj lossis cov khoom siv nrog cov kev ua haujlwm ntsig txog kev ua haujlwm.
Ua kom zoo peptide syntheses: los ntawm kev kho cov tshuaj thiab cov kev xav tau zoo, thiab cov tshuaj ntxuav tau zoo, thiab tawm los ntawm cov khoom tuaj yeem hloov kho.
EEDQ tseem muaj cov ntawv thov tseem ceeb hauv kev txhim kho cov tshuaj thiab kev tshawb fawb. Raws li ib tug irreversible membrane morphology real-referor tiv thaiv, nws tuaj yeem siv los txhim kho cov tshuaj tshiab kho lossis kuaj mob.
Daim Ntawv Thov Piv Txwv:
Kev tshawb fawb txog anti - cov tshuaj kho mob qog: Los ntawm kev tswj hwm cov qauv thiab kev siv cov kev ua haujlwm hauv anti- Kev tsim kho cov qog. Piv txwv li, EEDQ tuaj yeem khi rau tshwj xeeb cov receptors nyob rau ntawm cov qog ntawm cov qog, yog li inhibiting lawv txoj kev loj hlob thiab kis tau.
Anti Kev Tsim Tshuaj Yeeb: EEDQ tseem tuaj yeem ua tus neeg sib tw sib tw rau anti {{tawv. Los ntawm kev tswj hwm nws cov tshuaj ua noj ua haus, cov tshuaj tshiab nrog anti - qhov mob tshwm sim tuaj yeem tsim kho cov kab mob.
Kev npaj ntawm kev kuaj xyuas cov khoom qab zib: los ntawm kev siv lub peev xwm los ntawm EEDQ rau cov khoom siv tshwj xeeb, cov tshuaj ntsuam rau kuaj mob tuaj yeem npaj tau. Cov reagents no tuaj yeem khi cov lwg me me hauv tus neeg mob lub cev, pab cov kws kho mob raug txiav txim seb hom mob puas.
Nyob rau hauv teb ntawm polymer cov khoom hloov, EEDQ tseem tau ua tau nws cov txiaj ntsig tshwj xeeb. Los ntawm kev qhia EEDQ, lub cev thiab tshuaj lom neeg ntawm cov ntaub ntawv polymer tuaj yeem hloov kho, yog li txhim kho lawv cov kev ua tau zoo.
Daim Ntawv Thov Piv Txwv:
Txhim kho tshav kub ua kom tsis kam: thaum npaj tshav kub -}} Cov ntaub ntawv tiv thaiv polymer, tus nqi tsim nyog ntawm EEDQ tuaj yeem ntxiv. EEDQ tuaj yeem hnov mob nrog qee pab pawg ua haujlwm hauv polymer chains kom tsim cov khoom sib txuam nrog cov ntaub ntawv kub.
Txhim kho cov cuab yeej kho tshuab: los ntawm kev kho cov tshuaj thiab cov tshuaj tiv thaiv ntawm EEDQ, cov cuab yeej siv tshuab ntawm cov ntaub ntawv polymer tuaj yeem hloov kho. Piv txwv li, lub zog tensile thiab tawv ntawm cov khoom yuav tau nce kom nws ruaj khov.
Kev npaj ua haujlwm polymer: los ntawm kev siv cov tshuaj lom tshwj xeeb ntawm EEDQ, cov ntaub ntawv polymer nrog cov haujlwm tshwj xeeb tuaj yeem npaj tau. Piv txwv, cov ntaub ntawv tsim khoom, cov ntaub ntawv sib nqus, lossis cov khoom siv kho kom tau npaj tau.
Hauv kev thaj teb cov khoom siv hluav taws xob, EEDQ tseem tuaj yeem ua ib qho kev ua yeeb yam lossis nruab nrab rau qee yam tshuaj tiv thaiv lossis txhim kho kev xaiv ntawm cov tshuaj tiv thaiv.
Daim Ntawv Thov Piv Txwv:
Cov tshuaj ntsuam catalytic: EEDQ tuaj yeem ua cov tshuaj tiv thaiv kev siv tshuaj rau cov tshuaj esterification, txhawb cov tshuaj esterification ntawm dej cawv thiab acids. Qhov kev tawm tsam no muaj ntau yam hauv synthic thiab tuaj yeem siv los npaj cov khoom sib txuas ntxiv.
Synthesis ntawm Heterocyclic Teb Chaws: Los ntawm kev siv cov tshuaj tshwj xeeb ntawm EEDQ, ntau yam heterocyclic compound tuaj yeem ua ke. Cov tebchaw no muaj dav dav tus nqi hauv liaj teb xws li cov tshuaj siv tshuaj thiab cov tshuaj tua kab tsuag.
Raws li kev koom tes hauv nruab nrab nrog rau cov khoom siv hluav taws xob ua ke: EEDQ tuaj yeem pab ua qhov tseem ceeb hauv kev tawm tsam thaum lub sij hawm ua synthic synthesis. Organic tebchaw nrog cov qauv tshwj xeeb thiab cov khoom tuaj yeem tsim los ntawm reacting nrog lwm cov tebchaw.
EEDQ tseem muaj qee qhov kev thov muaj nuj nqis hauv cov liaj teb ntawm kev tiv thaiv dej kom zoo thiab kev tiv thaiv ib puag ncig. Nws tuaj yeem cuam tshuam nrog qee cov pa paug thiab hloov lawv mus rau hauv cov tshuaj phem lossis cov tshuaj lom tsawg.
Daim Ntawv Thov Piv Txwv:
Kho cov hlau wense wastewater hnyav: EEDQ tuaj yeem yauv cov nyom ntawm cov hlau hnyav nrog cov hlau hnyav hauv dej lwg kom tshem tawm lawv los ntawm cov dej ntas. Txoj kev kho mob no muaj cov yam ntxwv ntawm kev tiv thaiv siab thiab ib puag ncig kev tiv thaiv, thiab tuaj yeem siv los kho cov tshuaj khib nyiab uas muaj cov hlau hnyav.
Kev ua rau muaj kuab lom Txoj kev kho mob no tuaj yeem siv los kho cov dej khib nyiab organic, xws li luam tawm thiab zig Wastewater, tshuaj lim dej, thiab lwm yam.
Ntxiv nrog rau cov teb ua ntej, EEDQ tseem muaj cov ntawv thov txuas ntxiv hauv lwm qhov chaw. Piv txwv li, hauv kev sib xyaw ntawm electrochemistry, EEDQ tuaj yeem siv los ua cov khoom siv hluav taws xob los txhim kho kev ua tau zoo thiab ruaj khov ntawm electrodes; Hauv kev thaj teb ntawm Yees duab, EEDQ tuaj yeem siv ua cov duab lossis photocatinalalysts los koom nrog kev yees duab yees duab; Hauv cov biomedical teb, EEDQ tseem tuaj yeem ua kev sojntsuam biomarker lossis thev naus laus zis rau kev tshawb fawb thiab kuaj mob.
Hauv cov ntsiab lus, EEDQ ua ib qho tseem ceeb organic sib xyaw ua ke, tau ua kom pom nws cov ntawv thov dav hauv ntau daim teb. Los ntawm peptide kev tsim kho thiab tshawb fawb, los ntawm kev tiv thaiv polymer hloov kho thiab kev tiv thaiv ib puag ncig, thiab lwm daim ntawv thov cov ntawv thov, EEDQ tau ua lub luag haujlwm tseem ceeb. Nrog kev txhim kho kev kawm txuas ntxiv ntawm kev tshawb fawb thiab thev naus laus zis, tib neeg txoj kev nkag siab ntawm EEDQ yuav ua kom tob dua thiab nws daim ntawv thov yuav txuas ntxiv nthuav dav. Nyob rau yav tom ntej, peb tuaj yeem cia siab EEDQ los ua lub luag haujlwm tseem ceeb hauv kev teb ntau dua thiab ua rau muaj kev pab ntau dua rau kev txhim kho tib neeg. Nyob rau tib lub sijhawm, peb tseem yuav tsum tau tshawb nrhiav tas li thiab tshawb nrhiav thaj chaw thov cov chaw thov thiab siv Unleash rau cov nqi unleash nws lub peev xwm.
N {- Ete} Ete} Ey} Ethe ethoxy-1,2-diydroquinium(EEDQ), raws li ib qho tseem ceeb organic compound, tau tshwj xeeb cov kev siv hauv thaj teb ntawm biomedicine. Tshwj xeeb tshaj yog ua ib tug irreversible membrane {{
Lub tswvyim thiab qhov tseem ceeb ntawm kev tsis paub txog daim duab membrane {{0} Txoj kev ua txhaum cai anteptor
Tsis pub siv cov khoom siv molecules cond ntawm lub cell memcules tau los ntawm kev tsim cov khoom sib khi ntawm kev sib cav sib ceg. Cov xeeb ceem no muab dag ntxias li cas yog membrane {2} Txoj kev ua kom muaj kev tawm tsam kev tawm tsam kev tawm tsam kev tsim cov tshuaj. Lawv tuaj yeem nyob twj ywm receptor rau lub sijhawm ntev, ua kom muaj txiaj ntsig receptor {}} mediated signaling cov txheej txheem thiab ua tiav lub hom phiaj ntawm kev kho cov kab mob.
Qhov tseem ceeb ntawm kev txwv tsis pub muaj zog ntawm cov yeeb tshuaj, kev siv tshuaj tshiab rau cov kab mob uas nyuaj rau kev kho cov tshuaj ib txwm muaj. Tsis tas li ntawd, vim lawv cov khoom siv khi tsis tau, cov tshuaj no feem ntau muaj kev cuam tshuam ib zaug thiab kev pheej hmoo ntawm cov kev mob tshwm sim rau cov neeg mob.
Lub hauv paus ntsiab lus ntawm eedq raws li ib tug irreversible membrane {{0} Txoj kev tawm tsam kev tiv thaiv
Qhov laj thawj yog vim li cas eedq tuaj yeem ua ib qho kev ua txhaum cai membrane {}}}}}}}}}}}}}}}}}}}}}}}}} Tus qauv tshuaj thiab kev ua kom zoo. Lub ethoxCarboronyl moiety hauv EEDQ molecules nrog cov pab pawg ua haujlwm xws li cov pab pawg amino lossis hydroxyl ntawm lub chaw sib txuas lus sib xws. Qhov tsim ntawm cov kev sib khi sib khi no ua rau EEDQ kom khov kho khi rau lub receptor thiab tsis yooj yim discociated lossis tsiv chaw.
Ib qho ntxiv, EEDQ tseem muaj cov membrane nkag zoo thiab cov xaiv tau xaiv. Nws tuaj yeem txig lub cell membrane, mus txog qhov chaw nyob ntawm lub hom phiaj receptor, thiab kev khi tshwj xeeb rau lub receptor. Qhov kev xaiv tau no khi kom ntseeg tau tias EEDQ nthuav tawm cov teebmeem ntawm cov chaw muag hluav taws xob thaum muaj kev cuam tshuam tsawg rau cov hlwb thiab cov ntaub so ntswg.
Daim ntawv thov cov piv txwv ntawm EEDQ raws li tsis muaj cwj pwm membrane khi receptor antubrists
1. Daim ntawv thov hauv cov kab mob neurological
Daim ntawv thov ntawm EEDQ tshwj xeeb tshwj xeeb hauv cov kab mob neurological. Piv txwv li, hauv kev kho mob ntawm Parkinson tus kab mob, EEDQ tuaj yeem ua raws li kev tawm tsam DOPAMine D2, kev txo cov tsos mob ntawm cov txheej txheem ntawm cov teeb meem kev kho mob los ntawm DOPAMINE D2 RECTORS. Ib qho ntxiv, EEDQ tseem siv tau los kho cov kev mob neurological xws li schizophrating ntawm neurotransmitters thiab txhim kho cov neeg mob kev txawj ntse thiab kev coj cwj pwm.
2. Daim ntawv thov hauv cov kab mob cardiovases
Tus kab mob plawv yog ib qho ua rau muaj kev tuag thoob ntiaj teb. Daim ntawv thov ntawm EEDQ hauv cov kab mob plawv yog qhov yog feem ntau pom nyob rau hauv txoj cai ntawm cov kev cai ntawm plawv ion. Piv txwv li, EEDQ tuaj yeem ua raws li kev ntxub ntxaug ntawm cov kab mob iondium lossis calhium ion channel, yog inhibiting kev ua haujlwm ntawm lub plawv, yog ua rau muaj kab mob plawv, yog muab kho cov kab mob plawv, yog kho cov kab mob plawv thiab kho cov kab mob plawv xws li arhythmia.
3. Daim ntawv thov nyob rau hauv cov leeg kho
Cov kab mob qog ua cov kab mob nyuaj uas muaj ntau txoj kev teeb tsa txoj hauv kev hauv lawv qhov teeb meem thiab kev loj hlob. Daim ntawv thov ntawm EEDQ hauv cov kev kho mob qog yog qhov tseem ceeb ntawm cov kev cai ntawm cov qog cov khoom txais. Piv txwv li, EEDQ tuaj yeem ua raws li kev tawm tsam tsis txaus ntseeg ntawm cov qog ua los ntawm kev nkag mus rau cov tub ntxhais, yog li ua tiav lub hom phiaj ntawm kev kho mob qog. Tsis tas li ntawd, EEDQ tseem siv tau ua ke nrog lwm cov tshuaj ant-} Cov tshuaj qog ua kom tau cov kev pheej hmoo ntawm cov kev mob tshwm sim.
4. Daim ntawv thov nyob rau hauv cov kab mob mob
Cov kab mob muaj kab mob tshwm sim yog ib hom mob caj dab, nrog rau kab mob ntsws, thiab lwm yam ntawm cov kab mob plab zom mov Piv txwv li, EEDQ tuaj yeem ua raws li kev tawm tsam kho kom haum xeeb ntawm kev kho kom haum xeeb thiab kev ua haujlwm ntawm cov tsos mob kho kom haum xeeb thiab ua rau muaj cov tsos mob sib kho, muaj kev txo cov khoom siv hluav taws xob.
5. Thov hauv kev tsim cov tshuaj
Ntxiv rau qhov tau siv ncaj qha rau kev kho cov kab mob, EEDQ tseem ua lub luag haujlwm tseem ceeb hauv kev tsim kev tshuaj. Piv txwv li, tshuaj ntsuam xyuas tshuaj thiab kev ntsuas kev ua tau zoo, EEDQ tuaj yeem siv los ua cov khoom siv tshuaj los ntsuas qhov kev xaiv ntsej muag thiab xaiv cov tshuaj tshiab rau cov khoom siv tshwj xeeb. Ib qho ntxiv, EEDQ tseem tuaj yeem ua kev sojntsuam rau kev tshawb xyuas tshuaj metabolism thiab cov tshuaj tua kab mob ntawm cov qauv metabolic ntawm cov tshuaj moleculion hauv Vivo.
Qhov zoo thiab cov nyom ntawmN {- Ete} Ete} Ey} Ethe ethoxy-1,2-diydroquiniumRaws li ib tug irreversible membrane {{0} Txoj kev tawm tsam kev thaiv kev thaiv
yam uas pab
Ntev ua haujlwm:
Vim nws cov khoom siv khialent, EEDQ tuaj yeem nyob ntawm lub vev xaib receptor ntev, muab cov teebmeem ntev}}} kav cov chaw muag tshuaj.
Xaiv:
EEDQ muaj kev xaiv siab rau cov khoom plig tshwj xeeb thiab tuaj yeem txo nws cov kev cuam tshuam rau cov hlwb thiab cov ntaub so ntswg.
Tsawg Dose:
Vim qhov zoo ntawm ntev -} Kev xaiv kho mob thiab kev pheej hmoo ntawm EEDQ feem ntau yog tsawg, txo cov kev pheej hmoo thiab phiv rau cov neeg mob.
Cav
Qhov teeb meem toxicity:
Txawm hais tias EEDQ muaj cov kev xaiv siab rau cov receptors tshwj xeeb, ntev - lub sijhawm lossis ntau dhau yuav ua rau muaj tshuaj lom.
Metabolic stability:
Qhov kev ruaj khov metabolic ntawm EEDQ hauv lub cev yuav tsum tau ua kom zoo dua los xyuas kom haum nws cov kev xav tau thiab ntev hauv lub cev.
Xaiv los ntawm receptor subtypes:
Qee cov receptors muaj ntau yam subtypes, thiab sib txawv ntawm kev xaiv ntawm EEDQ rau cov sib txawv ntawm cov neeg sib luag yuav cuam tshuam nws qhov kev ua tau zoo thiab kev nyab xeeb.
Nyob rau hauv cov txheej txheem txheem txheem txheem txheej txheem, peb xub npaj ib qho kev ntxuav tau huv siab dua nrog 97% ib qho kev sib xyaw nrog 97 xyoo ntawm 1.26 grams, sib npaug rau 9.5 labales. Tom ntej no, peb tau ntxiv 3.2 milliliters ntawm ethanol, nrog cov nyiaj uas muaj 47 millilitters, thiab 0.4 millilitters dej, thiab 0.4 millimitters, los kho cov polarity ntawm cov tshuaj tiv thaiv kab mob. Tsis tas li ntawd, 1.1 gram ntawm sodium bicarbonate (Nahco3) tau ntxiv rau hauv 13 lab ntawm 13 lab ntawm cov tshuaj tiv thaiv rau cov peev xwm ntawm acidducts.
Ceev nrawm qhov tau txais daj ntseg sib xyaw ua ke rau 0 degrees Celsius kom ntseeg tau tias cov tshuaj tiv thaiv tom qab tuaj yeem ua tiav nyob rau hauv cov mob kub tsawg. Thaum tswj qhov kub thiab txias no, peb siv lub plab zom mov kom maj mam thiab tusyees ntxiv rau cov tshuaj tiv thaiv zoo tshaj plaws ntawm 20 feeb. Cov kauj ruam no yuav tsum ua kom ceev faj kev ua haujlwm kom tsis txhob muaj cov tshuaj tiv thaiv hauv zos lossis ntau dhau.
Cia cov tshuaj tiv thaiv txuas ntxiv mus do ntawm 0 degrees Celsius rau kom ntseeg tau tias txhua tus reactants yog tag nrho hauv kev sib cuag thiab kev xav tau tshuaj lom neeg tshwm sim. Tom qab, txhawm rau tshem tawm sai sai, peb ntxiv 10 milliliters ntawm dej rau lub kaw lus, txheej txheem hu ua "quenching".
Siv kev sib cais ua kom muaj kev sib cais, peb rho tawm cov tshuaj aqueous peb zaug nrog rau ntawm Dichhloromethane mus rho tawm cov organic theem uas muaj cov khoom lag luam organic muaj cov khoom lag luam. Tom qab txhua extraction, sau cov txheej organic thiab thaum kawg sib sau txhua ntu ntawm cov organic. Txhawm rau tshem tawm cov kev ua ke noo noo, peb qhuav cov txheej txheem organic siv anhydrous sodium sulium sulium, na2so4).
Cov tshuaj organic yog feeb txog qis dua kev txo qis siv lub teb chaws evaporator kom txog thaum lub amorphous sol zoo li cov khoom tau. Nyob rau hauv thiaj li yuav txuas ntxiv txhim kho qhov kev coj dawb huv ntawm cov khoom lag luam thiab tau txais ib daim foos zoo rau kev tshawb fawb ntxiv, peb yaj qhov kev tsim nyog ntawm hexane thiab tau txais ntshiabN {- Ete} Ete} Ey} Ethe ethoxy-1,2-diydroquiniumMuaju los ntawm recrystallization. Cov khoom no tsis tsuas yog muaj cov qauv siab, tab sis kuj tseem muaj cov qauv ntshiab, muab lub hauv paus ruaj khov rau kev tshawb fawb txuas ntxiv thiab cov ntawv thov.
N {- EtehiCyL-1,2-edihodroquinary (EEDQ) yog qhov kev siv hluav taws xob dav dav nrog cov khoom siv dav dav nrog cov tshuaj lom neeg hauv cev, tshuaj lom neeg muag khoom. Nws lub peev xwm los tsim cov kev sib tw mus pov tseg, cov dej cawv qhuav, thiab kho cov biomolecules ua rau nws tsis tseem ceeb hauv kev ua haujlwm niaj hnub. Thaum cov txheej txheem ib txwm cia siab rau cov kuab tshuaj organic, cov kev ua kom ntsuab tawm ntawm cov lus cog tseg kom txhim kho nws cov kev ruaj khov. Kev tshawb fawb yav tom ntej yuav tsom rau kev nthuav tawm nws cov nqi hluav taws xob hauv bioconugation, thiab kev tsim khoom zoo tshaj plaws synthesis, Solorifying EEDQ lub luag haujlwm raws li cov pob zeb ua haujlwm.
Cim npe nrov: n {- EtehfoCarbonyl-1,2-Dihydroquinycy-1,2-i9-8, cov chaw tsim khoom, chaw tsim khoom, yuav khoom, khoom, rau muag