4-Aminotetrahydropyran(oxolan-3-amine) yog ib qho tseem ceeb saturated nitrogen-muaj oxygen heterocyclic compound. Nws cov qauv molecular tuaj yeem suav tias yog hydrogen atom ntawm lub nplhaib tetrahydrofuran (ib qho rau - cov pa oxygen- muaj lub nplhaib) hloov los ntawm ib pawg amino (-NH₂). Cov tshuaj no muaj kev ruaj ntseg ntawm cyclic ether thiab cov reactivity ntawm ib tug thawj amine, nthuav tawm raws li ib tug tsis muaj xim rau daj ntseg kua, nrog rau tej yam alkalinity, thiab muaj peev xwm tsim cov ntsev nrog acids. Raws li ib qho tseem ceeb chiral hluavtaws tsev thaiv thiab cov kws tshuaj intermediate, nws cov cim nruj cyclic qauv thiab kev sib koom ua ke ntawm cov amino pawg thiab cov pa oxygen ether daim ntawv cog lus ua rau nws tseem ceeb heev hauv cov tshuaj molecule tsim, tshwj xeeb tshaj yog nyob rau hauv kev tsim complex molecular molecular molecular molecular tej yam kev mob, ua si ib tug irreplaceable lub luag hauj lwm nyob rau hauv lub synthesis pathways ntawm nitrogen-muaj cov khoom.
|
|
|
|
Tshuaj Formula |
C5H11 Nr |
|
Exact Mass |
101 |
|
Molecular Luj |
101 |
|
m/z |
101 (100.0%), 102 (5.4%) |
|
Elemental Analysis |
C, 59.37; H, 10.96; N, 13.85; O, 15.82 |
4-Aminotetrahydropyranyog ib qho tseem ceeb heterocyclic organic compound nrog rau qhov ruaj khov rau -cov pa oxygen- uas muaj cov qauv nplhaib thiab cov pab pawg ua haujlwm zoo amino. Nws cov qauv molecular tshwj xeeb endows nws nrog cov tshuaj zoo reactivity, cov qauv hloov kho thiab biocompatibility, ua rau nws ua lub luag haujlwm tsis tuaj yeem hloov pauv hauv kev siv tshuaj, tshuaj lom neeg tshawb fawb, khoom siv chemistry, kev ua liaj ua teb, zaub mov chemistry thiab lwm yam haujlwm. Cov ncauj lus kom ntxaws nthuav dav hauv ntau qhov chaw yog raws li hauv qab no:
1. Synthetic peptide thiab cov tshuaj protein
Oxolan-3-amine ua hauj lwm raws li tus nqi siab thiab core structural tsev thaiv nyob rau hauv lub synthesis ntawm peptide thiab protein tshuaj. Qhov nruj thiab ruaj khov tetrahydropyran nplhaib qauv hauv nws cov molecule tuaj yeem ua kom zoo dua qhov kev sib haum xeeb ntawm cov tshuaj molecules, thaum cov amino pawg neeg nquag tuaj yeem koom nrog peptide daim ntawv cog lus condensation cov tshuaj tiv thaiv, ua kom muaj txiaj ntsig kev tsim kho ntawm complex peptide thiab protein molecular molecular molecules.
Hauv kev tsim tshuaj niaj hnub no, cov kws tshawb nrhiav nquag qhia oxolan-3-amine cov txheej txheem rau hauv cov tshuaj molecules los hloov cov tshuaj hloov pauv cov alkyl chains lossis cov qauv heterocyclic tsis ruaj khov, uas tuaj yeem txhim kho cov metabolic stability, qhov ncauj bioavailability thiab lub hom phiaj khi tshwj xeeb ntawm cov tshuaj.
Raws li tus yam ntxwv no, nws yog dav siv nyob rau hauv cov synthesis ntawm ntau pawg ntawm biomedical tshuaj, nrog rau cov hom phiaj tshuaj tua kab mob, polypeptide tshuaj tiv thaiv adjuvants, recombinant loj hlob yam regulators thiab neurotransmitter analog tshuaj.
Hauv kev kho mob, cov tshuaj muab tau los npog cov kev kho mob ntawm cov qog nqaij hlav tsis zoo, cov kab mob neurodegenerative ntev xws li Alzheimer's thiab Parkinson's, thiab cov kab mob metabolic xws li ntshav qab zib thiab lipid metabolism abnormalities. Tsis tas li ntawd, nws kuj tuaj yeem siv rau kev hloov kho cov qauv ntawm cov tshuaj polypeptide tshiab los tiv thaiv - cov tshuaj qog nqaij hlav, txo cov tshuaj lom thiab cov kev mob tshwm sim ntawm cov tshuaj ntawm tib neeg lub cev thiab txhim kho cov kev kho mob ntawm cov tshuaj kho mob.
2. Kawm txog cov qauv protein
Hauv kev ua haujlwm ntawm cov txheej txheem biology thiab kev tshawb fawb txog kev tsim vaj tsev protein, oxolan-3-amine yog ib qho tseem ceeb hloov kho cov cuab yeej rau cov protein molecules.
Los ntawm kev paub txog tshuaj lom neeg grafting thiab qhov chaw- cov thev naus laus zis hloov kho tshwj xeeb, cov kws tshawb nrhiav tuaj yeem qhia cov pab pawg oxolan-3-amine rau hauv cov amino acid tshwj xeeb ntawm cov kab mob hauv nruab nrog cev thiab cov kab mob extracellular.
Kev taw qhia ntawm cov qauv heterocyclic nruj no tuaj yeem kho cov qauv theem nrab thiab qib tertiary spatial ntawm cov protein, hloov cov hydrophobicity, hydrophilicity thiab steric hindrance yam ntxwv ntawm cov protein molecular nto, thiab ntxiv tswj cov folding efficiency, stability thiab polymerization lub xeev ntawm cov proteins.
Los ntawm kev sib piv cov qauv sib txawv thiab kev ua haujlwm hloov pauv ntawm cov protein hloov pauv thiab cov proteins ntuj, cov kws tshawb fawb tuaj yeem tshawb nrhiav kev sib raug zoo ntawm cov qauv protein thiab kev ua haujlwm lom. Nws tuaj yeem saib xyuas cov kev hloov pauv ntawm cov protein hauv lub sijhawm tiag tiag thaum lub sijhawm cell metabolism thiab teeb liab kis tau tus mob, nthuav tawm cov txheej txheem kinetic ntawm kev ua kom cov protein, inactivation thiab kev sib cuam tshuam, thiab muab lub hauv paus tseem ceeb rau kev piav qhia lub neej thiab tshuaj xyuas cov hom phiaj tshiab.
3. Synthesis ntawm fluorescent probes
oxolan-3-amine yog ib qho tseem ceeb hluavtaws precursor rau siab -kev ua tau zoo lom fluorescent probes. Nws cov molecular amino pawg tuaj yeem ua tau zoo ua ke nrog fluorescent chromophores xws li coumarin, fluorescein thiab rhodamine, thiab lub nplhaib tetrahydropyran tuaj yeem txhim kho cov dej solubility thiab biocompatibility ntawm kev sojntsuam molecules thiab txo qis kev sib khi nrog cov ntaub so ntswg lom. Cov fluorescent probes synthesized raws li oxolan-3-amine muaj qhov zoo ntawm cov tshuaj lom neeg tsawg, muaj zog tiv thaiv kev cuam tshuam thiab ruaj khov fluorescence teeb liab, uas zoo tshaj rau cov tshuaj fluorescent yooj yim.
Hauv kev tshawb fawb txog roj ntsha thiab kev kho mob, cov kev sojntsuam no tuaj yeem ua tiav siab - kev tshawb pom thiab kev soj ntsuam kom muaj nuj nqis ntawm cov khoom siv me me (xws li cov pa oxygen reactive, amino acids, thiab hlau ions) thiab cov protein ua haujlwm hauv cov hlwb thiab cov ntaub so ntswg lom. Tsis tas li ntawd, lawv tuaj yeem siv tau tiag tiag -lub sijhawm taug qab ntawm lub hom phiaj biomolecules, dynamic saib xyuas cov protein-protein thiab protein-me me molecule kev sib cuam tshuam, thiab hauv -kev tsom xam qhov tob ntawm cell proliferation, apoptosis, metabolism thiab lwm yam txheej txheem kinetic. Lawv yog cov cuab yeej pabcuam tseem ceeb rau kev kuaj xyuas ntawm tes, hauv vivo cov ntaub so ntswg tracing thiab kev tshawb fawb subcellular qauv, thiab tau siv dav hauv kev tshawb fawb lom neeg, kev tshawb nrhiav pathological thiab kev tshuaj xyuas tshuaj preclinical.
4. Synthetic tshuaj tua kab thiab tshuaj tua kab mob
Hauv kev lag luam agrochemicals,4-Aminotetrahydropyranyog ib qho tseem ceeb ntawm cov txheej txheem cyclic rau cov synthesis ntawm siab -efficiency, low- tshuaj lom ntsuab tshuaj tua kab thiab tshuaj tua kab. Cov pa ruaj khov - muaj cov qauv heterocyclic ntawm oxolan-3-amine tuaj yeem nkag mus rau hauv cov molecular molecular ntawm cov tshuaj agrochemicals, uas tuaj yeem txhim kho cov tshuaj molecular affinity ntawm tshuaj tua kab thiab tshuaj tua kab mob rau cov nroj tsuag kab tsuag thiab nroj tsuag physiological sites, thiab txhim kho cov tshuaj siv tau thiab ib puag ncig stability. Los ntawm kev hloov kho thiab derivatizing oxolan-3-amine, cov kws tshawb fawb tuaj yeem tsim ntau yam tshuaj tua kab, tshuaj tua kab thiab tshuaj tua kab mob.
Ntawm lawv, fungicides muab tau los ntawm nws tuaj yeem cuam tshuam kev loj hlob thiab kab mob ntawm cov nroj tsuag pathogenic fungi xws li powdery mildew thiab xeb; Cov tshuaj tua kab tsom tuaj yeem ua rau lub paj hlwb thiab cov kab mob metabolic ntawm cov kab tsuag qoob loo kom ua tiav cov kab tsuag kom zoo; Kev xaiv tshuaj tua kab mob tuaj yeem cuam tshuam kev loj hlob ntawm malignant weeds yam tsis muaj kev puas tsuaj rau cov qoob loo. Cov khoom lag luam agrochemical no tuaj yeem tswj tau cov kab mob qoob loo, kab kab thiab nroj tsuag phom sij, txo qis cov khoom ua liaj ua teb, thiab txhim kho cov txiaj ntsig zoo thiab zoo ntawm cov nplej, zaub thiab cov qoob loo nyiaj ntsuab, thaum qhov qis - cov yam ntxwv seem ntawm cov qauv kuj ua tau raws li cov kev xav tau ntawm kev ua liaj ua teb ntsuab niaj hnub.
5. Cov khoom siv hluavtaws polymer
Oxolan-3-amine yog ib qho zoo heev ua haujlwm monomer thiab hloov cov khoom siv raw rau kev npaj cov ntaub ntawv polymer ua haujlwm siab. Relying ntawm dual reactivity ntawm cov amino pawg thiab cov qauv kev ruaj ntseg ntawm tetrahydropyran rings, nws tuaj yeem koom rau hauv cov tshuaj tiv thaiv polymerization xws li polycondensation thiab ntxiv polymerization, thiab yuav grafted thiab hloov kho ntawm ntau yam ntaub ntawv polymer rau endow cov ntaub ntawv nrog cov khoom siv tshwj xeeb. Tam sim no, nws tau ua tiav zoo rau kev npaj ntawm cov ntse hydrogels, ua haujlwm ntawm cov yeeb yaj kiab polymer, biomedical nanomaterials thiab cov ntaub ntawv sib xyaw polymer.
Cov ntaub ntawv polymer hloov kho los ntawm oxolan-3-amine muaj biocompatibility zoo heev, txhua yam hloov tau yooj yim, ib puag ncig teb thiab tshuaj lom neeg ruaj khov. Nyob rau hauv biomedical teb, cov npaj hydrogels yuav siv tau raws li sustained-tso tawm cov tshuaj, cov ntaub so ntswg engineering scaffolds thiab cov ntaub qhwv lub qhov txhab, uas muaj peev xwm paub qhov qeeb tso tshuaj thiab txhawb cov ntaub so ntswg kho; nyob rau hauv kev tshawb fawb ntawm ib puag ncig, cov khoom siv ua haujlwm polymer tuaj yeem siv rau adsorption thiab purification ntawm hnyav hlau ions thiab organic kuab paug hauv dej; Tsis tas li ntawd, cov khoom siv nanocomposite tau txais los kuj muaj cov ntawv thov dav dav hauv biosensing thiab saj zawg zog cov khoom siv.
6. Synthetic spices thiab condiments
Hauv kev lag luam khoom noj thiab tsw, oxolan -3-amine yog ib qho tseem ceeb nruab nrab rau kev sib txuas ntawm heterocyclic tsw thiab cov tshuaj tsw qab. Nws tuaj yeem raug cyclization, condensation thiab oxidation cov tshuaj tiv thaiv nrog aldehydes, ketones thiab sulfur-muaj cov sib txuas los ua ke ntau yam ntawm cov khoom tseem ceeb xws li pyrazine, thiazole thiab pyran derivatives. Cov heterocyclic tebchaw muaj nplua nuj thiab tshwj xeeb aroma yam ntxwv, nrog rau nutty, roasted, fruity thiab meaty flavors, thiab muaj zog fragrance li thiab tsw hloov los.
Cov txuj lom thiab condiments synthesized los ntawm oxolan-3-amine muaj kev nyab xeeb, ruaj khov thiab tsis yooj yim rau volatilize, thiab yog siv dav hauv kev ua zaub mov, dej haus blending, haus luam yeeb flavoring thiab catering seasoning. Lawv tuaj yeem txhim kho qhov saj thiab aroma ntawm ci zaub mov, khoom noj txom ncauj, dej haus thiab cov khoom lag luam luam yeeb, npog cov ntxhiab tsw ntxhiab ntawm cov khoom siv raw, thiab txhim kho cov txheej txheem thiab durability ntawm tsw, uas yog ib qho tseem ceeb raw khoom nyob rau hauv cov khoom noj niaj hnub tsw thiab kev lag luam fragrance niaj hnub.
7. Tshuaj lom neeg nruab nrab
Raws li ntau yam tshuaj lom neeg nruab nrab, oxolan -3-amine muaj qhov zoo heev ntawm cov khoom siv hauv cov organic synthesis thiab kev lag luam tshuaj zoo. Nws cov active thawj cov amino pawg thiab ruaj khov tetrahydropyran nplhaib qauv ua rau nws yooj yim rau kev ua hauj lwm pab pawg neeg hloov siab los ntseeg xws li alkylation, acylation thiab condensation, thiab tuaj yeem muab tau rau hauv ntau yam khoom muaj txiaj ntsig zoo.
Hauv kev lag luam tshuaj thiab tshuaj lom neeg, nws tuaj yeem siv rau kev sib txuas ntawm cov tshuaj atypical antidepressants tshiab, dav -spectrum tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv - inflammatory analgesics, thiab cov qauv qhia tetrahydropyran tuaj yeem txhim kho cov tshuaj solubility thiab hauv vivo stability; hauv agrochemical teb, nws tuaj yeem ua tiav rau hauv siab -kev ua haujlwm qis- cov tshuaj tua kab thiab acaricides; Hauv kev lag luam dyeing, nws tuaj yeem siv los ua tus hloov kho rau cov hluavtaws organic dyes, txhim kho cov xim ceev thiab tinting zog ntawm cov xim molecules. Tsis tas li ntawd, nws tseem tuaj yeem siv rau hauv kev sib txuas ntawm surfactant additives thiab chemical auxiliary agents, muab cov khoom siv tseem ceeb rau kev kho dua tshiab thiab iteration ntawm ntau yam khoom siv tshuaj zoo.
Cov nram qab no yog cov ncauj lus kom ntxaws kauj ruam ntawm peb txoj kev rau synthesizing4-Aminotetrahydropyran:
1. Hydroxyl tiv thaiv txoj kev:
4-OH-THP + NaH → 4-H-THP + NaOH
4-H-THP + O2→ 4-COOH-THP + OH-
4-COOH-THP + NH2R → NH2THP + COOH-R
(1) Synthesis ntawm triphenylmethyltetrahydropyranol (Tr-THP-}OH):
Nyob rau hauv cov dej tsis muaj dej thiab tsis kub (0 degree), cov hydroxyl pawg ntawm tetrahydropyran (THP) raug tiv thaiv, feem ntau yog siv triphenylmethyl pawg tiv thaiv (Tr), los ua ke triphenylmethyltetrahydropyranol (Tr-THP-OH). Cov kauj ruam tshwj xeeb yog: ntxiv anhydrous triphenylchloromethane thiab cov organic hauv paus (xws li NaH, NaNH2, thiab lwm yam) rau tetrahydropyran, nplawm ntawm 0℃rau ob peb teev kom tau txais triphenylmethyltetrahydropyran cawv.
(2) Tshem tawm triphenylmethyl:
Ntxiv cov acids muaj zog (xws li HCl, TFA, thiab lwm yam) rau triphenylmethyl tetrahydropyranol rau cov tshuaj tiv thaiv ntawm kev tshem tawm triphenylmethyl los tsim 4-hydroxytetrahydropyranol.
(3) Oxidizing hydroxyl thiab txo cov carboxyl pawg:
Cov tau txais 4-hydroxytetrahydropyran yog oxidized rau carboxyl pawg siv oxidants xws li KMnO4, mCPBA, thiab lwm yam., thiab tom qab ntawd txo mus rau cov amino pawg siv txo cov neeg ua haujlwm xws li NaBH4, DIBAL, thiab lwm yam kom tau 4Aminotetrahydropyran.
2. Amino tiv thaiv txoj kev:
4-OH-THP + HCl → 4-Cl-THP + H2O
4-Cl THP + O2→ 4-COOH THP + Cl2
4-COOH-THP + NH2R → NH2THP + COOH-R
(1) Synthesis of Diethoxymethane Tetrahydropyranol (DEM{1}}THP-OH):
Nyob rau hauv cov dej tsis muaj dej thiab tsis kub (0 degree), cov amino pawg ntawm tetrahydropyran raug tiv thaiv, feem ntau yog siv diethyloxymethane los ua pab pawg tiv thaiv los ua ke ntawm diethyloxymethane tetrahydropyranol (DEM-THP-OH). Cov kauj ruam tshwj xeeb yog: ntxiv cov anhydrous diethoxymethane thiab cov organic hauv paus (xws li NaH, NaNH2, thiab lwm yam) rau tetrahydropyran, nplawm ntawm 0℃rau ob peb teev kom tau txais cov cawv diethoxymethane tetrahydropyran cawv.
(2) Tshem Tawm Diethoxymethane:
Ntxiv cov acids muaj zog (xws li HCl, TFA, thiab lwm yam) rau diethyloxymethane tetrahydropyranol rau cov tshuaj tiv thaiv ntawm kev tshem tawm diethyloxymethane los tsim 4-hydroxytetrahydropyranol.
(3) Oxidizing hydroxyl thiab txo cov carboxyl pawg:
Cov tau txais 4-hydroxytetrahydropyran yog oxidized rau carboxyl pawg siv oxidants xws li KMnO4, mCPBA, thiab lwm yam., thiab tom qab ntawd txo mus rau cov amino pawg siv txo cov neeg ua haujlwm xws li NaBH4, DIBAL, thiab lwm yam kom tau 4Aminotetrahydropyran.
3. Cyclic compound method:
CbzOH + H+→ CbzH + OH-
CbzH + O2→ CbzCOOH + OH-
CbzCOOH + NH2R → NH2Cbz + COOH-R
(1) Synthesis ntawm cyclic compounds: Ua ntej, synthesize cyclic compounds xws li cyclobutanone (Cbz) thiab react nrog 4-hydroxytetrahydropyran kom tau cyclobutanone tetrahydropyranol (Cbz THP OH). Cov kauj ruam tshwj xeeb yog los ua rau cyclobutanone nrog anhydrous tetrahydropyran nyob rau hauv qhov kev txiav txim ntawm cov organic puag kom tau cyclobutanone tetrahydropyran cawv.
(2) Tshem tawm Cbz: Ntxiv cov kua qaub uas muaj zog (xws li HCl, TFA, thiab lwm yam) rau cyclobutanone tetrahydropyranol rau cov tshuaj tiv thaiv ntawm kev tshem tawm Cbz los tsim 4 aminotetrahydropyranol.
(3) Deamination: Cov tau txais 4 aminotetrahydropyran yog oxidized rau carboxyl pawg siv oxidants xws li KMnO4, mCPBA, thiab lwm yam., thiab tom qab ntawd txo mus rau amino pawg siv txo cov neeg ua haujlwm xws li NaBH4, DIBAL, thiab lwm yam.4-Aminotetrahydropyran.
Cov ntawv thov tseem ceeb hauv Kev Tsim Tshuaj Niaj Hnub Nyoog
Kev loj hlob ntawm Anticancer Tshuaj
Cov amino pawg ntawm oxolan-3-amine tuaj yeem koom nrog hauv kev tsim cov ntawv cog lus amide, tsim cov peptide analogues nrog kev ua haujlwm lom neeg. Piv txwv li, hauv kev tsim cov proteasome inhibitors, cov qauv nruj ntawm lub nplhaib pyran simulates -panicle conformation ntawm peptide saw, txhim khu lub peev xwm ntawm cov molecule rau lub active site ntawm proteasome. Cov kev tshawb fawb preclinical tau pom tias cov tebchaw nrog cov pob txha no nthuav tawm cov kev ua haujlwm nanomolar inhibitory tiv thaiv ntau cov kab mob myeloma, thiab lawv cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog kev thaiv cov protein degradation txoj kev kho los ntawm cov proteasome.
Optimization ntawm Antimicrobial Tshuaj
Txhawm rau ua kom tau raws li qhov xav tau kev kho mob rau tshuaj- cov kab mob tiv thaiv kab mob, cov kws tshawb fawb tau koom nrog oxolan-3-amine rau hauv cov qauv ntawm -lactam tshuaj tua kab mob. Cov ether oxygen atom ntawm lub nplhaib pyran tuaj yeem simulate lub ntuj substrate conformation ntawm penicillin-binding protein (PBP), thaum cov amino pawg pab txhawb kev affinity nrog lub active site ntawm PBP los ntawm hydrogen bonding. Cov tshuaj tua kab mob hloov kho tau ua tiav qhov tsawg kawg nkaus inhibitory concentration (MIC) ntawm 0.125 ug / mL tiv thaiv methicillin-resistant Staphylococcus aureus (MRSA), uas yog 8 npaug siab dua li cov tshuaj ib txwm siv.
Innovation hauv Drug Delivery Systems
Lub lipophilic xwm ntawm no compound ua rau nws yog ib tug zoo tagnrho cab kuj rau prodrug tsim. Los ntawm kev sib txuas los tiv thaiv-cov tshuaj qog nqaij hlav nrog cov carboxylic acid derivative ntawm oxolan-3-amine, daim nyias nyias permeability ntawm cov tshuaj tuaj yeem txhim kho tau zoo. Piv txwv li, kev sib sau ntawm paclitaxel-pyran ester prodrug hauv cov ntaub so ntswg yog 3.2 npaug siab dua li cov tshuaj niam txiv. Cov txheej txheem cuam tshuam nrog lub hom phiaj tso tawm tshwm sim los ntawm esterase thiab txhim kho cell uptake mediated los ntawm pyran nplhaib.
Yav tom ntej Prospects: Los ntawm cov cuab yeej Molecular mus rau Precision Tshuaj
Nrog rau kev koom ua ke ntawm kev suav chemistry thiab hluavtaws biology, daim ntawv thov ntawm oxolan-3-amine yog nthuav. Lub virtual kev tshuaj ntsuam xyuas platform raws li kev kawm tob tau txheeb xyuas hom kev khi ntawm cov pob txha no nrog lub ntsiab protease ntawm SARS-CoV-2, muab cov kev taw qhia tshiab rau kev txhim kho cov tshuaj tiv thaiv kab mob. Ntxiv mus, cov poov xab cell Hoobkas tsim los ntawm CRISPR-Cas9 thev naus laus zis tuaj yeem ua tiav cov biosynthesis ntawm oxolan-3-amine los ntawm cov piam thaj, ntxiv txo cov nqi tsim khoom thiab txhawb kev tsim tshuaj ntawm tus kheej.
Los ntawm cov txheej txheem ntawm cov suab thaj ntuj mus rau lub hauv paus tseem ceeb ntawm kev tiv thaiv - tshuaj mob qog noj ntshav, cov tshuaj lom neeg taug kev ntawm oxolan-3-amine piv txwv cov tshuaj lub tswv yim ntawm "cov qauv txiav txim siab ua haujlwm". Nrog rau kev ua tiav hauv kev sib koom tes thev naus laus zis, cov molecule no yuav txuas ntxiv mus ua lub luag haujlwm tseem ceeb hauv kev siv tshuaj tshiab, muab kev daws teeb meem ntau ntxiv rau tib neeg kev noj qab haus huv.
Cim npe nrov: 4-aminotetrahydropyran cas 38041-19-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom