Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov khoom lag luam ntawm 4 {}} Phenylalanine CAS 62561- 74-4 hauv Suav teb. Txais tos rau kev lag luam wholesale ntau qhov zoo 4-bromo-d-phenylalanine CAS 62561-74-4 Kev Muag Khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
4 {- bromo - d-phenylalanineFeem ntau muaj nyob rau hauv daim ntawv ntawm dawb txog yuav luag dawb crystalline cov khoom. Cov mis molecular yog c9Hhaisbrno2, CAS 62561 {{}}}}} {}} Soluble hauv qee cov kuab tshuaj organic, xws li methhanol, ethanol, thiab dichhloromethane. Lub solubility hauv dej yog qhov tsawg. Nws yog chiral molecule thiab belongs rau lub d- lub tsev. Nws muaj qhov hloov kho kho qhov muag thiab tuaj yeem ua rau pom kev sib hloov duab kom yauv hloov kho qhov muag. Ntxiv rau kev siv rau synthesizing peptide thiab cov tshuaj protein, nws kuj tseem tuaj yeem siv rau synthesizing peptide peptide {}} theem synthes itthests. Cov reagents no tuaj yeem siv los txuas cov amino acids nyob rau hauv cov khoom siv-theem synthesis, yog li npaj ntau peptide khoom-theem pepitionide-theem synthesis tshuaj lom neeg. Cov reagents no tuaj yeem siv los kawm cov qauv thiab cov haujlwm ntawm peptides thiab cov protein, nrog rau kev sib cuam tshuam ntawm peptides thiab cov protein.
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Tshuaj Cov Qauv |
C9H10BRNO2 |
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Muaj pes tsawg leej |
243 |
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Molecular hnyav |
244 |
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m/z |
243 (100.0%), 245 (97.3%), 244 (9.7%), 246 (9.5%) |
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Kev Ntsuam Xyuas |
C, 44.29; H, 4.13; Br, 32.74; N, 5.74; O, 13.11 |
4 {- bromo - d-phenylalanineyog qhov sib txuas nrog cov kev siv tseem ceeb, thiab cov hauv qab no yog txhua yam nws siv:
Nws yog ib qho uas nquag siv cov amino acids analogue uas tuaj yeem siv los ua ke peptide peptide thiab cov tshuaj protein. Nws muaj cov tshuaj zoo sib xws thiab cov qauv rau ntuj amino acids, ua rau nws hloov cov khoom siv zoo. Los ntawm kev qhia 4 {{- bromo-d phenylalanine rau hauv cov tshuaj pepylalan-d, yog li kev txhim kho nws txoj kev ua tau zoo thiab txo cov kev ua tau zoo thiab txo cov kev mob tshwm sim thiab txo cov kev mob tshwm sim.
4 {- bromo - d phenylalanine feem ntau yog siv los ua cov tshuaj thiab cov haujlwm tshwj xeeb. Cov tshuaj no tuaj yeem siv los kho ntau yam kab mob, muaj kab mob ua kom muaj kab mob thiab kev ruaj khov los ntawm kev ua tau zoo ntawm cov tshuaj thiab txo cov kev mob tshwm sim.
2. Siv los kawm cov qauv protein:
4 {- bromo - d phenylalanine tuaj yeem siv los kawm cov qauv protein. Vim nws cov tshuaj chemical zoo ib yam li cov amino acids, nws tuaj yeem siv los npaj cov protein mutants los kawm cov qauv muaj protein. Los ntawm kev qhia 4-bromo-d phenylalanine rau cov protein, tus qauv thiab cov protein tuaj yeem hloov, yog li cuam tshuam lawv cov haujlwm thiab kev ua haujlwm. Cov thev naus laus zis no tau siv dav hauv kev kawm ntawm cov qauv thiab kev ua haujlwm ntawm ntau cov protein.
Hauv kev kawm cov qauv protein, 4 {- bromo {} d phenylalanine feem ntau siv tau los sau cov chaw tshwj xeeb hauv cov protein. Los ntawm kev qhia 4 {{{{- bromo-d phenylalanine rau cov protein, cov qauv thiab kev ua tiav ntawm cov protein tuaj yeem kawm tau. Tsis tas li ntawd, hauv kev kawm cov qauv protein ntau, 4-bromo-d phenylanine kuj tseem siv tau los npaj cov txheej txheem molecular lees paub hauv kev txhaj tshuaj molecular lees paub hauv kev txhaj tshuaj
3. Siv rau synthesizing fluorescent probes:
4 {- bromo-bromo-phenylalanine tuaj yeem siv los ua cov lus txhawb tshuaj fluorescentize. Vim nws lub bromine atom, cov pab pawg fluorescent tuaj yeem nkag rau hauv kev sojntsuam los npaj cov khoom noj fluorescent. Cov kev ua fluorescent no tuaj yeem siv los tshawb xyuas cov khoom siv me me thiab cov protein hauv kev sib cuam tshuam thiab kev sib cuam tshuam ntawm cov roj ntsha molecules.
Fluorescent probes yog ib qho ntawm cov cuab yeej siv feem ntau hauv biology thiab tshuaj, uas tuaj yeem siv los kawm cov txheej txheem roj ntsha ntawm cov hlwb thiab cov ntaub so ntswg. Los ntawm kev qhia 4 {{{- bromo-d phenylalanine rau hauv cov kev sojntsuam fluoralt nrog cov wavelengtengt. Cov kev ua fluorescent no tuaj yeem siv los tshawb xyuas cov lus qhia txog kev kawm thiab cov protein rau lawv cov txheej txheem hauv zos, thiab cov txheej txheem dynamic. Ib qho ntxiv, fluorescent probates kuj tseem siv tau hauv xov tooj ntawm tes thiab tracing kev kawm kom kawm cov txheej txheem roj ntsha ntawm cov hlwb thiab cov ntaub so ntswg.
4. Siv rau synthesizing tsis yog ntuj amino acid analogues:
4 {- bromo-bromo-phenylalanine tuaj yeem siv los ua synthesize tsis muaj ntuj amino acid analogues. Los ntawm reacting nrog cov reagents tsim nyog, ib qho ntawm cov tsis muaj txiaj ntsig amino acids analogues muaj cov pab pawg sib txawv tuaj yeem npaj tau. Cov tebchaw no tuaj yeem ua cov neeg sib txuas lus zoo rau cov neeg siv tshuaj thiab cov ntaub ntawv ua haujlwm, rau kev kho mob ntawm cov kab mob thiab kev txhim kho cov ntaub ntawv tshiab.
Tsis muaj ntuj amino acids analogues yog ib qho kev tshawb nrhiav tseem ceeb hauv cov kev tshawb fawb niaj hnub thiab cov khoom siv tshiab. Los ntawm kev qhia 4 {{{- Bromo {}}} d phenylanine rau cov analogues, ib qho kev sib txuas nrog cov qauv tshwj xeeb thiab muaj nuj nqi tuaj yeem npaj tau. Cov tebchaw no tuaj yeem ua cov neeg sib tw ua haujlwm tau ua cov khoom siv tshuaj, thiab lwm yam, rau cov ntawv thov ua kom zoo xws li cov tshuaj tua kab mob, thiab cov ntaub ntawv tsim khoom tshiab, thiab tsim cov ntaub ntawv tshiab.
5. Siv rau synthesizing tshuaj tua kab thiab tshuaj ntsuab:
4 {- bromo - d-phenylalaninetuaj yeem siv los siv tshuaj tua kab thiab tshuaj tua kab. Nws tuaj yeem raug siv los ua kev thaiv kom synthesize cov qauv sib zog hauv ntau yam tshuaj tua kab thiab tshuaj tua kab molecules. Cov tshuaj tua kab no thiab cov tshuaj tua kab tuaj yeem siv los tswj cov nroj tsuag kab mob, kab tsuag, thiab nroj, txhim kho cov qoob loo tawm los thiab ua tau zoo.
Tshuaj tua kab thiab cov tshuaj tua kab yog ib qho ntawm cov tshuaj uas ib txwm siv hauv kev ua liaj ua teb, cov tshuaj tua kab, txhim kho cov txiaj ntsig zoo thiab ua kom zoo.
Los ntawm kev qhia 4 {{{{- bromo {}} kev ua tshuaj tua tshuaj, ua rau kev txhim kho cov tshuaj tua kab mob ntau dua lossis tshuaj tua kab ua haujlwm zoo dua. Tsis tas li ntawd, 4-bromo-d phenylalanine kuj tseem siv tau los npaj tshuaj tua kab thiab lwm yam tshuaj ua liaj ua teb kom tswj tau cov kab tsuag thiab kev tiv thaiv cov qoob loo.
4 {- bromo-bromo-phenylalanine yog qhov sib txuas nrog cov ntawv thov tseem ceeb, thiab nws cov tswv yim synthesis muaj xws li ob qho no:
Txoj kev 1:
Txoj kev synthesis ntawm hom qauv no yog siv acetophenone li cov khoom siv raw, thiab tau txais 4 {{1} {{1} {1} {1} bromo-delination, thiab daws teeb meem. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Dissve acetophenone nyob rau hauv cov carbon qhuav tetrachloride, maj mam qhia bromine hauv qhov txias thiab cuam tshuam rau qhov kub thiab ntsuas kub.
Tus br2 + C6H5Cooj3 → C6H5Cooj2Tus br
Tom qab cov tshuaj tiv thaiv brominate ua tiav, ib qho tshuaj pleev Hydrocium hydroxide muaj ntxiv thiab 10℃rau nucleophilic hloov cov kev ntxias kom tau txais 4-bromophenone.
C6H5Cooj2Br +h → c6H5Cooj2Tus ua mov noj
Dissolve 4-bromophenyl ketone hauv anhydrous ethanol thiab ntxiv sodium hydroxide tov rau cov khoom siv tshuaj tiv thaiv esterification kom tau txais 4-bromophenyl acetate.
C6H5Cooj2Cooking + Ch3Ch2Oh → c6H5Cooj2Txoj hlua khi2H5+ Koh
Dissololve Ethyl 4-Bromophenylacetate nyob rau hauv ib co methanol daws me me tshuaj methohos rau kom muaj methyl 4-bromophenyylpropionate.
C6H5Cooj2Txoj hlua khi2H5 + Ch3Oh + ch3Ona → c6H5Cooj2Txoj cai3+ Nabr + Naoh
Kev daws teeb meem hydrolysis tau nqa tawm ntawm methyl 4-bromothlenyfproctate thiab sodium carbonate aque oxe kua nyob rau 70 qib kom tau txais sodium 4-bromophenyylpropionate.
C6H5Cooj2Txoj cai3 + NA2Co las3 → C6H5Cooj2Coona + ch3Tus ntses
4-Bromophenylalanine tau txais los ntawm neutralizing 4-bromophenylalanine sodium nrog hydrochloric acid ntawm 80 degree.
C6H5Cooj2Coona + hc → c6H5CH (BR) COoH + Nacl
Crystallize 4 {{{{- bromopsylalanine nrog hydobromic acid kom tau txais kev coj siab4 {- bromo - d-phenylalanine.
C6H5CH (BR) COOH + HBR → C6H5CH (Br) COO (-) br (+)
Qhov zoo ntawm cov qauv no yog muaj kev yooj yim ntawm cov ntaub ntawv raw, cov kauj ruam yooj yim, cov tshuaj tiv thaiv me, muaj txiaj ntsig zoo, thiab cov khoom lag luam zoo.
Txoj kev 2:
The synthesis route of this method is based on chiral ring - Amino alcohol is used as the raw material to obtain 4-bromo-D phenylalanine through bromination, amination, and resolution. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
1. Chiral nplhaib -} chromicized ntawm amino Cawv nrog phosphorus Tribromide {2} brominated cawv:
Tus br2+ Ch (oh) r → ch (oh) rbr
2. Chairality -}}}}}}}}}}}}}}}}}}} Hydroassium- potassium bromate:
Ch (oh) rbr + koh → ch (oh → ch (oh → br ({-) k (+)
3. Chairality -}}}}}}}}}}}}}}}}}}}}}} {}- brominated Esters:
Ch (oh) rk + ch3Ch2Oh → ch (oh) rcooc2H5+ Koh
4. Chairality - kev tawm tsam ntawm brominated Esters nrog ammonium chloride los ua chairralide los ua chairmalide {} amino acid Esters:
Ch (oh) rcooc2H5+ NH4Cl → ch (oh) rnhocr2H5+ HCL
5. Chairality -}}}}}}}}}} ecoral ntawm amino acid esters nrog sodium carbonate- cov amino acids:
Ch (oh) rnhocr2H5 + NA2Co las3→ CH (OH) RNHCOOA + CO3Na
6. Chairality -}}}}}}}}}}}}}} acids nrog hydrochloric acid {}} amino cawv:
Ch (oh) rnhcoloon + hcl → ch (oh) rnh2+ Nacl
7. Chairrality -}}}}}}}}}}}}}} {Cawv Nrog Cov Hydobromic Acid {2} Brominated cawv:
Ch (oh) rnh2+ HBR → CH (Oh) rnhbr
8. Chairality -}}} chromality ntawm cov tshuaj tiv thaiv ntawm cov cawv nrog sodium hydroxide {2 2}} hydroxyl acid:
Ch (Oh) rnhbr + Naoh → Ch (Oh) Rcoona + NHBR (-) na (+)
9. Chairality - kev tawm tsam ntawm hydroxyloric acid los tsim cov siab purity chairality- hydroxyl acid:
Ch (Oh) Rcoona + HCL → CH (Oh) RCOOH + NACL
10. Chairality - hydroxyl acid reacts nrog hydobromic acid los tsim cov siab 4 {} bromo-d Phenylalanine:
Ch (oh) rcooh + hbr → c6H5CH (BR) COOH
Qhov zoo ntawm hom no yog siab xaiv, muaj cov khoom muaj txiaj ntsig siab, tab sis cov khoom siv raw yog siab.
Cim npe nrov: 4 {- bromo - d-phenylalanine CAS-}, cov chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag