4- mexoxytriphenylchlorometehaneyog cov organic sib xyaw ua ke nrog cas 14470-28-1}} thiab molecular mis c14h11Cllo. Feem ntau nws tshwm raws li cov khoom dawb rau lub teeb daj. Nws tuaj yeem yog cov soluble hauv cov kuab tshuaj organic xws li cov cawv, cov neeg raug ntxub, thiab lwm yam, tab sis tsis nyob hauv dej. Qhov no yog vim muaj qhov tsis-ncov qaum teb atoms thiab methoxy pawg nyob rau hauv nws cov qauv molecular, ua rau muaj kev cuam tshuam dej tsis muaj zog nrog dej lwg me me. Qhov ceev ntawm cov compound no feem ntau yog siab dua li ntawm cov dej, thiab tus nqi tshwj xeeb yuav txawv vim muaj kev huv thiab txias thiab txias. Ib yam li ntawd, nws qhov kev ntsuas tshiab yuav sib txawv vim yog qhov kub thiab huv, tab sis feem ntau yog ntau dua 1.5. Qhov no qhia tau tias qhov sib xyaw ua ke muaj kev ua kom siab dua. Qhia pom tseeb infrared spectral yam ntxwv. Qhov no compound muaj lub peev xwm nqus tau muaj zog rau lub teeb infrared nyob rau hauv ib qho wavelength. Nws muaj ntau cov kev siv hauv thaj chaw tshuaj. Nws tuaj yeem ua kev ntseeg tseem ceeb hauv kev sib raug zoo ntawm lwm cov tshuaj thiab koom nrog kev tsim kho cov tshuaj molecules. Piv txwv li, nws tuaj yeem siv los ua ke nrog cov kev sib txuas ua ke nrog cov kev ua haujlwm ntsig txog kev ua si, uas yuav muaj qhov ua kom muaj kev sib txuam, tiv thaiv kev tiv thaiv thiab lwm yam cuam tshuam. Ib qho ntxiv, nws kuj tseem siv tau los ua cov neeg siv tshuaj los txhim kho cov solubility thiab bioavailability ntawm cov tshuaj, yog li txhim kho cov tshuaj.
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C.F |
C20h17CLO |
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E.M |
308 |
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M.W |
309 |
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m/z |
308 (100.0%), 310 (32.0%), 309 (21.6%), 311 (6.9%), 310 (2.2%) |
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E.A |
C, 77.79; H, 5.55; Cl, 11.48; O, 5.18 |
Bioactivity
Ua ntej
MMT-CL raug lees paub rau nws lub luag haujlwm yog kev tiv thaiv pawg neeg tawm tsam hauv cov kev tshawb fawb biochemical. Tshwj xeeb, nws tau siv rau kev tiv thaiv kev tiv thaiv ntawm cov pawg hydroxyl. Qhov kev ua haujlwm no yog qhov tseem ceeb nyob rau hauv cov synthesis ntawm cov molecules uas tiv thaiv hydroxyl pawg yuav tsum tau tiv thaiv tsis xav tau ib ntus thaum lub sij hawm hluavtaws.
Thib ob
MMT-class cov khoom ua pov thawj qee qhov chaw muag tshuaj uas ua rau nws muaj tus neeg sib tw ua rau muaj kev tsim kho tshuaj ntxiv. Txawm hais tias cov kev tshawb fawb ntxaws ntxiv yog tseem niaj hnub kev tshawb fawb qhia tias nws yuav cuam tshuam nrog kev siv roj ntsha uas tuaj yeem ua rau kho cov ntawv thov kho. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nco ntsoov tias ntxiv kev tshawb nrhiav thiab chaw kuaj mob yog qhov tsim nyog kom nkag siab thiab siv tau nws lub peev xwm pharmacological.
Ntxiv mus
MMT-CL lub luag haujlwm thiab solubility cov yam ntxwv pab txhawb rau nws txoj kev ua haujlwm. Nws yog feem ntau ruaj khov nyob rau hauv cov txheej txheem kuaj mob thiab soluble nyob rau qee cov emolic cov kuab tshuaj, uas yog cov khoom haum rau cov kev siv rau kev siv roj ntsha.
Hauv cov ntsiab lus xaus,4- mexoxytriphenylchlorometehane, lossis mmt-cl, qhia qhov tseem ceeb ua ke los ntawm nws siv raws li kev tiv thaiv pawg reagent thiab muaj feem muaj peev xwm pharmacological. Raws li kev tshawb fawb tau nce zuj zus, peb yuav tshem tawm cov roj ntsha ntxiv thiab siv cov ntawv thov ntawm cov khoom sib txuas no ntau yam. Txawm li cas los xij, nws yog qhov tseem ceeb heev rau kev ua cov kev tshawb fawb ruaj khov kom nkag siab txog nws cov kev ua haujlwm ntawm kev txiav txim siab ua ntej txiav txim siab nws rau kev siv tshuaj.
Kev ntsuas tshuaj anchister
Hauv kev ntsuas tshuaj chemistry, nws tuaj yeem siv los ua cov tshuaj tiv thaiv lossis cov qauv tshuaj rau kev txheeb xyuas qhov zoo thiab kev ntsuas ntau ntawm lwm qhov chaw sib txuas. Piv txwv li, nws tuaj yeem siv los ua cov theem ruaj khov lossis mobile ntxiv rau hauv cov tshuaj sib cais los txhim kho kev sib cais thiab kev pom zoo. Ib qho ntxiv, nws kuj tseem tuaj yeem siv los ua kev sojntsuam molecule hauv kev tsom xam meej los kawm cov khoom siv hluav taws xob thiab cov qauv molecular ntawm lwm cov tebchaw.
Cov ntawv thov hauv Chromatographic tsom xam
- Theem nyob hauv theem ntxiv: hauv kua lossis roj chromatography, {} methoxytriphenmethanety, yog li kev txhim kho cov tshuaj lom neeg, yog li kev txhim kho cov tshuaj tsw qab, yog li kev txhim kho cov tshuaj sib cais. Qhov kev sib cuam tshuam no yuav yog raws li cov xwm txheej xws li polarity, hydrophobicity, hydogen nyiaj tsim, thiab lwm yam.
- Txawb theem ntxiv ntxiv: zoo sib xws, nws kuj tseem siv tau rau lub sijhawm khaws cia thiab sib cais ua kom sib cais ntawm cov chromatographic kem. Los ntawm kev kho cov concentration ntawm {{0} mexyoxytriphenylmethans hauv lub xov tooj mobile, qhov kev sib cais tuaj yeem ua tau zoo dua kom tau txais kev sib cais zoo dua.
Cov ntawv thov hauv Spectroscopic Kev Ntsuam Xyuas
- Kev sojntsuam Molecule: Hauv kev tsom xam spectral, {{} methoxytriphenylmutriphenylmutries thiab molecular qauv ntawm lwm cov tebchaw. Los ntawm kev sib sau ua ke lossis cuam tshuam nrog cov compound kom kawm tau, qhov kev hloov pauv ntawm cov ntaub ntawv lossis cov khoom ntawm cov compound.
- Cov Khoom Siv Cov Qauv: Ntxiv rau, nws kuj tseem tuaj yeem siv ua cov khoom siv txheem rau kev ntsuas ntsuas lossis tsim cov txheej txheem ntsuas. Los ntawm kev sib piv nrog 4- methoxytriphenytriphenytriphenyfmetylmetyl
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Synthesize entecavir raws li ib nrab
Entecavir belongs rau chav kawm ntawm deoxyguanosine nucleoside analogues. Nws muab nws cov tshuaj tiv thaiv antiviral los ntawm kev cuam tshuam HBV DNA polymerase, yog li thaiv primer txuas ntxiv thiab saw elongation. Qhov kev siv tshuab ntawm kev nqis tes ua no ua rau nws muaj txiaj ntsig zoo hauv kev txhawb nqa hbv replication. Tshwj xeeb, entecavir tau ua rau pom zoo tshaj plaws ntawm Lamivudine, ntxiv rau cov neeg sawv cev ntawm Libv thiab nthuav tawm HBV thiab nthuav tawm ntau dua.
Daim ntawv nquag ntawm entecavir, nws mus ncig ua si, muaj qhov ntev incacellular ib nrab-lub neej ntawm 15 teev. Los ntawm kev sib tw nrog lub ntuj substrate deoxyguanpualoine mus rau qhov kev sib tw HBIL, entecavir inhibits tag nrho peb cov haujlwm tsis zoo, thiab cov synthesis ntawm txoj kev sib tw ntawm HBV DNA.
Theem II / iii kev tshawb nrhiav cov chaw kuaj mob tau qhia tias kev ua raws li kev ua haujlwm HBV tsis zoo, nrog kev kho mob zoo tshaj li Lamivudine; Theem III cov chaw kuaj mob tau pom tias nce qhov koob tshuaj mus rau 1mg ib hnub twg tuaj yeem ua kom zoo rau HBV DNA replication nyob rau hauv cov tib neeg nrog ymdd sib hloov. Qhov tshwm sim ntawm cov tshuaj tiv thaiv nyob rau hauv thawj zaug kev kho mob yog 0, tab sis qhov tshwm sim ntawm cov neeg mob uas twb tau tsim los ntawm YMDD kev hloov kho tom qab 1 xyoo. SFDA nyob hauv Suav teb tau kuj tau pom zoo rau kev kho mob ntawm cov neeg mob uas muaj kev mob siab B.4- mexoxytriphenylchlorometehaneyog ib qho ntawm cov nruab nrab hauv cov synthesis ntawm entecavir.
Txawm li cas los xij, zoo li cov tshuaj noj, ensecavir yuav ua rau qee cov kev mob tshwm sim. Cov kev sib raug zoo xws li mob taub hau, kiv taub hau, qaug zog, xeev siab, thiab lub plab tsis xis nyob. Cov tsos mob no feem ntau yog me me rau qhov nruab nrab thiab tuaj yeem ploj zuj zus sijhawm. Cov kev mob hnyav dua, xws li lactic acidosis thiab cov nyiaj tau los ntawm cov tshuaj ntsuab, yog qhov yuav tsum tau saib xyuas, tshwj xeeb hauv cov neeg mob muaj kab mob siab siab siab.
Hauv cov ntsiab lus, entecavir yog ib qho kev xaiv thiab siv HBV inhibitor nrog ib qho zoo tsim kev nyab xeeb profile thiab tus nqi tsawg. Nws tseem yog thawj-kab kev kho mob rau kev tswj hwm tus kab mob siab B, muaj kev txhawb nqa thiab txhim kho cov neeg mob lub siab.
4- mexoxytriphenylchlorometehaneyog cov organic tshwj xeeb muaj cov cim ntawm nws cov qauv tshuaj tshwj xeeb thiab cov khoom. Cov molecule no yog rau cov chav kawm ntawm aryl chlorides, muaj ib pawg chlorinated methane hloov nrog peb pawg phenyrother thiab ib pawg neeg phenyl-hloov cov pab pawg phenyl. Tshwj xeeb, ib lub pheny phenyl rings nyob rau hauv no tetra-hloov metra-hloov chaw me me (-och} Txoj haujlwm, paub qhov txawv ntawm lwm qhov chaw pib kos npe mus ncig ua si.
Cov compound lub npe cov lus qhia ntawm nws cov mis molecular, c₂₅h₂₀₂₀Cllo, thiab nws cov qauv kev nyuaj. Lub xub ntiag ntawm cov neeg mexyxy cuam tshuam nws cov kev ua haujlwm thiab cov khoom siv lub cev, xws li solubility thiab polarity, piv rau kev ua haujlwm tsis tau txais txiaj ntsig. Cov chloromethyl (-chCl) moamility muaj ib qho kev ua kom muaj txiaj ntsig zoo hauv cov angomic sib txuas los ntawm kev hloov pauv, tshem tawm, lossis ntxiv cov tshuaj tiv thaiv.
Vim nws cov ntxhiab tsw thiab cov lus sib xyaw ua ke no yuav nthuav tawm cov kev sib txuas lus tshwj xeeb nrog cov hlau, thiab cov kua qaub. Nws tuaj yeem nrhiav cov ntawv thov hauv cov ntaub ntawv txuj ci, qhov twg nws cov kev hloov pauv ntawm cov khoom siv tshuaj ntsuab lossis muaj peev xwm them rau cov kev hloov pauv tshwj xeeb kom yielcically nquag molecules. Txawm li cas los xij, nws cov kev siv thiab cov ntaub ntawv siv tau yog txiav txim siab los ntawm cov hluavtaws hluavtaws thiab qhov tseem ceeb ntawm kev tshawb fawb ntxiv thiab cov khoom siv.
Hauv cov ntsiab lus xaus,4- mexoxytriphenylchlorometehaneyog ib qho txawv txav aryl chloride nrog tshuaj methoxy-hloov cov nplhaib phenyl nplhaib, muab ntau yam hluavtaws tau vim nws cov txheej txheem kab ntsig ntawm Chaloromethyl pab pawg. Nws cov ntawv thov yuav muaj cov lus luv luv teb ntau yam, los ntawm cov organic synthesis rau cov ntaub ntawv kev tshawb fawb, tos kev tshawb nrhiav ntxiv thiab kev tsim kho.
Cim npe nrov: 4- mexoxytriphenylchloromethane? {}}, Cov chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag