Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 4-methylcinnamic acid cas 1866-39-3 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 4-methylcinnamic acid cas 1866-39-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
4-Methylcinnamic acid, tseem hu ua p-methylcinnamic acid, yog ib qho organic compound teej tug mus rau tsev neeg ntawm cinnamic acids. Structurely, nws nta ib pawg yas (C=C-COOH) txuas ncaj qha mus rau lub nplhaib uas muaj ntxhiab, sib tham txog nws cov khoom xws li alkenes thiab cov tshuaj tsw qab. Cov methyl hloov pauv ntawm 4- txoj hauj lwm ntawm lub nplhaib phenyl cuam tshuam rau nws cov kev ua haujlwm thiab cov yam ntxwv spectral, xws li UV-Vis absorption, uas muaj txiaj ntsig zoo rau kev tsom xam.
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Tshuaj Formula |
C10H10O2 |
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Exact Mass |
162.07 |
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Molecular Luj |
162.19 |
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m/z |
162.07 (100.0%), 163.07 (10.8%) |
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Elemental Analysis |
C, 74.06; H, 6.22; O, 19.73 |
Kev lag luam kws tshuaj
Kev tiv thaiv - Cov khoom ua kom mob
- Cov derivatives tuaj yeem ua pov thawj los tiv thaiv- cov haujlwm ua mob, uas yog qhov tseem ceeb rau kev kho mob xws li mob caj dab, mob hawb pob, thiab lwm yam kab mob inflammatory.
- Cov tshuaj no tuaj yeem ua haujlwm los ntawm inhibiting kev tsim khoom lossis kev ua haujlwm ntawm cov neeg kho mob inflammatory, xws li cytokines thiab prostaglandins.
Antibacterial Properties
- Qee cov derivatives tau pom muaj cov kab mob tua kab mob tiv thaiv ntau yam kab mob, suav nrog cov tshuaj tiv thaiv kab mob.
- Cov tshuaj no tuaj yeem cuam tshuam cov kab mob cell membranes lossis inhibit qhov tseem ceeb ntawm cov kab mob enzymes, ua rau lawv muaj peev xwm sib tw rau cov kab mob tshiab.
Lwm Cov Khoom Kho Mob
- Tshaj li kev tiv thaiv- mob thiab tshuaj tua kab mob, cov derivatives kuj tseem tuaj yeem pom cov tshuaj tiv thaiv kab mob, antioxidant, neuroprotective, lossis lwm yam khoom siv kho mob.
- Cov dej num sib txawv no tuaj yeem ua rau muaj kev txhim kho tshiab rau kev kho mob qog noj ntshav, kab mob neurodegenerative, thiab lwm yam mob.
Perfume and Fragrance Industry
Lub luag hauj lwm ua tus precursor rau synthesizing complex thiab nuanced aromatic tebchaw underscores nws tseem ceeb nyob rau hauv cov tshuaj tsw qab kev lag luam. Los ntawm kev ua kom muaj kev tsim tshwj xeeb thiab ntev ntev - cov tshuaj tsw qab, qhov sib xyaw no ua rau muaj kev tsim kho tshiab, kev hloov kho, thiab kev ua lag luam sib txawv ntawm cov naj hoom, colognes, thiab lwm yam khoom siv tu tus kheej. Nws lub peev xwm rau kev tsim khoom ruaj khov txuas ntxiv nrog cov qauv tshiab hauv kev lag luam, ua rau nws muaj txiaj ntsig zoo rau cov khoom lag luam tshuaj tsw qab.
Creation ntawm Unique Fragrances
- Cov tshuaj tsw qab uas tau muab los ntawm nws tuaj yeem nthuav tawm ntau yam ntxhiab tsw, xws li paj, txiv hmab txiv ntoo, ntoo, lossis cov ntawv ntsim.
- Cov ntawv sib txawv thiab cov nuances no tso cai rau cov neeg tsim tshuaj tsw qab sib xyaw thiab txheej txheej sib txawv kom ua tiav qhov xav tau tus ntxhiab profile uas ua raws li cov neeg siv khoom nyiam.
Ntev -Ntaus Perfumes thiab Colognes
- Qee cov derivatives nthuav tawm kev txhim kho volatility thiab fixative zog, uas tuaj yeem ua rau lub neej ntev ntawm cov tshuaj tsw qab.
- Los ntawm kev sib xyaw cov tshuaj no rau hauv naj hoom thiab cologne formulations, manufacturers tuaj yeem xyuas kom meej tias cov fragrances tseem nyob ntawm daim tawv nqaij rau lub sijhawm ntev.
Txhim kho Volatility
Tswj Tso Tawm
- Lub volatility ntawm ib tug compound txiav txim nws tus nqi ntawm evaporation. Cov derivatives nrog txhim kho volatility tuaj yeem tsim kom evaporate ntawm tus nqi qis dua, kom ntseeg tau tias qhov kev tso tawm ntawm cov tshuaj tsw qab ntau dua lub sijhawm.
- Qhov kev tso tawm tswj hwm no pab tswj cov ntxhiab tsw zoo ib yam nyob rau ib hnub, muab qhov zoo siab thiab ntev - kev paub ntev rau tus neeg siv.
Cov Lus Sau Tseg
- Cov ntawv sib txawv hauv ib qho tshuaj tsw qab evaporate ntawm tus nqi sib txawv. Los ntawm kev sib txuas cov derivatives nrog volatility tailored, manufacturers muaj peev xwm sib npaug cov evaporation tus nqi ntawm ntau yam ntawv.
- Qhov kev sib npaug no ua kom ntseeg tau tias cov ntawv sau saum toj, nruab nrab, thiab hauv paus hauv cov tshuaj tsw qab sib xyaw ua ke, tsim kom muaj kev sib haum xeeb thiab muaj txiaj ntsig zoo.
Txhim kho Fixative Properties
Lub neej ntev
Fixative compounds yog ib qho tseem ceeb heev rau anchoring fragrances rau ntawm daim tawv nqaij, tiv thaiv lawv los ntawm dissipating sai heev. Derivatives nrog txhim kho fixative zog tuaj yeem ua rau kom lub neej ntev ntawm cov tshuaj tsw qab.
Cov tshuaj no pab khi cov khoom tsis haum ntawm cov tshuaj tsw qab rau ntawm daim tawv nqaij, kom ntseeg tau tias cov ntxhiab tsw tseem tuaj yeem tshawb pom tau ntev.
Subtlety thiab Persistence
Fixatives tsis tsuas yog ncua lub neej ntawm cov tshuaj tsw qab, tab sis kuj cuam tshuam lawv subtlety thiab persistence. Cov derivatives tuaj yeem tsim los muab cov ntxhiab tsw qab, uas tsis yooj yim los yog nrawm.
Qhov kev sib npaug no ua kom ntseeg tau tias cov tshuaj tsw qab tseem qab ntxiag thiab pom tau thoob plaws hauv ib hnub yam tsis muaj kev khaus lossis ploj tag nrho.
Kev lag luam Polymer
4-Methylcinnamic acidyog ib qho tseem ceeb nyob rau hauv kev lag luam polymer, muab lub peev xwm los tsim cov polymers nrog txhim kho thermal stability, mechanical zog, thiab optical transparency. Los ntawm kev sib xyaw cov kua qaub no rau hauv cov polymers los ntawm ntau lub tswv yim, cov tuam txhab tsim khoom tuaj yeem kho cov khoom siv kom tau raws li cov kev xav tau tshwj xeeb ntawm ntau hom kev siv. Qhov kev muaj peev xwm no yog qhov tseem ceeb rau kev tsim kho siab - cov polymers ua tau zoo uas ua tau raws li qhov xav tau nruj ntawm cov cuab yeej siv niaj hnub thiab kev lag luam.
Txhim khu Thermal Stability
Nce Decomposition Kub
- Kev sib xyaw ua ke rau hauv cov saw hlau polymer tuaj yeem nce qhov kub thiab txias ntawm cov khoom tshwm sim. Qhov kev nce hauv thermal stability yog qhov zoo rau cov ntawv thov uas xav tau cov polymers kom tiv taus qhov kub thiab txias yam tsis muaj degrading.
- Qhov muaj ntxhiab tsw thiab nws lub peev xwm los tsim cov ntoo khaub lig ruaj khov- txuas hauv cov polymer matrix pab txhawb rau qhov kev txhim kho thermal stability.
Txhim kho kev tiv thaiv rau Thermal Cycling
- Polymers uas suav nrog nws feem ntau pom tau tias muaj kev tiv thaiv zoo dua rau kev caij tsheb kauj vab, uas cuam tshuam nrog kev rov qab los rau qhov kub thiab txias. Qhov kev tiv thaiv no pab tswj cov txheej txheem kev ncaj ncees thiab kev ua tau zoo ntawm cov polymer nyob rau lub sijhawm.
Txhim kho Mechanical Properties
Nce tensile zog
- Kev koom ua ke rau hauv cov polymers tuaj yeem ua rau muaj zog tensile, uas yog ib qho kev ntsuas ntawm cov khoom muaj peev xwm tiv taus tensile rog yam tsis muaj kev tawg.
- Qhov kev txhim kho no yog ntaus nqi los ntawm tus ntoo khaub lig- kev sib txuas muaj peev xwm, uas ntxiv dag zog rau cov polymer matrix thiab txhim kho nws tag nrho cov tshuab robustness.
Txhim kho Impact Resistance
- Polymers uas muaj nws feem ntau pom kev txhim kho kev tiv thaiv, tso cai rau lawv tiv taus tam sim ntawd thiab hnyav zog yam tsis muaj kev tawg lossis tawg.
- Qhov kev txhim kho zoo dua qub no yog qhov tseem ceeb rau cov ntawv thov uas xav tau cov polymers los tiv thaiv siab - tej yam kev mob, xws li cov khoom siv tsheb thiab cov iav tiv thaiv.
Txhim kho Optical Transparency
Txo Haze thiab Clarity Txhim Kho
Nws tuaj yeem siv los tsim cov polymers nrog txo qis thiab ua kom pom tseeb. Qhov no yog tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau kev siv kho qhov muag, xws li lo ntsiab muag, qhov rais, thiab cov lus qhia, qhov uas qhov pom tseeb yog qhov tseem ceeb.
Cov qauv aromatic pab txhawb kev tsim cov polymers nrog tsawg qhov tsis xws luag thiab kev sib xyaw molecular ntau dua, ua rau cov khoom kho qhov muag zoo dua.
UV Resistance thiab Light Stabilization
Ntxiv nrog rau kev txhim kho pob tshab, cov polymers uas muaj nws tuaj yeem ua kom pom kev tiv thaiv UV thiab lub teeb stabilization. Qhov no yog vim nws muaj peev xwm nqus tau UV hluav taws xob, hloov nws mus rau hauv tshav kub thiab tiv thaiv nws los ntawm kev ua kom degradation ntawm polymer.
Qhov no UV-absorbing muaj peev xwm pab tswj qhov pom qhov pom tseeb thiab kev ncaj ncees ntawm cov khoom siv polymer tshaj qhov raug tshav ntuj thiab lwm qhov chaw UV.
I. Cov Txheej Txheem Txheej Txheem Tseem Ceeb: Knoevenagel Condensation (Txoj Kev Ua Lag Luam Nyiam)
Txoj kev no siv p-methylbenzaldehyde thiab malonic acid ua raw cov ntaub ntawv, uas dhau los ua condensation cov tshuaj tiv thaiv catalyzed los ntawm organic puag DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). Tam sim no nws yog txoj hauv kev tseem ceeb rau kev tsim khoom lag luam ntawm4-Methylcinnamic acid. Cov txheej txheem muaj cov tshuaj tiv thaiv me me, ob peb los ntawm - cov khoom lag luam, cov txiaj ntsig siab (txog 70%–85%), thiab yooj yim tshaj tawm - kho.
1. Cov khoom siv raw thiab qhov sib piv
Cov ntaub ntawv tseem ceeb yog p-methylbenzaldehyde thiab malonic acid, nrog DBU ua tus catalyst. Cov molar piv yog tswj raws li p-methylbenzaldehyde: malonic acid=1: 1.1–2, thiab DBU: p-methylbenzaldehyde=0.1–0.5: 1 kom paub meej cov tshuaj tiv thaiv.
2. Cov txheej txheem tshuaj tiv thaiv
Sib tov p-methylbenzaldehyde nrog malonic acid, ntxiv DBU, thiab do hauv chav sov li 2-3 teev. Tsis muaj qhov siab - qhov kub thiab txias yuav tsum tau ua, ua rau muaj kev siv hluav taws xob tsawg. Cov txheej txheem tshuaj tiv thaiv muaj kev sib xyaw ua ke ntawm pawg aldehyde thiab active methylene pab pawg neeg ntawm malonic acid nrog tshem tawm ntawm ib tug molecule ntawm dej, nrog decarboxylation ntawm malonic acid los tsim lub hom phiaj khoom nws.
3. Tshaj tawm -Kev kho mob thiab kev huv
Tom qab cov tshuaj tiv thaiv, 10% -30% hydrochloric acid yog ntxiv dropwise los kho cov pH mus rau 2. Cov sib tov yog stirred thiab txias kom crystallize cov khoom, thiab crude lim ncuav mog qab zib yog tau los ntawm suction pom nyob rau hauv txias txias. Cov lim dej yog alkalized nrog sodium hydroxide, thiab DBU catalyst rov qab los ntawm lub tshuab nqus tsev distillation kom txo cov nqi. Cov khoom nyoos yog ntxuav nrog dej, lim, thiab qhuav, ces recrystallized nrog ethanol, thiab lub tshuab nqus tsev - qhuav ntawm Tsawg dua los yog sib npaug li 70℃nyob rau hauv lub nqus tsev vacuum ntawm −0.09 rau −0.1 MPa kom tau siab -purity cov khoom (purity ntau dua los yog sib npaug rau 98%).
II. Txheej Txheem Txheej Txheem Txheej Txheem: Perkin Reaction (Feem ntau siv hauv Laboratories)
Cov tshuaj tiv thaiv Perkin yog ib txoj hauv kev zoo rau kev sib xyaw cinnamic acid derivatives. Nws siv p-methylbenzaldehyde thiab acetic anhydride ua raw cov ntaub ntawv nrog anhydrous sodium acetate raws li catalyst, haum rau me me - lab npaj.
1. Cov xwm txheej tshwm sim
Sib tov p-methylbenzaldehyde, acetic anhydride, thiab anhydrous sodium acetate ntawm molar ratio ntawm 1: 1.5: 0.6, kub rau 160-180℃hauv ib da dej roj, thiab reflux rau 4-5 teev. Cov tshuaj tiv thaiv no yuav tsum muaj qhov kub thiab txias, ua rau muaj kev siv hluav taws xob ntau, ntau dua los ntawm -cov khoom, thiab kev nyuaj tom qab{10}} kho.
2. Tshaj tawm -Cov kauj ruam kho
Tom qab txias cov tshuaj tiv thaiv sib tov, dej ntxiv thiab chav distillation yog ua kom tshem tawm cov tsis muaj tshuaj p-methylbenzaldehyde. Cov tshuaj residual yog neutralized nrog saturated sodium carbonate rau pH 8-10, ces acidified nrog hydrochloric acid mus rau pH 2 kom precipitate cov khoom crude. Cov khoom nyoos yog purified los ntawm dej ntxuav thiab recrystallization kom tau txais cov khoom kawg.
III. Txheej txheem sib piv thiab qhov zoo
Piv nrog rau cov tshuaj tiv thaiv Perkin, Knoevenagel condensation muaj qhov zoo ntawm chav - qhov kub thiab txias cov tshuaj tiv thaiv, lub sij hawm luv luv cov tshuaj tiv thaiv, recyclable catalyst, siab yield, thiab ib puag ncig tus phooj ywg, ua rau nws ntau haum rau loj -scale industrial ntau lawm. Txawm hais tias Perkin cov tshuaj tiv thaiv siv cov ntaub ntawv raw khoom yooj yim, nws qhov siab - qhov kub thiab txias txwv tsis pub siv rau kev lag luam, thiab nws tsuas yog siv rau kev tshawb fawb hauv chav kuaj lossis me me - ntsuas kev sim.
Daim tawv nqaij tsis zoo tshwm sim: mechanism thiab kev kho mob tshwm sim
Irritable contact dermatitis (ICD)
4-methylcinnamic acidTej zaum yuav ua rau muaj kev mob tshwm sim los ntawm kev cuam tshuam ntawm daim tawv nqaij kev ua haujlwm (xws li dissolving intercellular lipids) lossis ncaj qha stimulating keratinocytes. Nws cov pab pawg acrylic tuaj yeem khi nrog cov tawv nqaij cov proteins los tsim cov tshuaj tiv thaiv kab mob, ua kom lub zog ntxiv thiab degranulate mast hlwb, thiab tso tawm cov kab mob sib kis xws li histamine. Tsis pub dhau ob peb teev rau hnub tom qab kev sib cuag, liab, edema, papules, nrog rau qhov kub hnyiab lossis khaus khaus tuaj yeem tshwm sim. Cov mob hnyav tuaj yeem tshwm sim nrog cov hlwv lossis exudation, nrog cov ciam teb meej raws li qhov chaw sib cuag.
Allergic contact dermatitis (ACD)
Cov khoom, raws li ib tug hapten, yuav tsum tau metabolized los ntawm daim tawv nqaij thiab hloov mus rau hauv ib tug tiav antigen. Tom qab ntawd nws khi rau T cell receptors, qhib CD4 ⁺ T hlwb, thiab ua rau qeeb hom kev xav tsis zoo. Tom qab thawj qhov kev sib cuag, nws yuav siv li ob peb hnub rau lub lis piam kom nkag siab. Tsis pub dhau 24-72 teev tom qab kev sib cuag, khaus khaus hnyav, erythema, thiab hlwv tuaj yeem tshwm sim, uas tuaj yeem kis mus rau qhov chaw tsis sib cuag. Kev siv cov cinnamic acid derivatives hauv tshuaj pleev ib ce yog txuam nrog kev nce hauv qhov tshwm sim ntawm ACD. Piv txwv li, kev sib cuam tshuam ntawm hydroxybenzoic acid ester preservatives thiab cinnamic acid ester fragrances tuaj yeem ua rau ntau qhov chaw dermatitis.
Cov tshuaj tiv thaiv phototoxic
Nws tuaj yeem nqus tau ultraviolet (UV) hluav taws xob thiab hloov mus rau hauv cov tshuaj lom neeg metabolites, ncaj qha ua rau cov tawv nqaij ntawm tes DNA lossis ua rau oxidative kev nyuaj siab los ntawm kev tsim cov pa oxygen reactive (ROS). Tsis pub dhau ob peb teev tom qab hnub raug tshav, tej zaum yuav muaj tshav kub xws li erythema, edema, nrog rau qhov mob los yog kub hnyiab, uas tuaj yeem tsim ua pigmentation lossis nti. Cov analog 4-methoxycinnamic acid tuaj yeem ua rau apoptosis ntawm tib neeg keratinocytes nyob rau hauv UVA irradiation, thiab nws cov phototoxicity cuam tshuam rau methoxy hloov ntawm lub nplhaib benzene.
Cov lus nug nquag
4 formyl cinnamic acid yog dab tsi?
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4-Formylcinnamic acid yogib tug molecule uas yog tsim los ntawm condensation ntawm benzaldehyde thiab formic acid. Lub nmr spectra ntawm 4-formylcinnamic acid qhia tias nws muaj cov qauv nrog ob lub nplhaib uas muaj ntxhiab. Nws tau raug pom tias ua kom hu xov tooj zoo li receptor 4 (TLR4) hauv tib neeg lub siab hlwb.
Dab tsi yog cinnamic acid siv rau?
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Cinnamic acid yog ibCov tshuaj tsw qab siv nyob rau hauv ntau cov tshuaj tsw qab. Nws tuaj yeem pom muaj nyob hauv cov tshuaj tsw qab uas siv rau hauv cov tshuaj pleev ib ce zoo nkauj, cov tshuaj tsw qab zoo, tshuaj zawv plaub hau, xab npum thiab lwm yam khoom siv hauv chav dej nrog rau hauv cov khoom tsis yog- tshuaj pleev ib ce xws li tshuaj ntxuav tsev thiab tshuaj ntxuav tes.
Dab tsi yog qhov zoo ntawm methyl cinnamic acid piv rau cov cinnamic acid li niaj zaus?
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Tom qab qhia ib pab pawg methyl mus rau hauv txoj hauj lwm ntawm lub nplhaib benzene, cov khoom siv hluav taws xob pub dawb tau txhim kho, thiab tag nrho cov kab ke sib txuas yog ruaj khov dua.
Thermal stability thiab kev ua haujlwm antioxidant zoo dua li cov cinnamic acid;
Kev ua tau zoo ntawm UV nqus tau zoo, kev tiv thaiv lub hnub zoo dua thiab cov teeb pom kev ruaj khov;
Esterification khoom muaj ib tug purer aroma thiab tsawg impurities;
Txhim kho molecular lipid solubility thiab zoo dua dispersibility nyob rau hauv niaj hnub tshuaj thiab resin systems.
Dab tsi yog cov yam ntxwv ntawm cov qauv thiab cov ntsiab lus tseem ceeb ntawm methyl cinnamic acid?
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Muaj peb qhov kev ua haujlwm tseem ceeb: carboxyl (- COOH): tuaj yeem esterified, acylated, salted, txo, thiab amidated; Conjugated carbon ob daim ntawv cog lus: tuaj yeem muab ntxiv, hydrogenated, epoxidized, polymerized; Para methyl: tuaj yeem hloov kho los ntawm oxidation, halogenation, thiab dehydrogenation. Tag nrho cov system yog conjugated heev, nrog zoo heev optical thiab thermal zog thiab muaj zog derivatization muaj peev xwm.
Cim npe nrov: 4-methylcinnamic acid CAS 1866-39-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom