{{0 {{}} bromo -2- iodopyrimidineyog cov hmoov nplej dawb uas tau ruaj khov nyob rau hauv chav kub thiab siab {} nws yog cov kua roj afic af acid Ethanhanol, Etaws, thiab lwm yam} Kuv yog cov lus qhia ntawm cov khoom siv hluav taws xob nplua nuj thiab cov lus qhia txog kev nplua nuj, txhawb kev tshawb fawb thiab kev nthuav dav nyob rau hauv liaj teb xws li chemistry, biology, thiab tshuaj. Nws tuaj yeem siv cov tshuaj sib txawv, muab cov ntaub ntawv sib txawv ntxiv rau Kev Tsim Tshuaj Yeeb {{}}
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Tshuaj Cov Qauv |
C4h2brin2 |
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Muaj pes tsawg leej |
284 |
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Molecular hnyav |
285 |
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m/z |
284 (100.0%), 286 (97.3%), 285 (4.3%), 287 (4.2%) |
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Kev Ntsuam Xyuas |
C, 16.86; H, 0.71; Br, 28.05; Kuv, 44.55; N, 9.83 |
{{0 {{}} bromo -2- iodopyrimidineyog cov organic sib xyaw nrog cov qauv tshuaj tshwj xeeb, uas muaj ntau cov ntawv thov hauv kev tshawb xyuas tshuaj lom neeg.
1.} Cov tshuaj fluorescence spectroscopy
Vim tias muaj cov bromine thiab iodine ntsiab hauv cov qauv ntawm {}} i}} i}} i6} .}} los ntawm kev sib txuas nrog lwm pab pawg fluorescent, nws cov qauv fluorescence thiab cov qauv ntsuas fluorescence xws li cov qauv siv roj ntsha thiab cov qauv ib puag ncig tuaj yeem kawm ntxiv {{}
2.} UV pom tsom iav
UV pom spectrum ntawm 5- bromo {}} i}} Txoj kev ua tau zoo sib xws, thiab kev ntsuas qhov ntsuas cov ntsiab lus ntawm cov ntsiab lus thiab kev coj dawb huv ntawm kev sib xyaw, tshwj xeeb tshaj yog nyob rau hauv kev soj ntsuam ntawm cov tshuaj zoo xws li tshuaj thiab dyes .
{{0 {}} huab tais spectrometry
Pawg Spectrometry Kev Tshawb Xyuas yog ib txoj hauv kev cais cov qauv los ntawm kev ntsuas cov qauv molecular} ion peaks, uas tuaj yeem siv los txheeb xyuas cov molecular muaj pes tsawg leeg thiab cov qauv ntawm tshuaj . Nyob rau hauv ntxiv, cov ntsiab lus ntawm cov tshuaj sib xyaw tuaj yeem txiav txim siab los ntawm kev sib piv nrog tus qauv qauv.
4. nuclear sib nqus resonance spectroscopy tsom xam
Nuclear Sib Nqus Kev sib zog hluav taws xob yog ib txoj kev ntawm cov qauv {}} ua haujlwm, txuas ntxiv mus, thiab lwm yam}}} los ntawm kev sib piv nrog cov qauv qauv, cov hom thiab cov ntsiab lus ntawm cov sib xyaw tuaj yeem txiav txim siab {}}
5. chromatographic tsom xam
Cov qauv chromatography yog ib txoj kev sib cais thiab cov ntsiab lus ntawm cov qauv {}} Nws tuaj yeem txiav txim siab rau cov khoom sib xyaw ua ke, ntawm cov tshuaj lom neeg tuaj yeem txiav txim siab.
6.} kev tsom ntsuas cua sov
Kev soj ntsuam cua sov yog ib txoj kev ntawm kev kawm cov qauv, thiab cov ntaub ntawv cua sov los ntawm kev ntsuas cua sov {}}}} cov ntaub ntawm no cov ntaub ntawv yog qhov tseem ceeb tshaj plaws rau kev kawm lawv cov tshuaj lom neeg thiab cov khoom siv khoom {}}
{{0 {{}} bromo -2- iodopyrimidineyog ib qho tseem ceeb organic synthemes dav siv nyob rau hauv cov tshuaj thiab ua kom muaj kev nyab xeeb rau kev thauj mus los rau kev tsim khoom ntawm 5- bromo 2- ieodopyrimidine {}} Azaindole ua hauj lwm, uas siv {} {}} Azaindole hydrogenation, thiab tom qab ntawd npaj cov tshuaj tseem ceeb Intermediate5- bromo {{} Azarative Dehydole oxidor oxidor oxidogation dezos ntawm no tau tshaj 99%.
Firstly 5- bromo {}} brocoroprimete}}}}}}}}}}}}} tshwm sim lub teeb daj .
Tom ntej no, ntxiv cov poov tshuaj iodide thiab dej rau cov kev daws {}} Bromo {}} i6 4}} hauv cov txheej txheem no, iodine ions ua nucleophilic reagents los tawm tsam cov chlorine atom of {}} bromo {}} iodopyrimididble .
Tshuaj Muaj Tshuaj:
C4H2Brycln2 + KI + h2O → C4H2Tus xyoob2 + Koh
Nyob rau hauv cov tshuaj tiv thaiv saum toj no, txhawm rau txhim kho kev ua haujlwm ntawm phosphorus pentachloride, i6} Kuv tuaj yeem txhawb nqa cov chlorine atom ntawm 5- bromo-2- chloropyrimididididididididididididididididididide, tsim ntau dua 5} iodopyrimidididble {}}
Tshuaj Muaj Tshuaj:
C4H2Brycln2 + KI + PCL5 + H2O → C4H2Tus xyoob2 + Koh + hcL
Tom qab cov tshuaj tiv thaiv tau ua tiav, txhawm rau txiav tawm cov tshuaj tiv thaiv, peb ntxiv cov dej tawm ntawm {}} iOk .
Tom ntej no, rho tawm cov dej txheej .} i}}}} iodopyrimididine .
Thaum kawg, ua lub tshuab nqus tsev ntawm cov organic txheej . Lub sijhawm ua haujlwm ntawm cov txheej txheem ntawm cov txheej txheem no, tawm hauv qab highso i'} i6 4}
Add the crude 5-bromo 2-iodopyrimidine obtained to ethanol and heat up until dissolved. Ethanol is a commonly used organic solvent that can effectively dissolve crude 5 bromo-2-iodopyrimidine. During the dissolution process, impurities in the crude cov khoom yuav tau yaj los ntawm ethanol .
Tom qab txias rau chav sov, do rau ib lub sijhawm kom huv si tov rau cov khoom siv crude nrog ethanol {} {1 ces} Tom qab no ethanol .
Thaum kawg, cov khoom tau tau los ntawm kom qhuav hauv lub tshuab nqus tsev . purity tshuab hluav taws xob tau yooj yim 5 bromo {} iodopyrimididble {}}
Los ntawm cov ncauj lus kom ntxaws thiab sib piv tshuaj sib luag tau hais los saum toj no, peb tuaj yeem nkag siab tag nrho cov txheej txheem thiab PCL5, txo cov nqi ntawm kuv cov nqi thiab txuag cov nqi; Ib txhij ntau dua rau kev txuag thiab kev thauj mus los; Tsim nyog ntau rau kev sib tw loj; Ntau dua kev nyab xeeb rau kev nyab xeeb; Thaum kawg, lub siab purity dawb khoom sib xyaw{{0 {{}} bromo -2- iodopyrimidinetau txais .
Txoj kev txhim kho ntawm 5- bromo -2- i6}}}}}}}}} Cov ncauj lus qhia txuas ntxiv ntawm nws cov txheej txheem kev tshawb fawb thiab kev txhim kho:
Thaum ntxov qib ntawm kev txhim kho ntawm 5- bromo {}}} Txawm li cas los xij, thiab cov kws tshawb fawb tau zoo los ntawm cov kev tshawb fawb sib txawv cov ntsiab lus thiab cov ntaub ntawv thaum ntxov, nws tsis muaj peev xwm los muab lub sijhawm pib rau kev txhim kho thiab cov ntaub ntawv tshwj xeeb txog cov kws tshawb fawb thaum ntxov}
Nrog rau qhov tob zuj zus ntawm kev tshawb fawb, cov kws tshawb nrhiav tau pom ntau txoj hauv kev rau kev npaj {}} i}} i}}} {} piv txwv li:
Ib txoj kev npaj:
Dissolve 5- bromo -2-} chloropomrimidetine hauv dichhloromethane hauv Dichhloromethane, ntxiv cov poov tshuaj thiab dej.
Ntxiv phosphorus pentachloride nyob rau hauv cov batches nyob rau hauv kev txias txias, thiab tom qab ntxiv, rov ua kom sov thiab txuas ntxiv nplawm {}}
Taug qab cov txheej txheem tiv thaiv dhau los ntawm HPLC thiab nres qhov tshuaj tiv thaiv thaum cov khoom siv cov khoom siv yog hauv qab no qee yam kev ntsuas {}}
Tom qab txias, ntxiv dej rau quench cov tshuaj tiv thaiv, thiab tom qab ntawd ntxiv sodium carbonate thiab sodium sulfite carches rau tom qab-kho.
Crude 5- bromo -2- iedopyrimidine tau txais los ntawm cov kauj ruam, thiab cov organic txheej .
Ntxiv ethanol mus rau cov khoom crude thiab nce qhov ntsuas kub kom txog thaum {do nrog etrifuge thiab centrifuge hauv tau txais cov khoom siv kub dawb .
Cov kev tawm tsam
{{0 {{}} bromo -2- iodopyrimidine, raws li cov organic sib xyaw, tuaj yeem ua rau muaj kev phom sij rau tib neeg kev noj qab haus huv thiab kev tsim khoom, thiab muab cov ncauj lus piav qhia ntxaws ntxaws ntawm nws cov kev tsis zoo:
Mob Toxicity
Qhov ncauj toxicity
Kev noj khoom haus yuav ua rau mob plab zom mov, ntuav tsis zoo, nws yuav ua rau kiv taub hau
Daim tawv nqaij tiv toj toxicity
{{05- bromo -2- Ik. Lub cev khaus, lawv yuav ua rau cov tawv nqaij qhuav, lawv yuav nthuav qhia kev tsis haum tshuaj ntau heev {}}
Qhov muag hu rau Toxicity
Kev sib cuag ntawm lub qhov muag, ua rau mob, ua kua muag, nws yuav ua rau muaj kev pab cuam ntau thiab nrhiav kev pab kho mob kom txaus, nws yuav ua rau kev pab kho mob hnyav, nws yuav tsim nyog kho mob, nws yuav ua rau muaj kev pab cuam rau ntau thiab nrhiav kev kho mob yog qhov tsim nyog.
Inhalation Toxicity
Cov hmoov av lossis vapor ntawm 5- bromo {}} i6. i}}}}}}}} i}}}}}}}}} i}
Mob Toxicity
Lub sij hawm ntev raug rau cov teebmeem kev noj qab haus huv
Lub sij hawm ntev ua rau 5- bromo {}} i}} i6} i}} i6 2}} lub raum may experience tubular damage or decreased renal function due to long-term exposure. In terms of the central nervous system, it may cause symptoms such as headaches, memory loss, and lack of concentration.
Carcinogenicity
Tam sim no tsis muaj cov pov thawj meej los qhia kom 5- Ncaws kab ua ke tuaj yeem tsim kev pheej hmoo ntawm cov qog nqaij hlav, tshwj xeeb yog cov qog qog nqaij hlav nrog Halogenated hydrocarbons xws li daim siab mob cancer, mob ntsws, thiab lwm yam}
Muaj me nyuam yaus
Cov kev sim tsiaj tau pom tias qee lub pyrimidine yuav muaj kev phom sij me nyuam yaus uas muaj kev pheej hmoo ntawm cov menyuam cev xeeb tub, tshwj xeeb tshaj yog thaum ntxov cev xeeb tub
Daim tawv nqaij, qhov muag, thiab ua pa ua pa
Daim tawv Nyom Hlau Irritation Mechanism
5- bromo -2- i6 2}} Nws cov nqaij tawv nqaij. worsen .
Qhov muag
Tom qab kev sib cuag,5- bromo {}}}} i}} i}} ieks, yuav ua rau mob pob txha caj dab lossis ua rau pom kev ua kom pom kev zoo siab (
Kev phom sij ntawm txoj kev nqus pa
Cov hmoov av lossis vapor ntawm 5- bromo {}} i{}} i{}}} i}}} i}} i}} i}} Lub cev muaj pa xwm yeem, ua pa nyuaj rau kev ntxhov siab (mob) tshwm sim .
Kev Raug Mob Raug Cai
Hauv cov xwm txheej xws li cov tshuaj lom neeg xws li kev kuaj cov tshuaj, cov neeg ua haujlwm siv cov ntaub ntawv saib xyuas kev ua pa kom zoo rau cov pej xeem muaj zog yog li ntawd hauv cov pej xeem {}}
Cim npe nrov: 5- bromo -2- iekpetries Cas183438-24-6 i}, chaw tsim khoom, yuav khoom, nqe, loj, rau muag