5-Chlorosalicylaldehyde CAS 635-93-8

(1) Synthesis ntawm cov tshuaj tua kab mob
Cov tshuaj no yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm cov tshuaj tua kab mob. Piv txwv li, los ntawm nws cov condensation cov tshuaj tiv thaiv nrog amine tebchaw, Schiff puag tebchaw nrog dav -spectrum antibacterial kev ua si yuav raug generated. Kev tshawb fawb pom tau hais tias kev qhia txog cov tshuaj chlorine atoms txhim kho molecular lipophilicity, ua kom yooj yim rau lawv nkag mus rau cov kab mob ntawm tes thiab cuam tshuam cov kab mob metabolic. Patent WO2019/054328 qhia txog quinolone derivative uas muaj 5-chlorosalicylaldehyde qauv, nrog rau inhibitory concentration tsawg li 0.5 μ g / mL tiv thaiv Staphylococcus aureus.

(2) Kev tshawb fawb thiab kev txhim kho cov tshuaj tiv thaiv - mob
Cov tshuaj no tuaj yeem ua tus thawj coj rau kev sib txuas ntawm nonsteroidal anti-cov tshuaj tiv thaiv kab mob (NSAIDs). Nws pawg aldehyde tuaj yeem hnov ​​​​mob nrog cov pab pawg nquag xws li aminoacetic acid los tsim cov pob txha molecular nrog cyclooxygenase-2 (COX-2) inhibitory kev ua. Cov kev tshawb fawb hauv tsev kho mob tau pom tias cov derivatives no tuaj yeem txo qis kev qhia ntawm cov kab mob TNF - thiab IL-6.

(3) Kev tsim tshuaj tiv thaiv qog
Cov hlau complexes koom nrog hauv kev tsim kho pom muaj peev xwm tiv thaiv- qog nqaij hlav. Cov txheej txheem tsim nrog tooj liab (II) tuaj yeem siv nws cov teebmeem los ntawm kev ua rau qog cell apoptosis thiab inhibiting angiogenesis. Cov kev sim hauv vitro tau pom tias IC50 tus nqi ntawm cov complex rau HeLa hlwb yog 8.2 μ M, thiab nws cov toxicity rau lub cev ib txwm muaj tsawg.
Antiviral tshawb fawb
(4) Kev tshawb fawb tsis ntev los no (J. Med. Chem., 2022, 65 (8)): 5632-5640) pom tias 5-chlorosalicylaldehyde derivatives tuaj yeem cuam tshuam kev ua haujlwm ntawm SARS CoV-2 lub ntsiab protease (Mpro), muab kev taw qhia tshiab rau kev txhim kho cov tshuaj tiv thaiv COVID-19.

(1) Kev loj hlob ntawm fungicides
Raws li ib qho tseem ceeb nruab nrab ntawm benzoyl fungicides, 5-chlorosalicylaldehyde tuaj yeem ua ke rau hauv cov tshuaj tua kab mob zoo heev tiv thaiv cov pwm grey thiab cov pwm pwm los ntawm kev qhia cov khoom sib txawv. Piv txwv li, Fluxapyroxad, tsim los ntawm Bayer AG hauv lub teb chaws Yelemees, muaj cov qauv zoo sib xws thiab muaj EC50 tus nqi ntawm 0.1-1.0 mg / L.
(3) Insecticide synergist
Raws li ib tug synergist rau pyrethroid insecticides, aldehyde pab pawg neeg ntawm 5-chlorosalicylaldehyde tuaj yeem tsim intermolecular hydrogen bonds nrog tshuaj tua kab molecules, ncua lawv cov nqi photolysis. Cov kev sim teb tau pom tias qhov sib ntxiv ntawm qhov kev txhim kho no tuaj yeem txuas ntxiv lub sijhawm ua haujlwm ntawm cov tshuaj tua kab rau ntau tshaj 28 hnub.

(1) Synthesis of Functional Dyes
Cov azo dye generated los ntawm condensation ntawm cov khoom no nrog aniline tebchaw muaj lub teeb zoo heev thiab ntxuav ceev. Piv txwv li, CI Reactive Red 195 muaj cov txheej txheem no, thiab nws cov ntaub dyed tseem muaj xim ceev ntawm 4-5 qib tom qab 200 teev ntawm hnub raug.

(2) Kev tsim cov fluorescent probes
Lub synergistic nyhuv ntawm nws hydroxyl thiab chlorine atoms ua rau cov derivatives muaj feem xyuam rau muaj zog ntsuab fluorescence nyob rau hauv ultraviolet lub teeb (λ em=525 nm). Los ntawm kev hloov kho cov pab pawg paub, fluorescent sensors nrog kev xaiv siab rau cov hlau ions xws li Fe ³ ⁺ thiab Cu ² ⁺ tuaj yeem npaj tau, nrog rau kev kuaj pom txog li nM.
(3) Cov khoom siv thermal hloov xim
Los ntawm kev sib txuas nrog cov neeg pub khoom siv hluav taws xob xws li siv lead ua violet lactone, cov ntaub ntawv thim rov qab thermochromic tuaj yeem npaj tau. Kub hloov pauv induce intermolecular nqi pauv, ua tiav cov xim hloov pauv ntawm cov xim tsis muaj xim thiab xiav ntshav, thiab siv rau hauv kev ntim khoom ntse.

(2) Khoom noj khoom haus seasoning
Raws li cov zaub mov qib txuj lom, nws cov chlorinated derivatives tuaj yeem simulate lub ntuj nutty aroma thiab siv rau flavoring ci khoom thiab khoom noj siv mis. European Food Safety Authority (EFSA) tau pom zoo nws txoj kev txwv siv hauv cov khoom noj tshwj xeeb (tsawg dua lossis sib npaug li 5 mg / kg).
(3) Kev loj hlob ntawm antioxidants
Nws cov qauv phenolic hydroxyl endows nws nrog kev ua haujlwm antioxidant, thiab thaum ua ke nrog vitamin E, nws tuaj yeem txhim kho oxidative stability ntawm cov roj noj. Kev tshawb fawb tau pom tias ntxiv 0.02% ntawm cov tshuaj tiv thaiv kab mob no tuaj yeem txuas ntxiv lub neej ntawm cov roj taum pauv los ntawm 60%.

(1) Spectral tsom xam reagents
Raws li chromogenic reagent rau UV pom spectrophotometry, nws pawg aldehyde reacts nrog cov thawj amines xws li amino acids los ua Schiff puag, uas muaj cov yam ntxwv haum ntawm λ max =430 nm thiab nrhiav kom tau rhiab heev ntawm 0.1 μ g / mL.
(2) Chromatographic nyob ruaj ruaj theem
Los ntawm kev siv cov cuab yeej siv tshuaj sib txuas los kho nws ntawm qhov chaw ntawm silica gel, cov pa roj chromatography nyob ruaj khov nrog cov kev xaiv siab rau chlorinated organic tebchaw tuaj yeem npaj tau. Thaum sib cais chlorinated benzene tebchaw, theoretical tus naj npawb ntawm cov tais ntau tshaj 5000 / m.

(3) Electrochemical sensor
Hloov kho rau ntawm qhov chaw ntawm cov iav carbon electrode, lub tshuab hluav taws xob hluav taws xob nrog lub siab rhiab heev rau dopamine tuaj yeem tsim. Ntawm pH 7.0, qhov kev kuaj pom kab ntau yog 1.0 × 10 ⁻⁷ ~ 1.0 × 10 ⁴ M, muaj zog tiv thaiv - muaj peev xwm cuam tshuam.

(2) Photocatalytic degradation
Raws li kev hloov kho rau semiconductor photocatalysts, nws tuaj yeem txhim kho qhov nqus ntawm cov ntaub ntawv xws li TiO ₂ hauv thaj chaw pom lub teeb. Kev tshawb fawb tau pom tias TiO ₂ hloov nrog nws nce qhov degradation tus nqi tas li ntawm methylene xiav los ntawm 3.8 npaug.
(3) Kev kuaj pom cov pa phem
Cov khoom siv fluorescent tsim los ntawm cov tshuaj tiv thaiv nrog ozone tuaj yeem siv tau tiag tiag - lub sijhawm saib xyuas O3 concentration hauv huab cua. Tus qauv portable ntes tau ua tiav qhov tseeb ntawm qhov ppb.

(1) Cov khoom siv hluav taws xob
As an electrolyte additive for lithium-ion batteries, its chlorinated structure can improve the stability of SEI film and extend the battery cycle life to over 1500 times (capacity retention rate>80%).
(2) 3D luam ntawv cov ntaub ntawv
Los ntawm kev sib xyaw nrog cov khoom siv photosensitive, 3D luam ntawv cov ntaub ntawv nrog tus kheej - kho muaj nuj nqi tuaj yeem npaj tau. Nws lub zog aldehyde crosslinking network ua rau cov khoom siv rov qab tau 85% ntawm nws cov khoom siv kho tshuab hauv 24 teev tom qab kev puas tsuaj.

(3) Kev sojntsuam txog kev siv tshuaj lom neeg
Los ntawm kev sau npe cov pab pawg fluorescent, cov khoom siv tshuaj lom neeg sojntsuam tsom rau mitochondria tuaj yeem tsim. Cov kev sim ntawm tes tau pom tias lub sijhawm teb ntawm kev sojntsuam rau kev hloov pauv hauv mitochondrial membrane muaj peev xwm hauv cov cell nyob yog 2-5 vib nas this.

Hauv photochromic compounds ntawm lactone hom, hluav taws xob cov nyhuv ntawm chlorine atoms tuaj yeem tswj tus nqi thiab quantum tawm los ntawm photoisomerization cov tshuaj tiv thaiv. Piv txwv li, lub photoresponse ceev ntawm 5-chlorinated derivatives yog 20% ​​sai dua li cov unsubstituted system, uas yog vim cov kev cai ntawm molecular orbital zog theem los ntawm cov chlorine atom.

Hauv kev tsim cov tshuaj tua kab mob, cov hluav taws xob- tshem tawm cov tshuaj chlorine atom tuaj yeem txhim kho kev sib cuam tshuam ntawm cov molecule thiab qhov chaw nquag ntawm cov kab mob enzymes. Piv txwv li, kev ua haujlwm inhibitory ntawm 5-chloro salicylaldehyde amidinourea complex tiv thaiv Staphylococcus aureus (MIC=8 ug/mL) yog ob zaug ntawm qhov tsis hloov pauv (MIC=16 ug/mL).