Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm d-norvaline cas 2013-12-9 hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo d-norvaline cas 2013-12-9 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
D-Norvaline,Kuj tseem hu ua D-ib txwm valine lossis (R) - (-) -2-aminovaleric acid, nws yog ib qho tseem ceeb amino acid derivative, tshwj xeeb tshaj yog nyob rau hauv ib qho chaw hauv kev siv tshuaj intermediates. Cov tsos yog dawb mus rau yuav luag dawb crystalline hmoov, nrog ib tug molecular mis ntawm C5H11NO2, CAS 2013-12-9, thiab ib tug molecular luj ntawm 117.146. Nws muaj qee yam solubility nyob rau hauv ob qho tib si polar solvents (xws li dej) thiab cov kuab tshuaj tsis-polar.
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Tshuaj Formula |
C5H11NO2 |
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Exact Mass |
117 |
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Molecular Luj |
117 |
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m/z |
117 (100.0%), 118 (5.4%) |
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Elemental Analysis |
C, 51.26; H, 9.46; N, 11.96; O, 27.31 |
Txawm li cas los xij, vim nws tsis tshua muaj solubility hauv dej, cov kuab tshuaj organic feem ntau yog siv rau kev sib cais hauv kev siv tswv yim. Nws kuj muaj qee yam kev siv peev xwm hauv lwm qhov chaw. Piv txwv li, hauv kev lag luam tshuaj pleev ib ce, nws tuaj yeem muab ntxiv ua cov tshuaj moisturizing, antioxidants, thiab lwm yam khoom xyaw rau cov khoom siv tawv nqaij txhawm rau txhim kho daim tawv nqaij cov dej tuav thiab muaj peev xwm antioxidant. Tsis tas li ntawd, nws tseem tuaj yeem siv los tsim qee cov tshuaj tshwj xeeb thiab cov khoom siv.
D-Norvaline, D-n-valine, raws li cov amino acid uas tsis yog ntuj tsim, ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb thiab kev sim vim nws cov qauv molecular tshwj xeeb thiab kev ua haujlwm lom neeg. Nws tsis tsuas yog ua haujlwm raws li cov kws kho mob nruab nrab thiab koom nrog kev sib txuas ntawm ntau yam tshuaj, tab sis kuj muaj kev siv dav hauv ntau yam xws li biology, tshuaj, thiab khoom noj khoom haus.
1. Daim ntawv thov hauv kev tshawb fawb lom neeg
Kev tshawb fawb txog Amino Acid Metabolism
Raws li hom amino acd, nws txoj hauv kev metabolic thiab cov txheej txheem yog qhov tseem ceeb rau kev nkag siab tag nrho cov txheej txheem ntawm amino acd metabolism hauv cov kab mob. Cov kws tshawb fawb tuaj yeem siv isotope sau cov khoom lag luam txhawm rau taug qab lawv txoj hauv kev metabolic hauv cov kab mob thiab nthuav tawm cov txheej txheem tswj hwm ntawm amino acd metabolism.
Kev tshawb fawb txog Protein Synthesis
Nws tuaj yeem koom nrog cov txheej txheem ntawm cov protein synthesis thiab cuam tshuam rau cov qauv thiab kev ua haujlwm ntawm cov protein. Cov kws tshawb fawb tuaj yeem soj ntsuam cov txiaj ntsig ntawm kev ntxiv cov tshuaj no rau hauv kev sim hauv vitro ntawm cov protein synthesis thiab tshawb xyuas cov txheej txheem tswj hwm ntawm cov protein synthesis.
Nws muaj ntau yam kev siv hauv kev sim ntawm tes. Piv txwv li, hauv kev sim kab lis kev cai ntawm tes, nws tuaj yeem ua lub zog ntxiv uas cuam tshuam rau kev tso tawm ntawm cov tshuaj hluavtaws metabolic, roj muab thaum lub sijhawm ua haujlwm, thiab kev ua haujlwm ntawm lub hlwb thaum muaj kev ntxhov siab. Cov kws tshawb fawb tuaj yeem soj ntsuam cov txiaj ntsig ntawm kev ntxiv qhov sib txawv ntawm cov tshuaj no ntawm kev loj hlob ntawm tes, metabolism, kev hloov pauv, thiab lwm yam, yog li nthuav tawm nws cov teebmeem lom neeg thiab cov txheej txheem.
Daim ntawv thov hauv kev tshawb fawb kho mob
Tshuaj kho mob
Raws li ib tug kws tshuaj intermediate, nws muaj peev xwm koom nyob rau hauv lub synthesis ntawm ntau yam tshuaj. Cov kws tshawb fawb tuaj yeem siv cov tshuaj no los ua cov khoom siv raw los tsim cov tshuaj molecules nrog cov haujlwm tshwj xeeb lom neeg, thiab tom qab ntawd tsim cov tshuaj tshiab nrog cov txiaj ntsig kho. Piv txwv li, perindopril, raws li ib qho tshuaj zoo rau kev kho mob ntshav siab thiab lub plawv tsis ua hauj lwm, yog synthesized nrog L-ib txwm ua ib qho tseem ceeb nruab nrab.
Kab mob qauv tsim
Nws tuaj yeem siv los tsim cov qauv kab mob tshwj xeeb, xws li kab mob metabolic, kab mob hauv lub paj hlwb, thiab lwm yam. Los ntawm kev ntxiv cov tshuaj no rau cov tsiaj sim lossis cov kab ntawm tes, simulating amino acd metabolism abnormalities nyob rau hauv cov kab mob xeev, thiab kawm txog cov pathogenesis thiab kho cov tswv yim ntawm cov kab mob.
Pharmacodynamic ntsuam xyuas
Muaj cov chaw nyob hauv Tebchaws Meskas thiab hauv tebchaws Meskas. Lub koom haum tau tsim nyob rau hauv 2000 los ntawm lub hauv paus ntawm lub tswv yim me me xeeb los ntawm nws cov neeg txhawb nqa uas tau tsim.
Daim ntawv thov hauv Kev Tshawb Fawb Kev Noj Qab Haus Huv
Khoom noj khoom haus ntxiv
Cov khoom lag luam thiab nws cov qauv analogues tau tshwm sim los ua cov khoom cog lus hauv kev tsim cov khoom noj khoom haus tshwj xeeb, tshwj xeeb tshaj yog tsom rau cov pej xeem uas xav tau lub zog siab thiab kev tswj hwm kev xav tau. Cov khoom lag luam muaj nyob rau hauv kev siv zog nws yog cov khoom siv metabolic tshwj xeeb los txhim kho lub cev kev ua tau zoo thiab txhawb kev rov qab los - ua rau nws yog cov khoom tseem ceeb rau cov neeg ncaws pob, cov neeg nyiam kev tawm dag zog, thiab cov kws tshaj lij.
Hauv kev ua kis las khoom noj khoom haus, cov khoom lag luam ua raws li cov txheej txheem metabolic uas txhim kho kev siv lub zog thaum lub sijhawm ua haujlwm hnyav. Los ntawm kev cuam tshuam kev ua haujlwm ntawm cov ceg ntoo - cov saw amino acid (BCAA) thauj khoom thiab txo cov leeg nqaij protein, nws pab ncua kev qaug zog thaum lub sijhawm ua haujlwm siab (piv txwv li, ntev- khiav deb, caij tsheb kauj vab) thiab txhawb nqa cov leeg kho tom qab- kev cob qhia. Cov kev tshawb fawb qhia tau hais tias ntxiv nrog cov khoom analogues tuaj yeem txhim kho mitochondrial zog ntau lawm, tso cai rau cov neeg ncaws pob txhawb nqa cov zis ntau dua rau lub sijhawm ntev.
Tshawb nrhiav kev noj zaub mov Metabolism
Cov khoom ua haujlwm ua ib qho khoom siv tseem ceeb hauv kev tshawb fawb txog kev noj zaub mov metabolism, ua rau cov kws tshawb fawb los tshawb xyuas cov txheej txheem nyuaj hauv kev siv cov khoom noj thiab homeostasis. Nws lub hom phiaj cuam tshuam rau cov amino acid catabolism thiab lub zog metabolism ua rau nws zoo tagnrho rau kev kawm txog kev noj zaub mov zoo li cas cov txiaj ntsig metabolic hauv cov tsiaj qauv thiab tib neeg cov ntsiab lus.
Hauv kev tshawb fawb preclinical, cov khoom yog siv los tshawb xyuas qhov sib cuam tshuam ntawm kev noj haus muaj pes tsawg leeg thiab kev noj qab haus huv metabolic. Cov kws tshawb nrhiav suav nrog qib qib ntawm cov khoom lag luam rau hauv kev sim noj zaub mov kom pom nws qhov cuam tshuam rau cov txheej txheem metabolic tseem ceeb, xws li kev tswj cov piam thaj, lipid oxidation, thiab nitrogen metabolism. Piv txwv li, kev tshawb fawb siv cov qauv nas tau pom tias yuav ua li cas cov khoom noj ntxiv modulates hepatic enzyme kev ua haujlwm, muab kev nkag siab rau cov tswv yim muaj peev xwm los tswj cov kab mob metabolic xws li rog rog thiab ntshav qab zib hom 2.
Enzymatic synthesis yog ib txoj hauv kev los tsim cov phiaj xwm sib txuas siv cov kev xaiv siab thiab kev ua haujlwm ntawm biocatalysts (enzymes). Lub synthesis ntawmD-Norvaline(D-deaminocellulose) los ntawm enzymatic synthesis muaj siab stereoselectivity thiab tsis tshua muaj kev cuam tshuam ib puag ncig.
Rau kev sib txuas ntawm cov khoom no, feem ntau siv cov enzymes xws li transaminase (TA), amino acid dehydrogenase (AADH), thiab lwm yam. Transaminases tuaj yeem ua rau kev hloov pauv ntawm cov amino pawg ntawm cov amino acids, yog li tsim cov amino acids lub hom phiaj.
Nws cov synthesis tuaj yeem pib nrog ketone acids yooj yim, xws li alpha ketovaleric acd. Cov tshuaj no ua haujlwm ua lub substrate thiab tsim cov khoom hloov kho los ntawm kev qhia cov amino pawg los ntawm cov tshuaj tiv thaiv enzymatic.
3.1 Transaminase catalyzed cov tshuaj tiv thaiv
Cov kauj ruam tseem ceeb ntawm cov tshuaj tiv thaiv los ntawm transaminases yog raws li hauv qab no:
1. Kev npaj cov amino pub dawb:
Feem ntau cov amino pub muaj xws li L-glutamate lossis L-alanine.
2. Kev npaj cov tshuaj tiv thaiv sib tov:
Sib tov lub substrate alpha ketovaleric acid thiab amino pub rau hauv cov tshuaj tsis, thiab ntxiv qhov tsim nyog tus nqi ntawm transaminase.
3. Cov kev mob tshwm sim:
Cov tshuaj tiv thaiv feem ntau yog ua los ntawm qhov ntsuas kub uas tsim nyog (piv txwv li . 37℃C) thiab pH tus nqi (piv txwv li pH 7.0-8.0) kom ntseeg tau tias kev ua haujlwm zoo enzyme.
4. Cov khoom rho tawm:
Tom qab cov tshuaj tiv thaiv tiav lawm, cov tshuaj tiv thaiv cov khoom raug cais los ntawm centrifugation los yog filtration, thiab ces purified los ntawm chromatography kom tau D-deaminocellulose.
C5H8O3 + C3H7NO2 → C5H11NO2 + pyruvate
C5H8O3 + C3H7NO2 → C5H11NO2 + C3H4O3
Ntawm lawv, - ketovalerate (C5H8O3) thiab L-alanine (C3H7NO2) yog catalyzed los ntawm transaminases los ua D-Normal (C5H11NO2) thiab pyruvate (C3H4O3).
3.2 Amino acid dehydrogenase catalyzed cov tshuaj tiv thaiv
Lwm txoj kev enzymatic rau synthesizing D- Ib txwm yog siv cov amino acd dehydrogenase. Txoj kev no feem ntau sib txuas cov amino acid dehydrogenase nrog coenzymes (xws li NADH lossis NADPH) los tsim D-ib txwm los ntawm kev txo qis.
Cov kauj ruam tshuaj tiv thaiv yog raws li nram no:
1. Kev npaj substrate:
Siv alpha ketovaleric acid ua lub substrate.
2. Kev npaj cov tshuaj tiv thaiv sib tov:
Sib tov substrate, coenzyme (NADH lossis NADPH), amino acd dehydrogenase, thiab amino pub rau hauv cov tshuaj tsis haum.
3. Cov kev mob tshwm sim:
Cov tshuaj tiv thaiv yog nqa tawm ntawm qhov tsim nyog kub thiab pH tus nqi.
4. Cov khoom rho tawm:
Ib yam li ntawd, cov khoom siv tshuaj tiv thaiv tau sib cais los ntawm centrifugation lossis pom, thiab tom qab ntawd ua kom huv los ntawm chromatography kom tau D-deaminocellulose.
C5H8O3 + NH3 + NADH + H + → AADH + C5H11NO2 + NAD + + H2O
C5H8O3 + NH3 + NADH + H + → AADH + C5H11NO2 + NAD + + H2O
Ntawm lawv, alpha ketovaleric acid (C5H8O3), ammonia (NH3), coenzyme NADH, thiab proton (H+) yog catalyzed los ntawm amino acid dehydrogenase los tsim D-Normal (C5H11NO2), coenzyme NAD+, thiab dej (H2O).
Txhawm rau ua kom cov qoob loo thiab purity ntawm D-deaminocellulose, nws yog ib qho tsim nyog yuav tsum ua kom zoo dua cov tshuaj tiv thaiv, suav nrog:
1. Enzyme concentration:
Kho tus nqi ntawm cov enzyme siv kom ua tiav qhov zoo tshaj plaws catalytic nyhuv.
2. Substrate concentration:
Tswj qhov concentration ntawm substrates kom tsis txhob muaj kev cuam tshuam los yog tsim los ntawm - cov khoom.
3. Lub sij hawm teb:
Txiav txim siab lub sijhawm zoo tshaj plaws los xyuas kom meej cov tshuaj tiv thaiv tiav thaum tsis txhob muaj enzyme inactivation los ntawm lub sij hawm ntev.
4. Kub thiab pH:
Optimize kub thiab pH qhov tseem ceeb los tswj cov enzyme kev ua si thiab ruaj khov.
Tom qab cov tshuaj tiv thaiv ua tiav, cov txheej txheem ntawm kev sib cais thiab kev ua kom huv huv yuav tsum tau txais siab -purity D-deaminocellulose:
Centrifuge los yog filtration: cais cov khoom impurities thiab unreacted substrates.
Kem chromatography:D-deaminocellulose yog ntxiv purified siv kem chromatography tshuab kom tshem tawm lwm yam los ntawm - khoom thiab impurities.
crystallization los yog khov- ziab: Thaum kawg, cov khoom ntshiab D-deaminocellulose yog tau los ntawm crystallization los yog khov- txoj kev ziab.
Thaum kawg, lub purifiedD-Norvalinetau tus yam ntxwv thiab tshuaj xyuas siv ntau yam kev tshuaj ntsuam xyuas kom paub meej tias nws cov qauv thiab purity. Cov technologies no muaj xws li:
1. Kev ua haujlwm siab ua kua chromatography (HPLC):
siv los txiav txim qhov purity ntawm cov khoom.
2. Nuclear magnetic resonance (NMR) spectroscopy:
Siv kom paub meej cov qauv tshuaj.
3. Mass spectrometry (MS):
siv los txiav txim qhov hnyav molecular thiab cov ntaub ntawv ntawm cov qauv.
4. Optical rotation ntsuas:
siv los txiav txim chiral purity.
Valine, raws li ib qho tseem ceeb branched saw amino acid, occupies ib tug pivotal txoj hauj lwm nyob rau hauv lub teb ntawm biochemistry. Thiab D-valine, raws li ib qho isomer ntawm valine, txawm hais tias nws txoj kev tshawb pom yuav tsis meej npaum li valine, nws tseem embodies tus ntsuj plig ntawm cov kws tshawb fawb tsis muaj kev tshawb nrhiav thiab kev tshawb pom.
Kev tshawb pom ntawm valine tuaj yeem suav hais tias yog qhov tseem ceeb hauv kev tshawb fawb biochemical. Thaum ntxov li 1856, tus kws tshawb fawb Von Group Besanez thawj zaug cais cov amino acid no los ntawm pancreatic extract. Qhov kev tshawb pom no tsis tsuas yog nthuav tawm cov nplua nuj amino acd muaj pes tsawg leeg hauv pancreas, tab sis kuj tseem tsim lub hauv paus ruaj khov rau kev tshawb fawb tom ntej ntawm amino ads.
Txawm li cas los xij, nyob rau lub sijhawm no, valine tseem tsis tau muaj npe kom meej meej thiab tau kawm meej. Txog rau xyoo 1879, cov kws tshawb fawb tau cais tawm ib zaug ntxiv ntawm valine los ntawm albumin, uas tau lees paub ntxiv txog qhov muaj thiab qhov tseem ceeb ntawm valine hauv cov kab mob muaj sia. Txawm li cas los xij, txawm li ntawd los, cov qauv tshwj xeeb thiab cov khoom ntawm valine tseem tsis tau paub.
Qhov txiaj ntsig zoo ntawm H. Emil Fisher tau coj mus rau qhov kev txiav txim siab hauv kev kawm ntawm valine. Fisher ntse cais valine los ntawm casein thiab elucidated nws cov qauv -2-amino-3-methylbutyric acd - los ntawm kev siv tshuaj. Qhov kev tshawb pom no tsis tsuas yog nthuav tawm cov tshuaj lom neeg ntawm valine, tab sis kuj tseem muab cov ntaub ntawv tseem ceeb rau kev tshawb fawb tom ntej ntawm cov qauv thiab kev ua haujlwm ntawm amino ads. Nyob rau tib lub sijhawm, Fisher tseem hu ua cov amino acid no "valine", uas yog muab los ntawm cov tshuaj ntsuab Valerian, cim lub luag haujlwm tshwj xeeb thiab qhov tseem ceeb ntawm valine hauv cov kab mob muaj sia.
Kev phiv tshuaj
Cov khoom no yog ib qho tsis tshwm sim D-hom amino acid nrog cov tshuaj formula C ₅ H ₁₁ NO ₂ thiab molecular hnyav ntawm 117.15 g / mol. Nws cov qauv zoo ib yam li tej yam ntuj tso L- hom amino acids, tab sis nws qhov kev teeb tsa spatial yog qhov sib txawv, uas yuav ua rau muaj qhov sib txawv tseem ceeb hauv nws txoj kev lom zem thiab txoj hauv kev metabolic piv rau cov amino acids ntuj. Raws li lub zog ntxiv lossis cov khoom noj muaj txiaj ntsig zoo, cov khoom lag luam ntseeg tias yuav cuam tshuam rau kev tso tawm ntawm cov tshuaj hluavtaws metabolic, roj thaum lub sijhawm ua haujlwm, thiab kev puas siab puas ntsws hauv kev ntxhov siab-txog haujlwm, thiab tuaj yeem tiv thaiv cov leeg nqaij los ntawm kev tawm dag zog.
Digestive system teb
D-Novalin tuaj yeem cuam tshuam ncaj qha rau hauv plab hnyuv mucosa, ua rau cov tsos mob xws li xeev siab, ntuav, mob plab, thiab raws plab. Cov tshuaj tiv thaiv no muaj ntau dua nyob rau hauv qhov ncauj tshuaj thiab tej zaum yuav nyob ntawm seb qhov ntau npaum li cas. Lub sij hawm ntev los yog kev noj ntau dhau tuaj yeem ua rau lub nra ntawm lub plab zom mov, ua rau plab zom mov lossis kev puas tsuaj rau lub plab mucosa. Raws li cov amino acid uas tsis yog ntuj, D-demethyl selenide tuaj yeem cuam tshuam nrog cov amino acid metabolism hauv txoj hauv kev.
Neural teb
Kev noj ntau dhau ntawm D-novalin tuaj yeem ua rau muaj kev ntxhov siab ntau dhau ntawm neuronal, ua rau cov tsos mob xws li mob taub hau, kiv taub hau, insomnia, lossis ntxhov siab. Lub sij hawm ntev siab - siv koob tshuaj yuav ua rau muaj kev pheej hmoo ntawm peripheral neuropathy, tshwm sim raws li kev hnov lus txawv txav (xws li loog loog, tingling), cov leeg tsis muaj zog, lossis txo qis reflexes. Cov tshuaj tiv thaiv no feem ntau tshwm sim rau cov tib neeg muaj tus kab mob HIV lossis cov neeg uas siv lwm cov tshuaj neurotoxic (xws li qee cov tshuaj tiv thaiv kab mob), qhia tias D-norovirus tej zaum yuav muaj peev xwm ua rau muaj kev cuam tshuam neurotoxic.
Kev ua xua
D-Novalin tuaj yeem ua lub teeb liab ua rau lub cev tiv thaiv kab mob, ua rau cov tsos mob ntawm daim tawv nqaij xws li pob khaus, khaus khaus, urticaria, lossis erythema. Kev tsis haum tshuaj hnyav, xws li angioedema thiab laryngeal edema, tsis tshua muaj tab sis tej zaum yuav ua rau muaj sia nyob - hem thiab yuav tsum tau kho mob tam sim ntawd. Qee tus neeg yuav muaj cov tsos mob ua xua, suav nrog ua npaws, ua daus no, mob pob qij txha, lossis qog nqaij hlav loj. Hom tshuaj tiv thaiv no tuaj yeem cuam tshuam nrog kev tso tawm ntawm lub cev tiv thaiv kab mob lossis kev tso tawm cytokine, thiab yuav tsum muaj kev pom zoo ntxiv los ntawm kev kuaj tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob.
Lub siab toxicity
D-Novaline tuaj yeem ua rau lub siab puas tsuaj los ntawm kev cuam tshuam nrog lub siab metabolic enzymes xws li cytochrome P450 lossis ua rau muaj kev ntxhov siab oxidative. Cov tsos mob tshwm sim muaj xws li nce qib transaminase (ALT, AST), jaundice, lossis siab tsis xis nyob. Kev siv mus ntev yuav ua rau muaj kev pheej hmoo ntawm daim siab rog, kab mob siab, thiab txawm tias daim siab tsis ua haujlwm. Raws li ib qho exogenous amino acid, D-Novaline yuav tsum tau tawm los ntawm ob lub raum. Kev noj ntau dhau tuaj yeem ua rau lub raum pom lub nra, ua rau cov ntshav siab creatinine, proteinuria, lossis vascular puas tsuaj. Cov neeg mob lub raum tsis txaus yuav tsum siv nws nrog kev ceev faj ntxiv.
FAQ
Cov tshuaj norvaline siv rau dab tsi?
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Supplemental D-norvaline yog ua lag luam rau nws lub peev xwmboost nitric oxide ntau lawm, txhim kho cov ntshav khiav thiab kis las kis las. Nws cov qauv ua qauv ntawm valine kuj tuaj yeem cuam tshuam cov leeg nqaij protein synthesis.
DL valine siv rau dab tsi?
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Dl-valine yog lub stereoisomer ntawm l-valine thiab yog dav siv los ua ib qhonoj zaub mov zoovim nws tus nqi qis thiab kev nyab xeeb. Raws li ib qho ntawm kev txwv cov amino acids nyob rau hauv goose nqaij, dl-valine tuav lub peev xwm ua cov gel ntxiv rau cov nqaij goose thiab cov khoom tau los.
Puas yog norvaline ib qho amino acid?
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Norvaline (abbreviated li Nva) yog ib qho amino acidnrog cov formula CH3(CH2)2CH (NH2)CO2H. Cov compound yog ib qho qauv analog ntawm valeric acid thiab kuj yog ib qho isomer ntawm ntau cov amino acid valine. Zoo li feem ntau lwm yam -amino acids, norvaline yog chiral. Nws yog dawb, dej -soluble khoom.
Cim npe nrov: d-norvaline cas 2013-12-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom