Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm ethyl bromopyruvate cas 70-23-5 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo ethyl bromopyruvate cas 70-23-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Ethyl bromopyruvate hmoov, tseem hu ua 3-bromopyruvate ethyl ester, yog ib qho tshuaj lom neeg muaj zog heev siv dav hauv tshuaj synthesis thiab kev tshawb fawb tshuaj. Nyob rau hauv ib txwm muaj xwm txheej, nws zoo nkaus li cov xim tsis muaj xim rau daj ntseg daj nrog ib qho pungent, zoo li kua txob tsw, uas ua hauj lwm raws li ib tug notable sensory yam ntxwv.
Vim lub siab reactivity ntawm nws cov carbon-bromine daim ntawv cog lus, ethyl bromopyruvate ua raws li ib tug muaj zog C-Br activator thiab yog nquag ua hauj lwm raws li ib tug zoo brominating neeg sawv cev nyob rau hauv ntau yam organic transformations. Nyob rau hauv cov nqe lus ntawm solubility, cov compound no yog insoluble nyob rau hauv dej, tab sis qhia tau hais tias zoo compatibility nrog ntau yam organic solvents, xws li ethanol, diethyl ether, thiab lwm yam aprotic solvents.
Nyob rau hauv cov organic synthesis, ethyl bromopyruvate yog ib tug ntau yam tsev thaiv nrog dav siv. Nws yog dav siv los ua ib qho tseem ceeb reagent nyob rau hauv esterification, halogenation, thiab lwm yam kev hloov pauv los yog condensation tshwm sim. Tsis tas li ntawd, nws ua lub luag haujlwm tseem ceeb hauv heterocyclic chemistry, xws li hauv kev npaj ntawm thiazole derivatives los ntawm kev cuam tshuam nrog thawj amines thiab carbon disulfide. Tshaj li hluavtaws chemistry, nws kuj yog ib qho tseem ceeb ntawm cov tshuaj nruab nrab rau kev tsim cov tshuaj active tshuaj.
Ethyl bromopyruvate ua rau muaj kev pheej hmoo ntawm kev nyab xeeb. Nws yog khaus rau cov ntaub so ntswg thiab nthuav tawm cov tshuaj loog me me. Kev sib cuag ncaj qha rau ntawm daim tawv nqaij lossis ob lub qhov muag yuav ua rau mob hnyav, mob, lossis txawm tias muaj tshuaj lom neeg kub hnyiab. Yog li ntawd, cov cuab yeej tiv thaiv kom raug, suav nrog cov tsom iav kev nyab xeeb thiab cov hnab looj tes tiv thaiv tshuaj lom neeg, yuav tsum tau hnav thaum tuav. Kev khiav hauj lwm yuav tsum tau ua nyob rau hauv ib qho chaw zoo-ventilated kom tsis txhob nqus cov pa phem. Nyob rau hauv cov ntaub ntawv ntawm kev huam yuaj los yog inhalation, kev kho mob tam sim yog xav kom pom zoo.
Rau kev khaws cia thiab kev thauj mus los, ethyl bromopyruvate yuav tsum raug cais tawm ntawm cov khoom siv hluav taws xob thiab cov oxidizing cov neeg ua haujlwm kom tsis txhob muaj kev phom sij. Cov thawv ntim khoom yuav tsum tau muab kaw kom nruj, thiab cov khoom khaws cia rau hauv qhov chaw txias, ruaj ntseg kom deb ntawm qhov hluav taws kub thiab qhov kub thiab txias kom ruaj khov thiab nyab xeeb.
Cov ntaub ntawv ntxiv ntawm chemical compound:
|
Tshuaj Formula |
C5H7BrO3 |
|
Exact Mass |
193.96 |
|
Molecular Luj |
195.01 |
|
m/z |
193.96(100.0%),195.96(97.3%),194.96(5.4%),196.96(5.3%) |
|
Elemental Analysis |
C, 30,80; H, 3,62; Ib., 40,97; 24.61 Nws |
|
Boiling point |
98-100℃10 hli Hg (lit.) |
|
Qhov ntom |
1.554 g / mL ntawm 25℃(lit.) |
|
Cia tej yam kev mob |
2-8 degree |
|
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Ethyl Bromopyruvate hmoovyog ib qho tseem ceeb organic compound dav siv nyob rau hauv cov tshuaj, ua liaj ua teb, tshuaj engineering, thiab kev tshawb fawb. Nws cov khoom siv tshuaj lom neeg tshwj xeeb thiab kev ua haujlwm ntau ua rau nws yog qhov tseem ceeb hauv ntau cov kev tshawb fawb thiab kev siv. Cov hauv qab no yog nws cov ntawv tshwj xeeb hauv ntau qhov chaw:
Cov tshuaj no muaj peev xwm tseem ceeb hauv kev tiv thaiv - kev tshawb fawb tshuaj mob qog noj ntshav. Kev tshawb fawb tau pom tias nws tuaj yeem thaiv lub zog ntawm cov qog nqaij hlav qog noj ntshav thiab ua rau mob qog noj ntshav apoptosis los ntawm inhibiting cov enzymes tseem ceeb hauv txoj kev glycolytic, xws li hexokinase II. Cov txheej txheem no ua rau nws muaj peev xwm tiv thaiv - tus neeg mob qog noj ntshav, tshwj xeeb tshaj yog ua kom pom cov txiaj ntsig zoo hauv kev tawm tsam tshuaj - cov kab mob qog noj ntshav. Piv txwv li, ib txoj kev tshawb nrhiav pom tias nws tuaj yeem cuam tshuam kev loj hlob ntawm ntau yam qog nqaij hlav cancer, nrog rau mob ntsws cancer, mob qog noj ntshav mis thiab mob qog noj ntshav.
Tsis tas li ntawd, nws tau raug siv los tsim cov phiaj xwm xa cov tshuaj los ntawm kev sib txuas nrog cov nanocarriers los txhim kho cov phiaj xwm tshuaj thiab kev ua tau zoo, thaum txo cov kev mob tshwm sim ntawm cov hlwb ib txwm muaj. Nws kuj tau pom tias muaj kev cia siab rau daim ntawv thov kev cia siab hauv kev tsim cov tshuaj tua kab mob. Nws cov tshuaj tua kab mob muaj zog feem ntau yog vim nws lub peev xwm los cuam tshuam cov kab mob metabolic txoj hauv kev, tshwj xeeb yog glycolysis thiab tricarboxylic acid voj voog.
Kev tshawb fawb tau pom tias nws muaj kev cuam tshuam loj heev rau ntau yam tshuaj -cov kab mob tiv taus, xws li Staphylococcus aureus thiab Escherichia coli. Piv txwv li, ib txoj kev tshawb fawb tau pom tias nws tuaj yeem cuam tshuam kev loj hlob ntawm cov tshuaj - tiv thaiv Staphylococcus aureus, thiab nws cov tshuaj tua kab mob zoo dua rau qee cov tshuaj tua kab mob. Tsis tas li ntawd, nws tau siv los tsim cov tshuaj tua kab mob tshiab thiab hnav khaub ncaws rau kev tiv thaiv thiab kho mob ntawm qhov txhab. Cov ntawv thov no tsis tsuas yog txhim kho cov txiaj ntsig ntawm cov tshuaj tua kab mob, tab sis kuj txo qis kev siv tshuaj tua kab mob thiab kev txhim kho ntawm kev tiv thaiv.
Kev siv cov tshuaj no hauv kev lag luam tshuaj tsis txwv rau kev tiv thaiv - mob qog noj ntshav thiab tshuaj tua kab mob, tab sis kuj tau tshawb fawb txog kev kho mob ntawm lwm yam kab mob xws li mob thiab kab mob metabolic. Piv txwv li, cov kev tshawb fawb tau pom tias nws tuaj yeem muaj peev xwm los tiv thaiv - cov teebmeem inflammatory los ntawm inhibiting qhov kev tso tawm ntawm cov neeg kho mob inflammatory thiab txo cov inflammatory teb. Tsis tas li ntawd, nws kuj tseem siv los kawm txog nws daim ntawv thov hauv cov kab mob metabolic, xws li ntshav qab zib thiab rog, thiab txhim kho cov txheej txheem metabolic ntawm cov neeg mob los ntawm kev tswj cov txheej txheem metabolic.
Daim ntawv thov ntawmEthyl Bromopyruvate hmoovhauv kev ua liaj ua teb feem ntau tsom rau cov tshuaj tua kab thiab cog kev loj hlob regulators. Nws cov khoom siv tshuaj lom neeg tshwj xeeb thiab kev ua haujlwm lom neeg ua rau nws yog ib qho cuab yeej tseem ceeb rau kev nce qoob loo thiab tiv thaiv kab tsuag thiab kab mob. Nws tau pom muaj peev xwm loj hauv kev txhim kho tshuaj tua kab. Nws muaj zog antibacterial thiab antifungal kev ua haujlwm ua rau nws yog qhov kev xaiv zoo tshaj plaws rau kev tiv thaiv thiab tswj cov kab mob qoob loo. Kev tshawb fawb tau pom tias cov tshuaj no tuaj yeem cuam tshuam kev loj hlob ntawm ntau yam nroj tsuag kab mob, xws li grey pwm, nplej blast fungus, thiab anthracnose fungus. Piv txwv li, ib txoj kev tshawb nrhiav pom tias nws muaj kev cuam tshuam tseem ceeb ntawm cov pwm grey, thiab nws cov txheej txheem ntawm kev ua haujlwm yog cuam tshuam nrog cov txheej txheem metabolic ntawm cov kab mob, ua rau nws tuag.
Tsis tas li ntawd, nws tau raug siv los tsim cov tshuaj tua kab tshiab los ntawm kev sib txuas nrog cov nanocarriers los txhim kho kev ruaj ntseg thiab cov hom phiaj ntawm cov tshuaj tua kab, yog li txo qis kev siv tshuaj tua kab thiab ib puag ncig residues. Nws kuj qhia tau hais tias zoo daim ntawv thov kev cia siab nyob rau hauv cov nroj tsuag kev loj hlob regulators. Nws tuaj yeem txhawb cov nroj tsuag kev loj hlob thiab nce qoob loo tawm los ntawm kev tswj cov txheej txheem metabolic hauv cov nroj tsuag lub cev. Kev tshawb fawb tau pom tias nws tuaj yeem txhim kho kev ua haujlwm ntawm photosynthesis hauv cov nroj tsuag, txhim kho cov as-ham nqus thiab siv peev xwm, yog li txhawb cov nroj tsuag kev loj hlob thiab kev loj hlob.
Piv txwv li, ib txoj kev tshawb nrhiav pom tias cov nplej uas tau kho nrog cov tshuaj pom tau tias muaj kev loj hlob zoo dua thiab muaj txiaj ntsig zoo dua li pawg tswj tsis tau kho. Tsis tas li ntawd, nws tau siv los kawm txog nws daim ntawv thov nyob rau hauv cov xwm txheej tsis zoo xws li kev qaug zog thiab ntsev, los ntawm kev tswj cov metabolism hauv lub cev ntawm cov nroj tsuag thiab txhim kho lawv cov kev ntxhov siab thiab kev hloov pauv. Kev siv cov khoom siv no hauv kev ua liaj ua teb tsis txwv rau cov tshuaj tua kab thiab cov tswj kev loj hlob ntawm cov nroj tsuag, tab sis kuj tau tshawb nrhiav rau lwm lub hom phiaj xws li kev kho cov noob thiab kev txhim kho av.
Cov kev tshawb fawb tau pom tias nws tuaj yeem txhim kho tus nqi germination ntawm cov noob thiab cov robustness ntawm seedlings los ntawm kev ua lawv, nteg lub hauv paus rau siab thiab ruaj khov yields. Tsis tas li ntawd, nws tau siv los kawm txog nws daim ntawv thov hauv kev tswj cov av microbial zej zog, los ntawm inhibiting kev loj hlob ntawm cov kab mob tsis zoo thiab txhawb kev tsim cov kab mob uas muaj txiaj ntsig zoo, yog li txhim kho cov av ecological ib puag ncig.
Daim ntawv thov ntawm cov tshuaj no nyob rau hauv kev lag luam chemical yog feem ntau xav txog nyob rau hauv nws lub luag hauj lwm tseem ceeb raws li ib tug organic synthesis intermediate thiab ib tug polymer khoom additive. Nws cov qauv tshuaj tshwj xeeb thiab kev ua haujlwm ua kom nws ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem tshuaj. Nws yog dav siv raws li ib tug organic synthesis intermediate nyob rau hauv synthesis ntawm ntau complex organic tebchaw. Vim muaj cov active bromine atoms thiab ester pawg nyob rau hauv nws cov molecules.
Nws tuaj yeem koom nrog ntau yam kev hloov pauv nucleophilic thiab ester pauv cov tshuaj tiv thaiv, muab kev yooj yim rau kev sib txuas ntawm ntau cov organic tebchaw.Piv txwv li, hauv kev siv tshuaj synthesis, feem ntau yog siv los npaj cov tshuaj lom neeg, xws li tshuaj tua kab mob thiab tshuaj tua kab mob. Tsis tas li ntawd, nws tseem tuaj yeem siv los ua cov tshuaj zoo xws li cov tshuaj tsw qab thiab cov dyes. Los ntawm nws cov reactivity, cov pab pawg ua haujlwm tshwj xeeb tuaj yeem qhia tau zoo kom tau txais cov khoom siv tshuaj lom neeg uas xav tau. Nws tseem qhia tau hais tias muaj peev xwm siv tau zoo hauv thaj chaw ntawm cov khoom siv polymer additives.
04.Application in the field of chemical engineering
Ethyl Bromopyruvate hmoovtuaj yeem siv los ua tus neeg sawv cev crosslinking lossis hloov kho los txhim kho cov khoom ntawm cov ntaub ntawv polymer. Piv txwv li, nyob rau hauv polymer synthesis, nws muaj peev xwm tsim cross- txuas cov qauv los ntawm reacting nws active bromine atoms nrog functional pawg nyob rau hauv lub polymer saw, yog li txhim kho cov neeg kho tshuab zog thiab thermal stability ntawm cov khoom. Tsis tas li ntawd, nws tseem tuaj yeem siv los ua cov nplaim hluav taws kub thiab ntxiv rau cov khoom siv polymer txhawm rau txo cov txheej txheem combustion los ntawm nws cov khoom decomposition, yog li txhim kho cov nplaim hluav taws xob ua haujlwm ntawm cov khoom.
Cov ntawv thov kev lag luam
► Pharmaceutical Intermediate
Ethyl bromopyruvate yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm Xindanjing, ib tug cardioactive tshuaj siv los kho arrhythmias. Nws -bromo carbonyl pab pawg ua kom muaj kev sib txuas nrog cov nucleophiles, ua kom yooj yim rau kev tsim cov txheej txheem molecular complex.
► Anticancer Agent Development
Lub compound lub reactivity ua rau nws muaj nuj nqis nyob rau hauv lub synthesis ntawm bromopyruvate analogs, uas tau pom kev cog lus raws li inhibitors ntawm glycolytic enzymes (xws li, hexokinase II) nyob rau hauv cov qog nqaij hlav cancer. Cov analogues no cuam tshuam cov metabolism hauv lub zog, ua rau cov cell tuag hauv cov ntaub so ntswg.
► Enzyme Inhibitors
Ethyl bromopyruvate yog siv los tsim cov inhibitors ntawm pyruvate dehydrogenase kinase (PDK) thiab lwm yam metabolic enzymes. Cov inhibitors no tau kawm txog lawv lub peev xwm los kho cov kab mob metabolic thiab cov kab mob neurodegenerative.
► Organic Synthesis
Lub compound ua hauj lwm raws li ntau yam reagent nyob rau hauv:
Alkylation Reactions: Cov -bromo pab pawg tau hloov pauv nucleophilic nrog amines, thiols, thiab cawv.
Hla -Cov Kev Sib Txuas Sib Txuas: Pd-catalyzed couplings nrog boronic acids los yog stannanes yield aryl- los yog vinyl- hloov pyruvates.
Heterocycle Synthesis: Nws yog siv los tsim thiazolidines, oxazoles, thiab lwm yam nitrogen -muaj cov heterocycles ntawm cyclization cov tshuaj tiv thaiv.
kev phiv tshuaj
Ethyl Bromopyruvate hmoov(CAS naj npawb 70-23-5, tshuaj lub npe 3-bromo-2-oxopropionic acid ethyl ester) yog bromine uas muaj cov organic compound feem ntau siv hauv cov organic synthesis thiab biochemical tshawb fawb. Nws cov mis molecular yog C ₅ H ₇ BrO3, nrog rau qhov hnyav molecular ntawm 191.01 g / mol. Nws tshwm raws li cov xim tsis muaj xim rau daj ntseg daj kua nrog ib tug pungent tsw. Raws li kev kuaj reagent, nws tuaj yeem nkag mus rau tib neeg lub cev los ntawm kev sib cuag ntawm daim tawv nqaij, nqus pa, lossis nqus tau, ua rau muaj kev cuam tshuam tsis zoo.
Daim tawv nqaij: Kev sib cuag yuav ua rau liab, o, khaus, lossis kub hnyiab. Lub sij hawm ntev los yog rov qab sib cuag yuav ua rau dryness, tawg, los yog hu rau dermatitis ntawm daim tawv nqaij.
Qhov muag: Splashing rau hauv lub qhov muag tuaj yeem ua rau mob hnyav, tsim kua muag, photophobia, conjunctival congestion, thiab nyob rau hauv cov xwm txheej hnyav, tej zaum yuav ua rau corneal epithelial puas los yog tsis pom kev ib ntus.
Mucosa: Kev nqus pa ntawm vapors lossis aerosols tuaj yeem ua rau cov mucous ntawm qhov ntswg kab noj hniav, caj pas, thiab ua pa ua pa, ua rau hnoos, txham, los ntswg, lossis ua pa nyuaj. Nws qhov kev chim siab tshwm sim los ntawm bromine atoms thiab carbonyl pawg hauv nws cov qauv tshuaj. Bromine atoms muaj cov reactivity siab thiab muaj peev xwm hnov mob nrog cov proteins thiab lipids nyob rau hauv daim tawv nqaij los yog mucous daim nyias nyias, cuam tshuam kev ncaj ncees ntawm cell membranes; Carbonyl pawg tuaj yeem ua rau cov ntaub so ntswg puas tsuaj los ntawm oxidative kev ntxhov siab. Tsis tas li ntawd, nws cov khoom lipophilic ua rau nws yooj yim rau nkag mus rau ntawm daim tawv nqaij barrier, ua rau muaj kev pheej hmoo ntawm kev nqus dej.
Kev kis tus kab mob mus ntev: Kev raug mob rau lub sijhawm ntev tuaj yeem ua rau mob ntsws ntev, ua rau lub ntsws ua haujlwm tsis zoo, lossis kev ua pa ntawm txoj hlab pa. Decomposition khoom xws li hydrogen bromide tuaj yeem cuam tshuam cov ciliary clearance muaj nuj nqi ntawm txoj hlab pa, ua rau inflammatory cell infiltration thiab airway remodeling. Tsis tas li ntawd, cov txheej txheem absorbed hauv lub cev tuaj yeem cuam tshuam rau lub ntsws los ntawm cov ntshav ncig, inducing lossis exacerbating ntsws kab mob.
Kev raug mob hnyav: Thaum nqus tau cov pa ntau ntawm cov pa lossis aerosols, cov tsos mob ntawm nasopharyngeal irritation xws li hnoos, hauv siab nruj, ua tsis taus pa, lossis hawb pob tuaj yeem tshwm sim tam sim ntawd.
Kev pheej hmoo tshwj xeeb: Nyob rau hauv qhov kub thiab txias (xws li cua sov lossis combustion), Ethyl Bromopyruvate tuaj yeem decompose los tsim hydrogen bromide (HBr), ua rau muaj kev puas tsuaj ua pa ntxiv.
Kev noj ntawm qhov ncauj: Kev noj haus yuav ua rau mob kub hauv qhov ncauj, caj pas, thiab txoj hlab pas, nrog rau xeev siab, ntuav, mob plab, lossis raws plab. Cov mob hnyav tuaj yeem ua rau plab hnyuv los ntshav lossis perforation.
Kev nqus pa: Kev nqus pa ntev ntev tuaj yeem ua rau tsis qab los noj mov, poob phaus, lossis noj tsis txaus.
Lub plab zom mov cov tshuaj tiv thaiv feem ntau yog tshwm sim los ntawm qhov ncaj qha corrosive nyhuv ntawm cov tebchaw. Bromine atoms thiab carbonyl pawg tuaj yeem cuam tshuam rau lub plab hnyuv mucosal barrier, uas ua rau cov kab mob hauv zos thiab kab mob tsim. Tsis tas li ntawd, cov khoom sib xyaw ua ke tuaj yeem cuam tshuam rau daim siab metabolic muaj nuj nqi, tab sis cov ntaub ntawv uas twb muaj lawm tsis qhia txog qhov tseem ceeb ntawm hepatotoxicity.
Oral LD ₅₀: unclear, but based on toxicity data of similar structural compounds (such as bromoacetate), it is speculated that its acute oral toxicity is low (LD ₅₀>2000 mg/kg).
Kev nqus ntawm daim tawv nqaij: ntev ntev yuav ua rau cov tshuaj nkag mus rau hauv cov hlab ntsha los ntawm daim tawv nqaij, ua rau muaj kev cuam tshuam xws li mob taub hau, kiv taub hau, lossis qaug zog.
Carcinogenicity: Tsis tau muab cais ua carcinogen los ntawm IARC, NTP, lossis ACGIH.
Reproductive toxicity: Muaj cov pov thawj tsis txaus los qhia tias nws muaj kev sib deev lossis kev loj hlob toxicity, tab sis cov poj niam cev xeeb tub thiab lactating yuav tsum tsis txhob sib cuag.
Neurotoxicity: Lub sij hawm ntev raug tuaj yeem ua rau muaj kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb, tshwm sim raws li kev qaug zog, tsis muaj kev xav, lossis nco tsis tau.
Cim npe nrov: ethyl bromopyruvate cas 70-23-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom