5-Methylpyridine-3-Boronic Acid, tseem hu ua 3- (5-metylproyl) dolonics acid, yog ib pawg ntawm heterocyclic accounts nrog lub methyl pab pawg ntawm 5-txoj hauj lwm thiab ib pawg acid moiety ntawm 3-txoj hauj lwm. Qhov no cov qauv molecular loj no uas cuam tshuam nrog cov tshuaj sib txawv thiab cov ntawv thov hauv ntau thaj chaw, tshwj xeeb hauv cov suab hluav taws xob hauv keeb kwm thiab tshuaj chemistry.
Chemically, nws nta ib lub pyridyl nplhaib, uas yog rau- maned} Muab tswv yim atom, muab nws nrog aromaticity thiab ruaj khov. Lub xub ntiag ntawm boronic acid pawg (- miyaur cov txheej txheem rau kev ua cov pa roj carbon- bietbone ntawv cog lus hauv hluav taws xob organic. Qhov tshuaj tiv thaiv no tso cai rau kev txuas ntawm aryl lossis alkenylal halces nrog cov khoom siv me me, yog li ua rau cov synthesis ntawm cov kev ua tau zoo thiab xaiv tau.
Hauv cov tshuaj chemistry, nws tuaj yeem ua haujlwm nruab nrab tseem ceeb hauv kev npaj ntawm ntau yam ntawm kev kho cov sib txuas. Vim nws pyridyl moamiety, uas feem ntau ua rau cov khoom siv los ntawm ntuj ntawm cov khoom siv hluav taws xob tshwj xeeb lossis cov tshuaj enzymes rau kev txhim kho cov tshuaj ntawm cov khw ntawm cov kws tshuaj ntawm cov kws ua tshuaj tshiab.
Hauv cov ntsiab lus xaus,5-Methylpyridine-3-Boronic AcidSawv tawm raws li lub cuab yeej hluav taws xob muaj txiaj ntsig hauv cov organic kev tsim kho cov cuab yeej siv hluav taws xob molecular nrog cov ntawv thov yuav nyob ntawm kws tshuaj rau cov ntaub ntawv siab. Nws tshwj xeeb ua ke ntawm cov qauv nta thiab reactivity ua nws indispensable reagent nyob rau hauv niaj hnub hluavtaws.
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Tshuaj Cov Qauv |
C6H8bno2 |
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Muaj pes tsawg leej |
137 |
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Molecular hnyav |
137 |
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m/z |
137 (100.0%), 136 (24.8%), 138 (6.5%), 137 (1.6%) |
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Kev Ntsuam Xyuas |
C, 52.62; H, 5.89; B, 7.89; N, 10.23; O, 23.37 |
5-Methylpyridine-3-Boronic Acid, raws li cov organic boron compos compound, tau qhia tau cim cim cov ntaub ntawv muaj peev xwm nyob rau hauv teb ntawm cov khoom siv hluav taws xob hloov tau. Nws cov qauv tshuaj tshwj xeeb cov khoom lag luam thiab cov khoom ua rau nws muaj cov khoom siv hluav taws xob tsis sib haum. Saj zawg zog tau cov khoom siv hluav taws xob muaj cov kev cia siab hauv cov khoom siv hnav, thiab lwm daim teb vim yog lawv lub cev sib txawv, thiab cov yam ntxwv ncab. Ua ib qho khoom siv organic, nws ua lub luag haujlwm tseem ceeb hauv kev npaj thiab kev ua tau zoo ntawm cov khoom siv hluav taws xob hloov kho tau vim nws cov tshuaj hluav taws xob zoo, thiab kho qhov muag.
- Saj Zawg Zog Pob tshab Conductent Lauj Zaj Duab Xis
Yuav siv tau los ua dopant los yog hloov kho rau pob tshab pob tshab ua yeeb yaj kiab. Los ntawm kev qhia nws mus rau hauv cov txheej txheem npaj ntawm kev npaj cov yeeb yaj kiab nyias, qhov kev coj zoo thiab pob tshab ntawm cov yeeb yaj kiab tuaj yeem txhim kho. Qhov hloov tau pob tshab pob tshab pob tshab ua zaj duab xis muaj cov ntaub ntawv thov dav dav hauv cov liaj teb xws li cov lus qhia tawm, cov ntxaij vab tshaus sib tw, kov cov ntxaij vab tshaus, thiab lwm yam.
- Hloov tau cov lus qhia
Nws kuj tseem siv tau los npaj cov khoom siv hloov tau zoo. Los ntawm compounding nws nrog lwm cov ntaub ntawv polymer, fiber ntau cov ntaub ntawv nrog kev coj zoo tuaj yeem tsim tau. Cov lus tshaj tawm no muaj cov ntawv thov cov kev cia siab xws li cov ntawv nyeem ntse thiab cov khoom siv hnav tau.
nyob rau hauv cov conforsible
- Saj zawg zog siab sensor
Ua si lub luag haujlwm tseem ceeb hauv kev hloov kho lub siab. Nws cov qauv molecular tshwj xeeb ua rau lub sensor kom tsis txhob muaj kev hloov pauv tseem ceeb thaum raug ntsuas, yog li ua tiav kev ntsuas siab. Qhov hloov tau zoo ntawm siab sensor muaj cov ntawv thov thoob plaws hauv cov khoom siv hnav ris tsho, kev soj ntsuam biomedical thiab lwm daim teb.
- Saj zawg zog kub sensor
Nws kuj tseem siv tau los npaj qhov ntsuas kub hloov tau. Los ntawm kev sib txuas nrog lwm cov khoom siv thermosensitive, sensors nrog qhov kub zoo tshaj plaws rhiab tau. Cov kev kub siab no muaj cov kev cia siab thov cov kev cia siab xws li kev soj ntsuam biomedical thiab saib xyuas ib puag ncig.
- Npaj ntawm cov tawv nqaij hluav taws xob
Ua lub luag haujlwm tseem ceeb hauv kev npaj ntawm daim tawv hluav taws xob. Cov tawv nqaij hluav taws xob yog lub cuab yeej siv hluav taws xob uas muaj peev xwm sim ua cov kev thov sib luag ntawm cov teb zoo xws li tib neeg {1} kev sib cuam tshuam computer thiab biomedical. Los ntawm kev qhia nws mus rau hauv cov txheej txheem npaj ntawm cov tawv nqaij hluav taws xob, qhov rhiab thiab muaj kev ruaj ntseg ntawm cov tawv nqaij hluav taws xob tau txhim kho.
- Kev txhim kho cov tawv nqaij hauv
Ntxiv rau kev npaj cov tawv hluav taws xob, nws kuj tseem siv tau los txhim kho kev ua yeeb yam hluav taws xob hluav taws xob. Piv txwv li, los ntawm kev sib txuas nrog lwm cov ntaub ntawv ua haujlwm, cov tawv nqaij hluav taws xob nrog kev paub ntau dua, nrawm dua tuaj yeem tsim tau. Cov kev ua tau zoo no txhim kho cov tawv hluav taws xob los ua kom pom cov kev ua tau zoo hauv cov kab ntsig dav dav.
Hauv cov khoom siv hluav taws xob
- Saj zawg zog Solar hlwb
Ua dua lub luag haujlwm tseem ceeb hauv cov hlwb qhib hlwb. Nws cov khoom siv hluav taws xob zoo thiab kho qhov muag tau ua kom muaj zog hnub ci kom tswj tau kev ua tau ruaj khov txawm tias tsis muaj kev cuam tshuam thiab ncab. Lub xov tooj cua sov no hloov tau muaj dav muaj nuj nqis hauv cov khoom siv hnav ris tsho, cov khoom siv hluav taws xob Portable, thiab lwm thaj teb.
- Saj Zawg Zog Supercapacitor
Nws kuj tseem siv tau los npaj supercapacitors yooj ywm. Supercapacitors yog cov khoom siv hluav taws xob nrog lub zog muaj zog thiab muaj zog hluav taws xob, uas muaj cov ntawv thov cov kev cia siab hauv cov khoom siv hluav taws xob yooj ywm. Los ntawm kev qhia nws mus rau hauv txoj kev npaj txheej txheem ntawm Supercapacitors, lub zog tso chaw ua haujlwm thiab muaj peev xwm txhim kho tuaj yeem txhim kho.
- Saj zawg zog cov khoom siv hluav taws xob
Ua si lub luag haujlwm tseem ceeb hauv kev npaj ntawm cov cim hluav taws xob hloov khoom siv hluav taws xob hloov khoom siv. Cov khoom siv hluav taws xob yog hloov cov khoom hluav taws xob hloov khoom siv thiab xa cov ntaub ntawv, thiab muaj cov ntawv thov kev cia siab hauv kev tso chaw, chaw muag khoom, thiab lwm thaj teb. Los ntawm kev qhia nws mus rau hauv cov txheej txheem npaj ntawm cov khoom siv hluav taws xob, cov ntaub ntawv cia khoom thiab ruaj khov ntawm cov cim npe tuaj yeem txhim kho.
- Saj zawg zog hluav taws xob
Nws kuj tseem tuaj yeem siv los npaj hloov hluav taws xob hluav taws xob. Saj zawg zog hluav taws xob hloov pauv yog tuaj yeem khoov tau thiab ncab, thiab muaj cov kev cia siab ntawm cov khoom siv hnav, thiab lwm daim teb. Los ntawm kev npaj cov txheej txheem npaj ntawm hluav taws xob hloov pauv, qhov kev ua tau zoo thiab kev ruaj khov ntawm cov hluav taws xob tuaj yeem txhim kho.
5-Methylpyridine-3-Boronic Acidmuaj qhov dav ua daim ntawv thov kev cia siab hauv cov khoom siv hluav taws xob hloov tau. Nws cov qauv tshuaj lom neeg thiab cov khoom lag luam tshwj xeeb tau ua tiav qhov kev npaj ua tau zoo hauv kev npaj thiab kev ua haujlwm zoo ntawm cov khoom siv hluav taws xob. Yav tom ntej, nrog kev nce qib nruam kev tshawb fawb thiab thev naus laus zis thiab kev siv hluav taws xob hloov kho cov khoom siv hluav taws xob hloov tau zoo li qub thiab hauv {qhov tob.
Ua ntej
Cov ntawv thov tshiab nyob rau hauv cov khoom siv hluav taws xob hloov kho tau ntxiv. Piv txwv li, nws tuaj yeem siv los npaj cov khoom siv hluav taws xob hluav taws xob hluav taws xob xws li hloov kho hluav taws xob hluav taws xob thiab hloov hluav taws xob hluav taws xob hloov kho kom zoo dua thiab cov ntse dua cov ntse hloov kho cov khoom siv hluav taws xob.
Thib ob
Nws yog qhov ua tau los ua tus cwj pwm hauv - qhov tob tshawb nrhiav ntawm cov teebmeem sib xyaw nrog lwm cov ntaub ntawv. Los ntawm kev sib txuas nrog lwm cov ntaub ntawv ua haujlwm, ib qho tshiab ntawm cov khoom siv nrog kev ua tau zoo thiab ntau txoj haujlwm tuaj yeem tsim kho thiab kev ua tau zoo ntawm cov khoom siv hluav taws xob.
Kawg no
Kev saib xyuas tuaj yeem them rau kev nyab xeeb ib puag ncig thiab biocompatibility nyob rau hauv cov khoom hluav taws xob. Los ntawm kev ua nyob rau hauv - qhov tob tshawb xyuas ntawm nws cov ecological meticalsy thiab biocompatibility rau nws daim ntawv thov kev nyab xeeb hauv thaj chaw.
Mechanism ntawm 5-methylpyridine-3-boronic acid ua ib qho enzyme inhibitor: Kev sib txuas lus ntes thiab hloov Xeev Simulation
Enzyme inibitors yog ib qho ntawm cov kev qhia tseem ceeb hauv kev siv yeeb tshuaj no lossis kev teeb tsa cov txheej txheem los ntawm kev thaiv enzyme nquag cov chaw zov me nyuam lossis cuam tshuam nrog substrate khi. Hauv kev tsim qauv ntawm enzyme inibitors, kev sib cav sib ceg ntawm kev sim ua kom muaj kev cuam tshuam nrog cov kev sim ua kom ntev los ntawm kev sim ua kom muaj kev cuam tshuam ntawm enzyme catalenyzed Transition xeev.5-Methylpyridine-3-Boronic Acid(CAS naj npawb 173999-18-3), raws li ib tug boron uas muaj heterocyclic sib xyaw ua ke thiab kev hloov pauv ntawm lub xeev cov pab pawg thiab cov pyridine ntiv nplhaib.
Cov qauv tshuaj thiab cov kev tawm tsam ntawm 5-methylpyridine-3-boronic acid
Molecular Cov Qauv Txheej Txheem
Cov mis me ntawm 5-methylpyridine-3-boronic acid yog c ₆ h ₈ bno ₂, nrog molecular hnyav ntawm 136.94 g / mol. Nws cov qauv muaj ib lub pyridine, lub methyl hloov, thiab ib pawg acid
Pyridine ring: As an aromatic heterocyclic ring, the nitrogen atom of the pyridine ring endows the molecule with weak alkalinity and can form hydrogen bonds or ionic interactions with acidic amino acids such as glutamic acid and aspartic acid.
Methyl Petras: Cov methyl pawg ({0}}}} Txoj Haujlwm Pyrdine rau lub hnab ntim 5)
Boricid pab pawg neeg: boric acid ({{{{}} b (Of) yog cov pa oxygen, thiab nws khoob khi nrog hydroxyl thiab amino pawg.
Cov kev ua si ntawm cov hauv paus
Cov kev ua dhau los ntawm boronic acid pawg keeb kwm los ntawm lawv lewis acidity:
Cov tshuaj tiv thaiv nrog Diols / Polyols: boric acid tuaj yeem tsim pentagonal lossis hexagonal Cyclic Cyclic Esters nrog cov neeg nyob sib ze (xws li cov suab thaj) lossis xws li vitamins (xws li vitamins (xws li vitamins (xws li vitamins (xws li vitamins (xws li vitamin C). Qhov tshuaj tiv thaiv no tau thim rov qab ntawm lub phob pheeb suab physiological?
Cov tshuaj tiv thaiv cov amino: nyob rau hauv Alkaline tej yam kev mob tuaj yeem tsim cov kev sib tw sib txawv nrog pH, uas yog tus yuam sij rau kev tsim cov tib neeg inhibitors.
Cov tshuaj tiv thaiv nrog cov yaj saub: acids acid tau qis dua cov pab pawg neeg muaj peev xwm los ntawm cov txheej txheem hloov kho hluav taws xob xws li qhia cov txheej txheem hluav taws xob.
Kev Ncaj Ncees Sib Tham: phiaj xwm kab amino acid seem
Covalent inibitors ua tiav ntev -}} kav ntev los ntawm kev tsim cov kab ke uas muaj cov amino acid residues ntawm lub hom phiaj protein. Kev sib cav sib ceg ntawm 5-methylpyridine-3-boronic acid feem ntau yog koom nrog cov kauj ruam hauv qab no:
Lub hom phiaj lees paub thiab thim rov qab los
Tsis muaj kev sib cuam tshuam tsis sib xws: nyob rau theem pib, inhomitors khi rau cov chaw sib cav ntawm cov pyridine ntawm cov pyridine ntawm cov pyridine, thiab cov txheej txheem ionic. Piv txwv li, hauv kev tsim cov serine hydroxases tuaj yeem nyob hauv cov pab pawg hydrophobic yog nyob ze rau cov siayd pawg hauv Tiaalyd (ser nws ASP).
Kev ua txhaum cov nyhuv: thawj zaug pib khi cov enzymes thiab inhibitors yuav ua rau muaj kev sib txuas lus, xws li cov khoom seem thiab cov phiaj xwm ua kom ze rau cov pab pawg boronic acconics.
Kev sib cav sib haum
Cov tshuaj tiv thaiv nrog rau sab nrauv: nyob rau hauv ib pawg alkaline (xws li pH 7,5.0), cov pa roj ntsha tsis zoo, ua raws li los ntawm lub cev qhuav dej los ua cov kab ke sib xyaws. Qhov tshuaj tiv thaiv no muaj siab ireversibility thiab tuaj yeem tiv thaiv enzyme kev ua haujlwm ntev.
Cov tshuaj tiv thaiv nrog cysteine: txawm hais tias ntuj boric acid muaj tsawg reasonity ntawm boric acid thiab txhawb kev tsim ntawm thiol tuam did kev sib tw. Piv txwv li, kev ua yeeb yam ntawm 5-fluoro-3-pyridylbbobonic acid on csteine protteine yog qhov ntau dua li ntawm kev tsis muaj kev txwv tsis pub ua.
Cov tshuaj tiv thaiv nrog tyrosine: the phenrohol pab pawg ntawm tyrosine kuj tseem yuav ua qhov kev sib haum xeeb uas muaj kev sib cav sib ceg (xws li pylalyy) kom nrawm dua cov tshuaj tiv thaiv.
Cim npe nrov: 5-Methylyridine-3-Boronic Acid CASE 173999-18-3, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag