Ethyl Malonyl Chloride CAS 36239-09-5

Ethyl malonyl chloride hmoov, tseem hu ua ethyl malonate chloride los yog 3-chloro-3-oxobutanoic acid ethyl ester, yog ib qho organic compound uas yog nyob rau hauv chav kawm ntawm esters nrog ib tug tshwj xeeb functional pab pawg neeg uas combines cov yam ntxwv ntawm ob qho tib si malonic acid derivatives thiab chloroalkanes. Cov tshuaj lom neeg muaj ntau yam no pom cov ntawv thov hauv ntau qhov chaw, suav nrog cov organic synthesis, tshuaj chemistry, thiab ua ib qho nruab nrab hauv kev tsim khoom ntawm lwm yam tshuaj.

Raws li cov qauv, nws tuaj yeem piav qhia tias yog ester tsim los ntawm malonic acid (ib dicarboxylic acid nrog cov mis HOOC-CH2-COOH) thiab ethanol (ib qho cawv nrog cov mis C2H5OH), nrog rau ib qho ntawm cov carboxylic acid pawg hloov los ntawm chloro (Cl) hloov. Qhov kev hloov pauv no ua rau cov molecule muaj cov qauv ClC(O)CH2C(O)OCH2CH3.

Nyob rau hauv cov nqe lus ntawm nws lub cev lub cev, nws yog feem ntau ib tug tsis muaj xim rau daj ntseg daj kua nrog ib tug txawv tsw. Nws qhov kub thiab txias taw tes yog nyob ntawm qhov purity thiab tej yam kev mob ntawm kev ntsuas tab sis feem ntau poob nyob rau hauv ib tug tej yam. Vim muaj cov tshuaj chlorine atom thiab ester pawg, cov khoom sib xyaw ua pov thawj ob qho tib si halogenated thiab ester-zoo li reactivity.

Ethyl malonyl chloride hmoov(CAS naj npawb 36239-09-5), tshuaj npe malonic acid monoethyl chloride, molecular mis C ₅ H ₇ ClO3, yog ib tug heev reactive 1,3-dicarbonyl compound. Nws cov qauv molecular muaj ob pawg acyl chloride (- COCl) thiab ethyl ester pawg (- COOEt), muab nws ntau yam tshuaj hloov pauv muaj peev xwm. Raws li ib qho tseem ceeb nruab nrab ntawm cov organic synthesis, nws yog dav siv nyob rau hauv pharmaceuticals, tshuaj tua kab, ntaub ntawv science, thiab cov kev tshawb fawb chemistry.

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Nws nyob hauv txoj haujlwm tseem ceeb hauv kev siv tshuaj yeeb tshuaj, thiab nws pawg acyl chloride tuaj yeem raug hloov pauv cov tshuaj nucleophilic nrog cov tshuaj xws li amines, cawv, thiols, thiab lwm yam., ua kom muaj txiaj ntsig zoo tsim cov ntawv cog lus amide, ester bonds, lossis thioester bonds, qhia cov pab pawg tseem ceeb hauv cov tshuaj molecules.

1. Kev tsim cov tshuaj tiv thaiv kab mob
Cov ntaub ntawv qhia tau hais tias nws yog ib qho tseem ceeb raw khoom rau synthesizing HIV-1 tus kab mob tsom rau cov tshuaj molecules. Los ntawm kev cuam tshuam nrog cov tshuaj amine tshwj xeeb, lub cev pob txha nrog kev ua haujlwm inhibitory tiv thaiv kab mob rov ua dua tshiab tuaj yeem tsim.

 

Piv txwv li, nyob rau hauv cov synthesis ntawm non nucleoside thim rov qab transcriptase inhibitors (NNRTIs), lawv cov acyl chloride pawg tuaj yeem raug cov tshuaj tiv thaiv condensation nrog cov tshuaj tsw qab amines los tsim cov khoom siv roj ntsha imidazole lossis pyridine nplhaib. Cov tebchaw no tau nkag mus rau theem kev tshawb fawb preclinical.

2. Synthesis ntawm receptor antagonists
Hauv kev kho cov kab mob plawv, nws yog siv los npaj beta receptor antagonists (xws li propranolol analogs). Cov amide nruab nrab tsim los ntawm nws cov tshuaj tiv thaiv nrog cov amines theem nrab tuaj yeem hloov kho ntxiv nrog cov pab pawg ua haujlwm kom tau txais kev xaiv ntau dua rau kev kho mob ntawm cov kab mob xws li kub siab thiab angina.

 

3. Qhov nruab nrab ntawm cov tshuaj tiv thaiv -mob qog noj ntshav
Raws li cov khoom siv raw rau synthesizing topoisomerase inhibitors (xws li irinotecan analogs), ester intermediates yog tsim los ntawm reacting nrog hydroxyl tebchaw, thiab ces cyclized los tsim ntau lub nplhaib nrog DNA embedding kev ua si. Cov tebchaw no muaj kev cuam tshuam loj heev rau cov qog nqaij hlav xws li mob qog noj ntshav thiab mob ntsws cancer.
4. Tshuaj tua kab mob thiab tshuaj tua kab mob
Hauv kev sib xyaw ntawm - lactam tshuaj tua kab mob (xws li penicillin derivatives), lawv tuaj yeem hloov cov tshuaj chloroformate reagents los ntawm kev ua haujlwm nrog cov amino tebchaw los tsim kom muaj kev ruaj ntseg amide bonds, txhim kho cov tshuaj stability thiab tshuaj tua kab mob ntawm cov tshuaj tua kab mob.

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Daim ntawv thov nyob rau hauv cov tshuaj tua kab tsom mus rau kev sib txuas ntawm cov tshuaj tua kab tshiab, tshuaj tua kab, thiab cov nroj tsuag kev loj hlob regulators, uas muaj reactivity siab thiab ob peb los ntawm - khoom, nyob rau hauv txoj kab nrog rau txoj kev loj hlob ntawm ntsuab chemistry.
1. Cov tshuaj tua kab nicotine tshiab
Raws li qhov nruab nrab tseem ceeb rau kev sib txuas ntawm peb - tiam neonicotinoid tshuaj tua kab xws li fipronil thiab pymetrozine, ethyl chloroformate reacts nrog chlorinated hydrocarbons los tsim chloropropanedicarboxylate, uas yog cyclized los tsim cov qauv neurotoxic nitroguanide. Cov tebchaw no muaj kev sib cuag zoo thiab ua rau lub plab toxicity tawm tsam kev nqus cov qhov ncauj kab tsuag xws li nplej planthoppers thiab aphids.

 

2. Sulfonylurea tshuaj tua kab mob
Thaum synthesizing sulfonylurea herbicides xws li sulfonamide thiab bensulfuron methyl, ib tug sulfonylurea skeleton yog tsim los ntawm reacting nrog sulfonamide tebchaw. Nws cov qauv heterocyclic tshwj xeeb tuaj yeem cuam tshuam tshwj xeeb acetyl lactate synthase (ALS), thaiv txoj kev sib txuas ntawm cov ceg saw amino acids hauv cov nroj tsuag, thiab ua tiav cov tshuaj tsawg, cov tshuaj tiv thaiv cov nroj tsuag muaj ntau yam.
3. Cog kev loj hlob regulator
Los ntawm reacting nrog indole-3-acetic acid (IAA) analogues, ethyl chloroformate tuaj yeem tsim cov ester tebchaw nrog auxin kev ua. Cov tshuaj no tuaj yeem tswj cov nroj tsuag ntawm tes elongation thiab faib, txhawb cov txiv hmab txiv ntoo kom loj, thiab nce qoob loo, thiab siv dav hauv kev cog txiv ntoo.

Cov Khoom Siv Kev Tshawb Fawb: Cov Tsev Ua Haujlwm ntawm Cov Khoom Siv Ua Haujlwm Polymer

 

Nws pab pawg acyl chloride tuaj yeem hnov ​​​​mob nrog hydroxyl thiab amino pawg ntawm qhov kawg lossis sab chains ntawm cov saw hlau polymer, qhia cov pab pawg ua haujlwm thiab muab cov khoom siv tshwj xeeb.
1. Polyester cov ntaub ntawv hloov kho
Nyob rau hauv cov synthesis ntawm polyethylene terephthalate (PET), ethyl chloroformate yuav siv tau raws li ib tug comonomer los qhia propylene ester ntu los ntawm ester txauv cov tshuaj tiv thaiv, yog li ua kom cov iav hloov kub (Tg) thiab thermal stability ntawm lub polymer. Nws yog qhov tsim nyog rau kev ua haujlwm siab -kub engineering plastics.

 

2. Cov khoom siv biodegradable
Thaum copolymerized nrog polylactic acid (PLA), ester daim ntawv cog lus hydrolysis rhiab qhov chaw tuaj yeem qhia kom ceev cov degradation tus nqi ntawm cov khoom hauv vivo. Nyob rau tib lub sijhawm, lub voj voog degradation tuaj yeem tswj tau los ntawm kev kho qhov ntev ntawm malonate ester saw segment, uas yog tsim rau cov ntaub ntawv kho mob xws li absorbable sutures thiab tshuaj txhawb nqa - tso tawm cov cab kuj.
3. Synthesis ntawm cov ntaub ntawv photosensitive
Nws pawg acyl chloride tuaj yeem hnov ​​​​mob nrog cov tshuaj photochromic (xws li spiropyran) los tsim cov ester derivatives nrog photoresponsiveness. Cov ntaub ntawv zoo li no muaj peev xwm siv tau rau hauv thaj chaw xws li lub qhov rais ntse thiab cov khoom siv kho qhov muag.

Txheej txheem:

Pib Khoom: Siv ethyl malonate (tseem hu ua monoethyl potassium malote) ua cov khoom pib.

Chlorination Agent: Xaiv cov tshuaj chlorinating xws li thionyl chloride (SOCl2) lossis oxalyl chloride (COCl2).

Cov xwm txheej tshwm sim:

Sov cov monoethyl potassium malote nyob rau hauv ib qho hnyav hnyav, xws li toluene lossis dichloromethane.

Ntxiv cov chlorinating tus neeg sawv cev dropwise rau cov tshuaj nyob rau hauv kev tswj xyuas.

Tshav kub cov tshuaj tiv thaiv sib tov rau qhov kub nruab nrab (piv txwv li, 110℃rau thionyl chloride) thiab do rau ob peb teev kom ua tiav cov tshuaj tiv thaiv.

Ua haujlwm- nce:

Tom qab cov tshuaj tiv thaiv tiav, tshem tawm cov kuab tshuaj los ntawm distillation nyob rau hauv lub siab txo.

Cov khoom uas tau txais los ua cov roj los yog cov khoom, nyob ntawm seb cov tshuaj tiv thaiv thiab cov kauj ruam ua kom huv.

Piv txwv txheej txheem:

Pib nrog 14.9 g (112.8 mmol) ntawm ethyl malonate hauv 226 mL ntawm toluene, ntxiv 26.6 g (225.6 mmol) ntawm thionyl chloride.

Tshav kub cov tshuaj tiv thaiv sib tov rau 110℃thiab do rau 4 teev.

Concentrate qhov sib tov nyob rau hauv lub siab txo kom tauethyl malonyl chlorideraws li cov roj xim av.

Alternative Approach:

Txoj kev no suav nrog kev hloov pauv monoethyl potassium malote rau nws cov tshuaj chloride derivative, txawm hais tias cov piv txwv ncaj qha ntawm txoj kev tshwj xeeb no yuav tsis yooj yim. Txawm li cas los xij, lub hauv paus ntsiab lus yuav koom nrog chlorination ntawm carboxylic acid ester functionality.

Cov kauj ruam dav dav:

Kev npaj ntawm Malonic Acid Monoethyl Ester: Yog tias tsis yooj yim, muab cov monoethyl potassium malote los ntawm malonic acid lossis nws cov ntsev.

Chlorination:

Dissolve lub monoethyl potassium malote nyob rau hauv ib qho inert hnyav.

Ntxiv cov tshuaj chlorinating uas tsim nyog, xws li oxalyl chloride lossis thionyl chloride, raws li kev tswj xyuas.

Tshav kub cov tshuaj tiv thaiv sib xyaw kom haum rau qhov kub thiab txias rau ob peb teev.

Ua haujlwm- nce thiab Purification:

Tshem tawm cov kuab tshuaj thiab cov tsis muaj tshuaj reagents los ntawm distillation.

Ntxiv purify cov khoom raws li xav tau.

Chloroformylacetate ethyl ester, chemically denoted li CH2 (COOC2H5) 2Cl, yog ib tug tshwj xeeb organic compound exhibiting tshwj xeeb bioactivity yam ntxwv. Nws cov qauv molecular integrates ib chloride hloov nrog ob pawg ethyl ester txuas mus rau lub hauv paus malonic acid derivative, imparting nws nrog cov khoom tshwj xeeb uas ua rau nws intriguing rau ntau yam kev siv biochemical.

Ib qho tseem ceeb bioactivity feature nyob rau hauv nws lub peev xwm ua ib tug precursor nyob rau hauv lub synthesis ntawm bioactive compounds. Vim nws cov malonyl moiety, nws muaj peev xwm tswj tau cov tshuaj tiv thaiv los tsim intermediates tseem ceeb heev rau kev npaj cov tshuaj, agrochemicals, thiab lwm yam biologically active tshuaj. Cov pab pawg chloride pab txhawb cov kev hloov pauv hluavtaws, feem ntau ua haujlwm los ntawm kev txuas lossis hloov kho.

Tsis tas li ntawd, qhov sib xyaw no tuaj yeem pom muaj qhov nruab nrab mus rau qis qis, txawm hais tias nws qhov tshwj xeeb toxicity theem nyob ntawm daim ntawv thov cov ntsiab lus thiab raug mob. Nws biocompatibility, thaum tsim nyog tuav thiab koom ua ke, tuaj yeem siv los tsim cov tswv yim kho tshiab lossis txhim kho cov uas twb muaj lawm.

Nyob rau hauv hluavtaws biology thiab biotechnology, nws pom kev siv hluav taws xob hauv engineering ntawm metabolic txoj hauv kev, ua rau cov kws tshawb fawb los qhia lossis ntxiv cov tshuaj biochemical tshwj xeeb uas tsim nyog rau kev tsim cov khoom muaj txiaj ntsig siab. Nws lub peev xwm los ua kom muaj ntau hom tshuaj lom neeg ua kom pom tseeb nws qhov kev ua tau zoo hauv kev txiav txim siab bioactivities kom tau raws li kev tshawb fawb tshwj xeeb lossis kev xav tau ntawm kev lag luam.

Hauv cov ntsiab lus,ethyl malonyl chloride, nrog nws cov qauv tshuaj sib txawv, muaj ntau yam platform rau kev txhim kho bioactive molecules, pab txhawb rau kev nce qib hauv tshuaj chemistry, kev ua liaj ua teb, thiab lwm yam. Txawm li cas los xij, kev ntsuam xyuas kev nyab xeeb thiab kev tswj xyuas yog qhov tseem ceeb rau kev siv nws lub peev xwm tag nrho thaum txo cov kev pheej hmoo.

Cim npe nrov: ethyl malonyl chloride cas 36239-09-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom