Imidazole hmoov cas 288-32-4

Imidazole hmoov, molecular cov mis c3h4n2, dawb rau daj crystalline hmoov. Nws yog cov organic sib xyaw, ib hom diazole, thiab tsib tus tswv cuab uas muaj ntxhiab tsw qab nrog ob Meta Nitrogen atoms hauv nws cov qauv molecular. Qhov tsis suav nrog txoj kev sib txuas ntawm 1- txoj hauj lwm nitrogen atmes ntawm nitrogen atom yooj yim tawm hauv daim ntawv ntawm hydrogen ions.

Imidazole yog acidic thiab alkaline, thiab tuaj yeem tsim cov ntsev nrog cov hauv paus muaj zog. Cov tshuaj lom neeg ntawm imidazole tuaj yeem ua kom tau li piav qhia raws li cov hluavtaws ntawm pyridine thiab pyrrrole. Ob chav nyob ob qho tib si tsuas yog ua lub luag haujlwm tseem ceeb hauv kev ua si ntawm cov duab ntxiab ntawm cov neeg uas muaj kev hloov pauv ntawm enzyme. Imidazole derivatives muaj nyob rau hauv kev muaj sia muaj sia nyob rau hauv paus tsiaj thiab tseem ceeb tshaj imidazole nws tus kheej hauv kev tshawb fawb thiab kev tsim khoom, xws li DNA, hemoglobin, thiab lwm yam.

Imidazole hmoov, tsib tus tswv cuab uas muaj ntxhiab tsw qabies

Antifungal Kev Kho Mob

 

Mechanism ntawm Kev Ua:
Kev txwv ntawm Egrasterol Synthesis: Imidazole tshuaj (xws li Clorimazole thiab Ketoconazole) thaiv kev ua haujlwm ntawm fungal ntawm fungalol {}} dethylees.
Cov ntaub ntawv thov tau:
Daim tawv nqaij Randworm tus kab mob: Daim ntawv thov sab nraud ntawm Miconazole tshuaj pleev rau kev kho mob ntawm TAMEA Pedis, nrog kho tus nqi ntawm 85% ({}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} chav kawm).
Deep fungal infection: Fluconazole is used for candidemia, with oral bioavailability>90%.

Kev Kho Mob Thyroid Kev Kho Mob

 

Cov tshuaj tiv thaiv kab mob hauv cov tshuaj:
Mthimazole (MMI): Inhibits cov thyroid peroxidase, txo cov thyroid hormones synthesis, thiab siv {{} lub lis piam los ua kom muaj txiaj ntsig.
Qhov zoo ntawm cov muaj nuj nqi:
Kev Nyab Xeeb Kev Nyab Xeeb: MMI pom zoo ua qhov tseem ceeb thaum ntxov cev xeeb tub, nrog kev pheej hmoo ntawm Teratogenicity ntau dua li propylthiouracil.

Kev loj hlob ntawm cov tshuaj tiv thaiv qog

 

Imidazole derivatives:
Gambogic acid: ib qho hom phiaj ntau inhibitor, ic5 {1}} yog 0.8 μ m rau kev mob cancer mis thiab {3}} cells.
Kev Kho Mob:
Imidazole Platinum txoj kev sib txuas lus: tom qab kev sib koom tes nrog imidazole, cisplatin txo cov nankrotoxicity los ntawm 40% thiab nce cov tub yees kev tawm tsam los ntawm 2 zaug.

Central Ntshav Qab Zib Tshuaj

 

Sedative Hypnotic Fypnotic:
Piv txwv li etomidate: lub nplhaib immes li nws lipophilicity, sai crosses cov ntshav-lub hlwb lub hlwb, thiab muaj lub sijhawm tshuaj loog ntau dua 30 vib nas this.
antiepileptic:
Zonismide: Ib qho imidazole tetrahydrofuran qauv uas inhibits voltage-gated sodium raws cov nqi, kev tswj hwm hauv cov xwm txheej epilepticus.

Nceb

 

BenzimidAzole chav kawm:
Duojunling: Tiv thaiv thiab kho cov nplej fusarium taub hau blight, nrog ib daim teb ua tau zoo ntawm 82%. Nws cov tshuab kev ua yog los cuam tshuam nrog microlotubule protein polymerization.
Qhov zoo thiab cov yam ntxwv:
Intrinsic kev ua si: ua upwards los ntawm kev nqus hauv paus nqus, tiv thaiv cov ntaub so ntswg tshiab.
Kev tswj hwm kev tiv thaiv: lwm txoj kev siv nrog cov fiazole fungicides kom ncua kev txhim kho ntawm kev tiv taus.

Cov tshuaj tua kab

 

Neideotinoids:
Imidacloprid: acts on insect nicotinic acetylcholine receptors and has a 48 hour mortality rate of>95% tawm tsam aphids.
Hom ntawm kev nqis tes ua:
Kev haum sab hauv: Muab faib rau ntau qhov chaw ntawm cov nroj tsuag 24 teev tom qab thov, nrog lub neej txee ntawm 30 hnub.

Kev Cog Lus Cog Kev Cog Lus

 

Hauv paus kev loj hlob:
Imidazoacetic acid (ia): ib qho siab ntawm 0. 1 ppongation ntawm arabidopsis cov keeb kwm tseem ceeb hauv cov hauv paus hniav tom qab.
Kev txhim kho ntawm Rhuav:
Imidazole hmoovglycerophosphate (IGP): txhim kho nplej woob dreath kuj thiab nce cov kab ntsig ntawm cov ntsiab lus los ntawm 18%.

POST Sau qoob loo

 

Prochaloraz:
Kev tiv thaiv thiab tswj cov citrus penicillium tus kab mob: soaking kev kho mob tuaj yeem inhibit nthuav tawm ntawm cov kab mob me los ntawm 4 lub lis piam.
Mechanism ntawm Kev Ua:
Kev tiv thaiv pa tiv thaiv: txo qhov kev tso tawm ntawm ethylene los ntawm cov txiv hmab txiv ntoo thiab qeeb cov txheej txheem ripening.

 

(1) Epoxy Resin Chais Tus Neeg Sawv Cev
Kev Txhim Kho:
Cov Cuab Yeej Siv Cov Neeg Kho Tshuab: Ntxiv 2% Imidazole nce tus khoov lub zog ntawm Epoxy Resin los ntawm 35% thiab lub khob hloov ntsuas kub (TG) los ntawm 15 degree.
Cov txiaj ntsig thev naus laus zis:
Tsawg dua kev kho kub: Nws tuaj yeem kho tiav thaum 80 degree / 2 teev thiab tsim nyog rau cov ntim thermal rhiab lub Cheebtsam.
(2) Kev Kho Hlau Hlau Hlau
Tooj liab rust inibitor:
Benzotriazole (BTA) Hloov chaw: Imidazole derivatives muaj kev ua kom haum ntawm 92% thiab tus nqi txo ntawm 40%.
Txhuas anodizing:
Kev sib xyaw ntawm zaj duab xis txheej: Ntxiv 0}. 5%} imidazole zaj duab xis los ntawm oxide zaj duab xis los ntawm peb zaug.

 

(3) Tshuaj Synthes Keebkaum
Khoom siv hluav taws xob:
Carbonyl diimidazole (CDI): a peptide coupling reagent that promotes amino acid condensation with a yield of>95%.
Da Xim Kev Lag Luam:
Disperse Dyes: Imidazole Tus qauv ua kom muaj kev sib txuam ntawm cov neeg tuag rau polyester fibers, nrog ib tus xim ceev ntawm {{}} qib.
(4) Lwm Cov Kev Siv Muaj
Iav Kev Lag Luam:
Piav kom meej: Tshem tawm npuas hauv lub iav, txhim kho pob tshab, thiab haus 0. 2 kg ntawm imidazole ib tuj ntawm iav.
Roj hmab vulcanization:
Accelerator: iMidazole derivatives luv luv lub sij hawm ua ntej lub sij hawm los ntawm 30% thiab nce bosslinking ntom ntom.

 

(1) Khoom Siv Kev Tshawb Fawb
Ionic kua:
1-Ethyl-3-methylimidazolium tetrafluoroborate: melting point 12 ℃, electrochemical window>4V, haum rau cov roj teeb lithium-ion roj teeb electrolyte.
Hlau Organic Ua Haujlwm (MOFS):
ZiF -8} Imidazole Nigand tau siv los tsim cov qauv zawvolite nrog lub peev xwm hydrogen kev muaj peev xwm ntawm 2.6 wt% (77 k / 1 atm).
(2) catalytic teb
Asymmetric catalysis:
Chiral imidazoline ligand: In iridium catalyzed asymmetric hydrogenation, ee value>99%.
Photocatalysis:
Imidazole hloov kho TIO ₂: Pom pom lub teeb teb, methyl txiv kab ntxwv defadation tus nqi ntawm 85% (2 teev).

1. Nws tau txais los ntawm kev cycloterization thiab nruab nrab ntawm glyoxal. Tso glyoxal, formaldehyde thiab ammonium sulfate rau hauv cov lauj kaub cov tshuaj tiv thaiv lauj kaub, do thiab ua kom sov, thiab ua kom lawv sov rau 4H. Txias rau 50-60 degree, thiab siv cov kua txiv qaub, thiab siv cov kua txiv qaub kom txog thaum lub p yog siab dua 1 {8}}. Cua sov rau 85-90 degree, tso tawm cov lim dej kom ntau dua 1th, ua kom muaj cov dej ntws tsawg dua kom txog thaum txhua tus degree}. 267kpa) Distillate kom tau txais imidazole. Cov tau tawm los yog li 45%.

2. Lwm txoj kev npaj yog los cyclize o-phenylenediamine thiab formic acid los tsim cov nplhaib hydrogesAzyimidazole, thiab thaum kawg Decarboxylate kom tau txais imidazole. 4, {5-} Dihydroxyimidazole tseem tuaj yeem tau txais los ntawm nitration thiab cyclization ntawm d-tartaric acid. Cov txheej txheem ntawm kev txiav txim siab ntawm 4, {8}} {} {, {, {, {, {, {, {, {, {, {, { Cov khoom tiav nrog cov txiaj ntsig ntawm 76%.

3. Kev lag luam glyoxal synthesis synthes, formaldehyde thiab ammonium sulfate rau hauv reactor, do thiab ua kom sov rau nws sov rau 4H. Tom qab ntawd txias nws mus rau 50 ~ 60 degree, siv kua txiv qaub kom ncav cuag pH saum toj no 10, tom qab ntawd ua kom sov nws mus rau 85 ~) ammonia rau ntau dua 1h. Tom qab txias me ntsis, lim, ntxuav cov lim ncuav mog qab zib nrog cov dej kub, ua ntxiv kom txog thaum tsis muaj dej ntws ntxiv, thiab tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ tom qab ntawd sau 105 ~ Tom qab ntawd Cov tau tawm los yog li 45%. Txhua txhua lub khw muag khoom noj 4172kg glyoxal, 2344kg formaldehyde (37%), 3826kg ammonium sulfate (99%) thiab 2571kg txiv qaub. Cov tshuaj tiv thaiv cov tshuaj muaj raws li hauv qab no:

Vim yog qhov tsis txaus siab tawm los thiab cov khoom lag luam zoo, cov qauv zoo li siv errocium cov qauv ntawm kev siv ammonium oxalate es tsis yog ammonium sulfate. Yog tias ammonium oxalate yog siv hloov chaw ntawm ammonium sulfate, cov txiaj ntsig tuaj yeem nce rau 65%.

4. Cyclization ntawm O-Phenyylenediamine thiab formic acid: o-phenylenediams thiab cov kua ntses los ntawm hydrogrized peroxide, thiab thaum kawg decarboxylated los npaj imidazole.

5. BromoacetalHyde Txujci: Ntxiv yas acetate thiab bromine, tom qab ntawd kho nrog ethanol los tsim nrog hydrogen bromide thiab ethanol los tsim acetal. Acetal nthuav dav lub suab paj nruag cyclic nyob rau hauv kev ua ntawm ethylene glycoloric acid, thiab reacts nrog kev tshaj tawm ntawm ammonia los tsim kho imidazole nrog ib tug tawm los ntawm 50%.

Imidazole hmoovyog ntau dua mus rau electrictic hloov pauv dua li lwm 1, {} divlives, thiab cov tshuaj tiv thaiv feem ntau yuav siv rau ntawm c {2}}}}}. Qhov no yog vim tias muaj kev txwv tsis txaus ntseeg thaum hluav taws xob reagents thaum electrophilic reagents nres c {4}}}}}} Piv txwv li, cov tshuaj tiv thaiv ntawm imidazole nrog fuming nitric acid / concentrated sulfuric acid tuaj yeem tsim sai heev 4 (5) - Nitroimidazole nrog cov txiaj ntsig siab; Txawm li cas los xij, nitration ntawm 4, 5- dimethylimidazole tseem tsis tuaj yeem tshwm sim nyob rau hauv cov xwm txheej hnyav.

Lub tshuab hluav taws xob ntom ntom ntawm imidazole n -3 yog loj, yog li lub alkylation tshuaj feem ntau yuav siv rau ntawm no nitrogen atom xub thawj. Los ntawm KevTomerism, Monoalkylated khoom tuaj yeem tsim cov nitrogen atom zoo ib yam li cov khoom siv dialkylation imidazolium ntsev.

Lub acylation cov tshuaj tiv thaiv ntawm imidazole feem ntau tshwm sim ntawm n -3}

Cov nquag hydrogen ntawm imidazole tuaj yeem decompose grignard reagent los tsim n-magidaium ntsev ntawm imidazole, thiab tom qab ntawd muab hloov imidazole tom qab omerization. Cov tom kawg tuaj yeem kho nrog iodomethane los tsim 1, 2- dimethylimidagodimidazole.

Imidazole tuaj yeem ntxiv rau Dientophile, thawj zaug tsim ib {0}} nucleophilic ntxiv nrog lwm tus dii {1} {cyclized khoom. For example, 1-methyl-2-ethylimidazole reacts with two molecules of dimethyl succinate to obtain 8 - Ethyl-1-methyl-1,8 - Tetramethyl dihydroimidazolo [1,2-a] pyridine -5, 6,7, {13 8- tetracarboxylate.

Cim npe nrov: Imidazole hmoov cas {{288-32-4, cov chaw muag khoom, chaw tsim khoom, Hoobkas, yuav, nqe, loj, loj, rau muag