Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam zoo tshaj plaws thiab cov chaw muag khoom ntawm sodium triacetoxyborohydrige CAS 56553-60-7 hauv Suav teb. Txais tos rau kev lag luam wholesale tawm cov sodium zoo siab dua sodium triacetoxyborohydraulic Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Sodium triacetoxyborohydride(STB) yog cov hmoov dawb nrog tshuaj lom neeg Nabh (OAC) ₃, thiab nws txoj haujlwm molecular yog li 252.06 g / mol. Nws yog cov khoom ntawm chav sov. Nws yog feem ntau nyob rau hauv daim ntawv ntawm koob tau {{3} Zoo li muaju lossis cleative thiab kuj yog kov. Nws yog me ntsis soluble hauv dej, thiab muaj solubility zoo nyob rau hauv polar solvents xws li awreethyl sulfoxide thiab chloroform, thiab yog ib tug me me thiab xaiv borohydride reagent. Qhov no tso cai rau cov compound ua soluble nyob rau hauv feem ntau siv cov kuab tshuaj thiab ua haujlwm nyob rau hauv ntau yam tshuaj lom neeg. Ruaj khov rau qee yam, nws tuaj yeem khaws cia rau ob peb lub hlis mus rau ntau xyoo ntawm chav tsev kub, thiab yuav tsis yooj yim decomposed. Txawm li cas los xij, qhov sib txuas yog nquag ua rau kev txiav txim siab nyob rau hauv huab xws li kub siab lossis siab av noo, yog li nws yuav tsum tau tshwj tseg kom ntseeg tau tias nws zoo. Qhov sib txuas yog ruaj khov thiab khaws cia yooj yim. Cov khoom siv lub cev no ua rau nws yog tus neeg sawv cev tseem ceeb thiab ua lub luag haujlwm tseem ceeb hauv cov synthic synthesis. Txog kev kho kom tau txais kev noj haus ntawm Ketones thiab Aldehydes, lactoamylation ntawm carbonylation thiab amines, thiab kev sib cais ntawm kev noj qab zib ntawm aryl aldehydes. Cov tshiab reductive amination muaj cov kev xaiv ua zoo tshaj plaws thiab kev sib cais, cov tshuaj tiv thaiv zoo, cov tshuaj tiv thaiv zoo, thiab tsis muaj kuab paug rau ib puag ncig. Tau dhau los ua catalyst ntawm kev xaiv rau kev siv tshuaj tiv thaiv kev noj qab haus huv.
|
Tshuaj Cov Qauv |
C6h10BNAO6 |
|
Muaj pes tsawg leej |
212 |
|
Molecular hnyav |
212 |
|
m/z |
212 (100.0%), 211 (24.8%), 213 (6.5%), 212 (1.6%), 214 (1.2%) |
|
Kev Ntsuam Xyuas |
C, 34.00; H, 4.76; B, 5.10; Thiab, 10.85; O, 45.29 |
|
|
|
Sodium triacetoxyborohydride(CAS naj npawb 56553-60-7) yog qhov tseem ceeb organic boron compound. Raws li kev ua yeeb yam ntawm Sodium Borohydride, nws cov tshuaj tshwj xeeb ua rau nws nyob hauv txoj haujlwm tseem ceeb hauv thaj chaw muaj synthesis. Nws cov mis molecular yog c ₆ h ₁₀ bnao ₆, nrog molecular hnyav ntawm 211.94 g / mol. Nws zoo li hmoov dawb crystalline thiab yog yooj yim soluble hauv cov kuab tshuaj yeeb yaj kiab xws li Benzene, TetrahyDrile (MECN), thiab 1,2-dichloroethane (clch ₂ CH ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL ₂ CL. Txawm li cas los xij, nws cuam tshuam nrog dej los tsim cov ntsev hydrogen thiab acetate ntsev, thiab xav tau siv nyob rau hauv qhov tsis muaj dej.
1. Txo cov tshuaj tiv thaiv amination
Txo kev ua kom haum yog qhov cuam tshuam yuam kev uas hloov pauv carboryl compounds (aldehydes, ketones) rau hauv Amine compounds, thiab nws cov txheej txheem faib ua ob kauj ruam:
Imine Tsim: carbonyl cov lus teb tshwm sim nrog amines (thawj lossis theem nrab) hauv cov accetly acidy acidyyn) los tsim kho cov tawv nqaij me me (Schiff Basees).
Imine txo: Raws li tus neeg sawv cev txo, xaiv txo imine rau amine thaum zam carbonyl txo.
Cov tshuaj tiv thaiv zoo dua:
Yuav tsum muaj cov mob me: Tsis tas yuav muaj kev kub siab lossis qhov kub thiab txias, nws tuaj yeem ua tiav tau los ntawm kev ua kom tiav ntawm cov amines ua kom tsawg nucleophilicity.
Cov pab pawg ua haujlwm tau zoo: nws tsis muaj kev cuam tshuam rau cov pab pawg rhiab xws li pab pawg carbon monan, thiab cov pawg Cyrocum, thiab cov pawg Cyrochatic, thiab pawg Cyrochatic Hydrogenation (thiab cov pawg Cyro.
Kev xyaum ua kom zoo: Thaum siv 1,2-dichloroethane thaum siv cov kuab tshuaj, tus nqi tshuaj tiv thaiv yog qhov nrawm tshaj plaws thiab cov txiaj ntsig tau txhim kho; Thf thiab mekn kuj tseem siv tau, tab sis nrog qis me ntsis qis nyiaj.
Rooj plaub:
Cov tshuaj tsw qab aldomatic txo: Benzaldehyde thiab Aniline Acid los ua IMINE AB
Cov tshuaj molecle ua tau zoo li qub: Hauv cov xwm txheej ntawm cov aminino pab pawg los ntawm kev ua kom zoo nkauj ua kom muaj kev ua haujlwm thiab cov qauv txheej txheem kev ntseeg.
2. Txo ntawm carbonyl complexes
Xaiv txo ntawm CarbonyL pab pawg nyob rau hauv Carbonicl complexes (xws li ketones (xws li ketones thiab aldehydes) los tsim muaj cov cawv sib txuas thaum khaws lwm pab pawg.
Cov yam ntxwv tiv thaiv:
Xaiv tswj: Los kho cov tshuaj tiv thaiv xws li cov kuab tshuaj thiab kub, kev xaiv txo ntawm carbonyl thiab cov pa roj carbon pab tau. Piv txwv li, nyob rau hauv cov lus teb muaj alpha, beta unsaturated ketones, CarbonyL pab pawg yog qhov uas nyiam txo yam tsis muaj kev cuam tshuam ob daim ntawv cog lus ob.
Catalytic tus nqi ntawm acetic acid kev pab: rau Ketone subtrates, ntxiv cov lus qhia acetictic, ntxiv cov tshuaj acatalytic, los yog nws tuaj yeem nqa tawm ncaj qha hauv cov acetic acid.
Daim Ntawv Thov Piv Txwv:
Endoamidation kev tawm tsam: Cov khoom siv rov qab nrog cov amines los tsim cov lactams (cyclic amides), uas yog siv nyob rau hauv cov tshuaj tua kab mob xws li penicillins.
Kev npaj ntawm chiral Catalysts, sodium triacetoxyborcohybrid tuaj yeem tsim cov tshuaj tua kab (xws li antiviral tshuaj oseltamivir).
Tshwj xeeb Thov Txog Cov Xwm Txheej: Green Chemistry thiab Asymmetric synthesis
1. Green Chem Minemistry
Raws li hloov chaw rau sodium cyanoborohydride (Nabh α cn), nws muaj qhov tseem ceeb:
Txhim kho kev nyab xeeb: Tsis muaj centanide ions tam sim no, zam kev pheej hmoo ntawm Cyanide Toxicity thiab ua raws nrog cov ntsiab cai me me chemical.
Tsis tas yuav muaj cov kua qaub - Base Haum: NABTH α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α α
Cov Ntaub Ntawv Sib Piv:
Txwv ntawm Nabh α cn: thaum txo cov duab aldomatic aldomic, nws yog qhov tsim nyog kom tswj hwm tus nqi PH, txwv tsis pub nws yuav ua rau sab nraud; Nyob rau hauv ph 4-6 yam mob, cov tshuaj tiv thaiv tuaj yeem ruaj khov thiab cov txiaj ntsig tuaj yeem nce ntxiv los ntawm 20% -30%.
Daim Ntawv Thov: Lub Tuam Txhab Lag Luam Sivsodium triacetoxyborohydrideTxhawm rau siv hluav taws xob tiv thaiv kev ua xua, hloov NABH α cn, ua rau 30% txo hauv kev sib tw ntau thiab 50% txo qis hauv cov khib nyiab.
2. Asymmetric synthesis
Nyob rau hauv muaj chairal catalyststs xws li tsho tshaj hauv phosphates, aldehydes thiab ketones raug txo kom tsim cov tshuaj tua kab lossis tshuaj tua kab.
Cov tshuaj tiv thaiv kev cai:
Kev Induction Kev Qhia Hydrogalysts Hydrogen Qhia Hydrogen Anions Los xaiv cov pab pawg ntawm hydrogen kev cuam tshuam, ua tiav kev ua tiav kev ua tiav.
High enantioselectivity: nyob rau hauv cov kev kho kom zoo, tus enantiomer ntau dhau (EE) tuaj yeem ncav cuag tau tshaj 95%, ntsib lub siab yuav tsum muaj cov tshuaj tshuaj zoo.
Daim Ntawv Thov Piv Txwv:
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv hluavtaws: (s) {{0} fluoxetine txo, nrog tus nqi asymmetric, nrog tus nqi asymmetric, nrog tus nqi ntawm kev sib cais ntawm kev sib cais thiab cov nqi txo qis.
Tshuaj tua kab tsis muaj kev npaj (hluavtaws chiral tshuaj ntsuab hauv kev ua ub no kom paub cov kev ua tshuaj tua kab mob ntau.
Muaj cov ntawv thov piv txwv: Kws Tshuaj thiab tau zoo tshuaj
1. Kws ua teb
Synthesis ntawm anticancer tshuaj: nyob rau hauv synthesis ntawm imatinib, Amine pawg raug qhia los ntawm kev siv cov khoom seem, txhim kho cov khoom ua suab paj nruag kom dhau 99.5%.
Kev npaj ntawm cov tshuaj tiv thaiv kab mob: thaum synthesizing intermediat yog siv los tsim cov roj hmab cuaj caum ntawm 98%, uas ua tau raws li cov kws kho tshuaj hauv ntiaj teb.
2. Zoo tshuaj lom neeg lag luam teb
Synthesis: Txo cov khoom siv rawehyde rau dej cawv kom txhim kho aroma mob siab. Piv txwv li, Vanillin yog txo rau vanillin rau cov synthesis ntawm siab- cov naj hoom.
Kev npaj ntawm cov ntaub ntawv nruab nrab: thaum synthesizes polyimide monomers monomers, Amine pawg raug qhia los ntawm kev siv cov tshuaj tiv thaiv kev ua kom zoo dua los txhim kho cov cua sov ua kom zoo ntawm cov khoom siv.
Sodium triacetoxyborohydrideyog ib qho tshiab catalalyst tshwj xeeb tau tsim rau kev ua kom tau txais kev noj tshuaj tiv thaiv kev noj tshuaj tau zoo thiab yog qhov zoo siab vim nws cov txiaj ntsig tshwj xeeb. Nws muaj cov siab heev universality thiab xaiv lub siab, tuaj yeem hnoos xyuas cov kev hloov pauv maj mam muab, thiab ua rau pom kev txo qis kev txo qis. Tsis tas li ntawd, nws kev sib cais thiab cov txheej txheem lim dej yog yooj yim, thiab cov khoom siv tsis zoo rau kev ua kom tau txais kev noj haus zoo tshaj plaws thiab ib puag ncig phooj ywg.
Txawm hais tias hlau catalyzed hydrogenation hydrogenation xws li platinum, palladium, lossis Nickel yog kev lag luam loj, lawv cov khoom feem ntau tov nrog cov qoob loo qis. Cov qauv no tseem muaj kev txwv vim tias nws tsis tuaj yeem ua kom muaj cov pa roj carbon carbon monano thiab cov pab pawg cyro thiab cananotic los ntawm cov sullides.
Cov tub ntxhais ntawm cov tshuaj tiv thaiv zoo heev yog hloov carbonyl sib txuas rau hauv Amines los ntawm thawj zaug tsim kho kom haum rau lawv thiab tom qab ntawd txo cov sodium borohydride (suav nrog STB). Ntau hom sodium borohydride muaj cov kauj ruam txo cov kev txo qis tom qab tsim imines, feem ntau txo imines rau amines. Tus txheej txheem no yog nqa tawm nyob rau hauv cov khoom siv acidic tsis muaj zog los txhim kho cov pab pawg carborentall thaum tsis txhob txo nyob rau hauv nucleophilicity tshwm sim los ntawm kev sib tawm tsam ntawm amines.
Kev siv ntawm sodium cyanoborohydride rau kev txo qis dua li Selohydes kev ua haujlwm ntawm Aldehydes tau txo cov tshwm sim ntawm cov kev sib raug zoo. Los ntawm kev siv Nabh (OAC) 3 raws li tus neeg sawv cev txo qis thiab clch2ch2cl ua rau cov tshuaj tiv thaiv luv thiab cov txiaj ntsig ntawm cov khoom tuaj yeem hloov kho.
Sodium triacetoxyborohydrid yog hom organic synthesis reagent, uas tau siv dav hauv kev tawm tsam xws li txo qis, hws ntawm Heterocyclic teb. Nws yog feem ntau synthesized los ntawm ntau txoj kev, txhua yam uas yuav qhia tau hauv kev nthuav dav.
1. Canclic Tetraphenyphine ntsev Txoj Kev:
Lub voj Cyclic Tetraphenyphone ntsev txujctric yog ib txoj hauv kev tseem ceeb rau kev npaj khoom. Hauv txoj kev, Tripleenyfphine thiab triacetoxyborontriethboryl ester yog siv nyob rau hauv muaj ntawm tributylalinal thiab hydroxyethyltriphenylphosphs los tsim nws.
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:
B (OC)3+ 3 pH3P + 3 etoh → Nabh (OC)3+ 3 pH3PO + 3 Etroac
Cov qauv synthesis muaj qhov zoo ntawm cov txiaj ntsig siab, cov tshuaj tiv thaiv me me thiab kev ua haujlwm yooj yim. Txawm li cas los xij, vim tus nqi siab ntawm cov khoom nyoos, tus nqi ntau lawm yog qhov siab.
2. Boric acid thiab ethyl iodide txoj kev:
Cov txheej txheem boric acid thiab ethyl iodide yog cov qauv yooj yim synthesis, thiab nws tseem yog ib qho ntawm cov txheej txheem ntau ntawm kev npaj cov sodium triacetylbohydride. Cov txheej txheem yog ua raws cov alkyllophilicity ntawm Ethyl iodide boric acid thiab tom qab ntawd tau sodium triacetylbohydride los ntawm kev tawm tsam kev txo qis ntawm sodium.
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:
H3Lawm3 + 3I(C2H5) → B(I(C2H5))3 + 3H2O
B(I(C2H5))3+ 3 nah → Nabh (OC)3 + 3C2H5I
Cov qauv synthesis muaj qhov zoo ntawm kev ua haujlwm yooj yim thiab tsis tas yuav muaj kev coj dawb huv, tab sis cov khoom muaj qhov tsis tshua muaj tshuaj tiv thaiv los ntawm cov kauj ruam xws li recrystallization lossis kem chromatography.
Hauv kev xaus, nws yog ib qho tseem ceeb organic synthesis reagent nrog kev siv cov kev thov kev cia siab. Nws tuaj yeem suav los ntawm ntau txoj kev. Txhua txoj kev muaj nws cov txiaj ntsig tshwj xeeb thiab qhov tsis zoo, yog li ntawd nyob rau hauv cov txheej txheem tsim nyog tiag tiag, nws yog ib qho tsim nyog los xaiv cov qauv tsim nyog raws li qhov xwm txheej.
Sodium triacetoxyborohydrideYog tus tsis muaj kob, crystalline khoom nrog tshuaj lom neeg Nabh (OAC) 3, qhov twg BH (OAC) 3 sawv rau TriacetoxyDride. Nws cov molecular hnyav yog kwv yees li 252.4 G / Mol. Nyob rau hauv chav tsev kub, nws muaj siab thermal thiab tshuaj ruaj khov, thiab tuaj yeem khaws cia thiab siv nyob rau hauv cov xwm txheej sim ib txwm.
1. Molecular qauv:
Cov qauv molecular ntawm nws yog muaj los ntawm peb tus acetoxy pawg thiab ib pawg borohydride ion. Tus qauv ntawm borohydride ion yog zoo li tetrahedron, nyob rau hauv uas bom yog muab faib rau ib pawg OAC los ua daim ntawv cog lus nrog B Atom. Ntxiv rau borohydridide ions, sodium ions tseem ua lub luag haujlwm tseem ceeb hauv cov qauv kev ruaj khov hauv kev sib cav.
2. Crystal qauv:
Cov qauv siv lead ua ntawm cov ntsev triacetylorohydride tau txais xyoo 1973 los ntawm GW Parshall li al. Nws yog monoclinic nrog chaw pab pawg P21 / c. Chav tsev ntsuas yog=13.236 Å, b {}} Å, thiab {{9} degree. Chav tsev ntawm tes muaj plaub molecules, txhua qhov kev cuam tshuam nrog lwm cov molecules los ntawm hydrogen bonds, sau ib tug peb {{} didension network qauv. Nyob rau hauv lub lattice, borohydrube ion cov ntaub ntawv hydrogen bonds nrog peb pawg sib txawv ntawm h atcts, ua qhov kev ncua deb ntawm lawv txog 1.2 Å. Sodium ion ua ib daim ntawv cog lus ionic nrog ib ntawm peb pawg OAC.
Cov hauv qab no yog qhia luv luv txog cov tshuaj muaj zog tseem ceeb ntawm cov compound:
1. Cov nyiaj tau:
Sodium Triacetylbohydride yog tus neeg sawv cev muaj zog uas tuaj yeem txo ntau cov organic sib txuas rau cov oliidation qis olonidation xeev. Rau cov tebchaw muaj cov oxygen cov pab pawg, xws li aldehydes, cov roj ntsha, cov kua qaub, nws feem ntau nws yuav xaiv tau txo rau cov neeg haus dej lossis hydroxyl sib txuas. Rau cov tebchaw muaj cov pab pawg ua haujlwm sulfur
3. Stability:
Txawm hais tias STB yog tus neeg sawv cev muaj zog, nws yog qhov ruaj khov dua li lwm tus neeg txo qis xws li sodium borohydride. Thaum lub sij hawm cia thiab siv, qhov sib xyaw tsis yooj yim cuam tshuam los ntawm cov mob xws li huab cua, noo thiab kub. Nyob rau tib lub sijhawm, nws yuav tsum tau sau tseg tias nws yuav tsum zam kev sib cuag nrog oxidizing peroxide lossis poov tshuaj permanganate, lwm yam kev phom sij yuav tshwm sim.
Cim npe nrov: Sodium Triacetoxyborohydrid Cas 56553-60-7, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Kev Lag Luam, Yuav Khoom, Rau Cov Muag Khoom