N {- boc - piperidine-3-Methanol CAS 116574-1

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm n}} petchol cas}} Methanol CAS 116574-71-1 hauv Suav teb. Txais tos rau kev lag luam wholesale mis siab zoo n-boc-piperidine-3-Methanol CAS 116574-1 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

N - boc -} Piperidine-3-METANOL, tseem hu ua n - boc {}}}} piperidin-3-Methanol, yog ib hom orgeridin-3-methanol, yog ib hom orgeridin-3-organic, yog ib hom organic, yog cov organic sib sau ua ke hauv cov khoom nruab nrab hauv cov organic synthesis. Molecular Cov Qauv M1H21No3, CAS 116574-1, tshwm sim ua cov hmoov dawb lossis xim tawv dawb. Siv nyob rau hauv kev hloov kho thiab derivatinization kev tawm tsam ntawm cov tshuaj molecules thiab bioactive molecules. Cov pab pawg ester hauv nws cov qauv tuaj yeem txuas ntxiv rau cov pab pawg aldehyde, pawg hauv cov vaj tse hydroxyl, lossis npaj cov khoom sib txuas los ntawm kev hloov pauv amine ester hloov. Tsis tas li ntawd, BOC pawg ntawm cov nitrogen atom tuaj yeem raug tshem tau yooj yim los tau cov lus sib txuas lus theem qub. Nws muaj cov qauv tshuaj thiab cov khoom tshwj xeeb, thiab tseem siv tau ua cov khoom siv hluavtaws lossis hloov kho rau qee yam khoom siv polymer. Los ntawm kev qhia cov ntsiab lus no, qee yam tshuaj xyuas lub cev lossis tshuaj lom neeg ntawm cov khoom tuaj yeem txhim kho, tshuaj lom neeg tiv taus, lossis txhim kho cov tshuab zog.

1-Boc-3-hydroxymethylpiperidine (N - boc -} Piperidine-3-METANOL) Ua si lub luag haujlwm tseem ceeb hauv cov synthesis thiab kev hloov kho ntawm cov molecules bioactive vim nws cov qauv tshuaj lom thiab cov khoom siv tshuaj lom neeg. Qhov kev sib xyaw no tsis yog ua haujlwm nruab nrab tseem ceeb hauv cov khoom siv hauv nruab nrog cev, tab sis kuj tseem muaj cov ntaub ntawv thov kev pabcuam hauv khw thiab cov ntaub ntawv hydroxyl thiab BOC tiv thaiv pab pawg.

Cov mis nyuj molecular ntawm 1-boc-3-hydroxymethylpermeridididididididididididididididididididididididididididididididididididididididididididididididididididegine yog c11h2no3, nrog molecular hnyav ntawm 215.29. Lub hydroxyl thiab boc (tert butoxycarbonyl) tiv thaiv pawg nyob rau hauv nws cov qauv endow lub compound nrog cov tshuaj lom neeg tshwj xeeb. Hydroxyl pawg tuaj yeem koom nrog ntau yam tshuaj lom neeg cov tshuaj, xws li Etrerification, etherification, thiab lwm yam, los tsim cov tebchaw nrog cov kev sib txawv. BOC tiv thaiv pab pawg tuaj yeem tiv thaiv cov nitrogen atom thaum cov txheej txheem tshwm sim yooj yim, thiab tseem tuaj yeem tshem tawm cov kev tshwm sim sab nraud los rov ua cov kev siv ntawm cov nitrogen atom.

 

Kev hloov kho thiab derivatization ntawm cov tshuaj molecules:
1-boc-3-hydroxymethylpermerididine tuaj yeem siv los ua cov khoom pib rau cov tshuaj molecule hloov kho. Los ntawm kev qhia cov pab pawg ua haujlwm sib txawv, cov yeeb tshuaj derivatives nrog cov kev ua haujlwm ntsig txog kev ua haujlwm tau tuaj yeem ua ke. Piv txwv li, los ntawm Esterification Resistions, carboxylic acid tebchaw tuaj yeem ua ke thiab muaj cov khoom sib txuas zoo dua thiab cov chaw muag khoom zoo dua. Tsis tas li ntawd, Amino cov tebchaw tuaj yeem ua ke nrog cov nitrogen atom ntawm 1-hydroxymethylpiper los ua kom muaj cov ntawv thov tseem ceeb hauv kev tsim tshuaj.

 

Kev tsim kho ntawm cov xyoob molecules:
1 {- boc-} 3-hydroxymethylpiperidine kuj tseem tuaj yeem ua qhov tseem ceeb rau kev tsim cov molecules. Los ntawm coupling kev tawm tsam nrog lwm cov tebchaw, biologically nquag molecules nrog cov txheej txheem nyuaj tuaj yeem yog synthesized. Piv txwv li, thaum synthesizing tebchaw nrog kev tawm tsam qog, 1-boc-3-herocyclicth rings los tsim cov tshuab raj nrog cov kws muag tshuaj tshwj xeeb. Cov tebchaw no tau pom cov tub sab tseem ceeb hauv ob leeg hauv ob qho hauv Vitro thiab hauv Vivo kev sim.

 

Synthesis ntawm chairal tebchaw:
1-boc-3-hydroxymethylpermeridine kuj tseem siv tau ua khoom siv hluavtaws rau chiral tebchaw. Chiral cov tebchaw nrog cov stereoconfigents tshwj xeeb tuaj yeem ua tau los ntawm cov hau kev xws li kev txo cov khoom siv asymmetemes. Cov chairal no muaj cov ntawv thov tseem ceeb rau kev tsim tshuaj yeeb tshuaj, raws li kev ua tau zoo thiab lom neeg muaj ntau yam muaj feem xyuam nrog lawv cov chaw ua si.

Cov piv txwv tshwj xeeb

Synthesis ntawm cov lus teb nrog anti - qog nqaij

Researchers have synthesized a series of compounds with anti-tumor activity using 1-Boc-3-hydroxymethylpiperidine as a key intermediate. Cov tebchaw ua ke nrog 1-boc-3-hydroxymethylpiperidididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididididegidation los ntawm cov tshuaj uas muaj cov tshuaj sib xyaw nrog cov kws muag tshuaj tshwj xeeb. Hauv cov kev sim vito, cov tebchaw no pom tias muaj kev tiv thaiv tseem ceeb tawm tsam ntau cov qog ntawm tes kab. Cov kev tshawb fawb ntxiv qhia tau tias cov sib txuas no tau tsim tawm los tiv thaiv cov qog qog ntawm cov qog ntshav thiab ua qog cell agoptosis.

Synthesis ntawm tebchaw nrog cov tshuaj tiv thaiv kev ua haujlwm

1-boc-3-hydroxymethylpermeridine kuj tau siv los ua ke nrog cov tshuaj tiv thaiv kev tawm tsam. Los ntawm cov tshuaj tiv thaiv tshwj xeeb, sib xyaw ua ke muaj cov pab pawg ntawm cov pab pawg ua ke nrog cov neeg sib tw tshiab kom tsim cov tshuaj tiv thaiv tshiab rau cov tshuaj tiv thaiv tshuaj tiv thaiv. Cov lus teb no nthuav qhia cov yam ntxwv tsis muaj kev tiv thaiv loj hauv cov tsiaj tsiaj nrog cov kev mob tshwm sim tsawg. Cov kev tshawb nrhiav no muab cov tswv yim tshiab thiab cov hau kev rau kev txhim kho cov tshuaj tiv thaiv tshuaj tiv thaiv tshuaj tiv thaiv.

Synthesis ntawm cov tebchaw nrog anti - kev ua haujlwm

O yog cov tiv thaiv kev tiv thaiv ntawm tib neeg lub cev tiv thaiv kev raug mob lossis kis mob tuaj yeem ua rau cov ntaub so ntswg puas tuaj yeem ua rau cov nqaij mos thiab kab mob. Researchers have synthesized a series of compounds with anti-inflammatory activity using 1-Boc-3-hydroxymethylpiperidine as a key intermediate. Cov tebchaw no siv ntau yam cuam tshuam los ntawm kev tso tawm cov kev faib tawm ntawm cov neeg sib raug zoo thiab txo qhov infiltration hlwb. Hauv cov qauv tsiaj, cov tebchaw no tau pom cov teebmeem tseem ceeb rau ntau yam kab mob hnyav.

Hluavtaws ntawm cov tebchaw nrog antihypertensive kev ua si

Tawg siab yog ib tug kab mob nquag uas ua rau muaj kev hem thawj loj rau tib neeg kev noj qab haus huv. Researchers have synthesized a series of compounds with antihypertensive activity using 1-Boc-3-hydroxymethylpiperidine as a key intermediate. Cov tebchaw qis cov ntshav siab los ntawm kev ua haujlwm ntawm kev ua si ntawm angiotensin-hloov enzyme. Hauv kev sim tsiaj, cov tebchaw no qhia tau tias muaj txiaj ntsig zoo antihypertensive ntawm hypertensive qauv tsiaj nrog kev phiv tawm tsawg. Cov kev tshawb nrhiav no muab cov tswv yim tshiab thiab cov hau kev rau kev txhim kho cov tshuaj tiv thaiv kab mob antihyperensive.

N - boc -} Piperidine-3-METANOL(1 {{- boc {}}} hydrothicthylipermeriderger) yog cov orgone hydredocation dav hauv kev hloov tshuaj molecules thiab bioactive molecules. Nws cov mis molecular yog c ₁₁ h ₁₁ tsis α, thiab nws tus lej yog 116574-1. Cov ntais ntawv no muaj lub nplhaib pyridine tau hloov kho nrog ib pawg N-Boc tiv thaiv pab pawg ua nws cov pab pawg tseem ceeb, thiab cov neeg nquag ua haujlwm, uas tuaj yeem koom nrog hauv ntau yam kev tawm tsam. Txawm li cas los xij, ntau cov impurities yuav qhia nyob rau hauv cov txheej txheem hluavtaws, suav nrog cov khoom lag luam raw, thiab cov khoom lag luam, uas muaj kev nyab xeeb, thiab cov tshuaj ruaj khov, thiab cov tshuaj ruaj khov Yog li no, tsim kom muaj kev tsim lub cev ntas hluav taws xob kev tsom xam tshuab matrix yog qhov tseem ceeb rau kev ua kom cov khoom lag luam zoo.

Tsom xam ntawm cov ntsiab lus synthesis
Txoj kev lag luam synthesis ntawm n - boc {}} poceridine {3-piperidineclic anour Ester thiab xaiv cov khoom ester Cov tshuaj tiv thaiv yog nqa tawm ntawm chav tsev kub, thiab bi fert pab pawg (TERT BUTTORGYL) ntawm cov pab pawg nitrogen thaj chaw ntawm lub nplhaib ester ntawm lub nplhaib hydroxymethyl.

Qhov tshwm sim tseem ceeb:

Kaus: anhydrous tetrahydrofuran (thf) lossis ether
Kub: 0-25℃(chav sov)
Teb lub sijhawm: 4-8 teev
Kev Ua: Cov kua qaub quenching (xws li dilute hydrochloric acid), extraction, qhuav, thiab kem chromatography purification

Kev faib tawm cov peev txheej uas muaj peev xwm ua tau
Raws li cov txheej txheem ntawm tiam neeg loj, nws tuaj yeem faib ua plaub pawg hauv qab no:

Ntau cov txheej txheem tshuaj ntsuam yuav tsum tau muab sib xyaw ua ke rau cov kab ke sib txawv ntawm n {{}}} piperidin-3-methanol. Tsim cov thev naus laus zis matrix los ntawm peb qhov ntev: sib cais thev naus laus zis, cim thev naus laus zis, thiab ntau thev naus laus zis:

Cim npe nrov: n - boc - piperidine-3-Methanol CAS 116574-1, chaw tsim tshuaj paus, chaw tsim khoom, yuav khoom, rau muag