N -} shimethylsilslimimidazole CAS 18156-74-6

Trimethylsilazole, tseem hu uan - trimethylsylsylimidazole, chreesethylsilazole, tsis muaj kob rau cov kua daj. Cov khoom siv hluav taws xob uas muaj txiaj ntsig tshwj xeeb yog qhov tsim nyog rau kev siv cawv thiab imidazoles, tiv thaiv pawg hydroxyl hauv lub xub ntiag ntawm cov pab pawg amino. Nws yog qhov tseem ceeb hauv nruab nrab rau cov synthesis ntawm ntau acyl imidazoles thiab quinamide; Hydroxyl tiv thaiv sinslation reagent nyob rau hauv Amine ua haujlwm; Muaj zog systlation reagents, tshwj xeeb yog haus cawv; Synthesis ntawm imide imidazoline. Qhov muaj zog tshaj plaws silylation reagent; Nws tuaj yeem ua rau muaj kev cuam tshuam nrog hydroxyl thiab carboxyl pawg sai thiab tseeb. Nws tsis hnov ​​mob nrog amine lossis nyob hauv, yog li nws tuaj yeem siv los npaj ntau derivatives muaj ob pawg hydroxyl thiab amino. Nws tuaj yeem siv rau silylate qab zib nyob rau hauv lub xub ntiag ntawm cov dej me me; Thaum twg cov piam thaj yuav tsum tau tshuaj xyuas ua kua qab zib, nws yog qhov kev xaiv zoo tshaj plaws rau cov piam thaj silelated. Muaj peev xwm tau txais txiaj ntsig feem ntau ntawm cov pawg steroid hydroxyl uas tsis txaus siab thiab loj heev.

N - trimethylsylsylimidazolefeem ntau siv nyob rau hauv ntau yam tshuaj lom hluav taws xob thiab kev siv cov ntawv thov.

TSIM tau qhia nws cov versatility thiab tseem ceeb hauv ntau yam tshuaj lom neeg cov tshuaj thiab kev siv, tshwj xeeb hauv kev tshuaj thiab analytical chemistry.

Hauv kev siv tshuaj chemicalseccinal, tsim tau ua tiav siv nyob rau hauv synthesis ntawm aryl-5-arylideneimidazol-4-txhua yam los ntawm lub cev qhuav dej. Qhov tshuaj tiv thaiv no yog qhov tseem ceeb rau kev npaj ntawm cov chaw ua haujlwm muaj peev xwm, ua kom tsim nyog ib qho reagentable reagent txheej txheem. Lub peev xwm los synthesize cov immidazol-4-txhua yam tshuaj tiv thaiv nws qhov tseeb hauv kev txhim kho ntawm cov neeg sawv cev tshiab.

Hauv kev ntsuas tshuaj chemistry, tsim cov ntawv thov hauv kev tsom xam sterol tau muaj pov thawj yog qhov tseem ceeb tshwj xeeb. Los ntawm kev yooj yim nrawm GC / ms (roj chromatography / mass spectrometry) tsom xam kev ua tiav ntawm kev kawm sterol tsom xam nyob rau hauv 12,5 feeb. Lub sijhawm tsom xam ceev no yog qhov tseem ceeb rau ntau yam kev siv tshuaj ntsuam, xws li kev tshuaj xyuas kom zoo rau hauv cov tshuaj ntsuam, uas lub sijhawm}} qhov txiaj ntsig yog qhov tseem ceeb. Kev siv ntawm Tsim hauv kev tawm tsam tsis meej

Cov Txheej Txheem Sterol yog qhov tseem ceeb ntawm kev sim ua hauv biochemistry thiab anestal chemistry, muab kev pom rau hauv cov khoom siv thiab kev ua haujlwm ntawm kev kuaj txheeb xyuas biological. Sterols, xws li cov roj cholesterol, yog lipids pom nyob rau hauv lub mis nyuj ntawm cov tsiaj lub ntsej muag muaj flues, cov tshuaj synthesis, thiab cov kua qaub.

Cov tshuaj sterol tsis zoo li pib nrog kev rho tawm ntawm cov khoom tsis muaj roj ntsha los ntawm cov qauv roj ntsha, xws li cov ntaub so ntswg, ntshav qab zib, lossis ntshav. Qhov txheej txheem rho tawm no suav nrog kev siv cov kuab tshuaj organic kom cais cov solols los ntawm lwm cov khoom siv cellular. Thaum muab rho tawm, cov steracted feem ntau yog derivatized los txhim kho lawv cov kev tshawb nrhiav thiab ruaj khov thaum lub sij hawm kuaj xyuas tom ntej tom ntej.

Ib txoj kev sib xws rau kev tsom xam cov roj ntsha yog roj chromatography / Mass Spectrometry (GC / MS). Hauv cov txheej txheem no, derivatized sterols tau txhaj rau hauv cov roj roj Chromatograph, uas lawv tau sib cais raws lawv cov khoom siv lub cev, xws li tsis muaj zog thiab polarity. Raws li cov sterols elute los ntawm cov pa roj chromatograph, lawv tau tshaj tawm rau hauv cov molecules thiab ntsuas qhov loj} Cov ntaub ntawv no yog siv los txheeb xyuas thiab ntau ntxiv cov neeg tsis muaj mob hauv cov qauv.

Lwm txoj kev rau kev tsom xam ua kua nyob kua chromataphy / Mass Spectrometry (LC / MS). Cov txheej txheem no muaj ntau dua rhiab thiab muaj qhov tshwj xeeb tshaj GC / MS, tshwj xeeb rau kev tsom xam cov roj ntsha polar sterols thiab Sterab Metabolites thiab Sterab Metabolites thiab Sterab Mevolibites. Hauv LC / MS, cov kev sib cais tau sib cais raws lawv cov kev sib cuam tshuam nrog theem nyob ruaj ruaj hauv cov kua chromatograph thiab tom qab ntawd tshuaj xyuas los ntawm huab hwm coj los ntawm huab hwm coj.

Cov txiaj ntsig ntawm kev tshawb xyuas cov ntsiab lus tsis meej tuaj yeem muab cov ntaub ntawv muaj txiaj ntsig zoo txog cov qauv kev noj qab haus huv ntawm ib tus neeg lossis tshawb xyuas cov txheej txheem ntawm tus kabmob. Piv txwv li, nce qib cov roj hauv cov ntshav muaj feem cuam tshuam nrog kev pheej hmoo ntawm cov kab mob plawv, thaum muaj kev phom sij rau metabolic tuaj yeem qhia txog cov teeb meem metabolic lossis caj ces.

Zuag qhia tag nrho, kev tshuaj xyuas sedol yog cov cuab yeej sim muaj zog hauv biochemistry thiab anestal anemistry, muab kev pom rau hauv cov khoom siv thiab kev ua haujlwm ntawm kev siv ceg ntoo hauv kev siv hluav taws xob.

Tsim yog synthesized los ntawm ib tug zoo -}}}}}}}}}}}}}}}}}}}}}}}} akes awves ntawm imidazole nrog Hexamethandisilazane (HMDS). Lub synthesis feem ntau pib nrog kev xaiv ceevfaj thiab npaj cov reactants, kom lawv txoj kev coj dawb huv thiab tsim nyog cov sib piv.

Hauv cov txheej txheem safthesis zoo li distolves, xws li tetrahydroduran (thf) lossis toluene huab cua los tiv thaiv oxidation. Hexamethleelslisilazane yog tom qab ntawd ntxiv dropwise rau imidazole tov, thaum stirring yog tswj kom ua kom muaj kev sib xyaw kom huv. Cov tshuaj tiv thaiv yog rhuab rau qhov kub thiab txias, feem ntau nyob rau hauv ntau ntawm 50-80 degree, kom nrawm qhov kev tawm tsam.

Cov tshuaj tiv thaiv dhau los ntawm kev tsim ntawm cov khoom nruab nrab, uas tom qab ntawd cov khoom siv cawm siav. Qhov kev nce qib ntawm cov kev tawm tsam yog saib siv kev siv tshuaj ntsuam xyuas cov tshuaj aneveraphes xws li nyias {1} ВCR) lossis kev sib nqus magnumic resonance (NMR) spectroscopy.

Thaum ua tiav ntawm cov tshuaj tiv thaiv, cov kuab tshuaj thiab cov reagented yog muab tshem tawm los ntawm distillation lossis evaporation, tawm ntawm cov khoom lag luam tsis tau. Kev ntxuav kom huv yog tom qab ua tiav los ntawm cov kev qhia xws li distillation lossis crystallization kom tau txais cov ntshiab. Txoj kev ncaj ncees sab laj muab txoj kev ncaj thiab ua tau zoo rau tsim, ua rau nws muaj cov reagent yooj yim rau ntau yam tshuaj lom neeg.

N - trimethylsylsylimidazole, feem ntau cov npe hu ua tmsimidazole lossis TMSIM, yog ib qho kev sib xyaw ua ke thiab muaj cov qauv tshuaj sib xyaw nrog cov nplhaib siv tshuaj lom neeg nrog lub ntsej muag tsis sib xws nrog cov pab pawg txiav (TMS) pawg. Qhov tshwj xeeb hloov qauv muab cov molecule nrog cov khoom muaj txiaj ntsig thiab cuam tshuam cov qauv, ua rau nws tsis tseem ceeb hauv cov ntawv thov hluavtaws hluavtis.

Lub nplhaib Imidazole nws tus kheej paub txog nws lub peev xwm koom nrog cov pab pawg ua haujlwm thiab tsim kho cov solubility ntawm tmsimidazole hauv cov kuab tshuaj organic. Qhov kev sib xyaw ua ke no ua rau TMSimidazole Qhov zoo tshaj plaws lub hauv paus thiab nucleophile hauv cov organic cov tshuaj tiv thaiv, muaj peev xwm ntawm kev hloov pauv ntau yam kev hloov pauv.

Ib qho ntawm cov tseem ceeb tshaj plaws ntawm tmsimidazole yog nyob rau hauv lub teb ntawm silicon - raws incrediate rau cov synthesis ntawm synlation tebchaw. Cov kev ua haujlwm silylated no feem ntau ua haujlwm hauv kev tiv thaiv pawg pab pawg, thiab txhim kho kev ruaj ntseg ntawm cov pab pawg.

Ntxiv mus, TMSimidazole Nrhiav tau daim ntawv thov hauv cov hlau- kev sib txuas ua ke ntawm aryl lossis alkylal rau cov organometallic reagents. Nws lub luag haujlwm hauv cov kev mob siab rau qhov tseem ceeb nyob rau hauv synthesis ntawm cov orgules molecules, cov ntaub ntawv, thiab cov ntaub ntawv siab.

Hauv cov ntsiab lus xaus,N - trimethylsylsylimidazoleyog cov tshuaj lom neeg muaj txiaj ntsig zoo tshaj plaws uas nws tus qauv thiab cov qauv sib xws thiab muaj ntau yam pheej hmoo. Nws lub peev xwm los koom nrog cov tshuaj lom neeg dav dav ua rau nws lub pob zeb ua haujlwm thiab thev naus laus zis nyob thoob plaws kev lag luam science thiab kev lag luam.

N - trimethylsylsylimidazole(CAS naj npawb 18156 {-}} {}} ipicole silicon compound uas zoo li kua ntshav lossis daj daj ntawm chav sov. Nws yog hygroscopic thiab yooj yim reacts nrog dej los ua hexamethlisiloxane (flammable) thiab imidazole. Raws li qhov tseem ceeb Silanization reagent, tms imidazole tau siv dav hauv cov edthic synthesis, tshuaj kho yeeb tshuaj, thiab roj chromatography-huab hwm coj (GC-MS) tsom xam. Txawm li cas los xij, nws cov tshuaj lom neeg yog nquag thiab muaj qee yam toxicity, uas yuav ua rau cov kev tsis zoo hauv qab no:

• Daim tawv nqaij thiab mucosal khaus: Ncaj nraim tuaj yeem ua rau liab, hlwv, thiab hlawv tshuaj.
• Qhov muag puas tsuaj: qhov loj me ntsis kis tau tuaj yeem ua rau pob txha epithelial detachent thiab pom kev ib ntus.
• Ua pa chim: kev nqus tau ntawm cov vapors lossis cov aerosols tuaj yeem ua rau hnoos, hawb pob, thiab cov tub rog.
• Systemic toxicity: Cov kev sim tsiaj tau pom tias cov tshuaj muaj kev puas tsuaj ntau yuav ua rau lub siab puas zoo li daim siab thiab lub raum.
• Ib puag ncig toxicity: nws muaj kev lom zem me ntsis rau dej tsiaj muaj xws li ntses thiab algae, thiab yuav cuam tshuam kev sib npaug ntawm kev ua kom ecological.

Cim npe nrov: n -} luas} shreeshlsilysilimidAngimidagole