OXONIC ACID Potassium ntsev CAS 2207-75-2

Nws yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv kab mob qog noj ntshav S-1. S-1 yog ib qho tshuaj fluorouracil antitumor hauv qhov ncauj uas muaj Tegafur, Gimeracil, thiab potassium oxonate hauv qhov sib piv ntawm 1: 0.4: 1. Tigafur yog ib qho prodrug ntawm 5-fluorouracil (5-FU), uas tawm tsam cov qog nqaij hlav tom qab hloov mus rau 5-FU hauv vivo; Jimeipyrimidine slows down lub catabolism ntawm 5-FU los ntawm inhibiting cov kev ua ntawm dihydropyrimidine dehydrogenase (DPD), yog li prolonging nws zoo concentration nyob rau hauv lub cev; Raws li uricase inhibitor, nws txo qis toxicity ntawm 5-FU rau plab hnyuv mucosa los ntawm inhibiting nws phosphorylation rau 5-fluorouridine-5 '- mnophosphate (FUMP) nyob rau hauv lub plab hnyuv ib ntsuj av, tsis muaj zog nws tiv thaiv qog.

Cov yam ntxwv no ua rau S-1 tau siv dav hauv kev kho cov qog nqaij hlav xws li mob plab hnyuv, mob qog noj ntshav, mob ntsws cancer, mob qog nqaij hlav taub hau thiab caj dab thiab mob qog noj ntshav. Piv txwv li, hauv kev siv tshuaj kho mob ntxiv rau kev mob qog noj ntshav, S-1 monotherapy lossis kev sib xyaw nrog lwm cov tshuaj (xws li cisplatin) tuaj yeem txhim kho qhov ciaj sia taus thiab lub neej zoo ntawm cov neeg mob. Piv nrog rau cov tshuaj 5-FU intravenous infusion regimen, S-1 qhov ncauj tswj tau yooj yim thiab muaj kev tiv thaiv zoo dua, tshwj xeeb tshaj yog tsim rau cov neeg laus lossis cov neeg mob uas muaj lub cev tsis zoo.

Nws yog ib qho zoo uricase inhibitor uas tuaj yeem thaiv cov metabolism thiab kev tso tawm ntawm uric acid. Hauv kev sim tsiaj xws li nas thiab nas, poov tshuaj oxonate tuaj yeem raug ntxias los tsim hyperuricemia los ntawm kev txhaj tshuaj intraperitoneal lossis kev tswj qhov ncauj. Nws cov txheej txheem ntawm kev ua haujlwm yog inhibit qhov kev ua ntawm uric acid nyob rau hauv daim siab thiab ob lub raum, txo qhov kev tawg ntawm uric acid rau hauv allantoin, thiab inhibit reabsorption ntawm uric acid los ntawm lub raum tubules, ua rau kom nce qib ntawm cov ntshav uric acid.

Cov yam ntxwv no ua rau potassium oxonate yog ib qho cuab yeej tseem ceeb rau kev kawm txog cov kab mob ntawm cov kab mob xws li gout thiab metabolic syndrome. Los ntawm kev tsim tus qauv tsiaj uric acid siab, cov kws tshawb nrhiav tuaj yeem nkag mus rau hauv kev sib raug zoo ntawm qhov txawv txav uric acid metabolism thiab cov txheej txheem pathological xws li o, oxidative kev nyuaj siab, thiab insulin tsis kam, muab pov thawj kev sim txhim khu kev qha rau kev txhim kho cov tshuaj uric acid tshiab. Piv txwv li, siv tus qauv ntawm tus nas hyperuricemia tshwm sim los ntawm cov poov tshuaj oxonate, cov kws tshawb fawb tau pom tias qee cov tshuaj suav tshuaj suav tshuaj los yog cov khoom siv ntuj tsim (xws li baicalin thiab quercetin) muaj cov uric acid txo qis thiab tiv thaiv - cov teebmeem inflammatory, muab cov tshuaj tshiab rau kev kho mob gout.

Oxonic acid poov tshuaj ntsevkuj qhia tau hais tias muaj kev tiv thaiv qee yam hauv cov hlab plawv. Kev tshawb fawb tau pom tias poov tshuaj oxonate tuaj yeem txhawb kev sib txuas thiab tso tawm nitric oxide (NO) hauv cov hlwb endothelial, nthuav cov hlab ntsha, thiab txo cov ntshav siab. TSIS yog ib qho tseem ceeb vasodilator uas tuaj yeem cuam tshuam cov platelet aggregation thiab leukocyte adhesion, txo cov vascular inflammatory teb. Tsis tas li ntawd, nws tseem tuaj yeem ua rau qeeb qhov tshwm sim thiab kev loj hlob ntawm atherosclerosis los ntawm kev txo qis ntawm cov dawb radicals, inhibiting oxidative kev nyuaj siab, thiab tiv thaiv vascular endothelial hlwb los ntawm kev puas tsuaj.

Hauv kev sim tsiaj txhu, kev kho mob ua ntej tuaj yeem txo qhov mob myocardial ischemia - rov qab raug mob, txo qhov chaw myocardial infarction, thiab txhim kho kev ua haujlwm plawv. Cov txheej txheem yuav muaj feem xyuam rau inhibiting inflammatory teb, txo cell apoptosis, thiab txhawb angiogenesis. Cov kev tshawb pom no muab lub hauv paus theoretical rau kev siv cov poov tshuaj oxonate hauv kev tiv thaiv thiab kho cov kab mob plawv, tab sis kev tshawb fawb soj ntsuam ntxiv yog xav tau los txheeb xyuas nws txoj kev nyab xeeb thiab kev ua tau zoo.

Cov tshuaj tiv thaiv- cov khoom ua kom muaj zog ntawm cov poov tshuaj oxonate ua rau nws muaj txiaj ntsig zoo rau kev kho cov kab mob ua pa. Mob hawb pob thiab mob ntsws obstructive pulmonary (COPD) yog ob hom kab mob ua pa ntev, thiab lawv cov kab mob muaj feem cuam tshuam nrog kev mob ntsws, oxidative stress, thiab kev tiv thaiv kab mob. Nws tuaj yeem txo cov kab mob hauv cov hlab ntsws los ntawm inhibiting kev ua kom cov hlwb inflammatory (xws li macrophages thiab neutrophils) thiab tso tawm cov inflammatory yam (xws li qog necrosis factor - thiab interleukin-6).

Tsis tas li ntawd, los ntawm kev tswj hwm lub cev tiv thaiv kab mob, kev ua pa ntawm lub ntsws tuaj yeem txo qis, thiab cov tsos mob ntawm tus mob hawb pob thiab COPD tuaj yeem txo qis. Hauv cov qauv tsiaj, kev kho tshuaj poov tshuaj oxonate tuaj yeem txo qhov ua xua ua rau lub ntsws ua pa thiab kho, thiab txhim kho lub ntsws ua haujlwm. Cov kev tshawb fawb tshawb fawb no qhia tias nws yuav dhau los ua cov tshuaj kho tshiab rau cov kab mob ua pa, tab sis xav tau kev sim tshuaj ntxiv los ntsuas nws cov txiaj ntsig thiab kev nyab xeeb.

Kev tshawb fawb ua ntej qhia tias nws kuj muaj qee yam kev tiv thaiv ntawm lub paj hlwb. Hauv cov qauv kev raug mob ischemic hlwb, ua ntej- kev kho mob tuaj yeem txo qhov ntim ntawm cerebral infarction thiab txhim kho kev puas hlwb. Cov txheej txheem yuav cuam tshuam rau inhibiting inflammatory teb, txo cov kev qhia ntawm oxidative kev nyuaj siab thiab apoptosis ntsig txog cov proteins. Tsis tas li ntawd, kev txhawb nqa cov synthesis thiab tso tawm ntawm cov paj hlwb tseem tuaj yeem pab txhawb kev ciaj sia thiab rov tsim dua tshiab ntawm cov paj hlwb, muab cov tswv yim tshiab rau kev kho cov kab mob neurodegenerative xws li Alzheimer's disease thiab Parkinson's disease.

Piv txwv li, siv cov poov tshuaj oxazinate los kho cov hlwb lossis cov qauv tsiaj, cov kws tshawb fawb pom tias qhov chaw muaj uric acid siab tuaj yeem ua rau endothelial cell dysfunction, txhawb kev loj hlob thiab kev tsiv teb tsaws ntawm vascular du leeg hlwb, thiab ua kom muaj qhov tshwm sim ntawm atherosclerosis. Ntxiv rau,oxonic acid poov tshuaj ntsevKuj tseem siv tau los kawm txog kev sib cuam tshuam ntawm uric acid thiab oxidative kev nyuaj siab, inflammatory teb, muab cov ntsiab lus tseem ceeb rau kev nthuav tawm cov kab mob ntawm cov kab mob metabolic.

Hauv kev txhim kho cov tshuaj tiv thaiv- qog nqaij hlav, txo cov kab mob hauv plab hnyuv ntawm 5-FU muab cov qauv tsiaj zoo tshaj plaws rau kev ntsuas kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj khomob tshiab. Cov tshuaj 5-FU cov tshuaj intravenous infusion feem ntau ua rau mob plab hnyuv loj xws li xeev siab, ntuav, thiab raws plab, txwv tsis pub nws daim ntawv thov kho mob. S-1, muaj cov poov tshuaj oxonate, tuaj yeem txo cov kev mob tshwm sim no thiab txhim kho cov neeg mob siab ntev.

Los ntawm kev siv tus qauv tsiaj tsim, cov kws tshawb fawb tuaj yeem sib piv cov tshuaj tiv thaiv -cov qog nqaij hlav thiab cov tshuaj lom tshuaj lom neeg ntawm cov tshuaj kho mob sib txawv (xws li S-1 monotherapy lossis S-1 ua ke nrog lwm cov tshuaj), thiab kho cov phiaj xwm kho kom zoo. Tsis tas li ntawd, nws tseem tuaj yeem siv los kawm txog tshuaj pharmacokinetics thiab pharmacodynamics, muab cov kev sim tseem ceeb rau kev txhim kho tshuaj tshiab.

Tus qauv induced hyperuricemia tsiaj muab ib qho cuab yeej muaj zog rau kev kawm txog kev sib cuam tshuam ntawm uric acid thiab cov kab mob metabolic xws li rog, ntshav qab zib, kub siab, thiab lwm yam. Metabolic syndrome yog ib qho kev kho mob nrog insulin tsis kam ua nws cov tub ntxhais, nrog rau ntau yam metabolic abnormalities xws li kub siab, hyperglycemia, dyslipidemia, thiab rog. Nws pathogenesis yog complex thiab koom nrog ntau yam.

Los ntawm kev siv nws los tsim tus qauv tsiaj ntawm hyperuricemia, cov kws tshawb fawb pom tias hyperuricemia tuaj yeem ua rau cov tshuaj insulin tsis kam, txhawb cov nqaij adipose o thiab kev sib txawv ntawm adipocytes, nce siab rog synthesis, thiab yog li ua rau rog rog thiab ntshav qab zib. Tsis tas li ntawd, hyperuricemia tuaj yeem ua rau muaj kev kub ntxhov thiab ua rau kom muaj kev loj hlob ntawm atherosclerosis los ntawm kev ua kom renin angiotensin system (RAS) thiab oxidative kev ntxhov siab. Cov kev tshawb fawb tshawb fawb no muab qhov kev xav tshiab rau kev nkag siab tob dua ntawm cov kab mob ntawm cov kab mob metabolic thiab lub hauv paus theoretical rau kev txhim kho ntau yam - cov phiaj xwm cuam tshuam.