Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm antide cas 112568-12-4 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo antide cas 112568-12-4 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Antideyog ib qho luv luv peptide, feem ntau muaj cov kab ke tshwj xeeb ntawm cov amino acids uas ua rau thaj tsam bioactive ntawm VIP. Cov txheej txheem zoo sib xws no tso cai rau nws cuam tshuam nrog VIP receptors, feem ntau VPAC1 thiab VPAC2, uas tau nthuav tawm hauv ntau cov ntaub so ntswg, suav nrog hauv nruab nrab lub paj hlwb (CNS), lub cev tsis muaj zog, thiab cov leeg nqaij. Los ntawm kev khi rau cov receptors no, nws tuaj yeem hloov kho cellular signaling txoj hauv kev, ua rau muaj ntau yam kev xav ntawm lub cev.
Ib qho ntawm cov txiaj ntsig zoo tshaj plaws yog nws cov khoom tiv thaiv neuroprotective. Cov kev tshawb fawb tau pom tias tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj los ntawm excitotoxicity, oxidative kev nyuaj siab, thiab o. Qhov no ua rau nws muaj peev xwm sib tw rau kev kho mob ntawm cov kab mob neurodegenerative xws li Alzheimer's disease, Parkinson's disease, thiab ntau yam sclerosis. Lub peev xwm los txhim kho neuronal ciaj sia taus thiab txhawb synaptic plasticity ntxiv underscores nws cov peev xwm kho mob nyob rau hauv tej yam kev mob tshwm sim los ntawm neuronal poob los yog dysfunction.
Customized Bottle Caps & Corks
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Tshuaj Formula |
C82H108ClN17O14 |
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Exact Mass |
1590 |
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Molecular Luj |
1591 |
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m/z |
1590 (100.0%), 1591 (88.7%), 1592 (38.8%), 1592 (32.0%), 1593 (28.3%), 1594 (12.4%), 1593 (10.4%), 1591 (6.3%), 1592 (5.6%), 1595 (3.6%), 1592 (2.9%), 1593 (2.6%), 1593 (2.4%), 1593 (2.0%), 1594 (2.0%), 1594 (1.8%), 1591 (1.2%), 1594 (1.1%), 1592 (1.1%) |
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Elemental Analysis |
C, 61,89; H, 6,84; Cl, 2,23; N, 14,96; Nws, 14.08 |
txheej txheem synthesis
Txoj kev 1
Cov khoom siv raw: pyrrolidine, acetone, tetrahydrofuran, boric acid, iodomethane, diphenylphosphine, tert butyryl alumina, p-carboxyphenylthiourea, rhodium trichloride, isopropyl lithium
- Hauv tetrahydrofuran, pyrrolidine yog reacted nrog acetone kom tau N-propylpyrrolidine.
- Txo N-propylpyrrolidine nrog boric acid kom tau N-propylpyrrolidine borate ester.
- Ua cov tshuaj tiv thaiv condensation ntawm N-propylpyrrolidone borate thiab diphenylphosphine nyob rau hauv muaj tert butyryl alumina kom tau N-(2-diphenylphosphineethyl) pyrrolidine.
- Hloov cov tshuaj tiv thaiv ntawm N-(2-diphenylphosphineethyl) pyrrolidine nrog p-carboxyphenylthiourea kom tau N-(2-diphenylphosphineethyl) pyrrolidine p-carboxyphenylthiourea imide.
- Nyob rau hauv lub xub ntiag ntawm rhodium trichloride, N-(2-diphenylphosphineethyl) pyrrolidine p-carboxyphenylthiourea imide raug txo nrog isopropyl lithium kom tau txais antipeptide.
Txoj kev 2
Cov khoom siv raw: 1-methylpyrrolidine, chloro tert butyrate, tetrahydrofuran, NaH, Pd / C, acetic acid, iodomethane
- Siv NaH tshem tawm ib qho proton ntawm 1-methylpyrrolidine thiab tau txais 1-methylpyrrolidine ion.
- Hauv tetrahydrofuran, N-tert butyryl-1-methylpyrrolidine tau txais los ntawm kev hloov cov tshuaj tiv thaiv ntawm 1-methylpyrrolidine ion thiab tert butyrate chloride.
- Siv Pd/C los txo N-tert butyryl-1-methylpyrrolidine thiab acetic acid rau N-methyl-1-methylpyrrolidine.
- Hloov N-methyl-1-methylpyrrolidine nrog iodomethane kom tau N-methyl-2-iodoethylpyrrolidine.
- Hauv tetrahydrofuran, N-methyl-2-iodoethylpyrrolidine yog condensed nrog p-carboxyphenylthiourea kom tau N-(2-hydroxyethyl) pyrrolidine p-carboxyphenylthiourea imide.
- Nyob rau hauv lub xub ntiag ntawm Pd/C, N-(2-hydroxyethyl) pyrrolidine p-carboxyphenylthiourea imide raug txo nrog acetic acid kom tau txais antipeptide.
Nws yuav tsum tau muab sau tseg tias cov txheej txheem synthesis saum toj no koom nrog cov organic synthesis thiab kev kho cov intermediates tseem ceeb, thiab muaj qee yam kev pheej hmoo cuam tshuam. Cov neeg ua haujlwm uas muaj peev xwm tsim nyog thiab muaj peev xwm sim tshuaj lom neeg siab yuav tsum tau ua haujlwm hauv chav kuaj. Nyob rau tib lub sijhawm, txhawm rau ua kom muaj kev nyab xeeb thiab raug ntawm qhov kev sim, nws yog ib qho tsim nyog yuav tsum ua raws li cov txheej txheem kev sim tshuaj lom neeg thiab kev nyab xeeb ntawm kev ua haujlwm.
Ntxiv rau ob txoj hauv kev saum toj no, muaj ntau lwm txoj hauv kev rau kev sib txuastshuaj tiv thaivhauv chav kuaj. Cov hauv qab no yog qee txoj kev siv tshuaj lom neeg:
Amino acid condensation cov tshuaj tiv thaiv
Ntau yam amino acids (xws li phenylalanine, tryptophan, thiab lwm yam) yog condensed kom tau peptide fragments. Tom qab kev sib cais thiab kev ua kom huv si, cov khoom tawg no tuaj yeem txuas ntxiv mus rau hauv cov tshuaj antipeptide molecules tiav.
01
Txheej txheej txheej txheej txheej txheej
Siv kem chromatography technology, cov amino acid sib tov yog adsorbed ntawm silica gel los yog polymer carrier, thiab ces lub hom phiaj compound yog sib cais los ntawm cov cab kuj los ntawm elution nyhuv ntawm lub eluent. Txoj kev no tuaj yeem txhim kho kev ua kom zoo dua qub, txo cov pa phem thiab tshwm sim ntawm kev cuam tshuam sab.
02
Txoj kev ua kua theem synthesis
Antipeptide yog tsim los ntawm cov tshuaj tiv thaiv thiab enzyme catalysis hauv cov kuab tshuaj organic xws li acetonitrile thiab methanol. Txoj kev no yuav tsum tau siv cov catalysts tshwj xeeb thiab cov enzymes, thiab yuav tsum muaj kev sib cais thiab kev ua kom huv.
03
Genetic engineering method
Siv DNA recombination thev naus laus zis thiab thev naus laus zis thev naus laus zis, cov noob encoding antipeptide tau nkag mus rau hauv cov kab mob microbial los qhia txog cov protein uas xav tau. Txoj kev no yuav tsum muaj cov cuab yeej siv biotechnology tshwj xeeb thiab cov khoom siv, thiab raug nqi ntau.
04
Lwm txoj kev
Kuj tseem muaj lwm txoj hauv kev uas tuaj yeem siv rau hauv chav kuaj synthesis ntawm antipeptide, xws li enzymatic synthesis thiab photosensitization. Cov txheej txheem no xav tau cov cuab yeej tshwj xeeb thiab cov xwm txheej, thiab muaj qee yam kev nyuaj.
05
Antideyog ib qho tshuaj tiv thaiv androgenic dav siv nyob rau hauv kev kho mob siab heev castration resistant prostate cancer. Nws cov qauv molecular muaj benzene nplhaib, imidazole nplhaib, thiab ntau yam khoom siv, uas ua rau nws muaj kev lom zem tshwj xeeb. Nws cov mis molecular yog C21H16F4N4OS, nrog tus txheeb ze molecular hnyav ntawm 464.44 g / mol. Hauv cov qauv tshuaj no, peb tuaj yeem txheeb xyuas nws cov khoom sib txawv raws li hauv qab no:
Benzene nplhaib
Lub hauv paus tseem ceeb ntawm cov tshuaj antipeptide molecule yog lub nplhaib benzene. Lub nplhaib benzene yog ib lub voj voog uas muaj rau carbon atoms thiab peb ob daim ntawv cog lus. Lub nplhaib benzene plays lub luag haujlwm tseem ceeb hauv kev ruaj ntseg thiab hydrophilicity ntawm molecules.
Imidazole nplhaib
Antipeptide molecules kuj muaj lub nplhaib imidazole uas muaj tsib lub atoms (ob lub nitrogen atoms thiab peb carbon atoms). Imidazole nplhaib yog ib qho heterocyclic compound uas feem ntau pom nyob rau hauv ntau cov bioactive molecules. Nws ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm lom neeg ntawm Antipeptide.
Pab pawg hloov pauv:
Cov pab pawg hloov pauv hauv cov tshuaj antipeptide molecule suav nrog cov pab pawg nitrile (C ≡ N) thiab thioamidine pawg (S). Nitrile pawg muaj kev cuam tshuam rau lub polarity thiab pharmacological kev ua ntawm molecules, thaum thioamidine pawg koom nrog ntau yam kev cuam tshuam thiab kev cuam tshuam.
Cov kws tshaj lij
Antipeptide molecules kuj muaj ib pawg trifluoromethyl (CF3). Trifluoromethyl yog ib pawg electron enriched uas yuav ua rau kom polarity thiab solubility ntawm molecules, thaum tseem cuam tshuam rau lawv cov tshuaj pharmacological.
Los ntawm kev khi rau androgen receptors thiab inhibiting lawv cov haujlwm, antipeptide tuaj yeem thaiv txoj hauv kev androgen signaling thiab inhibit qhov kev loj hlob thiab kis ntawm cov qog nqaij hlav qog nqaij hlav. Nws cov qauv molecular tshwj xeeb thiab ntau pawg ua haujlwm ua lub luag haujlwm tseem ceeb hauv nws txoj haujlwm lom neeg thiab cov tshuaj pharmacological. Cov yam ntxwv no ua rau Antipeptide yog cov tshuaj kho tau zoo siv dav hauv kev kho mob qog noj ntshav prostate.
Antid yog ib qho tshuaj tseem ceeb nrog kev siv dav hauv kev lag luam kws tshuaj. Yog li, nyob rau hauv cov teb twg yog Antipeptide dav siv? Kab lus no yuav qhia koj txog ntau qhov chaw thov ntawm Antipeptide.
Ua ntej, Antipeptide yog dav siv nyob rau hauv kev loj hlob. Nws yog gonadotropin- tso tawm cov tshuaj hormones (GnRH) antagonist uas tuaj yeem siv los kho qee qhov gonadotropin- ntsig txog kab mob thiab cov tsos mob. Piv txwv li, Antipeptide tuaj yeem siv rau hauv kev pabcuam kev ua menyuam yaus (ART) kev kho mob los pab tswj kev ua haujlwm ntawm zes qe menyuam, txhawb kev loj hlob ntawm oocyte, thiab pab txhawb cov txheej txheem ovulation. Tsis tas li ntawd, Antipeptide tuaj yeem siv los kho qee yam gonadotropin- cov kab mob nyob hauv, xws li polycystic zes qe menyuam syndrome (PCOS) thiab endometriosis.
Qhov thib ob, Antipeptide kuj muaj cov ntawv thov tseem ceeb hauv kev kho mob qog. Nws yog siv los ua tshuaj tiv thaiv estrogen thiab tuaj yeem siv los kho qee cov tshuaj estrogen receptor zoo mob qog noj ntshav thiab qog noj ntshav ntawm zes qe menyuam. Antipeptide ua tiav cov txiaj ntsig kho mob los ntawm inhibiting qhov kev txiav txim ntawm estrogen, thaiv kev loj hlob thiab faib cov qog hlwb. Qhov no ua rau cov tshuaj antipeptide yog ib qho kev xaiv tshuaj tseem ceeb rau kev kho mob ntawm cov neeg mob qog noj ntshav thiab qog noj ntshav ntawm zes qe menyuam.
Tsis tas li ntawd, Antipeptide kuj tau siv rau hauv kev tshawb fawb thiab kev kho mob hauv lwm qhov chaw. Piv txwv li, nws yuav muaj peev xwm siv tau rau hauv kev kho mob ntawm cov kab mob prostate, xws li prostate hyperplasia thiab prostate cancer. Tsis tas li ntawd, Antipeptide tau kawm los kho cov kab mob endocrine xws li polycystic zes qe menyuam syndrome thiab endometriosis.
Hauv cov ntsiab lus, Antipeptide muaj ntau daim ntawv thov hauv kev lag luam kws tshuaj. Nws yog dav siv nyob rau hauv lub teb ntawm kev yug me nyuam rau kev pab kho cov me nyuam technology thiab kev kho mob ntawm gonadotropin- nyob rau hauv cov kab mob. Tsis tas li ntawd, antipeptide kuj tseem ua lub luag haujlwm tseem ceeb hauv kev kho mob qog noj ntshav, tshwj xeeb tshaj yog nyob rau hauv cov tshuaj estrogen receptor zoo mob qog noj ntshav mis thiab cov neeg mob qog noj ntshav ntawm zes qe menyuam. Tsis tas li ntawd, Antipeptide tau qhia txog qhov muaj txiaj ntsig zoo hauv kev tshawb fawb thiab kev coj ua hauv lwm qhov chaw.
Antid, tseem hu ua Iturelix los yog Orf 23541, yog ib qho tshuaj tseem ceeb ntawm cov tshuaj uas nws lub luag haujlwm tseem ceeb nyob hauv nws txoj haujlwm ua gonadotropin - tso cov tshuaj hormone (GnRH) antagonist.
Mechanism ntawm kev ua
Antipeptide sib tw khi rau GnRH receptor nyob rau hauv lub anterior pituitary caj pas, yog li thaiv kev tso tawm ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH) induced los ntawm GnRH. Cov txheej txheem ntawm kev ua haujlwm no ua rau Antipeptide muaj txiaj ntsig zoo hauv kev tswj hwm cov tshuaj hormones gonadal. Tshwj xeeb, Antipeptide tuaj yeem cuam tshuam cov lus teb ntawm lub qog pituitary anterior rau GnRH, ua rau txo qis ntawm LH thiab FSH, uas cuam tshuam rau kev ua haujlwm ntawm gonads.
Pharmacokinetic zog
Cov tshuaj pharmacokinetic ntawm Antipeptide hauv vivo txiav txim siab lub sijhawm thiab kev siv ntawm nws cov tshuaj ua haujlwm. Feem ntau hais lus, Antipeptide tuaj yeem nqus tau sai thiab ncav cuag qhov siab tshaj plaws plasma concentration tom qab kev tswj hwm. Nws lub ntim ntim yog me me, qhia tias cov tshuaj feem ntau yog faib rau hauv cov ntshav thiab cov ntaub so ntswg. Txoj kev metabolic ntawm Antipeptide tsis nkag siab tag nrho, tab sis nws paub tias metabolized thiab tawm los ntawm daim siab thiab ob lub raum.
Hauv kev sim tsiaj, kev tswj hwm ntawm Antipeptide feem ntau yog txhaj tshuaj subcutaneous, nrog ntau npaum li cas ntawm 1 txog 15 milligrams ib kilogram. Cov txiaj ntsig kev sim tau pom tias Antipeptide tuaj yeem ua rau lub sijhawm ntev - tshuaj castration nyob rau hauv cov laus txiv neej nas thiab roob ris noj liab, tshwm sim los ntawm koob tshuaj - nyob ntawm inhibitory cuam tshuam rau cov ntshav LH (tsuas yog nas) thiab testosterone ntau ntxiv, nrog rau qhov hnyav ntawm cov qog ntshav, prostate, thiab cov kab mob hauv lub cev. Ntawm cov koob tshuaj ntau dua, cov nas tau ua tiav tsis tu ncua castration zoo li cov teebmeem, thaum nyob hauv roob ris noj liab, tsuas yog cov koob tshuaj siab tshaj plaws ua rau lub sijhawm ntev inhibitory, tab sis nrog lub sijhawm luv dua.
Ntxiv rau nws cov teebmeem neuroprotective,tshuaj tiv thaivkuj tseem muaj peev xwm tiv thaiv - cov khoom inflammatory. Nws muaj peev xwm suppress zus tau tej cov pro- inflammatory cytokines thiab chemokines, yog li txo o nyob rau hauv ntau yam ntaub so ntswg. Qhov kev tiv thaiv no - qhov ua rau mob yog qhov tshwj xeeb tshaj yog nyob rau hauv cov kab mob autoimmune thiab cov kab mob inflammatory, qhov uas mob ntau dhau ua rau cov ntaub so ntswg puas thiab kab mob.
Multifaceted kev ua ntawmtshuaj tiv thaivua kom nws yog tus neeg sib tw txaus nyiam rau kev txhim kho cov kev kho tshiab. Nws lub peev xwm los tsom ob leeg neuronal thiab lub cev tiv thaiv kab mob muaj qhov tshwj xeeb zoo hauv kev kho cov kab mob nyuaj uas cuam tshuam nrog neuroinflamation thiab neurodegeneration. Kev tshawb fawb tsis tu ncua yog txhawm rau qhia ntxiv txog cov txheej txheem hauv qab cov teebmeem thiab tshawb nrhiav nws lub peev xwm hauv kev siv tshuaj kho mob.
Kev phiv tshuaj
Raws li cov tshuaj uas yuav tsum tau txhaj tshuaj, Antide tuaj yeem ua rau liab, o, mob, lossis khaus ntawm qhov chaw txhaj tshuaj. Cov tshuaj tiv thaiv no feem ntau yog hauv zos thiab mob me me, tab sis tuaj yeem cuam tshuam rau tus neeg mob txoj kev noj tshuaj.
Txawm hais tias tsis tshua muaj, txhua yam tshuaj muaj peev xwm ua rau muaj kev fab tshuaj. Antide tej zaum yuav ua rau pob khaus, khaus, urticaria, thiab txawm hnyav anaphylactic shock. Cov neeg mob uas tsis haum rau GnRH lossis cov tshuaj zoo sib xws muaj kev pheej hmoo siab dua.
Txo cov tshuaj estrogen: Antide tuaj yeem txo cov tshuaj estrogen sai sai los ntawm inhibiting qhov tso tawm ntawm gonadotropins. Qhov no tuaj yeem ua rau muaj cov tsos mob zoo ib yam li thaum cev xeeb tub, xws li kub kub, tawm hws hmo ntuj, qhov chaw mos qhuav, kev xav hloov pauv, mob taub hau, lossis qaug zog.
Bone density changes: Long term use of GnRH antagonists may affect bone density, increase the risk of osteoporosis or fractures, especially in cases requiring long-term treatment.
Kev hloov pauv hnyav: Qee tus neeg mob yuav muaj qhov hnyav nce lossis poob, uas tuaj yeem cuam tshuam nrog kev hloov pauv hauv cov tshuaj hormones lossis metabolic tus nqi.
Dyslipidemia: Txo cov tshuaj estrogen tuaj yeem cuam tshuam rau lipid metabolism, ua rau muaj cov roj cholesterol lossis triglyceride ntau ntxiv thiab muaj kev pheej hmoo ntawm cov kab mob plawv.
Kev siv lub sij hawm ntev los yog ib tus neeg rhiab heev tuaj yeem ua rau kiv taub hau, pw tsis tsaug zog, lossis kev xav hloov pauv, xav tau kev saib xyuas ze.
Menstrual disorders: Cov poj niam cov neeg mob tej zaum yuav muaj kev coj khaub ncaws tsis tu ncua, amenorrhea, los yog uterine los ntshav txawv txawv.
Ovarian hyperstimulation Syndrome (OHSS): Hauv kev pabcuam kev ua menyuam yaus, GnRH antagonists tuaj yeem ua rau muaj kev pheej hmoo ntawm OHSS, tshwm sim los ntawm zes qe menyuam, mob plab, mob plab lossis ua kua dej.
Cim npe nrov: Antide CAS 112568-12-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom