Triptorelin peptide cas 57773-63-4

Triptorelin Peptide, tseem hu ua Lupron, yog cov khoom siv hluavtaws tau zoo sib xyaw nrog lub ntsej muag zoo nkauj ntawm {}}}} nws yog soluble heev hauv dej, thiab nws Aqueous kev daws teeb meem nrog pka ntawm {{} Nws muaj qhov ntsuas hluav taws xob muaj ntau yam nyob hauv ib nrab ntawm cov neeg ua haujlwm ntawm Triptorelin yog qhov tseem ceeb rau nws kev ruaj khov. Nyob rau hauv kev daws, nws tsis yooj yim rau cov kev ua haujlwm ntawm lub cev, ua rau kom tau txais kev sib pauv ntawm lub cev, ua rau kom tau txais kev sib pauv ntawm lub cev, ua rau kom tau txais kev hloov kho cov tshuaj tiv thaiv kab mob qog noj ntshav, ua rau kom tau txais kev hloov kho cov tshuaj tsw qab ntawm cov paib hloov kho thiab ua rau lub zais cia ntawm Gonadotropins.}}}} aginity nrog lub ntsej muag zoo nkauj ntawm lub zes qe menyuam yaus thiab kev sim ua ntej, txo cov kev zais cia ntawm kev sib deev cov tshuaj hormones .

Triptorelin Peptideyog ib qho tshuaj lom neeg peptide nrog cov qauv tshuaj lom neeg zoo ib yam li kev ua haujlwm ntawm kev ua me nyuam, GNTE . Cov ncauj lus hauv qab no yog cov ncauj lus qhia ntxaws ntxaws ntawm nws lub hom phiaj:

Cov ntawv thov kev kho mob ua rau kev kho mob kheesxaws prostate

 

Prostate tshwj xeeb antigen (Psa) yog ib qho kev tshawb fawb postatory}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Cov khoom siv hauv prostate theem hauv cov neeg mob qog nqaij hlav prostate. Cov neeg mob ua kom cov neeg mob siab tshaj tawm (xws li 10 tus neeg mob prostorate (xws li siv prostorate) et6 {{{{{}}), mob pob txha (xws li kev kho mob bostorction}} kho nrog triptorelin peptide tsom nrhiav qhov tseem ceeb hauv cov tsos mob mob mob mob.

Txuas ntxiv txoj sia nyob thiab txo qhov kev pheej hmoo ntawm cov qog rov ua dua

 

Triptorelin Peptide kev kho mob tuaj yeem nthuav tawm cov neeg mob bostorelin pepting. Txoj Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Lub Neej Nag Hlis los ntawm cov neeg mob prostorelin Tau txais Triptorelin Peptide Kev Kho Mob Castration yog kwv yees li ntawm cov neeg mob tseem ceeb {}} Txawm li cas los xij, qee tus neeg mob tseem ceeb, tuaj yeem txo qhov kev pheej hmoo ntawm qog rov muaj dua . Piv txwv li cov neeg mob prostorelin muaj kwv yees li 15% siab dua li cov uas tsis tau txais kev kho mob khuav rau tom qab 15%

Daim ntawv thov nyob rau hauv kev kho mob ntawm endometrisosis

 

Cov kev kho mob triptorin peptide tuaj yeem ua rau cov kev mob siab rau cov neeg mob Zoo dua li ntawm cov pab pawg placebo. Kev kuaj mob hauv qab no (MRI) Cov neeg mob endometriosis muaj kev pab metorility, txo cov kev kawm tau zoo, thiab nce ntxiv) tau nce ntxiv tom qab kev ua haujlwm nrog Triptorelin peptide .

Daim ntawv thov nyob rau hauv kev kho mob ntawm uterine fibroids

 

Triptorelin peptide treatment can significantly reduce the volume of uterine fibroids. Generally speaking, after 3-6 months of treatment, the volume of fibroids can shrink by 30% -50%. The reduction of fibroid volume can alleviate pressure on surrounding tissues and alleviate related Cov tsos mob . rau cov neeg mob uas muaj kev coj khaub ncaws ua kom tsis txhob muaj sia, txhim kho kev coj noj coj ua tsis zoo thiab ua haujlwm rau kev kho mob. Txo Fibroid Volume, txo qis zog Pelvic, qis dua kev phais mob thiab kev phais mob siab, lossis kev phais mob hnyav ntawm kev phais mob thiab kev ua tiav ntawm kev phais mob.

Muaj ntau cov lus piav qhia ntawm txoj kev sim rau cov synthesis ntawmTriptorelin Peptidenyob rau hauv cov ntawv .}} Nyob rau hauv cov lus hauv qab no, peb yuav qhia ib qho ntawm cov khoom no hauv kev kuaj xyuas qhov no.

Cov kev sim tshwj xeeb yog raws li hauv qab no:

{{01. synthesis ntawm2- bromo-4- aminobenzoate Ethyl Ester

Ntxiv Ethyl 2- bromo {{1,}}}}}} econia dej (30mL) {14 {14} {14}. Tom qab cov tshuaj tiv thaiv ua tiav, ncuav cov tshuaj tiv thaiv ua cov dej khov, thiab kom muaj cov xim tsis muaj zog ntawm {}}}}}}}}

{{02. synthesis ntawm2- bromo-4-} (2 '- pyridyl) Byrzoyl Chloride

Hauv ib 500ml peb lub caj dab nruab nrog tus pas ntsuas kub, thiab tshuaj tua kab mob, tom qab ntawd kom txog thaum yaj, ces (10G, 0 . 25ml) ((20ml) () {{{} {132- bromo-4-}} paked lub raj mis, cua sov {19} pyridinecarboxylate (18g, 0 {{{{}} 1Mol), Cua sov} Tom qab muaj cov tshuaj tiv thaiv, thiab tau txais kev tawm tsam nrog {}}} (2 {- pyridyl) benzoate (30g) {{{{{{{{{{{{{}}}}}}}}}}}}}}} Reflux rau 3 teev. Tom qab cov tshuaj tiv thaiv tiav, ncuav cov tshuaj tiv thaiv ua cov dej khov thiab rho tawm nrog ether. Thanpill thiab rov qab los Etaws thiab Dichhloromethane Tom qab ua kom qhuav, thiab tau txais cov leb tsis muaj kua rau ntawm {}} (2 '- pykyl) byridyl) byraigyl) byroride benloride (27g). Melting taw tes: {66-68 degree.

3.} shatthetic triptorelin

Ntxiv 2- bromo -4- 0,}} 0, {}} 0 {}}} kub txog thaum yaj, tom qab ntawd ntxiv n-ethyl {{}} {} {}}}}. Tom qab ziab, distill thiab rov qab mob Tetranyydrofuran thiab ether, sau cov zauv feem ntawm165-167} degree, thiab tau txais dawb triptorelin (16G). Melting taw tes: 168-171 degree.

Triptorelin Peptideyog ib qho tshuaj tiv thaiv kab mob antipsychotic, thiab nws cov tshuaj papaconinetics tsuas yog suav cov txheej txheem xws li kev nqus, xa, cov metabolism, thiab ua kom zoo nkauj .

1.}}} nqus:

Tom qab kev tswj hwm tom qab, Triptorelin tau nrawm nrawm nrawm, tab sis nws tsis cuam tshuam rau qhov kev nqus ntawm lub siab, tab sis nws tsis muaj peev xwm ua kom muaj kev nqus dej num tag nrho, tsim cov metabolites ntau {}}

2. faib khoom:

Triptorelin tau faib dav hauv lub cev, nrog rau cov ntshav siab txog li 83% nrog cov ntshav siab}}}}}}}}.

3. metabolism:

Triptorelin feem ntau yog metabolized nyob rau hauv daim siab los ntawm CYR3A4 enzyme system {} HTTUSTYRTORSORRTORY thiab} HTTUSTOR anti} HTTEPTOR antagonisting {{}}

4. excretion:

Lub excretion ntawm Triptorelin feem ntau yog los ntawm cov zis, kev suav nyiaj txog li 73%, nrog feem ntau yog cov tshuaj metabbites {% ntawm cov tshuaj tau tawm los ntawm kev quav {}}

5. ib nrab lub neej:

Ib nrab-lub neej ntawm triptorelin yog {{1} {}} Yog li ntawd, triptorelin yog {}}

Cim npe nrov: Triptorelin Peptide Cas 57773-63-4, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag