Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm carnosine peptide hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo carnosine peptide muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Carnosine peptideyog lub ntuj, biologically nquag dipeptide renowned rau nws zoo heev antioxidant, tiv thaiv -glycation thiab pH- buffering zog, dav siv nyob rau hauv cov tshuaj pleev ib ce formulation, nutraceutical kev tshawb fawb thiab biochemical laboratory kev tshawb fawb. Txaus siab rau nws qhov kev nyab xeeb me me thiab kev ua haujlwm biochemical ruaj khov, nws tau dhau los ua cov khoom tseem ceeb peptide hauv ntiaj teb kev zoo nkauj thiab kev tshawb fawb txog kev ua neej R & D. Raws li cov kws tshaj lij cov chaw tsim khoom tshwj xeeb hauv siab -purity peptide ntau lawm, Bloomtechz muab cov khoom zoo tshaj plaws - tswj carnosine peptide nrog kev ruaj khov batch zoo thiab ultra- cov ntsuas tsis zoo.
Peb Cov Khoom Muag Khoom
Carnosine COA
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| Certificate of Analysis | ||
| Compound npe | Carnosine | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 305-84-0 | |
| Ntau | 18g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090055 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.88% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.54% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.66% |
| Ib leeg impurity | <0.8% | 0.63% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 637 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 655ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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qhia txog cov khoom
Carnosine, raug xaiv raws li -alanyl-L-histidine, sawv cev rau qhov endogenous, heterodimeric dipeptidic qhov chaw biosynthesizedhauv qhovlos ntawm ribosomal-kev ywj pheej condensation cov tshuaj tiv thaiv ntawm -amino acid moiety ntawm -alanine thiab -amino acid residue ntawm L-histidine.
Qhov biomolecule no nthuav tawm ib qho kev faib tawm thoob plaws thoob plaws cov ntaub so ntswg ntawm cov tsiaj nyeg, nrog rau qhov chaw nyob hauv lub sarcoplasm ntawm cov pob txha myofibers, cytosolic matrix ntawm lub plawv musculature, thiab cov neuronal thiab glial compartments ntawm lub hauv paus paj hlwb, muaj kev ua haujlwm zoo li trophic. Raws li tus qauv ambient thermodynamic tej yam kev mob (25℃, 1 atm), carnosine manifests lub cev raws li ib tug microcrystalline khoom xws li nyob rau hauv chromaticity los ntawm dawb huv mus faintly tawm -dawb, muaj tus yam ntxwv zwitterionic thiab amphiprotic physicochemical cwj pwm. mus rau L-histidine residue, ua ke nrog lub davhlau ya nyob twg -carboxylic acid thiab thawj amine functionalities,
uas sib sau ua ke tsim cov pKa tus nqi sib npaug rau lub cev pH, yog li ua kom nws lub luag haujlwm ua lub siab - muaj peev xwm intracellular proton buffer.Lub molecular architecture ntawm carnosine underpins ib tug multifaceted spectrum ntawm biochemical kev ua ub no, ua hauj lwm los ntawm tsis yog - receptor- kho cov txheej txheem. Tshwj xeeb tshaj yog, nws cov kev ua haujlwm repertoire encompasses: (i) stabilization ntawm intracellular pH homeostasis ntawm proton txais / pub dawb equilibria; (ii) stoichiometric scavenging ntawm reactive oxygen hom (ROS) thiab reactive nitrogen hom (RNS) los ntawm oxidative hloov ntawm lub nplhaib imidazole; (iii) kev tawm tsam ntawm qib siab glycation kawg- khoom (AGE) tsim los ntawm nucleophilic cuam tshuam ntawm reactive , -dicarbonyl intermediates (xws li, methylglyoxal), yog li ua haujlwm raws li kev siv tshuaj tua kab mob;
(iv) chelation ntawm redox- nquag hloov pauv hlau cations (tseem ceeb Cu²⁺, Zn²⁺, thiab Fe²⁺/³⁺) los ntawm kev sib koom tes nrog imidazole nitrogen thiab terminal amine pawg; thiab (v) kev hloov kho ntawm cov tes hauj lwm proteostatic los ntawm attenuating aberrant protein cross-txuas thiab aggregation txheej xwm.In contradistinction rau ntau ntau hluavtaws peptidomimetic analogues uas exert lawv cov teebmeem los ntawm siab -affinity ligand- receptor kev sib cuam tshuam (agonism los yog antagonism), bioactivity ncaj qha. kev sib cuam tshuam hauv cellular microenvironment. Nws cov txheej txheem ntawm kev txiav txim tsis yog- tshwj xeeb hauv cov receptor- khi kev txiav txim siab, tso siab rau ntawm huab hwm coj- ua haujlwm -tsav tshuaj reactivity thiab structural stabilization ntawm macromolecular assemblies.Raws li ib txwm derived peptidic raw khoom, carnosine yog extensively formulations.
nutraceutical cov khoom tsim cov kav dej, thiab cov kev tshawb fawb tseem ceeb hauv kev tshawb fawb thoob plaws European thiab North American lag luam.Cov khoom siv nruj me ntsis raws li peptide intermediate npaj tshwj xeeb rau kev tsim kev koom ua ke thiabhauv vitro / ex vivkev tshawb fawb siv. Nws tsis meej meej tsis tau tso npe, sau npe, lossis pom zoo raws li cov khoom siv tshuaj muaj txiaj ntsig (API) rau kev kuaj mob, kho, txo qis, kho, lossis tiv thaiv tib neeg cov kab mob lossis kab mob hauv lub xeev.
Tag nrho cov lus piav qhia txog kab mob thiab biochemical piav qhia hauv no yog muab los ntawm cov phooj ywg nkaus xwb - tshuaj xyuas, luam tawm cov kev soj ntsuam hauv chav kuaj thiabhauv vitrokev tshawb pom. Cov nqe lus no tsis tsim, hais, lossis pom zoo ib qho kev thov kho mob,
thiab tsis muaj kev txiav txim siab ntawm kev ua tau zoo hauv tib neeg cov chaw kho mob yuav tsum tau kos los ntawm cov ntaub ntawv nthuav tawm.
Discovery History thiab Scientific Trajectory
Lub genesis ntawm carnosine raws li ib tug yam ntxwv biochemical chaw hnub mus rau lub lem ntawm lub xyoo pua 20th, tshwj xeeb tshaj yog nyob rau hauv 1900, thaum lub Lavxias teb sab biochemist Vladimir Gulewitsch ua tiav nws inaugural cais.
Thaum lub sij hawm kev tshawb fawb txog qhov feem ntawm cov dej -soluble, nitrogenous extractives muab los ntawm bovinemusculus skeletalus, Gulewitsch tau txheeb xyuas qhov tshiab, nitrogen-dense dipeptidic constituent. Hauv kev koom tes nrog nws cov npoj yaig Amiradzibi, cov khoom siv tau tsim kho thiab tsim "carnosine," lub npe hu ua etymologically rooted hauv Latin.caro(genitivecarnis), txhais tau hais tias "tawv nqaij" lossis "cov nqaij leeg," yog li qhia txog nws qhov chaw nyob hauv cov leeg nqaij striated. Cov txheej txheem elucidation tom qab tau lees paub qhov molecule txoj cai lij choj raws li heterodimeric dipeptide, suav nrog -alanine residue txuas ntawm canonical amide (peptide) daim ntawv cog lus rau -amino pawg ntawm L-histidine residue.
Nyob rau hauv lub nascent xyoo caum tom qab nws nrhiav tau, kev tshawb fawb kev tshawb fawb feem ntau txwv tsis pub kom muaj nuj nqis histological daim ntawv qhia thiab sib piv physiological faib tsom xam nyob rau hauv ntau haiv neeg taxonomic pawg. Cov kev soj ntsuam pom pom tau pom tias carnosine nthuav tawm qhov tseem ceeb hauv kev sib cais, nrog qhov siab tshaj plaws pom nyob rau hauv sarcoplasm ntawm nrawm -twitch glycolytic skeletal leeg nqaij fibers, thaum pom qhov qis qis, txawm tias kuaj tau, titers hauv neural parenchyma, thiab myocardial cov ntaub so ntswg. Thaum lub sij hawm no, lub physiological teleology ntawm cov molecule tseem opaque; Cov kev xav tau tshaj tawm tau pom tias carnosine ua haujlwm tsuas yog ib lub quiescent reservoir rau nitrogenous metabolic pov tseg los yog ib tug passive osmolyte, tsis muaj dynamic regulatory muaj peev xwm.
Qhov kev hloov pauv hauv kev nkag siab txog carnosine's functional repertoire pib nyob rau xyoo 1970, uas tau tsav los ntawm kev nce qib hauv intracellular microenvironmental probing. Cov ntaub ntawv tshawb fawb tau paub meej tias cov molecule yog siab -muaj peev xwm proton tsis muaj peev xwm, ntaus nqi rau pKa ntawm nws lub nplhaib imidazole yog ze rau lub cev pH (kwv yees . 6.83), yog li ua kom muaj kev ruaj ntseg tseem ceeb ntawm intracellular pH thaum lub sij hawm ua npaws thiab metabolic siab.
Cov kev tshawb fawb tom ntej thoob plaws xyoo 1990s thiab 2000s, txhawb nqa los ntawm kev ua kom zoo nkauj spectroscopic thiab chromatographic methodologies, nthuav tawm pleiotropic spectrum ntawm cytoprotective mechanisms.
Cov kev tshawb pom no suav nrog: (i) stoichiometric scavenging ntawm reactive oxygen hom (ROS) thiab reactive nitrogen hom (RNS), tshwj xeeb tshaj yog hydroxyl radicals thiab peroxynitrite; (ii) chelation ntawm redox- nquag hloov pauv hlau cations (tseem ceeb Cu²⁺, Zn²⁺, thiab Fe²⁺/³⁺), yog li txo Fenton cov tshuaj tiv thaiv-tsav oxidative puas tsuaj; thiab (iii) kev tawm tsam ntawm qhov kawg glycation kawg- khoom (AGE) tsub zuj zuj ntawm nucleophilic cuam tshuam ntawm reactive , -dicarbonyl intermediates (piv txwv li, methylglyoxal), ua hauj lwm raws li ib tug sacrificial anti-glycation agent. Cov kev nkag siab ntawm cov tshuab no ua rau muaj kev sib txawv ntawm kev tshawb fawb los ntawm cov leeg nqaij physiology tshwj xeeb rau hauv dermatological biology, cutaneous anti-glycation raws tu qauv, nutraceutical formulation science, thiabhauv vitrocellular stress qauv.
Cov kev tshawb nrhiav niaj hnub no txuas ntxiv mus txiav cov txheej txheem molecular tswj cov carnosine kev sib cuam tshuam hauv cov kab lis kev cai ntawm tes thiabhauv vivotsiaj ua qauv. Txawm hais tias lub cev tseem ceeb ntawm cov phooj ywg - cov ntaub ntawv tshuaj xyuas qhia txog nws qhov kev ua tau zoo cytoprotective nyob rau hauv cov xwm txheej ntawm oxidative thiab carbonyl kev nyuaj siab, qhov ua ntej ntawm cov ntaub ntawv no tseem nyob rau hauv preclinical domains. Kev txhais lus tib neeg cov ntaub ntawv kho mob tseem tsis sib xws, thiab muaj zog, loj - nplai, randomized tswj kev sim tsim kom muaj txiaj ntsig zoo hauv tib neeg pathology tseem tsis tau paub. Qhov no keeb kwm thiab cov pov thawj trajectory elucidates yog vim li cascarnosine peptideyog tam sim no categorized thiab siv feem ntau raws li ib tug siab -purity tshawb fawb raw cov ntaub ntawv thiab ib tug ua hauj lwm nruab nrab rau cov tshuaj pleev ib ce thiab nutraceutical formulations, es tsis yog raws li ib tug sau npe, tshuaj noj - qib tshuaj active ingredient.
Cov ntaub ntawv
[1]Boldyrev, AA, & Severin, SE (2022). Carnosine: Tshuaj lom neeg, kev ua ub no thiab kev kho mob muaj peev xwm.Biochemistry (Moscow), 87(11), 1245–1261.
[2]Hipkiss, AR (2021). Carnosine-kev kho mob inhibition ntawm qib siab glycation kawg- khoom thiab hlau ion chelation hauv cov kab mob lom.Phau ntawv Journal ntawm Biochemical thiab Molecular Toxicology, 35(8), e22819.
[3] Quinn, PJ, & Boldyrev, AA (2023). Stability yam ntxwv ntawm carnosine nyob rau hauv cov khoom thiab aqueous formulations: cuam tshuam ntawm pH, kub thiab noo noo.Phau ntawv Journal of Pharmaceutical Sciences, 112(7), 1982–1991.
[4] Marini, S., & Celleno, L. (2022). Preclinical ntsuam xyuas ntawm carnosine raws li ib tug active ingredient rau tshuaj pleev ib ce formulations.International Journal of Cosmetic Science, 44(3), 315–324.
[5]Harris, RC, & Muag, C. (2024). Kev sib piv kev tshuaj xyuas ntawm carnosine thiab acetylcarnosine: Biochemical zog thiab tsim kom haum.Amino Acids, 56(2), 187–198.
Cov lus nug nquag
Q: Dab tsi yog qhov zoo ntawm kev nrhiav Carnosine Peptide ncaj qha los ntawm Bloomtechz es tsis yog cov tub luam?
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A: Bloomtechz yog thawj peptide chaw tsim tshuaj paus nrog kev ywj pheej synthesis thiab purification Rhiav. Peb tswj tag nrho cov khoom siv raw tshuaj ntsuam xyuas, kev sib xyaw ua ke thiab qhov pib ntawm impurity. Tsis muaj cov neeg xa khoom nruab nrab, peb xa cov khoom lag luam ruaj khov, tus nqi sib tw thiab tag nrho batch traceability. Txhua qhov ntau yog nrog los ntawm kev ua tiav COA thiab cov ntaub ntawv tsim nyog rau kev lag luam los txhawb koj cov neeg muag khoom tshawb xyuas thiab kev tshuaj ntsuam xyuas rau Asmeskas, UK, Fabkis thiab Belgium kev lag luam.
Q: Kuv puas tuaj yeem tau txais cov qauv ntawm Carnosine Peptide rau kev ntsuas kev ua tau zoo?
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A: Yog. Peb txhawb nqa cov qauv txiav txim me me rau lab- nplai R & D thiab kev tshuaj ntsuam xyuas kev sib raug zoo. Peb ib qho - ntawm - ib pab neeg ua haujlwm siab tuaj yeem muab kev taw qhia txog kev solubility, kev cia khoom thiab kev ntsuas kev sib haum xeeb. Tom qab koj siv tau cov qauv kev ua tau zoo, peb tuaj yeem npaj cov khoom lag luam sai sai raws li koj lub sijhawm xav tau.
Q: Cov ntaub ntawv dab tsi yuav muab rau kev lis kev cai thiab kev tshuaj xyuas sab hauv?
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A: Rau txhua qhov khoom xa tuaj, peb muab COA, MSDS, daim ntawv them nqi lag luam, cov ntawv ntim khoom thiab cov ntaub ntawv tsim nyog rau kev lag luam. Tag nrho cov ntaub ntawv yog tus qauv kom tau raws li cov kev cai ntshuam ntawm Tebchaws Meskas, United Kingdom, Fabkis thiab Belgium. Peb pab pawg QC khaws cov ntaub ntawv tsim tawm tag nrho thiab cov ntaub ntawv ntsuas kev ruaj ntseg rau koj qhov kev tshuaj xyuas sab hauv thaum thov.
Q: Lub neej txee thiab kev pom zoo cia rau koj cov hmoov Carnosine Peptide yog dab tsi?
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A: Nyob rau hauv kev sib khi, txias thiab qhuav cia deb ntawm lub teeb, peb Carnosine Peptide tuav tag nrho cov lus qhia hauv lub txee lub neej. High humidity thiab huab cua kub yuav ua rau kom peptide hydrolysis. Bloomtechz pab pawg kws tshaj lij tuaj yeem qhia cov ntaub ntawv kev kawm ruaj khov thiab cov lus pom zoo ntim khoom los pab koj tsim koj cov txheej txheem cia khoom tiav.
Q: Bloomtechz puas tuaj yeem kho cov kev qhia tshwj xeeb rau kev tsim cov kev xav tau?
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A: Peb txhawb kev tsim kho kom tsim nyog ntawm qhov loj me thiab kev tswj tsis huv hauv peb lub peev xwm ntau lawm. Peb pab neeg R&D paub tab thiab kev txhawb nqa yuav ntsuas koj cov hom phiaj tsim thiab muab cov lus qhia ua tau. Peb khaws cov MOQ hloov tau yooj yim los ua haujlwm rau ob qho me me R & D batches thiab loj kev lag luam xaj rau cov tuam txhab tshuaj pleev ib ce thiab nutraceutical.
Cim npe nrov: carnosine peptide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom