AOD 9604 hmoov CAS 221231-10-3

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm aod 9604 hmoov cas 221231-10-3 hauv Suav teb. Zoo siab txais tos rau cov lag luam wholesale bulk zoo aod 9604 hmoov cas 221231-10-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

AOD 9604 uar yog cov khoom siv peptide uas muaj qhov hnyav ntawm 5138.77 g / mol, CAS npe 221231-10-3, thiab cov mis mos molecular C₇₈H₁₂₃N₂₃O₂₃S₂. Nws qhov hnyav molecular hnyav tau muab cov ntaub so ntswg permeability zoo thiab muaj txiaj ntsig zoo rau kev nqus dej hauv ib puag ncig lom neeg, txhawb nqa nws lub peev xwm rau kev xa khoom zoo thiab kev ua haujlwm hauv lub cev. Cov khoom sib xyaw ua ke nthuav tawm cov yam ntxwv zoo solubility, yooj yim yaj hauv dej thiab ntau qhov chaw kuaj thiab tshuaj cov kuab tshuaj, thiab feem ntau yog tsim thiab muab los ua cov hmoov hmoov ruaj khov, uas yog rov tsim dua hauv kev daws ua ntej kev sim lossis kev siv tshuaj kho mob. AOD 9604 qhia tau hais tias muaj kev ruaj ntseg thermal, tso cai cia thiab tuav ntawm qhov ntsuas kub nruab nrab hauv qhov kev ua haujlwm tau hais tseg; Txawm li cas los xij, kev raug mob ntev heev rau qhov kub thiab txias tuaj yeem ua rau cov txheej txheem degradation thiab poob ntawm cov khoom lom lom tom qab. Nws kuj tseem tswj kev ruaj ntseg thoob plaws pH spectrum, khaws kev ua haujlwm zoo ntawm acidic rau alkaline tej yam kev mob, thiab tseem tiv taus degradation thiab deactivation nyob rau hauv aqueous ib puag ncig. Qhov profile ruaj khov no txhim kho nws qhov kev tsim nyog rau kev txhaj tshuaj, kev daws teeb meem, lossis lwm cov ntawv siv tshuaj, txhawb kev npaj thiab kev tswj hwm. Raws li cov txheej txheem crystallization tsim nyog, AOD 9604 tuaj yeem tsim cov qauv siv lead ua tau zoo, suav nrog ib leeg-crystal thiab polycrystalline morphologies, cov cuab yeej uas muaj txiaj ntsig zoo rau cov qauv kev ua haujlwm, kev txheeb xyuas qhov tseeb, thiab qee yam kev tshawb fawb. Biochemically, AOD 9604 yog cais raws li tib neeg txoj kev loj hlob hormone fragment, feem ntau piav raws li ib tug kho-hom los yog regenerative hGH fragment, muaj 44 sib law liag amino acid residues muab los ntawm lub C-terminal cheeb tsam ntawm haiv neeg txoj kev loj hlob hormone polypeptide saw.

AOD 9604 hmoov COA

TIAB SA 9604hmoovyog ib qho hluavtaws peptide compound. Lub npe tshuaj yog L-Phenylalanine. L - tyrosyl - L - leucyl - L - arginyl - L - isoleucyl - L - valyl - L - glutaminyl - L - L - arginyl - L - seryl - L - valyl - L - alpha glutamylglycyl - L -Seryl-L {{{{27gly}}Cyl, (7 → 14) -disulfide, nrog rau cov mis molecular C78H123N23O23S2 thiab molecular hnyav ntawm 1815.1. Cov nram qab no piav qhia txog nws cov khoom siv tshuaj lom neeg los ntawm ntau yam.

Kev ruaj ntseg thiab siv ceev faj

 

Cia tej yam kev mob

Rau luv- lub sij hawm cia (hauv ib lub hlis), nws tuaj yeem khaws cia ntawm -20℃. Rau kev khaws cia ntev, nws yuav tsum khaws cia ntawm -80℃hauv qhov txias txias thiab tsis txhob rov khov thiab thawing.

Kev npaj daws teeb meem

Nws raug nquahu kom yaj hauv dej tsis muaj menyuam rau kev txhaj tshuaj lossis physiological saline. Tom qab kev npaj, nws yuav tsum tau aliquoted thiab khaws cia kom tsis txhob hla- paug.

Kev ceev faj txog kev nyab xeeb

Cov hnab looj tes tiv thaiv thiab tsom iav yuav tsum tau hnav thaum lub sijhawm ua haujlwm kom tsis txhob nqus los yog tawv nqaij. Cov khib nyiab yuav tsum raug kho tsis raug mob raws li cov cai rau kev kho cov tshuaj reagents.

AOD 9604 hmoovyog ib qho tshuaj polypeptide nrog cov haujlwm tseem ceeb ntawm kev ua haujlwm lom neeg ntawm stimulating axunge breakdown thiab combustion, qhia tshwj xeeb zoo hauv kev poob phaus thiab tswj qhov hnyav. Cov nram qab no piav qhia meej los ntawm cov yam xws li cov txheej txheem ntawm kev nqis tes ua, kev sim pov thawj, thiab kev sib piv nrog cov txheej txheem.

 

 

Qhov cuam tshuam ntawm kev siv txoj kev thiab lub sij hawm ntawm qhov tshwm sim

AOD 9604 feem ntau yog siv rau hauv daim ntawv txhaj tshuaj thiab zoo tshaj plaws siv rau ntawm lub plab khoob thaum sawv ntxov. Thaum lub plab khoob thaum sawv ntxov, lub cev tseem tshaib plab heev. Lub sijhawm no, kev siv AOD 9604 tuaj yeem ua kom cov tshuaj nkag mus rau hauv cov hlab ntsha zoo dua thiab siv tau tam sim ntawd. Nyob rau lub sijhawm no, lub cev cov metabolism hauv lub cev tseem ua haujlwm ntau dua, thiab cov tshuaj muaj peev xwm ua kom muaj zog axunge tawg thiab hlawv.

Yog tias nws raug xaiv los siv rau lwm lub sijhawm, xws li tom qab noj mov, kev zom zaub mov thiab kev nqus ntawm cov zaub mov tuaj yeem cuam tshuam rau kev nqus thiab kev siv ntawm cov tshuaj. Tsis tas li ntawd, tom qab noj mov, cov ntshav qab zib hauv lub cev nce thiab kev tso tawm ntawm insulin nce. Insulin muaj cov txiaj ntsig ntawm inhibiting axunge tawg, uas tuaj yeem ua rau tsis muaj zog stimulating nyhuv ntawm AOD 9604 ntawm axunge tawg.

 

 

Synergistic Effects nrog lwm yam tshuaj

AOD 9604 tseem tuaj yeem muaj kev sib koom ua ke nrog lwm cov tshuaj hauv kev txhawb nqa axunge tawg thiab hlawv. Piv txwv li, thaum ua ke nrog kev tawm dag zog, kev tawm dag zog tuaj yeem ua rau lub cev xav tau lub zog thiab txhawb nqa kev siv oxidative ntawm cov rog dawb. Cov fatty acids dawb tso tawm los ntawm AOD 9604, uas txhawb nqa axunge tawg, tuaj yeem ua tau raws li qhov xav tau ntawm lub zog thaum lub sijhawm ua haujlwm, yog li txhim kho cov txiaj ntsig ntawm kev poob phaus.

Tsis tas li ntawd, qee cov khoom xyaw poob phaus, xws li tshuaj yej ntsuab extract thiab caffeine, kuj muaj qee yam cuam tshuam rau kev txhawb nqa axunge metabolism. Thaum siv ua ke nrog AOD 9604, lawv yuav ua rau muaj kev sib koom ua ke, ntxiv dag zog rau cov nyhuv ntawm axunge tawg thiab hlawv. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias thaum siv cov tshuaj no, cov txheej txheem tshawb fawb thiab tsim nyog yuav tsum tau ua raws li kom tsis txhob muaj kev phiv los ntawm kev siv ntau dhau.

 

 

Kev nyab xeeb thiab muaj peev xwm txaus ntshai

Txawm hais tias AOD 9604 qhia tau hais tias muaj txiaj ntsig zoo hauv kev txhawb nqa axunge tawg thiab hlawv, nws tam sim no tsuas yog siv rau kev tshawb fawb txog kev tshawb fawb thiab tsis pom zoo rau kev siv ncaj qha rau tib neeg lub cev. Thaum ua kev tshawb fawb nrog AOD 9604, nws yog ib qho tsim nyog yuav tsum ua raws li cov cai tswj kev nyab xeeb thiab cov txheej txheem ua haujlwm kom ntseeg tau tias muaj kev nyab xeeb ntawm cov neeg ua haujlwm hauv chav kuaj.

Vim tias cov txheej txheem ntawm kev ua ntawm AOD 9604 yog qhov nyuaj heev, nws yuav muaj qee yam cuam tshuam rau cov kab mob endocrine ntawm lub cev, thiab lwm yam. Yog tias nws siv tsis pom kev ntawm tib neeg lub cev yam tsis muaj kev tshawb fawb thiab tshuaj xyuas, nws yuav ua rau qee qhov kev pheej hmoo, xws li kab mob endocrine thiab lub cev tsis muaj zog. Yog li ntawd, ua ntej siv nws rau tib neeg lub cev, ntau qhov kev sim tshuaj thiab kev ntsuas kev nyab xeeb yuav tsum tau ua.

AOD 9604 hmoovyog ib yam khoom peptide ntsig txog kev loj hlob hormone (GH), uas tau pom muaj peev xwm siv tau tus nqi hauv kev tswj axunge metabolism thiab lwm yam. Kev loj hlob hormone activates ib tug series ntawm signaling txoj kev los ntawm khi rau txoj kev loj hlob hormone receptor (GHR) nyob rau saum npoo ntawm lub hom phiaj hlwb, yog li tswj ntau yam physiological dab xws li kev loj hlob, kev loj hlob, thiab metabolism hauv lub cev. GH receptor binding domain yog ib cheeb tsam tseem ceeb rau kev sib cuam tshuam ntawm GH thiab GHR, thiab kev ruaj ntseg thiab tshwj xeeb ntawm nws cov kab ke thiab cov qauv yog qhov tseem ceeb rau kev ua haujlwm ntawm lub cev. Lub hnub nyoog dej khov yog lub caij txias heev hauv ntiaj teb keeb kwm, thaum cov tsiaj tau ntsib teeb meem ib puag ncig hnyav xws li kev txias txias thiab khoom noj khoom haus tsawg hauv lawv qhov kev hloov pauv mus ntev -. Txhawm rau hloov mus rau qhov chaw tshwj xeeb no, tsiaj txhu thaum lub caij ntuj sov muaj kev hloov pauv loj hauv physiology, morphology, thiab tus cwj pwm. GH system, uas yog ib qho tseem ceeb rau kev tswj hwm lub cev kev loj hlob thiab cov metabolism, zoo li yuav tau ua lub luag haujlwm tseem ceeb hauv kev hloov pauv hloov pauv ntawm cov tsiaj muaj hnub nyoog dej khov. Yog li ntawd, kev kawm txog qhov sib txawv ntawm qhov sib txawv ntawm GH receptor binding domains hauv cov tsiaj muaj hnub nyoog dej khov tuaj yeem pab nthuav tawm cov kev hloov pauv ntawm cov tsiaj hauv ib puag ncig huab cua thiab tseem pab txhawb rau kev txhim kho GH raws li tshuaj.

Cov ntaub ntawv tshawb fawb
Xaiv cov neeg sawv cev glacial thiab tsis glacial tsiaj raws li kev tshawb fawb. Cov tsiaj muaj hnub nyoog dej khov muaj xws li cov tsiaj txhu uas ploj lawm xws li mammoths, woolly rhinoceroses, thiab qhov tsua bears (uas cov ntaub ntawv muaj feem cuam tshuam tau los ntawm DNA thev naus laus zis qub), nrog rau cov tsiaj uas twb muaj lawm hloov mus rau qhov chaw txias xws li polar bears thiab reindeer; Cov tsiaj uas tsis yog glacial xaiv hom tsiaj xws li tib neeg, nas, nas, nyuj, thiab yaj. Sau cov amino acid lossis nucleotide sequences ntawm GH receptor binding domain ntawm cov tsiaj no.

Txoj kev tshawb fawb

Tshawb nrhiav thiab rub tawm GH receptor binding domain sequence ntawm cov tsiaj xaiv los ntawm pej xeem databases xws li NCBI's GenBank database, Ensembl database, thiab lwm yam. Rau cov tsiaj txhu uas ploj lawm, xa mus rau cov ntaub ntawv tshawb fawb DNA txog keeb kwm yav dhau los kom tau txais cov ntaub ntawv sib raug zoo.

Siv bioinformatics software xws li BioEdit, DNAMAN, thiab lwm yam los txhim kho thiab kho cov kab ke tau txais, tshem tawm cov kab lus tsis zoo thiab cov ntaub ntawv tsis txaus ntseeg, thiab xyuas kom raug thiab sib xws ntawm cov kab ke. Rau nucleotide sequences, txhais lawv mus rau hauv cov amino acid sequences raws li lub codon lub rooj rau kev saib xyuas raws li nram qab no cov kab ke kev sib raug zoo.

Siv ntau yam cuab yeej sib txuas ua ke rau kev sib txuas ua ke, suav nrog ClusalW, MAFFT, thiab T-Coffee. Cov cuab yeej no siv cov algorithms sib txawv thiab cov tswv yim los ua kom cov kab ke los ntawm cov kev xav sib txawv, txhim kho qhov tseeb ntawm cov txiaj ntsig kev sib tw. Ntshuam qhov kev sib piv cov txiaj ntsig mus rau hauv kev soj ntsuam xyuas software (xws li MEGA, Jalview, thiab lwm yam) rau kev pom kev pom thiab kev tshuaj xyuas ntxiv.

Raws li kev saib xyuas kev sib raug zoo ua ntu zus, txheeb xyuas qhov sib txawv hauv GH receptor binding domains ntawm cov tsiaj hnub nyoog dej khov thiab cov tsiaj tsis muaj hnub nyoog dej khov. Tshwj xeeb, nws suav nrog cov hauv qab no:

Qhov sib txawv ntawm cov amino acid muaj pes tsawg leeg: suav qhov zaus ntawm ntau yam amino acids nyob rau hauv kev sib txuas ntawm GH receptors hauv ntau hom, thiab sib piv qhov sib txawv ntawm cov amino acid muaj pes tsawg leeg ntawm cov tsiaj hnub nyoog dej khov thiab cov tsiaj tsis muaj dej khov.

Sib txawv Analysis

Conservative site tsom xam: Txiav txim siab qhov chaw khaws cia thiab sib txawv hauv GH receptor binding domain, thiab txheeb xyuas cov amino acid hloov hauv cov tsiaj thaum lub hnub nyoog dej khov ntawm cov chaw no. Conservative sites feem ntau nyob ruaj khov thaum lub sij hawm evolution thiab tseem ceeb heev rau kev tswj cov qauv thiab kev ua ntawm cov proteins; Thiab qhov sib txawv ntawm loci tuaj yeem cuam tshuam qhov hloov pauv hloov pauv hloov pauv ntawm hom.

Sib txawv Analysis

Cov qauv kev twv ua ntej: Siv cov txheej txheem bioinformatics xws li SWISS-MODEL, I-TASSER, thiab lwm yam. los kwv yees peb - qhov loj me ntawm GH receptor binding domains thiab sib piv cov qauv sib txawv ntawm cov tsiaj muaj hnub nyoog dej khov thiab cov tsiaj tsis muaj dej khov. Cov qauv sib txawv tuaj yeem ua rau muaj kev hloov pauv hauv kev sib raug zoo thiab qhov tshwj xeeb ntawm GH khi rau GHR, yog li cuam tshuam rau kev ua haujlwm lom neeg ntawm kev loj hlob hormone.

Conservative sequence alignment tau tshwm sim

 

GH receptor binding domain sequences ntawm glacial thiab non glacial tsiaj tau ua raws li siv cov cuab yeej xws li ClustalW, MAFFT, thiab T-Coffee, thiab tau txais cov txiaj ntsig zoo sib xws. Zuag qhia tag nrho, qhov sib txuas ntawm GH receptors muaj qee qhov kev txuag ntawm ntau hom, tab sis kuj tseem muaj qhov sib txawv tseem ceeb.

Hauv kev sib piv cov txiaj ntsig, qee thaj chaw muaj kev saib xyuas zoo thiab thaj chaw sib txawv kuj tuaj yeem pom meej meej. Cov cheeb tsam uas tau txais kev cawmdim heev yuav muaj cov amino acid tseem ceeb uas khi rau GH, uas yog qhov tseem ceeb rau kev tswj hwm kev sib cuam tshuam ntawm receptor ligand; Cov cheeb tsam sib txawv tuaj yeem cuam tshuam txog kev hloov pauv ntawm cov tsiaj sib txawv thaum lub sij hawm evolutionary txheej txheem.

Qhov sib txawv ntawm Amino Acid Composition

 

Cov txiaj ntsig tau pom tau tias muaj qee qhov sib txawv ntawm cov amino acid muaj pes tsawg leeg ntawm GH receptor binding domain ntawm cov tsiaj muaj hnub nyoog dej khov thiab cov tsiaj tsis muaj hnub nyoog dej khov. Piv txwv li, nyob rau hauv cov tsiaj muaj hnub nyoog dej khov, cov ntsiab lus ntawm qee yam hydrophobic amino acids (xws li leucine, isoleucine, valine, thiab lwm yam) yog qhov siab, thaum cov ntsiab lus ntawm hydrophilic amino acids (xws li serine, threonine, asparagine, thiab lwm yam) kuj tsawg.

Qhov sib txawv ntawm cov amino acid muaj pes tsawg leeg yuav muaj feem xyuam rau lub cev xav tau ntawm cov tsiaj muaj dej khov kom hloov mus rau qhov chaw txias.Qhov kev nce ntawm hydrophobic amino acids tuaj yeem pab txhim kho kev ruaj ntseg thiab te tiv thaiv cov proteins, tso cai rau GH receptors tswj lawv cov qauv zoo thiab ua haujlwm nyob rau hauv qis - qhov kub thiab txias.

Ib theem zuj zus qhov kev twv ua ntej

 

 

Qhov peb -seem qauv ntawm GH receptor binding domain tau kwv yees siv cov cuab yeej xws li SWISS-MODEL thiab I-TASSER, thiab cov txiaj ntsig tau pom tias muaj qee qhov sib txawv ntawm cov tsiaj muaj hnub nyoog dej khov thiab cov tsiaj tsis muaj dej khov. Kev sib txuas ntawm cov qauv ntawm GH receptors nyob rau hauv cov tsiaj muaj hnub nyoog dej khov tuaj yeem ua kom sib haum xeeb, nrog rau kev hloov pauv ntawm cov txheej txheem thiab qhov ntev ntawm cov txheej txheem thib ob hauv qee thaj tsam, xws li alpha helices thiab beta folds. Cov kev sib txawv ntawm cov qauv no tuaj yeem cuam tshuam rau hom kev khi thiab kev sib raug zoo ntawm GH thiab GHR. Piv txwv li, cov qauv kev cog lus yuav ua rau kev sib txuas ntawm GH receptors rau GH hauv cov tsiaj muaj hnub nyoog dej khov ruaj khov, uas muaj txiaj ntsig zoo rau kev siv cov tshuaj hormones loj hlob los tswj cov txheej txheem metabolic hauv cov khoom noj khoom haus tsawg.

Conservative Site Analysis

Ntau qhov chaw khaws cia tau raug txheeb xyuas nyob rau hauv GH receptor binding domain, uas tau txais kev pom zoo thoob plaws ntau hom, qhia txog lawv qhov tseem ceeb ua haujlwm tseem ceeb hauv cov txheej txheem evolutionary. Txawm li cas los xij, thaum lub hnub nyoog dej khov, cov tsiaj tau nthuav tawm tshwj xeeb amino acid hloov pauv ntawm qee qhov chaw khaws cia. Piv txwv li, ntawm qhov chaw khaws cia tseem ceeb, cov tsiaj tsis muaj glacial feem ntau siv aspartic acid, thaum qee cov tsiaj glacial hloov nws nrog glutamic acid. Txawm hais tias qhov kev hloov pauv ntawm cov amino acid no muaj cov khoom zoo sib xws, nws yuav muaj qhov cuam tshuam me me ntawm kev khi ntawm GH thiab GHR, yog li tswj cov teeb liab hloov txoj hauv kev ntawm kev loj hlob hormone kom hloov mus rau qhov tshwj xeeb ib puag ncig ntawm dej khov hnub nyoog.

Cim npe nrov: aod 9604 hmoov cas 221231-10-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom