Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm elsiglutide cas 914009-84-0 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo elsiglutide cas 914009-84-0 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
ELSIGLUTIDE(tseem hu ua ZP1846) yog ib qho tshuaj tshiab uas koom nrog cov analogues thiab receptor agonists ntawm glucagon zoo li peptide-2 (GLP-2). CAS 914009-84-0, peptide muaj li ntawm 39 amino acids teem nyob rau hauv ib theem zuj zus, endowing nws nrog lom lom. Qhov tseeb ntawm cov kab ke no yog qhov tseem ceeb rau nws txoj haujlwm. Molecular hnyav yog ib qho ntawm cov tsis tseem ceeb ntawm nws lub cev. Qhov nruab nrab molecular hnyav ntawm no peptide muab nws tshwj xeeb zoo hauv kev faib thiab metabolism hauv lub cev. Tsis tas li ntawd, lub isoelectric point ntawm ZP1846 tseem muaj kev cuam tshuam loj rau nws tus cwj pwm hauv cov kab mob uas muaj sia nyob, suav nrog nws cov kev cuam tshuam thiab kev ruaj ntseg nrog biomolecules. Raws li cov tshuaj peptide, solubility thiab stability ntawm ZP1846 muaj kev txiav txim siab rau nws cov bioavailability thiab kho cov nyhuv. Cov peptide no muaj cov solubility zoo thiab tuaj yeem ruaj khov nyob hauv ntau cov kuab tshuaj. Lub caij no, nws cov qauv kev ruaj ntseg kuj ua rau nws tswj hwm nws cov kev ua haujlwm lom neeg nyob rau hauv ib puag ncig sib txawv. Kev ua haujlwm hauv lub cev muaj feem cuam tshuam nrog nws txoj kev sib haum xeeb thiab kev hloov pauv hloov pauv. Lub conformation ntawm peptide yog hais txog nws cov qauv peb-dimensional nyob rau hauv qhov chaw, thaum conformational transformation yog hais txog cov kev hloov nyob rau hauv cov qauv no nyob rau hauv txawv tej yam kev mob. Kev kawm txog cov khoom no yog qhov tseem ceeb rau kev nthuav tawm lawv cov kev ua haujlwm lom neeg.
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Customized Bottle Caps Thiab Corks:
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Elsiglutide, tseem hu ua ZP1846, yog ib qho tshuaj tshiab uas yog cov analogues thiab receptor agonists ntawm glucagon zoo li peptide-2 (GLP-2). Hom tshuaj peptide no tau nyiam ntau yam hauv kev kho mob biomedical vim nws cov haujlwm tshwj xeeb thiab kev siv dav dav.
1. Ua kom cov cell proliferation
ZP1846, raws li GLP-2 analogue, tuaj yeem txhawb kev loj hlob ntawm cov hnyuv. Qhov kev ua haujlwm no muaj qhov tseem ceeb hauv kev kho mob rau kev kho mob ntawm qee yam kab mob hauv plab, xws li plab plob tsis so tswj thiab kab mob plab hnyuv. Los ntawm kev nce cell proliferation, ZP1846 pab kho cov qauv thiab kev ua haujlwm ntawm cov hnyuv, yog li txhim kho lub neej zoo ntawm cov neeg mob.
2. Txo cov plab hnyuv cell apoptosis
Ntxiv nrog rau kev nce cell proliferation, ZP1846 kuj tseem tuaj yeem txo cov apoptosis ntawm cov hnyuv. Apoptosis yog txheej txheem kev tuag ntawm tes uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov ntaub so ntswg homeostasis thiab tiv thaiv kab mob tshwm sim. Txawm li cas los xij, hauv qee lub xeev cov kab mob, cov txheej txheem apoptosis ntawm cov hnyuv tuaj yeem ua haujlwm dhau, ua rau cov hnyuv puas tsuaj. ZP1846 pab tiv thaiv cov kab mob hauv plab los ntawm kev puas tsuaj ntxiv thiab txhawb txoj hnyuv kho thiab rov tsim dua tshiab los ntawm inhibiting cell apoptosis.
3. Txhim kho txoj hnyuv ua haujlwm
Lwm qhov haujlwm tseem ceeb ntawm Elseglutide yog txhawm rau txhim kho txoj hnyuv. ZP1846 pab txhim kho cov qauv qub thiab kev ua haujlwm ntawm cov hnyuv los ntawm kev ua kom cov cell proliferation thiab txo cov cell apoptosis. Tsis tas li ntawd, nws tuaj yeem txhawb kev loj hlob thiab kho cov hnyuv mucosa, thiab txhim kho txoj hnyuv nqus ntawm cov as-ham. Cov teebmeem no sib sau ua ke txhawb kev txhim kho txoj hnyuv ua haujlwm, uas yog qhov tseem ceeb rau kev kho cov kab mob plab hnyuv.
4. Tiv thaiv kab mob raws plab los ntawm kev siv tshuaj khomob
Hauv kev tshawb fawb preclinical, ZP1846 tau pom tias txuas ntxiv txhawb kev loj hlob ntawm cov hnyuv mucosa, txo qhov tshwm sim thiab qhov hnyav ntawm cov tshuaj kho mob -mob raws plab (CID). Qhov kev ua haujlwm no ua rau Elseglutide muaj peev xwm siv tau tus nqi hauv kev tiv thaiv thiab kho cov tshuaj tua kab mob ua rau mob raws plab. Los ntawm kev txhawb kev loj hlob thiab kho cov hnyuv mucosa,Elsiglutidepab txo qhov kev puas tsuaj ntawm cov tshuaj chemotherapy rau txoj hnyuv, txo qhov mob raws plab, thiab txhim kho lub neej zoo ntawm cov neeg mob.
5. Txhim kho txoj hnyuv ua haujlwm
Elseglutide tuaj yeem txhim kho txoj hnyuv ua haujlwm. Cov kab mob plab hnyuv yog cov qauv tseem ceeb uas tiv thaiv lub cev los ntawm cov kab mob sab nraud thiab cov khoom tsis zoo. Txawm li cas los xij, hauv qee lub xeev cov kab mob, cov kab mob hauv plab hnyuv tuaj yeem cuam tshuam, ua rau cov kab mob thiab cov khoom tsis zoo nkag mus rau hauv lub cev thiab ua rau muaj cov kab mob ntau ntxiv. ZP1846 txhawb kev loj hlob ntawm cov kab mob hauv cov hnyuv thiab txo cov apoptosis, pab kho thiab txhim kho txoj hnyuv ua haujlwm, thiab txhim kho lub cev tiv thaiv.
6. Anti-inflammatory teebmeem
ZP1846 kuj muaj cov tshuaj tiv thaiv- mob. Kev mob plab yog ib qho tseem ceeb ntawm cov txheej txheem pathological hauv ntau yam kab mob, nrog rau cov kab mob hauv plab, kab mob plawv, thiab kab mob autoimmune. ZP1846 txo cov ntaub so ntswg puas tsuaj los ntawm o los ntawm inhibiting zus tau tej cov thiab tso tawm inflammatory mediators, pab txo cov tsos mob ntawm tus kab mob thiab txhawb kev kho cov ntaub so ntswg.
7. Txhawb nqa angiogenesis
Tsis tas li ntawd, ZP1846 tseem tuaj yeem txhawb nqa angiogenesis. Angiogenesis yog ib qho ntawm cov txheej txheem tseem ceeb hauv kev kho cov ntaub so ntswg thiab rov tsim dua tshiab, uas yog qhov tseem ceeb rau kev kho cov qauv thiab kev ua haujlwm ntawm cov ntaub so ntswg puas. ZP1846 muab cov khoom noj txaus txaus thiab cov pa oxygen rau cov ntaub so ntswg puas los ntawm kev txhawb nqa angiogenesis, ua kom cov txheej txheem ntawm cov ntaub so ntswg kho thiab rov tsim dua tshiab.
Elsiglutideyog ib qho analogue thiab receptor agonist ntawm glucagon zoo li peptide-2 (GLP-2), thiab nws cov haujlwm lom neeg tshwj xeeb ua rau nws muaj kev cia siab rau kev siv dav hauv kev kho mob plab hnyuv thiab lwm yam.
1. Synthesis ntawm peptide chains
Kauj Ruam 1: Ua kom cov amino acids
Ua ntej, nws yog ib qho tsim nyog los xaiv cov pab pawg tiv thaiv tsim nyog los tiv thaiv cov amino acids uas yuav tsum tau ua, txhawm rau tiv thaiv qhov tsis tsim nyog tshwm sim thaum peptide saw synthesis. Tom qab ntawd, cov amino acids tiv thaiv yog reacted nrog ua kom reagents (xws li N-hydroxysuccinimide ester) los tsim cov amino acid activation intermediates.
Piv txwv ntawm chemical equation:
R-AA-OH+NHS → R-AA-O-NSU
Ntawm lawv, R sawv cev rau sab saw ntawm cov amino acids, AA sawv cev rau cov amino acids, thiab NHS yog N-hydroxysuccinimide.
Kauj Ruam 2: Tsim cov peptide bonds
React lub activated amino acid intermediate nrog cov amino acid tom ntej (los yog nws daim ntawv activated) los tsim ib daim ntawv cog lus peptide. Cov kauj ruam no feem ntau yog ua nyob rau hauv lub xub ntiag ntawm tsim nyog cov kuab tshuaj thiab catalysts (xws li hauv paus).
Piv txwv ntawm chemical equation:
R1- UA1- O-NSU+R1- UA1- OH → R1- UA1- CO-NH-R1- UA1- OH
Ntawm lawv, R1 thiab R1 sawv cev rau cov saw hlau ntawm ob cov amino acids uas nyob ib sab, thaum AA 1 thiab AA1 sawv cev rau ob cov amino acids uas nyob ib sab.
Kauj Ruam 3: Maj mam txuas cov saw peptide
Rov ua kauj ruam 2 thiab maj mam txuas cov amino acids uas yuav tsum tau mus rau cov saw peptide kom txog rau thaum cov saw hlau peptide ua tiav. Txhua kauj ruam yuav tsum tau ua kom tiav cov tshuaj tiv thaiv thiab tshem tawm unreacted amino acids thiab los ntawm - khoom.
2. Kev hloov kho ntawm peptide chains
Kauj Ruam 4: Tshem tawm kev tiv thaiv los ntawm cov saw hlau sab
Tom qab peptide saw synthesis tiav, cov pab pawg tiv thaiv ntawm cov amino acid sab chains yuav tsum tau muab tshem tawm rau kev hloov kho tom ntej lossis kev sib txuas nrog lwm cov molecules. Cov kauj ruam no feem ntau yog ua los ntawm kev siv cov tshuaj reagents tsim nyog lossis cov xwm txheej.
Piv txwv ntawm kev sib npaug tshuaj (kev tshem tawm ntawm tert butoxycarbonyl tiv thaiv pawg ua piv txwv):
(Boc)2O-R-AA-OH+HCl/MeOH → R-AA-OH+(Boc)2Cl + MeOH
Ntawm lawv, (Boc)2O sawv cev rau pawg tiv thaiv tert butoxycarbonyl, thiab R-AA-OH sawv cev rau cov amino acids nrog pab pawg tiv thaiv.
Kauj Ruam 5: Cyclization cov tshuaj tiv thaiv
Vim ZP1846 yog cyclic peptide, nws yog ib qho tsim nyog los tsim cov loops ntawm ob qho kawg ntawm peptide saw. Cov kauj ruam no feem ntau ua tiav los ntawm intramolecular acylation lossis lwm yam kev cuam tshuam cyclization.
Piv txwv ntawm kev sib npaug tshuaj (siv intramolecular acylation ua piv txwv):
R1-UA1-CO-NH-R1- UA2-CO-NH-Ræ-AAæ-CO-NH-R4-AA4-CO-NH-Ræ-AAæ-OH →R-AA
3. Kev huv huv thiab kev txheeb xyuas
Kauj Ruam 6: Purification
Cov khoom siv tsis zoo, los ntawm - cov khoom thiab lwm yam impurities raug tshem tawm los ntawm txoj kev ua kom huv huv (xws li kev ua haujlwm siab ua kua chromatography, gel pom, thiab lwm yam) kom tau txaisElsiglutidenrog siab purity.
Kauj Ruam 7: Kev txheeb xyuas
Siv ntau txoj hau kev (xws li huab hwm coj spectrometry, nuclear magnetic resonance, thiab lwm yam) los txheeb xyuas cov khoom purified thiab xyuas kom meej tias nws cov qauv thiab purity ua tau raws li qhov yuav tsum tau ua.
Elsiglutide (tseem hu ua ZP1848 lossis GSK716155) yog qhov ntev - ua glucagon zoo li peptide-1 (GLP-1) receptor agonist, pib tsim los ntawm Zealand Pharma thiab tom qab tso cai rau kev tshawb fawb soj ntsuam los ntawm GlaxoSmithKline (GSK). Raws li GLP-1 analog, Elsiglutide yog npaj los siv los kho mob ntshav qab zib hom 2 (T2DM) thiab muaj peev xwm rog rog, tab sis nws cov txheej txheem kev loj hlob tau ntsib los ntawm kev tshawb pom ntxov mus rau kev sim tshuaj, thiab thaum kawg raug txiav tawm vim kev hloov kho tswv yim. Glucagon zoo li peptide-1 (GLP-1) yog ib qho insulinotropic hormone secreted los ntawm plab hnyuv L hlwb thiab tau pom nyob rau hauv 1980s. Nws lub luag haujlwm tseem ceeb suav nrog:
- Txhawb nqa insulin secretion (qabzib nyob ntawm seb, txo qhov kev pheej hmoo ntawm hypoglycemia)
- Inhibit glucagon tso tawm (txo cov piam thaj hauv siab)
- Ua kom lub plab zom mov qeeb (nce satiety thiab txo cov zaub mov noj)
- Txhawb nqa - cell proliferation (tej zaum yuav tiv thaiv pancreatic islet muaj nuj nqi)
Txawm li cas los xij, ib nrab ntawm - lub neej ntawm ntuj GLP-1 yog luv heev (kwv yees li 2 feeb), uas txwv tsis pub nws daim ntawv thov kev kho mob vim nws qhov cuam tshuam rau degradation los ntawm dipeptidyl peptidase-4 (DPP-4).
Txhawm rau kov yeej cov kev txwv ntawm ntuj GLP-1, cov tuam txhab tshuaj tau pib tsim cov tshuaj ua haujlwm ntev GLP-1, xws li:
- Exenatide (tawm xyoo 2005, thawj GLP-1 receptor agonist)
- Liraglutide (tawm hauv xyoo 2010, kev hloov pauv fatty acid txuas ntxiv ib nrab-lub neej)
- Dulaglutide (tawm hauv 2014, Fc fusion protein technology)
- Txoj kev loj hlob ntawm Elsiglutide tau ua tiav hauv cov ntsiab lus no.
Elsiglutide yog hloov kho raws li cov qauv ntawm ntuj GLP-1 (7-36):
- DPP-4 kuj hloov kho: Hloov cov amino acids uas yooj yim cleaved los ntawm DPP-4 (xws li Ala8 → Gly8).
- Fatty acid side chain modification: Qhia txog cov saw hlau palmitic ntawm Lys20 lossis Lys26 qhov chaw txhim kho albumin khi muaj peev xwm thiab ua kom ntev ib nrab - lub neej mus rau ob peb hnub.
Qhov kev tsim no tso cai rau tsuas yog 1-2 txhaj tshuaj subcutaneous ib lub lim tiam, txhim kho kev ua raws li tus neeg mob.
Kev phiv tshuaj
Gastrointestinal tshuaj
Ntshai
Qhov no yog ib qho ntawm cov tshuaj tiv thaiv tsis zoo ntawm Elsiglutide. Vim muaj kev cuam tshuam ntawm cov tshuaj nyob rau hauv cov kev cai ntawm neural regulation thiab cov tshuaj hormone secretion ntawm lub plab zom mov, ib txwm digestive kev ua hauj lwm yog cuam tshuam, ua rau lub plab zom mov qeeb, lub sij hawm noj zaub mov nyob rau hauv lub plab, stimulation ntawm gastric mucosal receptors, thiab xeev siab. Qhov kev xeev siab no feem ntau pom tseeb dua nyob rau theem pib ntawm kev siv tshuaj, thiab raws li lub sijhawm tshuaj ntev thiab lub cev maj mam hloov mus, cov tsos mob yuav maj mam txo.
ntuav
Qee tus neeg mob yuav hnov xeev siab nrog rau cov tsos mob ntuav. Kev ntuav hnyav tsis tsuas yog cuam tshuam rau tus neeg mob noj zaub mov kom zoo thiab lub neej zoo, tab sis kuj tseem tuaj yeem ua rau lub cev qhuav dej thiab electrolyte tsis txaus. Cov txheej txheem ntawm ntuav yog zoo ib yam li xeev siab, uas yog ib qho kev tiv thaiv reflex ntawm lub plab zom mov tom qab raug txhawb los ntawm cov tshuaj.
Mob plab
Elsiglutide tuaj yeem cuam tshuam qhov sib npaug ntawm plab microbiota, ua kom cov hnyuv tso tawm, lossis hloov cov permeability ntawm plab hnyuv mucosa, ua rau raws plab. Qhov hnyav ntawm raws plab txawv ntawm ib tus neeg mus rau lwm tus. Cov mob me me tsuas yog ua rau muaj kev nce hauv plab hnyuv, thaum cov mob hnyav tuaj yeem tshwm sim nrog cov quav dej nrog cov tsos mob xws li mob plab thiab tsam plab. Ntev ntev raws plab kuj tuaj yeem ua rau muaj kev noj zaub mov tsis txaus thiab plab hnyuv tsis ua haujlwm.
cem quav
Nyob rau hauv sib piv rau raws plab, ib tug me me ntawm cov neeg mob yuav muaj cov tsos mob ntawm cem quav. Qhov no tej zaum yuav yog vim cov tshuaj inhibiting plab hnyuv peristalsis ib txwm, ua rau cov quav nyob rau hauv txoj hnyuv ntev dhau lawm thiab ua rau kom nqus dej ntau dhau. Kev cem quav tuaj yeem ua rau muaj teeb meem hauv qhov quav, quav quav, thiab tsis xis nyob rau cov neeg mob.
Qhov chaw txhaj tshuaj tiv thaiv
Mob
Qee tus neeg mob yuav hnov mob ntawm qhov chaw txhaj tshuaj tom qab txhaj tshuaj Elsiglutide. Qhov no tej zaum yuav tshwm sim los ntawm stimulation ntawm cov ntaub so ntswg hauv zos los ntawm cov tshuaj los yog cov txheej txheem txhaj tshuaj tsis raug. Qhov kev mob ntawm qhov mob feem ntau yog mob me thiab feem ntau yuav txo qis ntawm nws tus kheej hauv lub sijhawm luv luv, tab sis yog tias qhov mob tshwm sim los yog hnyav dua, tus kws kho mob yuav tsum tau ceeb toom tam sim ntawd.
Redness thiab o
Kuj tseem muaj qhov liab liab thiab o ntawm qhov chaw txhaj tshuaj, uas yog qhov tshwm sim ntawm cov lus teb hauv zos. Qhov ntau thiab qhov hnyav ntawm qhov liab thiab o txawv ntawm ib tus neeg mus rau lwm tus thiab feem ntau maj mam txo qis hauv ob peb hnub. Yog tias qhov liab thiab o nthuav dav, nrog ua npaws lossis mob hnyav, nws yuav qhia tau tias muaj kab mob thiab yuav tsum tau kho mob sai.
Khaus khaus
Qee tus neeg mob me me yuav hnov qhov khaus ntawm qhov chaw txhaj tshuaj, uas tej zaum yuav yog ib qho kev tsis haum tshuaj hauv zos los ntawm kev siv tshuaj. Cov tsos mob khaus feem ntau yog me me, tsis txhob khawb, thiab feem ntau tuaj yeem txo tau ntawm lawv tus kheej. Tab sis yog tias khaus khaus hnyav lossis nrog rau lwm cov tsos mob ua xua xws li pob khaus, cov tshuaj yuav tsum raug tso tseg thiab yuav tsum tau sab laj nrog kws kho mob.
Kev phiv loj heev
Hypoglycemia
Txawm hais tias Elsiglutide muaj qhov pheej hmoo tsawg ntawm hypoglycemia thaum siv ib leeg, kev pheej hmoo ntawm hypoglycemia nce thaum siv nrog lwm cov tshuaj hypoglycemic xws li sulfonylureas, insulin, thiab lwm yam. Cov tsos mob ntawm hypoglycemia suav nrog palpitations, tes tshee, tawm hws, tshaib plab, kiv taub hau, qaug zog, thiab lwm yam. lub neej- tej zaum yuav muaj xwm txheej hem. Yog li ntawd, thaum siv Elsiglutide ua ke nrog lwm cov tshuaj hypoglycemic, nws yog ib qho tsim nyog yuav tsum tau saib xyuas cov ntshav qab zib kom zoo thiab kho cov tshuaj noj raws li cov ntshav qab zib.
Pancreatitis
Cov kev tshawb fawb tau pom tias GLP-1 receptor agonists tuaj yeem ua rau muaj kev pheej hmoo ntawm kev tsim kab mob pancreatitis. Cov tsos mob ntawm tus mob pancreatitis yog mob hnyav hauv plab plab, uas tuaj yeem tawg mus rau sab nraub qaum, nrog rau cov tsos mob xws li xeev siab, ntuav, thiab kub taub hau. Yog tias tus neeg mob tau ntsib cov tsos mob saum toj no thaum siv Elsiglutide, cov tshuaj yuav tsum raug tso tseg tam sim ntawd thiab kev kho mob yuav tsum tau nrhiav kev tshuaj ntsuam xyuas kom paub meej tias qhov kev kuaj mob.
Kev tsis haum tshuaj
Cov neeg mob tsawg heev tuaj yeem ua xua rau Elsiglutide thiab muaj kev tsis haum tshuaj hnyav, xws li anaphylactic shock. Allergic shock yog lub neej - hem qhov xwm txheej kub ntxhov uas tshwm sim los ntawm kev poob qis hauv cov ntshav siab, ua pa nyuaj, thiab tsis nco qab. Thaum muaj kev tsis haum tshuaj tshwm sim, kev cawm tam sim ntawd yuav tsum tau ua los ntawm kev siv tshuaj xws li adrenaline thiab glucocorticoids txhawm rau tswj cov cim tseem ceeb ntawm tus neeg mob.
Kev tsis zoo tshwm sim hauv cov neeg tshwj xeeb
Cov laus
Cov neeg laus muaj kev cuam tshuam ntau dua thaum siv Elsiglutide vim kev ua haujlwm ntawm lub cev tsis muaj zog, ua haujlwm ntawm lub cev tsis muaj zog, thiab txo qis kev muaj peev xwm metabolize thiab tso tawm tshuaj. Piv txwv li, cov neeg laus tej zaum yuav ua rau mob plab hnyuv thiab cov tsos mob yuav hnyav dua; Qhov kev pheej hmoo ntawm hypoglycemia yog qhov siab, vim cov neeg laus muaj peev xwm txo qis kev tswj cov ntshav qab zib thiab nce rhiab heev rau cov tshuaj hypoglycemic. Yog li ntawd, thaum siv Elsiglutide rau cov neeg laus, nws raug nquahu kom pib nrog cov koob tshuaj me me, saib xyuas cov ntshav qab zib kom zoo thiab tsis zoo, thiab kho cov tshuaj noj raws li tus neeg mob.
Cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm
Lub siab thiab ob lub raum yog cov kabmob tseem ceeb rau cov tshuaj metabolism thiab tso tawm. Thaum cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm siv Elsiglutide, cov tshuaj metabolism thiab kev tawm dag zog tuaj yeem cuam tshuam, ua rau cov tshuaj tsub zuj zuj hauv lub cev thiab ua rau muaj kev pheej hmoo tsis zoo. Piv txwv li, cov neeg mob uas muaj lub siab ua haujlwm tsis zoo tuaj yeem ua rau cov tshuaj metabolism qeeb thiab nce ntshav cov tshuaj ntau ntxiv, yog li ua rau muaj qhov tshwm sim ntawm plab hnyuv thiab hypoglycemia; Cov neeg mob lub raum tsis txaus yuav ua rau txo cov tshuaj tso tawm, uas tuaj yeem ua rau muaj tshuaj lom thiab lom. Yog li, cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm yuav tsum ntsuas lawv lub siab thiab lub raum ua haujlwm ua ntej siv Elsiglutide, kho cov tshuaj noj raws li qhov xwm txheej tshwj xeeb, thiab saib xyuas cov tshuaj tiv thaiv tsis zoo.
Cim npe nrov: Elsiglutide CAS 914009-84-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom