Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm Desmopressin Acetate CAS 16789-98-3 hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo desmopongressin acetate CAS 16789-98-3 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Desmopressin acetate, yog qhov sib txuas uas ua lub luag haujlwm tseem ceeb hauv kev muaj sia. Nws feem ntau muaj nyob rau hauv ib daim foos thiab yog dawb lossis me ntsis daj daj Crystalline hmoov. Nws cov ntsej muag yuav txawv me ntsis vim cov txheej txheem ntau lawm thiab kev coj dawb huv. Tus lej cas yog 62288 - 83-9, uas yog tus cim tshwj xeeb siv los txheeb xyuas qhov tseeb thiab taug qab qhov sib xyaw ua ke hauv cov ntaub ntawv siv tshuaj lom neeg. Nws molecular tus qauv yog c48h68non14s2, uas muaj qhov hnyav molecular ntawm 1129.269, uas yog muaj cov pa roj carbon, hydrogen, nitrogen, Oxygen, thiab Sulphen, thiab leej faj. Nws yog ib qho kev ua kom zoo nkauj ntawm ntuj arginine vaseopressin thiab kuj tseem ua rau Vasopressin. Cov solubility nyob rau hauv cov kuab tshuaj sib txawv yog qhov tseem ceeb rau nws daim ntawv thov. Feem ntau hais lus, nws solubility hauv dej yog siab, uas ua rau nws yooj yim rau kev npaj cov kev daws teeb meem. Txawm li cas los xij, hauv qee cov tshuaj kuab tshuaj organic, lawv cov solubility tej zaum yuav tsawg, uas yuav tsum tau hloov kho raws li cov xwm txheej thov txim. Nws muaj cov txiaj ntsig zoo antidiuretic thiab cov nyhuv ntev ntev, tab sis tsis pom vasoconstriction, yog li nws cov kev cuam tshuam nrog tshuaj muaj tsawg. Hauv cov teb kho mob, nws tau nyiam ntau dua vim nws cov kev ua haujlwm tshwj xeeb thiab tau pom muaj peev xwm thov cov ntawv thov hauv ntau daim teb.
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Customized raj yas thiab corks:
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Tshuaj Cov Qauv |
C50H72N14O16S2 |
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Muaj pes tsawg leej |
1188 |
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Molecular hnyav |
1189 |
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m/z |
1188 (100.0%), 1189 (54.1%), 1190(14.3%), 1070 (9.0%), 1069 (5.2%), 1071 (4.5%), 1070 (2.6%), 1070 (2.5%), 1069 (1.6%), 1071 (1.2%), 1071 (1.1%), 1072 (1.1%) |
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Kev Ntsuam Xyuas |
C, 51.67; H, 6.03; N, 18.34; O, 17.96; S, 6.00 |
1. Kev kho mob ntshav qab zib insipidus
Desmopressin acetatePuas yog cov tshuaj uas zoo tshaj rau kev kho mob ntawm Central Ntshav Qab Zib Insipidus (CDI). Mob Ntshav Qab Zib Insipidus yog ib tus kab mob tshwm sim los ntawm kev zais cia tsis txaus ntawm Antidiuretic Hormone (AVECHED LOS NTAWM COLYURIA, thiab tsawg lub ntiajteb paug zis. Nws cov qauv zoo ib yam li kev ua vaj ntxwv ntuj thiab tuaj yeem txhawb lub reabsorption ntawm dej los ntawm lub raum sau duct, yog li txo cov zis tawm.
2. Kev kho mob ntawm nocturnal polyuria
Nws kuj tseem siv los kho cov duab nocturnal polyuria, cov tsos mob uas muaj feem cuam tshuam rau kev pw tsaug zog zoo. FDA tau pom zoo siv Noctiva rau cov neeg mob laus uas tau txais tsawg kawg ob zaug thaum hmo ntuj kom tso zis. Los ntawm kev txo cov zis tsis ua yeeb yaj kiab, cov tshuaj no pab txhim kho tus neeg mob pw tsaug zog zoo.
3. Tswj los ntshav
Nws muaj cov nyhuv ntawm kev txhim kho cov kev ua ntawm plasma procoagulant factor viii thiab tuaj yeem siv los tswj thiab kho mob hemorrhagic. Piv txwv li, nws yog siv los kho los ntshav los ntawm hemophilia a (ib qho khoom siv tshuaj ntsuab tsis muaj peev xwm ua tau) thiab mob cirrhosis. Ntxiv rau, nws kuj tseem siv tau los tswj thiab tiv thaiv kom ntshav thaum lub sijhawm phais menyuam me me.
4. Lwm cov kev siv
Ntxiv rau cov ntsiab lus siv tau hais los saum, vasopressin acetate kuj muaj lwm yam kev thov nyob rau qee yam xwm txheej tshwj xeeb. Piv txwv li:
(1) Hauv thaj teb ntawm cov kab mob plawv, nws tuaj yeem siv los kho cov kab mob xws li lub plawv tsis ua haujlwm thiab mob mouseCardial infarction. Los ntawm kev txo cov zis tso zis, nws pab kom txo lub nraaj cardiac thiab txhim kho lub plawv ua haujlwm.
(2) Hauv thaj teb ntawm neurology, nws yuav muaj cov teebmeem neuroprotecive thiab tuaj yeem siv los kho qee yam kab mob neverologon thiab Alzheimer tus kab mob.
(3) Hauv lub raum, nws tuaj yeem siv los kho qee yam mob raum, xws li mob raum raug mob thiab mob raum mob ntev. Los ntawm kev tswj cov dej ntsev sib npaug thiab kev txhim kho cov muaj nuj nqi raum, nws pab kom txo lub nra txog lub nra thiab ncua cov kab mob zuj zus.
Desmopressin acetateyog cov tshuaj hluavtaws feem ntau siv los kho cov kab mob xws li ntshav qab zib insipidus thiab hemophilia.
Kauj Ruam 1: Ua ntej, rov qab ua rau cov tshuaj methanil hauv methanyl los tsim benzyl mthyl ester.
C6H5Ch2Cocl + ch3Oh → c6H5Ch2Txoj cai3+ HCL
Kauj ruam 2: Kev tshuaj mehlyl benzoate nrog Dosethyl sulfoxide hauv qab cov neeg mob ua haujlwm los tsim cov phenylacetyl imine.
C6H5Ch2Txoj cai3+ (Ch3)2Yog li + naoh → c6H5Ch=ch2+ Ch3O - na++ (Ch3)2Yog li2
Kauj ruam 3: Rov qab phenylacetyl imine nrog butyryl chloride nyob rau hauv Alkaline tej yam kev mob los tsim cov penylacetyl betyryl imine.
C6H5Ch=ch2+ Ch3(Ch2)2Cocl + Naoh → C6H5CH=c (ch2)2Ch3+ Ch3O - na++ HCL
Kauj Ruam 4: Rov qab siv phenylacetylsuccinimide nrog dimethylformamide hauv qab kev mob Alkaline los tsim Desmopressin Butyryl Imine.
C6H5CH=c (ch2)2Ch3+ Dmf + naoh → c6H5Ch=n (ch3) C (ch2)2Ch3+H2O + naoh
KAUJ RUAM 5: Kev ua tiav kev ua tiav nrog cov txheej txheem anetic anhydride nyob rau hauv alkaline tej yam kev mob los tsim desmopressin acetylamide.
C6H5Ch=n (ch3) C (ch2)2Ch3+ (Ch3CO)2O + naoh → c6H5Ch=n (ch3) Coch3+ Ch3Coona + h2O
Kauj Ruam 6: Rov tshwm sim Desmopressin acetamine nrog ethanoline los tsim desmopressin acetamide.
C6H5Ch=n (ch3) Coch3+ NH2Ch2Ch2Oh → c6H5Ch (Nhcoch3) N (ch3) Ch2Ch2Huag
Kauj Ruam 7: Thaum kawg, rov qab ua rau demethyl acetate nrog acetic anhydride nyob rau hauv alkaline tej yam kev mob los tsim cov txheej txheem ethyl demetths.
C6H5Ch (Nhcoch3) N (ch3) Ch2Ch2Oh + (ch3CO)2O + naoh → c6H5Ch (Nhcoch3) N (ch3) Ch2Ch2Nyiaj sawv ntxov3+ Ch3Coona + h2O
Cov saum toj no yog cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug ntawm cov hluavtaws hluavtaws rau Ethyl Vicenate hauv Bundesliga. Thov nco ntsoov tias qhov no tsuas yog ib qho ntawm cov qauv hluavtaws, thiab tej zaum yuav muaj lwm txoj kev sib txawv hauv chav kuaj. Ntxiv rau, cov tshuaj siv hluavtaws yuav tsum tau nqa tawm hauv ib puag ncig kev ua raws thiab hauv qab cov lus qhia ntawm cov kws tshaj lij, thiab tsis txhob sim ua cov tshuaj nyob hauv tsev.
Desmopressin acetateyog ib qho synthesialized vasopressin analogue. Nws tau txais los ntawm kev hloov tshuaj lom neeg ntawm ntuj arginine vasgessin (1 {}} cysteine damination, 8} l-arginine hloov los ntawm d-arginine). Nws cov nyhuv antidiuretic yog 10-100 lub sij hawm muaj zog dua li ntawm lub ntuj hormone, thiab nws tsis muaj vasoconsconsconsive phiv los. Nws yog dav siv nyob rau hauv cov chaw kuaj mob rau cov mob insipidus insipidus, nocturnal enuresis, hemophilia, thiab tswj kev phais mob. Cov kev ntsuas hauv qab no yog ua los ntawm plaub qhov ntev: qauv tshuaj lom neeg, chaw muag tshuaj, kuaj xyuas, thiab cov ntawv thov kho mob.
Cov qauv tshuaj lom neeg thiab tshuaj kho mob lub cev thiab tshuaj
Cov qauv molecular ntawm desmopressin acetate yog c₄₈h₆₈n₁₄o₁₄s₂, nrog txoj kev molecular hnyav ntawm 1129.27. Nws cov qauv kev teeb tsa yog:
Cysteine Damination:Tshem tawm cov amino pab pawg ntawm cysteine hauv cov tshuaj hormones ntuj, txo qhov metabolic tus nqi;
D -}}} hloov hloov l -}}}}}}}}}} arginine:Txhim kho cov receptor yuav tshwj xeeb, ntev ntev lub sijhawm ntawm kev nqis tes ua (ib nrab {0} lub neej 3-4 teev).
Cov tshuaj no yog cov hmoov dawb, soluble hauv dej, DMOPS thiab ethanol. Nws cov ruaj khov yog cuam tshuam los ntawm qhov kub thiab nws yuav tsum khaws cia rau hauv tub yees (2-8 degree). Nws qhov ntom ntom yog 1.56 g / cm³, melting taw tes tsis tau teev, tab sis nws yog nquag mus rau kev txiav txim siab ntawm qhov kub thiab xav tau kev tiv thaiv los ntawm lub teeb thiab noo ib puag ncig.
Pharmacological mechanism thiab analytical txoj kev
Lorem ipsum dolor zaum amet consectetur adipisicing elit.
Antidiuretic Mechanism
Desmopressin ua haujlwm rau V2 tus receptor nyob rau hauv Renal lub tubules, txhawb nqa cov dej ntawm lub raum, yog li txo cov zis tawm. Kev tsom xam yuav tsum them sai sai rau:
Receptor khi kev sim: Siv cov radiolabeled ligands (xws li - descosine) los txiav txim siab rau kev sib txawv nrog V2 txais kev ua yeeb yam;
Nrhiav tau ntawm AQP2 kev hais tawm: dhau ntawm Western blot lossis immentofluorescence yog ntsuas los ntsuas cov tshuaj muaj kev cuam tshuam rau cov dej reabroorption;
Cov zis osmotic siab ntsuas ntsuas: Kev xyaum ntawm cov zis, cov zis siv dej khov Osmometer, ncaj qha rau cov tshuaj tiv thaiv kab mob antidiuretic.
Mechanism ntawm hemostasis
Desmopressin tuaj yeem txhawb cov hlwb endothelial los tso von Chopand Factor (Fⅷ) thiab kev txhim kho Platelet Adhesion muaj nuj nqi. Cov txheej txheem tsom xam nrog:
Elisa rau kev txiav txim siab VWF / FUNITUSTIVATION ntawm kev txhawb nqa cov kev cuam tshuam ntawm cov tshuaj ntawm kev tso tawm ntawm coagulation yam;
Platelet Freatuance Test: Xav txog cov txiaj ntsig ntawm cov tshuaj ntawm platelet kev sib cais siv ib qho platelet sib cais;
Kev los ntshav lub sijhawm ntsuas: Classically II txoj kev siv tau los ntsuas lub sijhawm los ntshav ntawm cov tshuaj.
Tshuaj ntsuam xyuas cov kws tshuaj ntsuam
Ntshav kev txiav txim siab ntshav: Siv HPLC {{ms} ms / ms {{1-4 teev (kwv yees li ntawm 85% rau kev txhaj tshuaj ntxiv);
Kev faib ntaub daim ntaub so ntswg: Saib kev faib tawm cov tshuaj hauv plab hnyuv xws li lub raum thiab txiav txim siab siv hluav taws xob autoradiography, thiab txiav txim siab kev xav hauv hom phiaj plab hnyuv siab.
Kev Tswj Xyuas Kev Ntsuas Xyuas Zoo
Kev coj dawb huv thiab impurity nrhiav
HPLC Txuj Ci: Siv C18 raws li lub chaw nyob ruaj khov, acetonitrile-}}}}}}}}}} cov pa peak (ntau dua lossis sib npaug ntawm 98% yuav tsum muaj);
Pawg Spectrometry Kev Ntsuam Xyuas: Paub meej tias cov khoom hnyav molecular thiab xws li deacetylated impurities) los ntawm Esi {{ms.
Cov Ntsiab Lus Kev Txiav Txim Siab
Tsis - aqueous ayoous Txoj Cai: Siv acetic acid raws li cov kuab tshuaj thiab perchloric acid li cov npe los txiav txim siab cov ntsiab lus siv tshuaj;
Ultraviolet spectrophhotometry: ntsuas qhov nqus ntawm 280 nm thiab suav cov siab.
Residual kev nrhiav pom kev
Siv gc - ms los ntes cov khoom seem (xws li DMOs, kom ethandines (xws li DMOs nyob qis dua lossis sib npaug nrog 0.5%).
Cov ntaub ntawv raug mob thiab tshuaj xyuas
Qhia tau thiab koob tshuaj
Central Bloretes insipidus: Cov neeg laus 0.1-0.2 mg ib koob tshuaj, peb zaug ib hnub; Cov menyuam yaus 0.05-0.1 mg ib koob;
Nocturnal enuresis: 0.2-0.4 mg ua ntej yuav mus pw;
Kev phais mob hemostasis: Intravenous Txoj kev lis ntshav ntawm 0.3 ug / kg.
Kev soj ntsuam ntawm cov nyom kev sib raug zoo
Hyponatremia: Nquag Saib Ntshav Qab Zib (<130 mmol/L requires discontinuation of the medication);
Dej khaws cia: pom cov cim qhia seb puas muaj qhov hnyav thiab mob taub hau, thiab txwv tsis pub noj thaum tsim nyog.
Kev soj ntsuam ntawm cov tshuaj sib cuam tshuam
Cov tshuaj tiv thaiv kev ntxhov siab / chlorpromazine: tuaj yeem txhim kho cov nyhuv tshuaj tiv thaiv antidiuretic, nce txoj kev pheej hmoo ntawm hyponatremia;
Indomethacin: tuaj yeem txhim kho zis kev xav, tab sis tsis cuam tshuam lub sijhawm ntawm kev ua tau tshuaj.
Kev Tshawb Nrhiav Cov Pem Hauv Ntej thiab cov nyom
Antitumor muaj peev xwm:Cov kev tshawb fawb tsis ntev los no tau qhia tias Desmopressin tuaj yeem ua rau cov qog qog ntawm tes (xws li CT-26 tus kab mob chructors, tab sis cov tshuab tseem yuav tsum tau meej;
Cov teeb meem tiv thaiv:Ntev -}}}}} siv tau yuav ua rau kom tau txais cov tshuaj ntsuam xyuas, thiab yuav tsum tau tshawb xyuas cov tshuaj sib dhos ua ke;
Kev Tsim Qauv Tshiab:Nanoparticles, tsom iav, thiab lwm yam raws li kev tso tawm- tso cov formulations tau ntev lub sijhawm ntawm kev ua thiab txo cov zaus ntawm kev tswj hwm.
Tag
Kev tshuaj ntsuam ntawmDesmopressin acetateXav tau kev koom ua ke ntawm cov qauv tshuaj lom neeg, tshuaj xyuas pharmacologism, kev tswj hwm zoo, thiab soj ntsuam thiab kev nyab xeeb. Kev tshawb fawb yav tom ntej yuav tsum tsom rau kev txhawb nqa elucidation ntawm kev tiv thaiv me me thiab kev txhim kho cov neeg xa khoom tshiab los nthuav nws cov chaw kuaj mob.
Cim npe nrov: Desmopressin Acetate CASE 16789-98-3, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, nqi, loj, rau muag