Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov chaw muag khoom ntawm hgh fragment 176 191 peptide hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo hgh fragment 176 191 peptide muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
HGH Fragment 176-191 Peptideyog ib qho khoom siv peptide tawg tau los ntawm C-terminus ntawm human growth hormone (HGH) molecule. Ua los ntawm 16 amino acids hla txoj haujlwm 176 txog 191, nws yog tus cwj pwm los ntawm nws lub hom phiaj ntawm cov roj metabolism thaum tshem tawm cov teebmeem ntawm lub cev tsis muaj zog ntawm tag nrho -ntev HGH, ua rau nws muaj lipolytic peptide nrog kev ua haujlwm siab thiab tsis tshua muaj kev phiv.Nws qhov tseem ceeb tshaj plaws ntawm cov roj metabolism hauv qab yog cov txiaj ntsig zoo ntawm -} ntev HGH, ua rau nws muaj lipolytic peptide nrog kev ua haujlwm siab thiab tsis tshua muaj kev phiv. lub peev xwm lipolytic 12.5 npaug ntawm qhov puv -ntev HGH. Nws txo cov rog hauv lub cev los ntawm ob qho kev ua haujlwm ntawm kev txhawb nqa lipolysis thiab inhibiting adipogenesis, ua rau muaj txiaj ntsig zoo tshaj plaws tshwj xeeb tshaj yog rau cov rog tawv nqaij xws li plab thiab ncej puab. Lub caij no, nws txhawb kev nce hauv lean lub cev loj thiab protein synthesis, tiv thaiv cov leeg nqaij thaum lub sij hawm txo cov rog.
Peb cov khoom Form
HGH 176-191 COA
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| Certificate of Analysis | ||
| Compound npe | HWV 176-191 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 66004-57-7 | |
| Ntau | 35g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.77% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.15% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.31% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 432 pwm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Kev tswj cov roj metabolism thiab txo cov rog
Mechanism ntawm Action
HGH Fragment 176-191 Peptide nthuav tawm lub peev xwm lipolytic 12.5 npaug ntawm qhov ntev ntawm tib neeg kev loj hlob hormone (HGH), nrog rau nws cov txheej txheem tseem ceeb ntawm kev txhawb nqa lipolysis thiab inhibiting adipogenesis.
Hais txog kev nce qib lipolysis, peptide khi rau kev loj hlob hormone receptors ntawm qhov chaw ntawm adipocytes. Thaum receptor activation, ib qho cascade ntawm cov teeb liab kis tau tus mob tshwm sim, ua rau txhim khu kev ua haujlwm ntawm cov enzymes tseem ceeb xws li cov tshuaj hormone-sensitive lipase (HSL). HSL catalyzes hydrolysis ntawm triglycerides rau hauv fatty acids thiab glycerol, uas tom qab ntawd tso rau hauv cov hlab ntsha kom oxidized rau lub zog los ntawm lwm cov ntaub so ntswg ntawm lub cev, yog li ua kom cov txheej txheem ntawm cov rog rog.
Tsis tas li ntawd, peptide nce qib ntawm cov piam thaj hauv lub cev hauv lub cev ntawm adenosine monophosphate (cAMP) hauv adipocytes, ntxiv cov teeb liab lipolytic thiab txhawb nqa cov nyhuv lipolytic.
Nyob rau hauv cov nqe lus ntawm adipogenesis inhibition, HGH Fragment 176-191 Peptide exerts nws cov txiaj ntsig los ntawm kev tswj hwm ntawm cov noob caj noob ces thiab cov kev taw qhia. Nws inhibits cov haujlwm ntawm peroxisome proliferator-activated receptor (PPAR), qhov tseem ceeb ntawm kev hloov pauv rau adipocyte txawv thiab adipogenesis. Txo cov kev ua PPAR txo qis qhov sib txawv ntawm preadipocytes rau hauv cov neeg laus adipocytes thiab txo qis kev qhia ntawm lipogenic enzymes hauv adipocytes (xws li, fatty acid synthase thiab acetyl-CoA carboxylase), txo qis cov synthesis ntawm fatty acids thiab triglycerides thiab curbing fatty acids.
Tsis tas li ntawd, peptide modulates lub zog metabolism ntawm adipocytes los ntawm kev nce cellular basal metabolic tus nqi thiab lub zog siv nyiaj, uas ua rau cov roj oxidation ntau dua li cov synthesis, yog li ua tiav cov txiaj ntsig txo cov rog.
Daim ntawv thov Scenario
Kev kho mob rog
Rau cov neeg mob uas muaj kev rog yooj yim, tshwj xeeb tshaj yog cov uas muaj roj ntau dhau ntawm lub plab, lub duav thiab lwm thaj chaw, HGH Fragment 176-191 Peptide tuaj yeem ua kev ntsuas kev kho mob ntxiv. Los ntawm kev tswj cov roj metabolism, nws yuav pab txo cov rog hauv lub cev, txhim kho cov rog, thiab txo qhov kev pheej hmoo ntawm kev rog rog - cuam tshuam xws li mob ntshav qab zib hom 2, ntshav siab thiab dyslipidemia. Hauv kev xyaum kho mob, nws tuaj yeem ua ke nrog kev tswj hwm kev noj haus thiab kev tawm dag zog txhawm rau txhim kho kev poob phaus. Nws qhov profile muaj kev nyab xeeb siab kuj ua rau nws haum rau kev siv mus sij hawm ntev hauv kev saib xyuas qhov hnyav.
Kev Tswj Xyuas Kev Nyuaj Siab
Hauv kev sib tw kis las, qee qhov xwm txheej txwv nruj rau cov neeg ncaws pob lub cev hnyav thiab feem pua ntawm cov rog hauv lub cev. HGH Fragment 176-191 Peptide pab cov neeg ncaws pob kom txo qis feem pua ntawm cov rog hauv lub cev, ua kom lub cev muaj zog thiab txhim kho kev ua kis las yam tsis muaj kev cuam tshuam rau cov leeg nqaij. Piv nrog rau cov tshuaj txo cov rog ib txwm muaj, nws tsis cuam tshuam rau cov neeg ncaws pob lub paj hlwb lossis kev muaj peev xwm ua kis las, thiab nws tsis ua rau muaj teeb meem tshuaj lom, ua raws li cov kev cai ntawm kev sib tw kis las.
Fat Reduction nyob rau hauv Anti-Kev Tiv Thaiv Kev Laus
Nrog rau kev laus, tib neeg lub cev metabolic tus nqi poob qis, rog tsub zuj zuj zuj zus, thiab kev loj hlob hormone secretion txo. HGH Fragment 176-191 Peptide tuaj yeem siv los tiv thaiv- kev laus laus los pab nruab nrab- cov neeg laus thiab cov neeg laus tswj cov roj metabolism, txo cov rog hauv lub cev, thiab txhim kho cov teeb meem ntawm lub cev los ntawm cov rog. Nws kuj tseem ncua cov txheej txheem metabolism hauv kev laus thiab txhim kho lub neej zoo.
Adjuvant hauv Anti-Kev Tshawb Fawb Txog Kab Mob
Txhim kho Cytotoxicity ntawm Cov Tshuaj Kho Mob ntawm Cov Kab Mob Cancer
HGH Fragment 176-191 Peptide tau ua pov thawj tias muaj peev xwm ua kom muaj txiaj ntsig zoo ntawm kev siv tshuaj khomob hauv kev tiv thaiv- kev tshawb fawb mob qog noj ntshav, nrog rau kev ua tau zoo tshwj xeeb hauv kev tshawb fawb txog kev kho mob cancer mis. Kev tshawb fawb tau pom tias peptide tuaj yeem txhim kho cytotoxicity ntawm doxorubicin -loaded chitosan nanoparticles tiv thaiv cov qog nqaij hlav cancer mis. Doxorubicin yog ib qho chaw kho mob feem ntau siv tshuaj tua kab mob qog noj ntshav uas ua rau muaj kev cuam tshuam cytotoxic los ntawm kev sib cuam tshuam rau hauv DNA ob txoj hlua thiab inhibiting DNA replication thiab transcription.
Txawm li cas los xij, qee cov qog nqaij hlav qog nqaij hlav tuaj yeem tiv thaiv nws, thiab nws cov kev mob tshwm sim tseem ceeb txwv nws txoj kev kho mob. Chitosan nanoparticles, raws li cov neeg nqa tshuaj, muaj cov txiaj ntsig zoo xws li biocompatibility zoo thiab muaj peev xwm tsom tau zoo, uas tuaj yeem txhim kho kev xa khoom ntawm doxorubicin.
HGH Fragment 176-191 Peptide tuaj yeem txhim kho cov tshuaj tiv thaiv- mob qog noj ntshav ntawm doxorubicin los ntawm kev tswj cov cellular metabolism lossis cov kev taw qhia. Ntawm qhov tod tes, peptide tuaj yeem hloov kho lub zog metabolism ntawm cov qog nqaij hlav cancer ntawm lub mis, ua rau lawv rhiab heev rau doxorubicin. Piv txwv li, nws tuaj yeem txo qis glycolysis ntawm cov qog nqaij hlav cancer, txiav tawm lub zog, thiab yog li cuam tshuam DNA kho lub peev xwm ntawm cov qog nqaij hlav cancer- ua rau lawv tsis tuaj yeem kho doxorubicin-induced DNA puas, uas ua rau nce tus nqi apoptotic.
Ntawm qhov tod tes, nws tuaj yeem tswj hwm apoptotic signaling txoj hauv kev hauv cov qog nqaij hlav cancer (xws li, ua kom cov caspase tsev neeg proteases) los txhawb kev mob qog noj ntshav cell apoptosis, uas ua ke nrog cov txheej txheem ntawm kev txiav txim ntawm doxorubicin los txhim kho cytotoxicity. Tsis tas li ntawd, HGH Fragment 176-191 Peptide tuaj yeem cuam tshuam rau kev txhawb nqa thiab tso tawm ntawm chitosan nanoparticles hauv cov qog nqaij hlav cancer, ua kom cov ntshav hauv lub cev ntawm doxorubicin thiab txhawb kev siv tshuaj khomob ntxiv.
Muab Lub Hom Phiaj Muaj Peev Xwm rau Kev Tshawb Fawb Txog Kab Mob
HGH Fragment 176-191 Peptide tuaj yeem khi rau Ki-67, MiB proteins thiab estrogen receptors (ER), muab lub hom phiaj tshiab rau kev tshawb nrhiav qog nqaij hlav, tshwj xeeb tshaj yog rau cov tshuaj estrogen{10}} mob qog noj ntshav xws li mob cancer mis. Ki-67 thiab MiB cov proteins yog cov cim qhia txog kev loj hlob ntawm tes, uas nws cov qib qhia tau zoo sib xws nrog kev ua haujlwm ntawm cov qog nqaij hlav cancer. Tom qab khi rau cov proteins no, HGH Fragment 176-191 Peptide tuaj yeem cuam tshuam rau lub voj voog ntawm cov qog nqaij hlav cancer thiab inhibit lawv qhov kev loj hlob. Piv txwv li, nws tuaj yeem thaiv cov hlwb los ntawm kev hloov pauv ntawm G1 mus rau theem S, txo DNA rov ua dua, thiab cuam tshuam kev faib cov peev xwm ntawm cov qog nqaij hlav cancer - muab lub hom phiaj tshiab rau kev txhim kho cov tshuaj tiv thaiv kab mob qog noj ntshav uas tsom rau kev loj hlob ntawm tes.
Hauv cov tshuaj estrogen-mob qog noj ntshav, qhov txawv txav thiab ua kom cov tshuaj estrogen receptors yog qhov tseem ceeb ua rau muaj kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer. HGH Fragment 176-191 Peptide khi rau cov tshuaj estrogen receptors, uas tuaj yeem cuam tshuam nrog kev sib txuas ntawm cov tshuaj estrogen rau nws cov receptors lossis cuam tshuam receptors -txoj kev kho kom haum xeeb (piv txwv li, MAPK/ERK thiab PI3K/Akt pathways), yog li inhibiting kev loj hlob ntawm cov hlwb. Qhov kev tshawb pom no muab kev nkag siab tshiab rau kev txhim kho cov tshuaj estrogen receptor antagonists thiab cov tshuaj muaj feem cuam tshuam, pab daws cov tshuaj tiv thaiv ntawm qee tus neeg mob qog noj ntshav rau cov tshuaj kho endocrine uas twb muaj lawm. Tsis tas li ntawd, kev tshawb fawb tob txog kev sib txuas ntawm HGH Fragment 176-191 Peptide rau cov proteins thiab receptors tuaj yeem pab txhawb kev tsim kho cov qauv kuaj mob qog noj ntshav kom raug, muab cov biomarkers tshiab rau kev kuaj mob qog noj ntshav thaum ntxov thiab kev soj ntsuam kuaj mob.
Lub luag hauj lwm nyob rau hauv txoj cai ntawm Tumor Microenvironment
Cov qog microenvironment plays lub luag haujlwm tseem ceeb hauv kev loj hlob, metastasis thiab kev loj hlob ntawm cov tshuaj tiv thaiv hauv cov qog nqaij hlav cancer. HGH Fragment 176-191 Peptide tuaj yeem muab cov kev taw qhia tshiab rau kev tiv thaiv-kev tshawb fawb mob qog noj ntshav los ntawm kev tswj cov qog microenvironment. Cov qog nqaij hlav microenvironment muaj ntau lub cev tiv thaiv kab mob, fibroblasts, cytokines thiab lwm yam, qee yam uas txhawb cov qog nqaij hlav. Cov kev tshawb fawb tau pom tias peptide tuaj yeem hloov pauv qhov polarization ntawm qog- txuam nrog macrophages (TAMs), ua rau muaj kev hloov pauv ntawm TAMs los ntawm M2 phenotype (uas txhawb cov qog loj hlob) mus rau M1 phenotype (uas inhibits qog loj hlob), yog li txhim kho lub cev tiv thaiv kab mob.
Lub caij no, nws tuaj yeem txo qhov kev qhia ntawm pro-angiogenic yam xws li vascular endothelial growth factor (VEGF) nyob rau hauv cov qog microenvironment, inhibit qog angiogenesis, txiav tawm cov as-ham thiab oxygen mov rau cov qog nqaij hlav cancer, thiab yog li suppress qog loj hlob thiab metastasis. Cov teebmeem no muab lub hauv paus ntsiab lus rau kev txhim kho kev tiv thaiv - cov tswv yim mob qog noj ntshav rau cov qog nqaij hlav microenvironment, uas tuaj yeem ua ke nrog cov kev kho mob ib txwm muaj xws li tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob txhawm rau txhim kho kev tiv thaiv - mob qog noj ntshav.
Basic Physicochemical yam ntxwv
HGH Fragment 176-191 Peptide yog dawb los yog tawm -dawb hmoov tsis muaj ntxhiab tsw. Nws yog yooj yim soluble nyob rau hauv dej, ib txwm saline thiab dilute acetic acid tov, me ntsis soluble nyob rau hauv organic solvents xws li methanol thiab ethanol, thiab insoluble nyob rau hauv non-polar solvents xws li acetone thiab ether. Nws solubility yog txiav txim los ntawm cov polar functional pawg nyob rau hauv lub molecule xws li amino, carboxyl thiab hydroxyl pawg.
Cov peptide no yog ib qho amphoteric molecule nrog cov amino pawg (N-terminus) thiab pawg carboxyl (C-terminus) ntawm nws ob qhov kawg raws li, thiab nws cov saw hlau sab muaj ntau pawg dissociable. Nws muaj qhov taw tes isoelectric (pI) ntawm kwv yees li 9.2 thiab nqa tus nqi zoo hauv lub cev ib puag ncig nrog pH ntawm 7.0 ~ 7.4. Cov yam ntxwv no ua rau nws muaj nyob ruaj khov hauv cov kua hauv lub cev thiab yooj yim cuam tshuam nrog cov khoom tsis zoo ntawm cov roj ntsha macromolecules hauv lub cev.
Tsis tas li ntawd, cov molecule muaj ib daim ntawv cog lus disulfide thiab tsis muaj ob daim ntawv cog lus. Nws nthuav tawm cov yam ntxwv zoo ntawm qhov siab ntawm lub wavelength ntawm 280 nm vim muaj tryptophan (Trp) thiab phenylalanine (Phe), uas tuaj yeem ua lub hauv paus tshuaj rau kev ntsuas ntau.
Cov yam ntxwv ruaj khov thiab muaj feem cuam tshuam
Lub spatial qauv ntawm no peptide yog ib tug xoob linear conformation nrog luv luv -ntau cov qauv helical tsim hauv zos los ntawm hydrogen bonding, uas yog qhov tseem ceeb spatial morphology rau nws cov kev ua lom lom. Nws stability yog cuam tshuam los ntawm kub, pH thiab enzymatic hydrolysis.
Hais txog qhov kub thiab txias, nws tuaj yeem khaws cia ruaj khov rau ntau tshaj 6 lub hlis hauv qhov qis - qhov kub thiab txias ntawm 2 ~ 8℃. Thaum qhov kub siab tshaj 40 degree, cov intramolecular hydrogen bonds tawg, cov qauv spatial unwinds, thiab cov kev ua ub no tau ploj mus sai. Nyob rau hauv cov nqe lus ntawm pH, nws cov qauv yog ruaj khov nyob rau hauv thaj tsam ntawm pH 5.0 ~ 8.0; muaj zog acidic los yog alkaline ib puag ncig yuav ua rau cov peptide bonds thiab ua rau molecular hydrolysis thiab cleavage.
Lub caij no, peptide no raug cuam tshuam rau kev degradation los ntawm peptidases thiab proteases hauv lub cev, tshwj xeeb tshaj yog aminopeptidases thiab carboxypeptidases, uas tuaj yeem maj mam hydrolyze nws cov amino acid residues. Qhov no kuj yog ib qho tseem ceeb tshuaj vim li cas rau nws luv luv nyob rau hauv vivo ib nrab -lub neej. Kev hloov kho cov qauv (xws li acylation thiab methylation) feem ntau yuav tsum tau txhim kho nws cov kev tiv thaiv rau enzymatic hydrolysis.
FAQ
HGH frag 176-191 ua dab tsi?
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GH fragment 176-191 yog ib feem ntawm Human Growth Hormone molecule uastswj cov rog txo qhov kev cuam tshuam nrog cov tshuaj no. Tsis tas li ntawd, kev siv GH Fragment tsis tshwm sim ua rau qee qhov kev mob tshwm sim tsawg dua cuam tshuam nrog kev siv GH, xws li nce insulin tsis kam.
Dab tsi yog HGH frag siv rau hauv bodybuilding?
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Txhawb kom muaj txiaj ntsig zoo rog: Lub Fragment HGH combo txhawb cov roj metabolism los ntawm kev txhawb kev tawg ntawm cov roj khaws cia, ua rau nws muaj txiaj ntsig zoo ntxiv rau koj lub voj voog txiav. Nws pab hauv sculpting lub cev leaner los ntawm kev pab txo qis feem pua ntawm lub cev rog thaum khaws cia cov leeg nqaij.
Cim npe nrov: hgh fragment 176 191 peptide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom