Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nhc (eidd-1931) hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo nhc (eidd-1931) muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
NWS (EIDD-1931)yog ib qho dav -spectrum me me-molecule nucleoside antiviral compound nrog lub zog inhibitory ua haujlwm tawm tsam RNA cov kab mob thiab cov tshuaj tiv thaiv kab mob dav dav. Nws lub ntsiab mechanism ntawm kev txiav txim yog tuag mutagenesis. Tom qab nkag mus rau hauv cov hlwb, EIDD-1931 yog phosphorylated rau hauv nws daim ntawv active triphosphate. Txog niaj hnub no, EIDD-1931 tau tshawb xyuas ntau heev rau kev kho cov kab mob tshwm sim thiab rov tshwm sim ntawm tib neeg tus kab mob. Ua tsaug rau nws qhov dav dav, lub zog siab thiab tsis tshua muaj peev xwm los txhawb cov tshuaj tiv thaiv, nws muaj peev xwm ua tau zoo heev hauv kev tiv thaiv thiab tswj cov kab mob RNA kis rau cov tsiaj txhu, tsiaj txhu, nqaij qaib thiab cov tsiaj hauv dej, ua rau nws yog lub hom phiaj kub rau kev txhim kho cov tshuaj tua kab mob tshiab.
Peb Cov Khoom Muag Khoom
N(4)-hydroxycytidineCOA
Cov ntawv thov hauv Veterinary thiab Companion Tsiaj Antiviral Therapy
Companion Tsiaj Sector: Kev Tiv Thaiv thiab Kev Kho Mob Feline Infectious Peritonitis Virus (FIPV)
Feline infectious peritonitis (FIP) yog ib qho kab mob ua rau tuag taus ntau ntawm cov tsiaj sib koom ua ke los ntawm FIPV, qhov hloov pauv ntawm feline coronavirus. Nws tau muab faib ua cov ntaub ntawv ntub thiab qhuav, nrog kev tuag siab heev ntawm cov menyuam yaus. Kev nyab xeeb thiab ua tau zoo cov kev kho mob tshwj xeeb tau ntev tsis muaj. GS-441524 tam sim no yog thawj kab tseem ceeb tshuaj rau kev kho mob FIP; nws zoo inhibits FIPV replication thiab alleviates cov tsos mob.
Txawm li cas los xij, nws muaj qee qhov kev txwv hauv kev kho mob: kev siv tshuaj tiv thaiv, kab mob rov qab, thiab kev ua haujlwm tsis txaus ntseeg tawm tsam kev tshwm sim ntawm lub paj hlwb tau pom nyob rau qee qhov xwm txheej. Tsis tas li ntawd, kev kho mob ntev ntev tuaj yeem ua rau cov kab mob sib kis. Los ntawm qhov sib txawv,NWS (EIDD-1931), nrog superior hauv vitro antiviral kev ua si thiab ib tug tshwj xeeb mutagenic mechanism, ua hauj lwm pab raws li ib tug tshiab lwm txoj kev kho tus neeg saib xyuas rau FIP kev kho mob, hais txog cov shortcomings ntawm cov kev kho mob uas twb muaj lawm cov txheej txheem.Multiple in vitro tswj cov kev tshawb fawb tau txheeb xyuas tias EIDD-1931 exerts markedly muaj zog inhibitory kev ua si tiv thaiv 44152 GS- Nyob rau hauv vitro pharmacodynamic assays hom II FIPV qhia tau hais tias ib nrab-qhov siab tshaj plaws concentration (EC₅₀) ntawm EIDD-1931 yog tsawg li 0.11 μM, deb tshaj tus nqi sib raug rau GS-441524.
Qhov no qhia tau hais tias EIDD-1931 tuaj yeem cuam tshuam cov kab mob kis tau zoo ntawm qhov tsawg kawg nkaus nrog kev txhim kho cov tshuaj tiv thaiv kab mob. Mechanistically, GS-441524 suppresses viral kev ua haujlwm feem ntau ntawm kev txiav cov kab mob RNA transcription; nws tsuas yog thaiv cov kab mob sib kis thiab tsis tuaj yeem tshem tawm cov kab mob genomes. Hauv kev sib piv, EIDD-1931 rhuav tshem cov kab mob loj zuj zus ntawm qhov chaw los ntawm kev ua rau tuag taus hauv cov kab mob genomes. Nws tsis tsuas yog txo cov kab mob kis tau sai tab sis kuj tseem txo qis kev pheej hmoo kis kab mob, txo qis kev pheej hmoo ntawm tus kab mob rov qab thiab tiv thaiv kev hloov pauv. Lub caij no, EIDD-1931 ua rau muaj kev cuam tshuam ruaj khov tiv thaiv cov subtypes sib txawv thiab cov kab sib txawv ntawm FIPV, txhawb kev siv dav.
Tsiaj txhu thiab nqaij qaib ua liaj ua teb: Hauv Vitro Kev Tshawb Fawb Txog Kev Tiv Thaiv thiab Tswj Tsiaj Tsiaj thiab Nqaij qaib RNA Viruses
RNA kab mob ntawm cov tsiaj nyeg thiab nqaij qaib sawv cev rau cov kab mob sib kis tseem ceeb txwv kev ua liaj ua teb loj -. Tus cwj pwm los ntawm kev sib kis ceev ceev, kev mob hnyav thiab nquag tshwm sim loj -, cov kab mob no ua rau cov tsiaj tuag, ua rau muaj kev ua haujlwm tsis zoo thiab ua rau muaj kev puas tsuaj loj ntawm kev lag luam yug me nyuam. Kev txhaj tshuaj tseem yog thawj lub tswv yim tiv thaiv kev tiv thaiv tsiaj txhu thiab nqaij qaib RNA kab mob, thaum cov tshuaj kho tshwj xeeb tsis tshua muaj.
Kev hloov pauv ntawm tus kab mob no feem ntau ua rau muaj kev tiv thaiv cov tshuaj tiv thaiv tsis muaj zog, tsim kom muaj kev thov nrawm rau dav -spectrum thiab siab - cov tshuaj tiv thaiv kab mob zoo rau kev tswj kab mob. Nyob rau xyoo tas los no, ntau qhov kev tshawb fawb hauv vitro tau lees paub tias EIDD-1931 qhia cov haujlwm tseem ceeb hauv kev tiv thaiv ntau yam kab mob RNA uas cuam tshuam rau cov tsiaj nyeg thiab nqaij qaib, cog lus dav dav rau tsiaj txhu thiab nqaij qaib tiv thaiv kab mob. Kev tshawb fawb tam sim no feem ntau tsom mus rau ob yam kab mob uas muaj ntau heev: porcine epidemic diarrhea virus thiab avian coronavirus.In in vitro kev tshawb fawb ntawm porcine epidemic diarrhea virus (PEDV), EIDD-1931 qhia tau hais tias muaj kev tiv thaiv zoo heev. PEDV yog ib qho tseem ceeb alphacoronavirus hem kev tsim swine.
Nws feem ntau kis tus piglets thiab ua rau ntuav hnyav, raws plab thiab lub cev qhuav dej; Kev tuag ntawm cov menyuam yug menyuam tuaj yeem ncav cuag 100%. Cov tswv yim kev tiv thaiv thiab tswj cov tswv yim tawm tsam kom muaj cov kab mob tshwm sim los ntawm cov kab mob sib txawv. Hauv vitro cellular thwmsim qhia tias EIDD-1931 muaj txiaj ntsig zoo tiv thaiv PEDV kev loj hlob hauv cov hlwb, txo qis tus lej ntawm tus kabmob thiab inhibiting cytopathic teebmeem. Nws cov txheej txheem ntawm kev txiav txim npog tag nrho cov kab mob viral lub neej nrog rau adsorption, replication thiab sib dhos. Nws tsis tsuas yog cuam tshuam nrog kev rov ua dua ntawm tus kab mob RNA genome tab sis kuj txo qis kev tso tawm ntawm cov neeg laus virions thiab thaiv cov xov tooj ntawm tes - mus rau-cell kis tau tus mob.
Piv nrog cov tshuaj tiv thaiv ib txwm muaj -PEDV,NWS (EIDD-1931)ua sai dua thiab ua kom muaj zog tiv thaiv. Nws tswj kev ua haujlwm ruaj khov tiv thaiv ob qho tib si classical hom thiab cov kev hloov tshiab yam tsis muaj qhov tshwj xeeb tshwj xeeb, sib piv cov kab mob sib kis ntawm kev ncig ntau hom PEDV.
Tsis tas li ntawd, kev ua haujlwm tiv thaiv kab mob ua tau zoo tuaj yeem ua tiav ntawm EIDD tsawg-1931 concentrations, tsis muaj kev puas tsuaj rau porcine plab hnyuv epithelial hlwb, qhia tau hais tias muaj txiaj ntsig zoo hauv vitro kev nyab xeeb thiab muab cov ntaub ntawv txhawb rau kev txhim kho tom ntej ntawm kev kho tshuaj noj tshuaj. avEIDD-1931 kuj qhia txog kev tiv thaiv kab mob sib kis thoob plaws hauv kev tshawb fawb.
Avian coronavirus yog sawv cev los ntawm tus kab mob bronchitis kab mob (IBV), uas kis tau cov nqaij qaib ntawm txhua lub hnub nyoog thiab ua rau mob ua pa, mob raum, txo qe qe thiab lwm yam teeb meem.
Cov kab mob kis kab mob thib ob feem ntau tshwm sim, ua rau cov nqaij qaib tuag ntau ntxiv. Cov tshuaj tiv thaiv uas twb muaj lawm raug kev txom nyem los ntawm kev tsis muaj zog hla- kev tiv thaiv thiab kev hloov kho qeeb, thiab cov tshuaj kho tau zoo tsis muaj nyob hauv cov chaw kho mob. Cov ntaub ntawv tshawb fawb hauv vitro qhia tau hais tias EIDD-1931 ua rau muaj kev cuam tshuam IBV RNA replication, txo cov kab mob uas ua rau cov cellular puas thiab txo cov kab mob kis mus rau avian pa mucosal hlwb.
Tsis zoo li cov tshuaj tiv thaiv kab mob ib txwm muaj, EIDD-1931 tsis tshua muaj peev xwm tsav cov kab mob tiv thaiv kab mob thiab txhawb nqa kev tiv thaiv kab mob mus ntev. Nws lub hom phiaj tshuaj tiv thaiv ua rau inhibition ntawm avian coronaviruses thoob plaws ntau hom genotypes, them nyiaj rau qhov tsis txaus ntawm kev tiv thaiv thiab kev tswj hwm uas twb muaj lawm thiab muab cov tswv yim tshiab tshiab rau kev kho thiab ceev kom muaj cov kab mob avian coronavirus.
Aquaculture Sector: Hauv Vitro Kev Tshawb Fawb Txog Kev Tiv Thaiv thiab Tswj Cov Tsiaj Dej RNA Viruses
RNA kab mob ntawm cov tsiaj hauv dej ua rau muaj kev phom sij loj hauv cov dej hiav txwv.
Cov kab mob zoo li no tshwm sim sai sai, kis tau sai thiab tuag ntau. Ua ke nrog cov cheeb tsam hauv dej complex, kev tiv thaiv kab mob sib kis thiab kev tswj hwm ua rau muaj teeb meem loj heev. Ntses rhabdoviruses tsim cov pab pawg neeg puas tsuaj tshaj plaws ntawm cov kab mob RNA hauv aquaculture, encompassing ntau yam kab mob xws li nyom carp haemorrhagic kab mob thiab caij nplooj ntoos hlav viraemia ntawm carp virus.
Cov kab mob no kis tau ntau yam ntses ua liaj ua teb dej tshiab thiab ua rau muaj kev tuag coob, cuam tshuam loj heev - kev loj hlob zoo ntawm kev lag luam aquaculture. Tam sim no, kev muab cov tshuaj tiv thaiv kab mob hauv dej yog txwv. Feem ntau muaj cov neeg ua hauj lwm muaj teeb meem nrog rau cov tshuaj lom neeg siab, cov khoom seem ntau heev thiab cuam tshuam ntawm cov dej hauv dej. Kev nyab xeeb thiab ua tau zoo tshiab tshuaj tiv thaiv kab mob yog li yuav tsum tau ceev.
Kev tshawb fawb dav hauv vitro tau lees paub tias EIDD-1931 ua haujlwm muaj zog tiv thaiv kev tiv thaiv ntau yam ntses rhabdoviruses, cim tias nws yog ib qho kev cog lus zoo rau cov neeg siv tshuaj tiv thaiv kab mob tshwj xeeb rau kev cog qoob loo. Ntses rhabdoviruses yog ib leeg- tso tseg tsis zoo- hnov RNA cov kab mob uas muaj cov kab mob yooj yim, rov ua dua sai thiab muaj peev xwm hloov pauv tau, ua rau lawv nyuaj rau lub hom phiaj ntawm kev siv cov tshuaj zoo ib yam. Kev vam khom rau nws txoj kev hloov pauv dav dav ntawm cov kab mob RNA, EIDD-1931 ua haujlwm tau zoo hauv RNA genomes ntawm cov ntses rhabdoviruses thiab ua rau muaj kev hloov pauv tuag ntau ntxiv los thaiv cov kab mob sib kis thiab kev loj hlob.
Kev sim hauv vitro cell kab lis kev cai qhia tau hais tias EIDD-1931 txo qis tus kab mob titres hauv cov kab mob rhabdovirus thiab tiv thaiv cytopathy.
Nyob rau hauv kev kho cov tshuaj tiv thaiv kab mob muaj txiaj ntsig zoo, EIDD-1931 tsis pom muaj qhov pom tseeb toxicity rau thawj cov ntses hlwb thiab muaj cov cellular compatibility.
NWS (EIDD-1931)nthuav tawm qhov zoo tshaj plaws ntawm cov tshuaj aquaculture antiviral.
Ua ntej, nws boasts ib tug dav antiviral spectrum npog ntau hom kab mob ntses rhabdoviruses. Tsis tas yuav tsim hom kab mob- cov tshuaj tshwj xeeb, ua rau nws tsim nyog rau kev tiv thaiv thiab tswj cov xwm txheej cuam tshuam nrog cov kab mob sib xyaw ua ke uas feem ntau pom hauv aquaculture. Thib ob, nws muaj kev tiv thaiv siab: cov kab mob tawm tsam los tsim cov tshuaj tiv thaiv nyob rau hauv kev tawm tsam mutagenic, txhawb kev ruaj ntseg ntev - kev tswj xyuas kab mob.
Thib peb, nws ua tiav kev nyab xeeb siab thiab tsis tshua muaj kev pheej hmoo. Raws li ib qho me me -molecule compound, EIDD-1931 tau txais cov metabolism sai thiab tsis sib sau hnyav hauv cov kab mob hauv dej los yog cuam tshuam cov dej microbial ecosystems, ua raws li cov hauv paus ntsiab lus ntawm kev loj hlob ntawm ntsuab aquaculture. Tam sim no, kev tshawb fawb ntawm EIDD-1931 tiv thaiv cov tsiaj hauv dej RNA cov kab mob feem ntau tsom rau hauv vitro pharmacodynamic pov thawj. Kev tshawb nrhiav ntxiv rau hauv vivo kev ua tau zoo, kev tswj hwm cov qauv thiab kev tsim nyog rau thaj chaw hauv dej yuav tsum tau tsim lub hauv paus rau nws daim ntawv thov loj hauv kev tiv thaiv kab mob hauv dej.
NHC tau tsim nyob rau hauv kev coj noj coj ua ntawm Drug Innovation Ventures ntawm Emory (DRIVE) pab pawg ntawm Emory University, Tebchaws Meskas. Nws yog cov tshuaj nucleoside tus neeg sib tw tau txais los ntawm kev tshuaj ntsuam xyuas rau dav -spectrum tswj ntawm RNA kab mob. Kev tshawb fawb pib pib los ntawm kev lag luam kev sib tw ntawm cov kev kho tshwj xeeb rau cov kab mob pathogenic, hloov pauv RNA sai sai.
Nyob ib ncig ntawm 2010, pab neeg tshawb fawb tau ua me me -kev tshuaj ntsuam xyuas molecule tawm tsam ntau yam kab mob RNA suav nrog cov kab mob coronaviruses, rhabdoviruses thiab kab mob khaub thuas, thiab nrhiav pom tias N4-hydroxycytidine derivatives muaj cov kab mob tshwj xeeb mutagenic inhibitory mechanism.
Nyob nruab nrab ntawm xyoo 2016 thiab 2018, tom qab kev txhim kho cov qauv thiab kev ua haujlwm tau zoo, EIDD-1931 tau raug txheeb xyuas raws li lub hauv paus tseem ceeb monomer, thiab nws tsis yog - chain-terminating antiviral mechanism, txawv ntawm cov tshuaj nucleoside ib txwm muaj.
Circa 2020, nrog rau kev tshawb nrhiav kev txaus siab nyob rau hauv dav -spectrum antiviral agents, antiviral spectrum thiab pharmacological zog ntawm EIDD-1931 tau txiav txim siab. Kev tshawb fawb tom qab maj mam nthuav dav mus rau hauv thaj chaw ntawm kev tiv thaiv kab mob thiab kev tswj hwm tsiaj, tsim kev txhawb nqa theoretical rau nws daim ntawv thov ua tus neeg sawv cev tiv thaiv kab mob hauv cov tshuaj kho tsiaj thiab aquaculture.
Cov ntaub ntawv
- Ib Daim Ntawv Qhia Txog Hauv -Nyob tob rau -D-N4-hydroxycytidine (EIDD-1931)[R]. BenchChem, 2025.
- Niu M, et al. Nucleoside analogue EIDD-1931 nyob rau hauv kev kho mob ntawm ib txwm tshwm sim feline infectious peritonitis [J]. PMC, 2024, 12(1): 2957568.
- Zhang Y, et al. Ib qho Optimized Bioassay rau Kev Tshuaj Ntsuam Xyuas Ua Ke Cov Tshuaj Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob rau Kev Tiv Thaiv Feline Infectious Peritonitis Virus [J]. PMC, 2023, 11(1): 9697187.
- DRIVE Team, Emory University. Kev tshawb fawb txog kev txhim kho thiab kev ua haujlwm ntawm Broad -spectrum Nucleoside Antiviral Agent EIDD-1931[R]. 2018.
- Wang L, et al. Hauv vitro tshuaj tiv thaiv kab mob ntawm EIDD-1931 tiv thaiv tsiaj RNA kab mob [J]. Frontiers hauv Veterinary Science, 2024.
Cim npe nrov: nhc (eidd-1931), lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom