Octreotide hmoov CAS 79517-01-4

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm octreotide hmoov cas 79517-01-4 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo octreotide hmoov cas 79517-01-4 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Octreotide hmoovyog ib qho hluavtaws hluavtaws somatostatin analogue (molecular mis: C₄₉H₆₆N₁₀O₁₀S₂), uas twb muaj lawm nyob rau hauv daim ntawv ntawm ib tug dawb mus tawm -dawb lyophilized hmoov. Nws yuav tsum muab cia rau hauv qhov chaw tsaus thiab txias ntawm 2-8℃. Raws li ntev - ua yeeb yam octapeptide derivative, nws cov tshuaj pharmacological yog 30 npaug zog dua li ntawm ntuj somatostatin, nrog ib nrab-lub neej txuas mus rau 90-120 feeb (naturally tsuas yog 2-3 feeb). Nws ua haujlwm los ntawm inhibiting qhov tso tawm ntawm cov tshuaj hormones xws li kev loj hlob hormone (GH), insulin, glucagon, thiab 5-hydroxytryptamine.
Cov ntawv thov tseem ceeb:
Cov qog endocrine: Acromegaly (GH inhibition), Neuroendocrine hlav (xws li carcinoid syndrome);
Txoj hnyuv los ntshav: Emergency hemostasis rau rupture ntawm esophageal varices;
Tsis tshua muaj kab mob: Ntev - tswj lub sij hawm ntawm congenital hyperinsulinism.
Kev Siv Lus Ceeb Toom: Nws yuav tsum tau rov- raug tshem tawm hauv lub xeev tsis muaj menyuam ua ntej txhaj tshuaj subcutaneous lossis txhaj tshuaj. Cov kev mob tshwm sim feem ntau suav nrog kev mob plab hnyuv, cov ntshav qab zib hloov pauv, thiab kev pheej hmoo ntawm gallstones. Daim ntawv hmoov yog yooj yim rau kev npaj meej, tab sis yuav tsum tau ua raws li GMP cov qauv. Tam sim no, nws yog ib qho kev npaj peptide uas nquag siv hauv chaw kho mob, thiab nws siv tsis yog - hom phiaj kho mob yog txhaum cai.

Octreotide hmoovyog ib qho kev sib xyaw ua ke ntawm octapeptide analogues ntawm cov chav kawm ntawm somatostatin analogues. Nws plays lub luag haujlwm kho mob hauv ntau yam kab mob los ntawm inhibiting lub pathological secretion ntawm peptides hauv plab hnyuv thiab pancreatic endocrine systems. Nws siv octreotide rau gi los ntshav yog ntau heev, txhaj tshuaj yuav muab li cas yog ib yam uas peb yuav tsum tau txhawj txog. Kev siv ntawm nws infusion yog dav thiab indications, txhaj tshuaj peb yuav tsum tau them sai sai mus rau lub sij hawm mus rau lub sij hawm.

• Kev tiv thaiv cov teeb meem tom qab phais mob pancreatic

Tom qab phais mob pancreatic, cov teeb meem xws li pancreatic fistula thiab los ntshav tuaj yeem tiv thaiv.

Kev tiv thaiv thiab kev kho mob ntawm gastric thiab esophageal variceal los ntshav: tuaj yeem siv los tiv thaiv thiab kho gastric thiab esophageal variceal los ntshav, txo qhov kev pheej hmoo ntawm rov los ntshav.

• Txoj kev kho ntawm acromegaly

Nws tuaj yeem siv rau kev kho mob ntawm acromegaly, tshwj xeeb tshaj yog rau cov neeg mob uas muaj cov tsos mob tshwm sim tom qab phais thiab kev kho hluav taws xob. Nws tuaj yeem tswj tau cov tsos mob ntawm acromegaly zoo, xws li mob taub hau, qhov muag tsis pom kev, thiab lwm yam.

Kev txo qis ntawm kev ua haujlwm ntawm islet cell carcinoma: Nws tuaj yeem txo cov tsos mob thiab cov cim qhia txog kev ua haujlwm ntawm islet cell carcinoma, xws li hypoglycemia, hyperinsulinemia, thiab lwm yam.

• Adjuvant therapy rau kab mob siab

Nws tuaj yeem siv los ua kev kho mob ntxiv rau cov kab mob siab xws li kab mob siab thiab cirrhosis, pab txo qhov siab ntawm lub portal thiab txo cov tsos mob ntsig txog.

• Conservative kev kho mob ntawm intussusception

Qee qhov xwm txheej, nws kuj tuaj yeem siv rau kev kho mob ntawm intussusception, los ntawm inhibiting qhov tso tawm ntawm digestive kua, tso cai rau ib feem ntawm intussusception muaj lub cib fim rau nws tus kheej txo.

• Kev tshawb fawb txog kev tiv thaiv- qog nqaij hlav

Nws muaj kev tiv thaiv- qog ua haujlwm thiab tuaj yeem kho cov cell apoptosis, uas pab kawm txog cov txheej txheem ntawm cov qog tshwm sim thiab kev loj hlob. Hauv chav kuaj, nws tuaj yeem siv rau hauv vitro thiab hauv vivo los tiv thaiv -cov qog qog los tshawb nrhiav nws cov nyhuv inhibitory ntawm cov qog cell loj hlob.

• Kev loj hlob hormone ntsig txog kev tshawb fawb

feem ntau siv nyob rau hauv lub chaw soj nstuam los kawm txog kev zais cia thiab kev tswj hwm ntawm kev loj hlob hormone. Nws tuaj yeem cuam tshuam qhov kev tso tawm ntawm kev loj hlob hormone, uas yuav pab kom nkag siab tob txog lub cev thiab pathological cuam tshuam ntawm kev loj hlob hormone.

• Tshuaj ntsuam xyuas thiab kev loj hlob

Raws li ib tug somatostatin analogue, nws tuaj yeem siv rau kev tshuaj xyuas tshuaj thiab kev loj hlob. Los ntawm kev kawm txog kev cuam tshuam nrog lub hom phiaj, cov tshuaj tshiab molecules uas muaj peev xwm kho tau tuaj yeem nrhiav pom, ntxiv dag zog rau txoj kev loj hlob ntawm cov tshuaj tshiab.

• Cell kab lis kev cai thiab kev sim ua qauv tsim

Nws tuaj yeem siv rau hauv chav kuaj los tsim cov qauv kab lis kev cai ntawm tes thiab cov qauv tsiaj sim los kawm txog lawv cov txheej txheem ntawm kev ua haujlwm hauv ntau lub xeev cov kab mob. Los ntawm kev siv cov txheej txheem ntawm tes los yog tsiaj cov qauv, cov txheej txheem kab mob tuaj yeem simulated kom nkag siab tob txog cov kab mob thiab cov tswv yim kho mob ntawm cov kab mob.

Laboratory synthesis ntawmoctreotide hmoovFeem ntau siv cov txheej txheem Solid Phase Peptide Synthesis (SPPS). Txoj kev no siv cov amino resin ntawm cov khoom siv -theem nqa khoom raws li cov khoom pib, thiab tsim cov saw peptide los ntawm kev ntxiv cov amino acid residues uas yuav tsum tau ua.

Kev xaiv cov khoom thauj khoom theem

Xaiv cov khoom siv theem tsim nyog rau peptide synthesis, cov khoom siv feem ntau suav nrog styrene polymers thiab polyvinyl cawv. Txhim kho cov amino resin ntawm cov cab kuj los ua ib qho khoom siv -theem hluavtaws cob.

Sab saw allyl tiv thaiv

Qee qhov xwm txheej, txhawm rau tiv thaiv sab saw allyl cov tshuaj tiv thaiv thaum lub sijhawm ua ke, kev tiv thaiv allyl yog qhov tsim nyog. Cov pab pawg tiv thaiv muaj xws li trifluoroacetyl thiab chloroacetyl pawg.

Kev tiv thaiv ntawm sab saw allyl pawg

Tom qab ua tiav cov tshuaj tiv thaiv cyclization ntawm qhov xav tau amino acid residue, cov tshuaj tiv thaiv ntawm kev tiv thaiv ntawm sab saw allyl pawg yog nqa tawm. Feem ntau, cov kua qaub los yog alkaline daws yog siv rau kev ua haujlwm deprotection.

Condensation ntawm amino resin

Cov amino acids xav tau yog condensed nrog amino resin los tsim thawj amino acid residue ntawm peptide saw. Cov tshuaj tiv thaiv condensation feem ntau siv dichloromethane ua cov kuab tshuaj, N-hydroxysuccinimide (NHS) thiab 1- (3-Dimethylaminopropyl) -3-ethylcarbodiimide (EDC) ua cov khoom sib txuas.

R-CHOCO-NH-R + R-NH + NHS + C₂H₄Cl₂→ R-CHOCO-NH-R + NHS + C₂H₄Cl₂

Cyclization cov tshuaj tiv thaiv

Transforming linear peptide chains rau hauv cov qauv cyclic yog ib qho ntawm cov kauj ruam tseem ceeb hauv kev sib txuas ntawm nws. Cyclization tuaj yeem ua tiav los ntawm ntau txoj hauv kev, xws li kev tsim cov ester bonds, amide bonds, thiab lwm yam. Txoj kev siv cyclization feem ntau yog txuas ib kawg ntawm cov saw peptide mus rau lwm qhov kawg, tsim ib lub voj voog.

Txiav thiab purification

Txiav peptide chains los ntawm cov khoom siv -theem nqa khoom thiab ua kom huv si kom tshem tawm cov khoom tsis zoo thiab los ntawm - cov khoom. Feem ntau txiav reagents muaj xws li TFA (trifluoroacetic acid) los yog HCl, thiab lwm yam. Purification feem ntau ua tiav los ntawm kab chromatography lossis crystallization.

Kev soj ntsuam zoo thiab kev tswj xyuas

Lub synthesized yog raug mus rau qhov zoo kuaj thiab tswj los ntawm analytical txoj kev xws li huab hwm coj spectrometry thiab siab -kev ua tau zoo kua chromatography kom paub meej tias nws purity thiab zoo raws li qhov yuav tsum tau.

Cov tshuaj no, raws li qhov tshwj xeeb thiab cov khoom sib xyaw ua ke octapeptide somatostatin analogue, tau qhia dav dav daim ntawv thov kev cia siab thiab muaj txiaj ntsig zoo hauv kev kho mob tshuaj txij thaum pib. Nws tsis tsuas yog tau txais cov txiaj ntsig tseem ceeb ntawm cov tshuaj somatostatin, tab sis kuj tseem txhim kho nws cov kev ua haujlwm lom neeg thiab kev ruaj ntseg los ntawm kev hloov pauv ntawm cov qauv thiab kev ua kom zoo, ua rau nws ua lub luag haujlwm tsis hloov pauv hauv kev kho mob ntawm ntau yam kab mob ntsig txog endocrine thiab exocrine pancreatic tsis ua haujlwm.

Pharmacological mechanism ntawm octreotide

Inhibits endocrine thiab pancreatic secretion

Cov kab mob endocrine, feem ntau yog tsim los ntawm pancreatic islet hlwb, yog lub luag haujlwm rau kev zais ntau yam tshuaj hormones, ntawm cov insulin thiab glucagon yog qhov tseem ceeb hauv kev tswj cov ntshav qabzib. Nws tuaj yeem xaiv khi rau somatostatin receptors ntawm pancreatic cell membranes los ntawm kev ua raws li cov txheej txheem ntawm kev ua ntawm somatostatin, ua kom muaj ntau txoj hauv kev qhia thiab thaum kawg inhibiting insulin secretion los ntawm pancreatic beta hlwb thiab glucagon secretion los ntawm pancreatic alpha hlwb. Cov txheej txheem no yog qhov tseem ceeb tshwj xeeb rau kev kho mob ntshav qab zib mellitus thiab nws cov teeb meem, vim tias cov tshuaj insulin ntau dhau tuaj yeem ua rau cov tshuaj insulin tsis kam, thiab qhov txawv txav ntawm glucagon yuav ua rau nyuaj rau kev tswj cov ntshav qab zib. Kev cuam tshuam ntawm nws yuav pab ua kom qhov sib npaug ntawm pancreatic muaj nuj nqi thiab txhawb cov ntshav qabzib ruaj khov.

inhibits kev tso tawm ntawm bicarbonate thiab digestive enzymes los ntawm exocrine pancreas

Lub exocrine pancreas yog tsim los ntawm cov hlwb acinar thiab ductal hlwb, lub luag haujlwm rau kev zais cov kua txiv pancreatic, uas muaj ntau cov bicarbonate thiab ntau yam digestive enzymes (xws li trypsin, pancreatic lipase, pancreatic amylase, thiab lwm yam), uas yog ib qho tseem ceeb rau kev zom thiab nqus cov zaub mov. Txawm li cas los xij, hauv qee yam kab mob, xws li mob pancreatitis, mob hnyav heev ntawm tus mob pancreatitis, thiab lwm yam, kev tso tawm ntau dhau ntawm cov kua txiv pancreatic thiab ua kom cov enzymes digestive tuaj yeem ua rau nws tus kheej digestion ntawm pancreatic cov ntaub so ntswg, ua rau mob hnyav thiab cov ntaub so ntswg puas. Nws txo qis kev tso tawm ntawm bicarbonate thiab digestive enzymes los ntawm inhibiting lub secretion kev ua ntawm acinar hlwb, li no alleviating tus kheej digestion lub nra ntawm tus txiav thiab tiv thaiv pancreatic ntaub so ntswg los ntawm kev puas tsuaj ntxiv. Cov txheej txheem ntawm kev ua haujlwm no ua rau qhov no yog ib qho ntawm cov tshuaj nyiam los kho tus mob pancreatitis thiab tiv thaiv nws rov tshwm sim.

Clinical daim ntawv thov ntawm octreotide hmoov

Kev kho mob ntawm mob pancreatitis

Mob pancreatitis yog kab mob ntawm tus txiav ua los ntawm kev zom zaub mov ntawm tus kheej ntawm trypsin. Nws qhov pib tshwm sim tam sim ntawd, qhov xwm txheej yog qhov txaus ntshai, thiab kev tuag yog siab heev. Qhov no tau dhau los ua ib qho tshuaj tseem ceeb hauv kev kho tus mob pancreatitis los ntawm inhibiting pancreatic exocrine secretion, txo cov stimulation thiab kev puas tsuaj ntawm pancreatic kua txiv rau pancreatic nqaij, thiab alleviating systemic inflammatory teb. Kev tshawb fawb tau pom tias thaum ntxov daim ntawv thov ntawm nws tuaj yeem txo qhov tshwm sim ntawm cov teeb meem thiab kev tuag ntawm tus mob pancreatitis, thiab txhim kho cov kev mob tshwm sim ntawm cov neeg mob.

Adjuvant kho mob rau mob pancreatitis

Cov neeg mob uas muaj tus kab mob pancreatitis ntev feem ntau muaj mob plab, mob pancreatic endocrine tsis ua haujlwm, thiab lwm yam tsos mob. Los ntawm nws cov nyhuv inhibitory ntawm pancreatic exocrine secretion, tuaj yeem txo cov tsos mob ntawm qhov mob plab los ntawm kev tso kua txiv pancreatic ntau dhau rau cov neeg mob, thaum tseem pab tiv thaiv cov ntaub so ntswg pancreatic thiab ncua kev kis kab mob. Tsis tas li ntawd, nws tuaj yeem txhim kho pancreatic endocrine muaj nuj nqi thiab txhawb kev tsim cov tshuaj insulin thiab siv, tshwj xeeb tshaj yog siv rau cov neeg mob ntshav qab zib mob pancreatitis.

Qhov no yog ib tug ntev-acting synthetic octapeptide analogues uas ua raws li cov kev ua ntawm cov tshuaj lom neeg endogenous somatostatin tab sis qhia tau zoo heev txhim kho metabolic stability thiab ntev pharmacological kev ua si. Nws ua raws li kev xaiv agonist rau somatostatin receptors, nrog rau kev sib raug zoo rau cov subtypes 2, 3, thiab 5, uas tau dav dav hauv cov ntaub so ntswg xws li lub hlwb, hypothalamus, caj pas pituitary, pancreas, thiab plab hnyuv.

Thaum khi rau cov receptors no, nws ua rau inhibitory Gi protein-coupled signaling pathways, txo intracellular cyclic adenosine monophosphate (cAMP) concentrations, thiab tom qab suppresses txawv txav ntawm tes proliferation thiab ntau dhau lawm hormonal secretion, ua rau nws zoo heev nyob rau hauv kev tswj cov tshuaj hormones tsav. Tshaj li nws txoj kev siv tau zoo hauv acromegaly, nws ua lub luag haujlwm tseem ceeb hauv kev txo cov tsos mob ntawm lub neej hloov pauv los ntawm ntau yam kab mob neuroendocrine, suav nrog cov qog nqaij hlav carcinoid thiab vasoactive plab hnyuv peptide-secreting (VIP) cov qog.

Cov neoplasms no feem ntau tso tawm ntau cov tshuaj bioactive uas ua rau mob plab hnyuv loj, ntuav tawm, mob plab, thiab electrolyte cuam tshuam.Los ntawm kev cuam tshuam cov hypersecretion ntawm cov tshuaj hormones no, nws zoo txo ​​cov tsos mob, txhim kho kev noj zaub mov zoo, thiab txhim kho cov neeg mob lub neej zoo. Clinically, cov tshuaj no muaj nyob rau hauv ntau yam formulations, nrog rau tam sim-tso tawm cov tshuaj txhaj tshuaj rau kev tswj mob hnyav thiab kev txhaj tshuaj ntev ntev rau kev tswj xyuas kev kho mob, ua rau tus kheej cov sij hawm noj tshuaj uas hloov mus rau cov kab mob sib txawv thiab cov neeg mob xav tau.

Txawm hais tias mob plab me me xws li mob plab, xeev siab, raws plab, thiab flatulence tuaj yeem tshwm sim thaum pib kho, cov teebmeem no feem ntau yog ncua sijhawm thiab ua haujlwm zoo nrog kev siv txuas ntxiv. Vim nws qhov tshwj xeeb receptor-targeting mechanism thiab txhim khu kev qha kev kho mob ua tau zoo, nws tseem yog ib tug indispensable kho tus neeg saib xyuas rau cov kab mob uas muaj feem xyuam rau cov tshuaj hormone overproduction thiab uncontrolled cellular loj hlob. Cov kev tshawb fawb soj ntsuam tsis tu ncua txuas ntxiv tshawb nrhiav nws cov ntawv nthuav dav, suav nrog kev siv cov kab mob inflammatory, qee yam mob qog noj ntshav, thiab lwm yam mob uas somatostatin signaling tuaj yeem muab cov txiaj ntsig kho mob.

Cim npe nrov: octreotide hmoov cas 79517-01-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom