Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm palmitoyl tripeptide-1 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo zoo palmitoyl tripeptide-1 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Palmitoyl tripeptide-1, CAS Tsis yog . 147732-56-7, yog ib qho ntawm cov paub tab biomimetic matrix signaling peptides dav siv hauv tshuaj pleev ib ce. Nws cov molecule muaj hydrophobic palmitoyl fatty acid saw nrog 16 carbon atoms covalently khi rau glycine -histidine-lysine (GHK) tripeptide sequence, nrog ib tug molecular hnyav ntawm kwv yees li 623 Da. Tam sim no, cov khoom xyaw no feem ntau yog sib xyaw nrog palmitoyl tetrapeptide-7 los ua Matrixyl 3000 peptide complex, uas yog siv dav hauv kev tiv thaiv kev laus ntawm cov tawv nqaij thiab cov tawv taub hau. Nyob rau hauv xyoo tas los no, nws daim ntawv thov tus nqi tau nce siab nyob rau hauv ob ntu ntu: tawv taub hau tiv thaiv - kev laus thiab kev tiv thaiv plaub hau, nrog rau kev kho cov tawv nqaij glycation-induced aging.
Peb Cov Khoom Muag Khoom
Palmitoyl tripeptide-1COA
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| Certificate of Analysis | ||
| Compound npe | Palmitoyl tripeptide-1 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 147732-56-7 | |
| Ntau | 27g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.26% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.15% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 400 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 600ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C30H54N6O5 |
| Exact Mass | 578.42 |
| Molecular Luj | 578.8 |
| m/z | 578.42 (100.0%), 579.42 (32.4%), 580.42 (5.1%), 579.41 (2.2%), 580.42 (1.0%) |
| Elemental Analysis | C, 62.25; H, 9.40; N, 14.52; O, 13.82 |
Daim ntawv thov hauv Scalp Anti-Kev laus thiab kev tiv thaiv plaub hau
Core Mechanisms Linking Scalp Aging to Hair Poob
Cov tawv taub hau yog lub thickest cutaneous cheeb tsam ntawm tib neeg lub cev thiab muaj hnub nyoog sai dua ntawm daim tawv nqaij ntawm lub ntsej muag, nrog ib tug ncaj causal kev sib raug zoo ntawm tawv taub hau senescence thiab alopecia. Ua los ntawm kev laus, hluav taws xob ultraviolet, yav tsaus ntuj thiab oxidative kev nyuaj siab, collagen nyob rau hauv tawv taub hau dermis undergoes tsis tu ncua, ua rau slack tawv taub hau fascia thiab txo cov tawv taub hau thickness, uas tsis muab ib tug ruaj khov kev txhawb nqa lub hauv paus rau plaub hau follicles. Lub caij no, tawv taub hau microcirculation deteriorates, dermal papilla cell kev ua ub no, thiab cov hauv paus plaub hau maj mam miniaturize.
Thick terminal plaub hau hloov mus rau hauv cov plaub hau zoo vellus nrog luv luv anagen theem thiab nkag mus rau telogen theem, thaum kawg ua rau cov plaub hau rov qab, thinning crowns thiab diffuse plaub hau poob.
Tsis tas li ntawd, kev laus ntawm tawv taub hau yog nrog los ntawm kev mob qis - qib o. Cov kab mob ua paug tsis tu ncua tawm tsam cov hauv paus plaub hau thiab cuam tshuam cov homeostasis ntawm cov plaub hau follicle, uas yog thawj qhov ua rau tsis yog -androgenetic alopecia ntawm cov hluas thiab nruab nrab- cov neeg laus. Cov khoom siv los tiv thaiv-cov plaub hau poob feem ntau tsom rau kev tswj roj thiab kev tiv thaiv androgen thaum tsis quav ntsej txog cov hauv paus hauv paus ua rau- hnub nyoog ntawm tawv taub hau matrix thiab kev txhawb nqa follicular tsis txaus.Palmitoyl tripeptide-1hais txog qhov sib txawv no hauv kev tu plaub hau los ntawm kev xav ntawm tawv taub hau los tiv thaiv -aging.
Tom qab nkag mus rau ntawm tawv taub hau, tus txiv neej -Tripeptide-1 hla lub stratum corneum ntawm cov transdermal permeability zoo heev thiab mus txog dermal papilla txheej ntawm cov hauv paus plaub hau, xa tawm los tiv thaiv- plaub hau poob, plaub hau- kho thiab tawv taub hau los tiv thaiv kev laus: los ntawm peb txoj kev
Kho cov tawv taub hau dermal matrix: ua kom tawv taub hau fibroblast kev ua, elevate cov ntsiab lus ntawm tawv taub hau collagen thiab elastin, thicken lub tawv taub hau dermis, zawm slack tawv taub hau thiab stabilize lub rooting ib puag ncig ntawm cov hauv paus plaub hau kom lub cev txo cov plaub hau los ntawm xoob cov hauv paus hniav.
Txhim kho qhov kev nthuav qhia ntawm vascular endothelial kev loj hlob zoo (VEGF): txhim kho tawv taub hau microcirculation thiab ua kom cov pa oxygen thiab cov as-ham los ntawm cov ntshav mus rau cov hauv paus plaub hau, daws cov plaub hau poob los ntawm cov khoom noj tsis txaus follicular.
inhibits tawv taub hau inflammatory pathways: inhibit qhov tso tawm ntawm inflammatory yam tseem ceeb IL-6 thiab TNF- , txo cov tawv taub hau mob me ntsis, thaiv inflammatory-mediated follicular apoptosis thiab prolong cov plaub hau anagen theem.
Tsis zoo li cov tshuaj tua kab mob los tiv thaiv- cov khoom xyaw plaub hau xws li minoxidil, cov peptide no ua rau tsis muaj kev phiv xws li tawv taub hau erythema lossis ntau dhau thawj zaug, ua rau nws tsim nyog rau lub sijhawm ntev - kev tu tawv taub hau txhua hnub.
Formulation Application Protocols for Scalp Anti-Kev laus thiab kev tiv thaiv plaub hau
Nyob rau hauv cov txheej txheem kev saib xyuas tawv taub hau, qhov sib ntxiv ntawm cov pal -Tripeptide-1 yog li ntawm 0.001% mus rau 0.01%, qhov ntau txaus los ua kom muaj kev ua haujlwm lom neeg zoo. Cov concentrations siab dua tsis tuaj yeem txhawb nqa kev ua tau zoo tab sis nce tus nqi tsim. Cov txheej txheem sib xyaw feem ntau yog siv rau hauv cov qauv kev tu plaub hau txhua hnub kom ntxiv dag zog tiv thaiv cov plaub hau tsis zoo:
Blended nrog acetyl tetrapeptide-3: synergistically qhib dermal papilla hlwb thiab txuas cov plaub hau anagen theem bidirectionally.
Blended nrog piroctone olamine: integrate roj tswj, tawv taub hau soothing thiab tiv thaiv - laus plaub hau fixation, zoo tagnrho rau oily tawv taub hau alopecia cov neeg mob.
Blended nrog panthenol thiab ceramides: kho cov tawv taub hau barrier thiab alleviate plaub hau poob txuam nrog rhiab tawv taub hau.
Tam sim no, mainstream 3T thev naus laus zis peptide los tiv thaiv-cov plaub hau poob tsuaj zawv plaub hau thiab cov khoom ua kom txias hauv khw txhua tus coj pal-Tripeptide-1 ua cov tseem ceeb los tiv thaiv- kev laus peptide los tsim ib qho peb -dimensional anti-hair poob system featuring scalpriicle nourishing.
Cov khoom xyaw no yog sib xws nrog txhua pawg ntawm cov khoom siv tawv taub hau:
Nyob rau hauv cov tshuaj zawv plaub hau: nws zam anionic surfactant ib puag ncig thiab tseem tso rau ntawm daim tawv taub hau nto ncej- ntxuav kom ua rau muaj kev kho tsis tu ncua.
Nyob rau hauv cov tawv taub hau serums: anhydrous formulas maximize peptide kev ua si, thiab thaum hmo ntuj kho tawv taub hau serums ncaj qha rau follicular senescence.
Nyob rau hauv hnyav textures xws li cov plaub hau qhov ncauj qhov ntswg thiab tawv taub hau balms: occlusive matrices pab txhawb ntev -peptide nkag mus ntev, haum rau kev tu tawv nqaij qhuav thiab laus.
Thib peb- tog hauv-vivo xeem cov ntaub ntawv qhia tau hais tias tom qab 84 hnub sib law liag ntawm kev siv cov khoom tu tawv taub hau uas muaj pal-Tripeptide-1, cov neeg mob pom tau tias muaj kev txhim kho ntawm tawv taub hau laxity, qhov nruab nrab 57.08% txo qis hauv tag nrho cov plaub hau, thiab tshem tawm cov plaub hau zoo.
Cov kev txwv ntawm daim ntawv thov uas twb muaj lawm thiab cov lus qhia ua kom zoo
Ob tug loj drawbacks txwv cov tawv taub hau daim ntawv thov ntawmpalmitoyl tripeptide-1: ua ntej, cov ntshiab peptide molecule tawm tsam mus rau pilosebaceous ducts, ua rau tsis txaus follicle hom phiaj; thib ob, nws cov dej num degrades thaum lub sij hawm ntev - khaws cia hauv cov tshuaj aqueous.
Kev tsim kho tom ntej tuaj yeem siv liposomal encapsulation thev naus laus zis kom ua tiav lub hom phiaj peptide xa mus rau cov hauv paus plaub hau thaum txhim kho cov khoom ruaj khov. Tsis tas li ntawd, kev sib xyaw ua ke nrog caffeine thiab pom palmetto extracts tuaj yeem sib cais txhim kho microcirculation thiab tswj cov androgens, npog ntau hom alopecia suav nrog androgenetic alopecia, kev laus -txog plaub hau poob thiab kev ntxhov siab- cuam tshuam los, yog li nthuav dav cov neeg siv khoom siv rau kev saib xyuas tawv taub hau.
Cov ntawv thov hauv Ameliorating Glycation-Induced Aging
Tshem Tawm Kab Mob Khaub Ncaws thiab Thaiv Cov Vicious Glycation Cycle
Thaum ua kom RAGE receptors los ntawm qib siab glycation kawg cov khoom (AGEs), NF-κB inflammatory pathway yog persistently stimulated, tso loj oxidative dawb radicals thiab inflammatory yam uas ua rau kom cov cutaneous oxidative puas thiab collagen degradation. Pal-Tripeptide-1 modulates TGF- txoj hauv kev txhawm rau txhawm rau NF-κB txoj hauv kev ua kom, txo qis cov tawv nqaij oxidative kev nyuaj siab, txo cov dawb radical nres ntawm daim tawv nqaij cov proteins, thiab txwv tsis pub overexpression ntawm matrix metalloproteinases (MMPs), yog li tiv thaiv oxidative kev nyuaj siab ua ke hauv qab.
Kev sim hauv vitro cellular tau txheeb xyuas tias glycation- cov tawv nqaij puas lawm fibroblasts kho nrog pal-Tripeptide-1 tau pom 41% poob rau hauv cov kab mob inflammatory thiab qhov txo qis ntawm collagen degradation.
Txhim kho qhov Dermal Collagen Network thiab Rov Qab Cov Cim Ntawm Cov tawv nqaij Glycated
Rau cov ntoo khaub lig- txuas thiab denatured collagen cov ntaub so ntswg, pal-Tripeptide-1 ua haujlwm raws li cov tub ntxhais matrix signaling peptide los txhawb de novo synthesis ntawm noj qab haus huv collagen. Tshiab zoo-txheej txheem collagen fibers hloov cov laus, hla- txuas glycated collagen kom maj mam loosen nruj cross-linked collagen qauv.
Meanwhile, nws txhawb glycosaminoglycan synthesis, boosts daim tawv nqaij lub hauv paus chiv keeb muaj peev xwm tuav, thiab ameliorates qhuav, ntxhib, dull thiab salllow ntawm daim tawv nqaij tshwm sim los ntawm glycation.Piv nrog ib tug anti-glycation cov khoom xyaw, cov peptide no fundamentally kho dermal structural kev puas tsuaj rau ntawm daim tawv nqaij ntau dua li glycation. Kev siv sijhawm ntev - txo qis glycation laus cov tsos mob xws li lub ntsej muag sagging thiab qhov muag plooj plooj.
Formulation Applications and Efficiency Tests of Anti-Glycation Products
Hauv kev tiv thaiv- kev laus thiab tiv thaiv-glycation cov khoom tu tawv nqaij, pal-Tripeptide-1 yog qhov sib xyaw ua ke ntawm 0.005%–0.01%.
Nws nquag sib xyaw nrog carnosine thiab ferulic acid los tsim kom muaj tag nrho - saw tiv thaiv -glycation system: carnosine ntes cov suab thaj dawb nyob rau hauv pem hauv ntej - theem kawg, pal-Tripeptide-1 blocks inflammatory pathways nyob rau hauv nruab nrab - theem thiab kho cov txheej txheem rov qab-sib zog collagen. tshem tawm cov dawb radicals, tiv thaiv kev laus dua los ntawm glycation thiab oxidation thoob plaws peb qhov ntev.
Cov txheej txheem sib xyaw no tau siv dav hauv cov tshuaj tiv thaiv -glycation serums, firming creams thiab brightening lub ntsej muag lub ntsej muag.A 28-hnub tib neeg sim ua pov thawj tias anti-glycation formulas uas muaj cov peptide no txo qis qis AGE, nrog rau cov ntaub ntawv sau tseg 22% txo qis ntawm daim tawv nqaij dullation, 3% ntawm daim tawv nqaij dullation, pom tseeb ntawm daim tawv nqaij dullation, elasticity. Tsis tas li ntawd, cov khoom muaj me me thiab tsis yog- khaus, haum rau kev saib xyuas kev laus niaj hnub ntawm cov neeg uas muaj suab thaj ntau, nquag tsaus ntuj thiab ua neej nyob ntev.
Mainstream Synthetic Method: Solid Phase Peptide Synthesis (SPPS)
Basic Synthetic Workflow
Industrial loj ntau lawm ntawmpalmitoyl tripeptide-1Feem ntau siv Fmoc- tiv thaiv cov theem peptide synthesis. Cov txheej txheem no muaj cov tshuaj tiv thaiv me me, ob peb los ntawm - cov khoom lag luam thiab cov khoom lag luam siab purity, ua rau nws haum rau loj - nplai tsim cov khoom siv tshuaj pleev ib ce. Lub synthesis muaj peb theem:
Xaiv Wang resin ua cov khoom thauj khoom theem, ua raws li ob peb Fmoc- tiv thaiv cov amino acids (Fmoc-lysine, Fmoc-histidine thiab Fmoc-glycine), thiab ua cov txheej txheem condensation kom tau GHK tripeptide resin.
Tshem tawm N-terminal Fmoc tiv thaiv pab pawg ntawm peptide, tom qab ntawd ob peb palmitoyl fatty acid ua kom tiav hydrophobic saw hloov.
Tshem tawm cov resin nrog trifluoroacetic acid cleavage tov thiab ib txhij deprotect amino acid sab chains kom yield crude pal -Tripeptide-1.
Purification thiab Quality Control Process
Cov khoom lag luam tsis zoo tau thim rov qab -theem chromatographic purification los ntawm kev npaj siab -kev ua haujlwm ua kua chromatography (HPLC) kom tshem tawm cov condensation los ntawm - cov khoom thiab cov monomers unreacted. Lyophilization tom qab xa khoom siab - purity raw khoom hauv cov hmoov dawb, nrog rau kev lag luam - qib purity tshaj 98%.
Piv nrog rau cov kua-theem synthesis, solid-theem synthesis tshem tawm cov theem purification nruab nrab, txiav tag nrho cov synthesis voj voog los ntawm 40%, thiab txais tag nrho cov aqueous-theem cov tshuaj tiv thaiv rau eco- phooj ywg ntau lawm. Tam sim no optimized industrial processes kho cov amino acid pub piv thiab cov tshuaj tiv thaiv kub kom txo tau cov nqi tsim khoom, ua kom dav siv cov khoom siv peptide no hauv huab hwm coj- khw muag khoom tu tawv nqaij thiab cov khoom tu plaub hau.
Cov ntaub ntawv
- Ketide Biotech. Palmitoyl Tripeptide-1 Raw Material Product Manual & Application Guidelines[EB/OL]. 2025.
- Pepperpedia. Palmitoyl Tripeptide-1 Mechanism and Cosmetic Application[EB/OL]. 2026.
- National Intellectual Property Administration ntawm Tuam Tshoj. Cov kua dej -Phase Synthesis Method of Palmitoyl Tripeptide-1 (CN114891063A)[Patent]. 2022.
- MDhair. Biomimetic Peptides rau Scalp Anti-aging thiab Hair Regeneration[J]. International Journal of Cosmetic Science, 2025.
- Replexiumpeptide. Kev tshawb fawb ntawm Anti-Glycation Mechanism ntawm Matrixyl Peptide Complex[EB/OL]. 2025.
FAQ
palmitoyl Tripeptide-1 yog dab tsi?
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Ib peptide uas txhawb nqa collagen synthesis, pab txhawb nqa firmer - saib daim tawv nqaij thiab pab txo qis cov tsos ntawm cov kab zoo.
Palmitoyl Tripeptide-1 piav qhia
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Nws yog categorize raws li ib tug "neeg xa xov liaison peptide" vim hais tias ntawm nws muaj peev xwm "qhia" daim tawv nqaij yuav ua li cas kom zoo, tshwj xeeb tshaj yog hais txog kev txo cov cim ntawm lub hnub puas tsuaj xws li wrinkles thiab ntxhib ntxhib ntxhib los mos.Qee qhov kev tshawb fawb tau pom tias cov peptide no muaj qhov zoo sib xws los tiv thaiv - cov txiaj ntsig kev laus rau retinol.
Cim npe nrov: palmitoyl tripeptide-1, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom