Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm beta-neoendorphin cas 77739-21-0 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo beta-neoendorphin cas 77739-21-0 rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Beta-Neoendorphin, molecular mis C54H77N13O12, CAS 77739-21-0, feem ntau dawb hmoov. Los ntawm cov qauv molecular foundations, beta Neoendorphin yog ib qho endogenous opioid peptide nrog ib qho tshwj xeeb amino acid sequence thiab spatial conformation. Cov qauv molecular tshwj xeeb no endows beta Neoendorphin nrog cov kev ua haujlwm lom neeg tshwj xeeb, ua rau nws khi rau cov neeg txais kev sib raug zoo thiab siv cov tshuaj pharmacological. Hauv cov kab mob uas muaj sia nyob, lawv lub cev lub cev muaj feem cuam tshuam nrog lawv txoj haujlwm lom neeg. Piv txwv li, nws solubility thiab stability ncaj qha cuam tshuam rau nws nqus thiab metabolic dab nyob rau hauv lub cev, yog li cuam tshuam rau nws pharmacological teebmeem. Lub caij no, cov qauv molecular thiab nqi zog ntawm beta Neoendorphin kuj txiav txim siab nws txoj kev khi hom thiab kev sib raug zoo nrog cov receptors, yog li txiav txim siab lub zog thiab qhov tshwj xeeb ntawm nws cov haujlwm lom neeg.
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Customized Bottle Caps Thiab Corks:
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Tshuaj Formula |
C54H77N13O12 |
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Exact Mass |
1100 |
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Molecular Luj |
1100 |
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m/z |
1100 (100.0%), 1101 (58.4%), 1102 (16.7%), 1101 (4.8%), 1103 (3.1%), 1102 (2.8%), 1102 (2.5%), 1103 (1.4%) |
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Elemental Analysis |
C, 58.95; H, 7.05; N, 16.55; O, 17.45 |
Vim lub fact tiasBeta-Neoendorphinyog qhov dav thiab hauv- qhov kev tshawb fawb tob uas muaj ntau yam xws li neuroscience, pharmacology, tshuaj tsim, thiab biosensors. Los ntawm kev ua nyob rau hauv - kev tshawb fawb tob txog nws lub cev lub cev thiab daim ntawv thov tus nqi, peb tuaj yeem muab cov tswv yim tshiab thiab cov hau kev rau kev kho cov kab mob neurological thiab mob, kev tsim tshuaj, thiab kev tsim cov biosensors. Hauv qab no, peb yuav muab cov lus qhia ntxaws ntxaws rau ntau yam kev siv thiab kev tshawb fawb qhia.
1. Raws li endogenous opioid peptide, nws muaj dav daim ntawv thov kev cia siab nyob rau hauv lub teb ntawm neuroscience thiab pharmacology. Nws cov qauv molecular tshwj xeeb thiab lub cev muaj zog ua kom nws khi rau cov receptors tshwj xeeb, yog li ua lub luag haujlwm hauv kev tswj hwm kev sib kis ntawm neural thiab kev nkag siab ntawm qhov mob. Yog li, kev kawm lub cev ntawm beta Neoendorphin, xws li cov qauv molecular, stability, solubility, thiab lwm yam, tuaj yeem pab peb nkag siab tob txog nws cov tshuaj siv tshuaj thiab muab cov tswv yim tshiab thiab txoj hauv kev rau kev kho cov kab mob neurological thiab mob.
2. Nws kuj tseem muaj txiaj ntsig zoo hauv kev tsim tshuaj thiab kev tsim kho. Los ntawm delving rau hauv kev sib raug zoo ntawm nws lub cev thiab kev ua si lom neeg, peb tuaj yeem tshawb nrhiav yuav ua li cas txhawm rau txhim kho cov qauv ntawm beta Neoendorphin los txhim kho nws cov tshuaj pharmacological thiab txo cov kev mob tshwm sim. Tsis tas li ntawd, kev sib cuam tshuam ntawm beta Neoendorphin thiab lwm yam tshuaj tuaj yeem raug tshawb nrhiav los tsim cov tshuaj tshiab ua ke nrog cov teebmeem kev sib koom ua ke thiab txhim kho cov txiaj ntsig kev kho mob.
3. Nws kuj tseem muaj peev xwm siv tau rau hauv biosensors thiab tshuaj ntsuam xyuas technologies. Los ntawm kev siv nws cov khoom tshwj xeeb ntawm lub cev thiab lub peev xwm paub txog biometric, biosensors tuaj yeem tsim thiab tsim kho kom pom cov qib neurotransmitter lossis cov cim kab mob. Cov sensors no tuaj yeem ua tiav kev kuaj mob ntxov thiab saib xyuas cov kab mob cuam tshuam, muab kev txhawb zog rau kev kuaj mob thiab kev kho mob.
Beta-Neoendorphin, raws li endogenous opioid peptide, plays lub luag haujlwm tseem ceeb hauv cov hlab ntsha. Nws cov khoom siv tshuaj tshwj xeeb ua rau nws muaj txiaj ntsig zoo hauv kev tswj qhov mob, tiv thaiv kab mob, thiab kho cov kab mob neurodegenerative.
Beta Neoendorphin feem ntau exerts nws cov tshuaj pharmacological los ntawm kev khi rau cov receptors tshwj xeeb. Cov receptors no tau nthuav dav hauv nruab nrab thiab lub paj hlwb peripheral, kho ntau yam txheej txheem physiological thiab pathological. Tom qab khi rau receptors, beta Neoendorphin tuaj yeem ua kom muaj cov teeb liab hloov pauv txoj hauv kev, yog li tswj kev tso tawm ntawm cov neurotransmitters, neuronal excitability, thiab synaptic plasticity.
Pharmacodynamic yam ntxwv
(1) Cov nyhuv analgesic: Beta Neoendorphin muaj cov nyhuv analgesic tseem ceeb thiab tuaj yeem txo ntau hom mob, nrog rau mob ntev, mob neuropathic, thiab lwm yam.
(2) Cov nyhuv Neuroprotective: Beta Neoendorphin muaj kev tiv thaiv zoo rau cov neurons, uas tuaj yeem txo cov neuronal puas thiab tuag. Qhov kev tiv thaiv no yuav cuam tshuam nrog nws cov tshuaj tua kab mob antioxidant, tiv thaiv - mob, thiab cov tshuaj tiv thaiv apoptotic.
(3) Kev tswj cov kev xav thiab kev coj cwj pwm: Beta Neoendorphin tseem koom nrog hauv kev tswj cov kev xav thiab kev coj tus cwj pwm, uas tuaj yeem cuam tshuam rau kev xav tsis zoo xws li kev ntxhov siab thiab kev nyuaj siab, nrog rau kev txawj ntse xws li kev kawm thiab kev nco.
3. Pharmacokinetic khoom
(1) Kev nqus thiab kev faib tawm: Kev nqus thiab faib cov yam ntxwv ntawm beta Neoendorphin hauv vivo raug cuam tshuam los ntawm ntau yam, suav nrog txoj kev tswj hwm, cov ntawv siv tshuaj, thiab qhov sib txawv ntawm tus kheej. Feem ntau hais lus, beta Neoendorphin tuaj yeem nkag mus rau hauv nruab nrab lub paj hlwb los ntawm cov ntshav - lub hlwb thaiv thiab siv nws cov teebmeem.
(2) Metabolism thiab excretion: Cov txheej txheem metabolic thiab excretion qauv ntawm beta Neoendorphin hauv lub cev tsis nkag siab tag nrho, tab sis cov kev tshawb fawb tau pom tias nws tuaj yeem metabolized los ntawm lub siab thiab tawm hauv lub raum.
(3) Ib nrab lub neej thiab lub sijhawm ntev: Ib nrab- lub neej thiab lub sijhawm ntawm kev ua tau zoo ntawm beta Neoendorphin nyob ntawm seb muaj pes tsawg leeg xws li kev siv ntau npaum li cas thiab ntau zaus ntawm kev tswj hwm, nrog rau qhov sib txawv ntawm tus kheej. Feem ntau hais lus, nws txoj kev ua tau zoo yuav siv sijhawm ntev thiab tuaj yeem ua rau muaj txiaj ntsig zoo.
Raws li cov tshuaj pharmacological ntawm beta Neoendorphin, nws muaj cov ntawv thov dav dav hauv kev tswj kev mob, kev tiv thaiv kab mob, thiab kev kho mob ntawm cov kab mob neurodegenerative. Tam sim no, qee qhov kev tshawb fawb soj ntsuam ua ntej tau tshawb fawb txog kev ua tau zoo thiab kev nyab xeeb ntawm beta Neoendorphin hauv kev kho mob ntev, mob neuropathic, thiab Alzheimer's disease. Txawm li cas los xij, cov kev tshawb fawb no tseem nyob rau theem pib thiab xav tau kev sim tshuaj ntxiv kom paub tseeb tias lawv ua tau zoo thiab kev nyab xeeb.
Qhib Erk1/2 signaling pathway
Nws tuaj yeem qhib lub Erk1/2 (extracellular teeb liab tswj kinase 1 thiab 2) taw qhia txoj hauv kev. Erk1/2 yog ib tug tswv cuab tseem ceeb ntawm MAPK (mitogen activated protein kinase) tsev neeg, ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes, sib txawv, apoptosis, thiab kev ntxhov siab. Cov tshuaj no tuaj yeem cuam tshuam rau kev coj tus cwj pwm lom neeg xws li kev loj hlob ntawm tes, kev ciaj sia, thiab kev tsiv teb tsaws los ntawm kev ua kom lub Erk1/2 signaling pathway, yog li cuam tshuam rau tag nrho lub cev kev ua haujlwm ntawm lub cev. Piv txwv li, kev ua haujlwm ntawm Erk1/2 signaling pathway tuaj yeem txhawb kev loj hlob ntawm tes thiab kev tsiv teb tsaws, uas yog qhov tseem ceeb rau cov txheej txheem xws li kho cov ntaub so ntswg thiab kho qhov txhab.
Txhawb kev ua haujlwm ntawm matrix metalloproteinase (MMP).
Nws tseem tuaj yeem txhawb nqa kev ua haujlwm ntawm matrix metalloproteinases (MMPs), tshwj xeeb tshaj yog MMP-2 thiab MMP-9. Matrix metalloproteinases yog ib chav kawm ntawm cov enzymes uas tuaj yeem degrade extracellular matrix proteins, ua lub luag haujlwm tseem ceeb hauv kev hloov kho cov cellular matrix, kho cov ntaub so ntswg, inflammatory teb, thiab qog invasion. Nws tuaj yeem ua kom lub cev tsis zoo thiab hloov kho ntawm cov kab mob extracellular los ntawm kev txhawb nqa kev ua haujlwm ntawm MMP-2 thiab MMP-9, yog li koom nrog hauv kev tswj hwm lub cev thiab cov txheej txheem pathological xws li cov ntaub so ntswg puas tsuaj, cov lus teb, thiab cov qog loj hlob. Cov txheej txheem ntawm kev ua haujlwm no yog qhov tseem ceeb rau kev tswj hwm lub koom haum homeostasis thiab teb rau cov stimuli sab nraud.
Analgesic thiab tshuaj tiv thaiv kev ntxhov siab
Raws li ib qho endogenous opioid peptide, Beta Neoendorphin muaj cov tshuaj tua kab mob tseem ceeb thiab tiv thaiv kev ntxhov siab. Cov txheej txheem ntawm kev ua haujlwm no tuaj yeem cuam tshuam nrog lawv cov kev faib tawm thiab cov receptor khi cov yam ntxwv hauv lub hauv paus paj hlwb. Beta Neoendorphin tuaj yeem ua rau muaj kev cuam tshuam lom neeg los ntawm kev khi rau opioid receptors, nrog rau qhov tseem ceeb tshaj plaws yog nws lub peev xwm los txo qhov mob. Cov yam ntxwv no ua rau nws ua lub luag haujlwm tseem ceeb hauv kev tswj qhov mob. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem tiv thaiv kev ntxhov siab los ntawm kev tswj hwm cov haujlwm ntawm neurotransmitters thiab neural networks, yog li txhim kho lub siab lub ntsws thiab kev noj qab haus huv ntawm cov neeg mob.
Lwm yam muaj peev xwm mechanisms ntawm kev ua
Ntxiv nrog rau cov txheej txheem tseem ceeb ntawm kev ua tau hais los saum toj no,Beta-Neoendorphinkuj tseem yuav muaj lwm yam kev ua tau zoo. Piv txwv li, nws tuaj yeem koom nrog hauv kev tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, ua rau muaj kev tiv thaiv immunomodulatory los ntawm kev cuam tshuam rau kev loj hlob, kev sib txawv, thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Tsis tas li ntawd, cov tshuaj no kuj tseem tuaj yeem cuam tshuam ntau yam kev ua haujlwm ntawm lub cev ntawm lub cev los ntawm kev sib cuam tshuam nrog lwm cov neurotransmitters lossis cov tshuaj hormones.
Txoj kev loj hlob zeem muag ntawm qhov sib txuas no feem ntau yog nyob ntawm nws txoj kev tshawb fawb hauv biomedical teb, muaj peev xwm siv tshuaj kho mob, kev xav tau ntawm kev ua lag luam, thiab lwm yam kev nce qib. Cov hauv qab no yog cov ncauj lus kom ntxaws tsom xam ntawm nws txoj kev loj hlob zeem muag:
Kev nce qib hauv Biomedical Research
Raws li cov tshuaj endogenous peptide, nws ua lub luag haujlwm tseem ceeb hauv lub paj hlwb thiab yog li ntawd yog ib qho ntawm cov khoom tseem ceeb tshawb fawb hauv thaj tsam ntawm neuroscience. Nrog rau kev sib sib zog nqus txuas ntxiv ntawm kev tshawb fawb neuroscience, kev nkag siab ntawm lub cev lub cev ntawm kev ua haujlwm ntawm qhov sib xyaw no yuav ua tiav ntau dua. Qhov no yuav pab qhia tawm qhov tsis meej ntawm lub paj hlwb thiab cov txheej txheem ntawm cov kab mob tshwm sim, muab cov kev hloov tshiab rau kev kuaj mob thiab kev kho mob ntawm cov kab mob.
Muaj peev xwm siv tshuaj kho mob
Nws muaj ntau yam teebmeem ntawm lub cev, nrog rau kev txo qhov mob, cuam tshuam rau lub siab lub ntsws, thiab tswj cov kab mob endocrine. Cov yam ntxwv no ua rau cov khoom muaj txiaj ntsig zoo rau kev siv tshuaj kho mob hauv kev kho mob, tswj kev xav, thiab kho cov kab mob endocrine. Nrog rau kev tshawb fawb ntxiv ntawm nws cov teebmeem pharmacological, nws xav tias yuav dhau los ua cov tshuaj kho tshiab lossis kev kho mob ntxiv.
Kev lag luam xav tau
Nrog rau kev siv zog ntawm cov pej xeem thoob ntiaj teb kev laus thiab kev nce ntxiv ntawm qhov mob ntev thiab lwm yam kab mob, qhov kev thov rau cov tshuaj kho tau zoo kuj tseem nce ntxiv. Raws li cov tshuaj endogenous peptide uas muaj peev xwm kho tau, kev lag luam xav tau rau qhov sib xyaw no xav kom nthuav dav ntxiv. Tshwj xeeb tshaj yog nyob rau hauv kev tswj qhov mob, nws yuav dhau los ua kev kho mob tshiab kom tau raws li qhov xav tau ntawm cov neeg mob ntau dua.
Kev vam meej
Nrog rau kev nce qib ntawm biotechnology tsis tu ncua, kev rho tawm, kev ua kom huv, thiab kev sib xyaw ua ke ntawm cov khoom sib xyaw no yuav ua kom zoo dua qub. Qhov no yuav pab txhim kho nws cov txiaj ntsig thiab purity, txo cov nqi tsim khoom, thiab yog li txhawb nws txoj kev lag luam. Tsis tas li ntawd, kev txhim kho cov tshuab xa tshuaj tshiab kuj tseem yuav pab txhim kho lawv cov bioavailability thiab kho tau zoo.
Kev loj hlob prospects thiab outlook
Ua raws li cov xwm txheej saum toj no, nws txoj kev loj hlob zeem muag yog qhov dav. Nrog rau kev tshawb fawb txog biomedical txuas ntxiv mus thiab nthuav dav ntawm kev siv tshuaj kho mob, qhov sib xyaw no yuav tsum dhau los ua cov tshuaj kho mob tshiab lossis kev kho mob ntxiv, ua lub luag haujlwm tseem ceeb hauv kev tswj qhov mob, tswj kev xav, thiab kho kab mob endocrine. Lub caij no, nrog kev nce qib ntawm biotechnology tsis tu ncua thiab kev loj hlob ntawm kev xav tau ntawm kev lag luam, nws cov txheej txheem kev lag luam tseem yuav nrawm ntxiv.
Nyob rau hauv nruab nrab-20th caug xyoo, cov kws tshawb fawb tau pib kawm cov tshuaj lom neeg cov cim qhia txog lub hlwb hauv lub hlwb thiab lub paj hlwb. Xyoo 1954, Asmeskas cov kws tshawb fawb John Hughes thiab Hans Kosterlitz thawj zaug cais peptides nrog cov tshuaj tua kab mob los ntawm npua hlwb, uas yog enkephalins (1975). Qhov kev tshawb pom no tau ua rau muaj kev tshawb fawb dav dav ntawm endogenous opioid peptides. Hauv xyoo 1970, cov kws tshawb fawb tau tshawb pom ntau hom endorphins, suav nrog alpha endorphins, beta endorphins, thiab gamma endorphins, txhua tus tau los ntawm precursor protein pro melanocortin (POMC) thiab qhia nyob rau hauv lub hypothalamus thiab pituitary caj pas. Txawm li cas los xij, cov kws tshawb fawb tau pom tias cov haujlwm ntawm qee yam endorphins tsis tuaj yeem piav qhia tag nrho los ntawm cov paub POMC muab los ntawm peptides, uas tau ua rau lawv tshawb nrhiav cov tshuaj endorphin tshiab. Xyoo 1981, tus kws tshawb fawb Nyij Pooj Yoshio Tanaka thiab nws pab pawg tau tshawb pom ib qho tshiab opioid active peptide thaum kawm cov extracts ntawm npua hypothalamus. Nws cov qauv zoo ib yam li paub beta endorphins, tab sis nws muaj zog receptor binding peev xwm. Lawv hu nws Beta Neoendorphin kom paub qhov txawv ntawm cov tshuaj beta endorphins. Nyob rau hauv tib lub xyoo, American kws tshawb fawb Avram Goldstein pab neeg ntawm nws tus kheej cais cov peptide zoo sib xws los ntawm bovine hlwb thiab paub tseeb hais tias lawv tshwj xeeb opioid receptor activation zog. Cov kev tshawb fawb no tau sib sau ua ke tsim Beta Neoendorphin ua ib qho tshiab endorphin. Cov amino acid sib lawv liag ntawm Beta Neoendorphin tau ua tiav hauv xyoo 1982, thiab nws cov qauv yog Tyr Gly Gly Phe Leu Arg Lys Tyr Pro Lys (10 amino acids)
Cim npe nrov: beta-neoendorphin cas 77739-21-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom