Taw qhia
Thiamine hydrochloride, tseem hu ua vitamin B1 hydrochloride, yog ib qho tseem ceeb ntawm cov dej-soluble vitamin uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological hauv tib neeg lub cev. Nws qhov tseem ceeb hauv kev tswj hwm lub cev ua haujlwm ntawm tes, tshwj xeeb hauv cov piam thaj metabolism thiab kev ua haujlwm ntawm lub paj hlwb, tau sau tseg zoo. Tsab ntawv xov xwm no yog npaj los muab kev tshuaj xyuas tag nrho ntawm kev ua haujlwm ntawm lub cev ntawm thiamine hydrochloride, nws lub luag haujlwm hauv cov txheej txheem metabolic, thiab nws cov peev txheej hauv kev tshawb fawb thiab kev kho mob.
Peb muab Thiamine Hydrochloride Powder CAS 67-03-8, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Chemical Structure thiab Properties
Thiamine hydrochloride muaj cov tshuaj formula C12H17ClN4OS · HCl, nrog rau qhov hnyav molecular ntawm 337.27 g / mol. Dawb mus rau yellowish dawb zoo crystals, los yog crystalline hmoov, nrog ib tug me ntsis peculiar tsw zoo li mov qab zib, iab saj, yooj yim nqus dej noo, cov khoom qhuav sai absorbs txog 4% ntawm cov dej nyob rau hauv cov huab cua. 1g ntawm cov khoom no yog soluble hauv li 1mL dej thiab 100mL ethanol, soluble hauv glycerol tab sis tsis nyob rau hauv ether thiab benzene. Melting point yog hais txog 248 degree (decomposition). Nws yog ib qho ruaj khov rau cua sov hauv acidic tej yam kev mob. Thaum pH sib npaug rau 3, txawm tias nws yog boiled ntawm 140 degree rau 1h, nws yuav tsis tshua puas. Txawm li cas los xij, nws yooj yim rau decompose hauv nruab nrab thiab alkaline daws. Yog hais tias nws yog boiled ntawm pH ntau tshaj 7, feem ntau los yog tag nrho cov ntawm nws yuav raug puas tsuaj, thiab tej zaum nws yuav maj mam rhuav tshem txawm yog khaws cia nyob rau hauv chav tsev kub. Nws tuaj yeem deactivated los ntawm oxidation lossis txo. Nws yog rhiab heev rau lub teeb. Nws yog ib qho yooj yim kom nqus noo noo thaum raug huab cua. Cov khoom qhuav sai absorbs 4% ntawm cov dej hauv huab cua.
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Lub luag haujlwm ntawm metabolic
Thiamine hydrochloride ua ib cofactor rau ntau lub hauv paus metabolic enzymes, ua lub luag haujlwm tseem ceeb hauv cov piam thaj metabolism. Nws yog ib qho tseem ceeb rau kev hloov cov piam thaj mus rau hauv lub zog los ntawm txoj kev pentose phosphate, glycolysis, thiab lub voj voog Krebs. Raws li ib tug cofactor rau pyruvate dehydrogenase thiab alpha-ketoglutarate dehydrogenase, thiamine hydrochloride pab txhawb lub decarboxylation ntawm alpha-keto acids, kom ntseeg tau tus du ntawm ATP, lub cell lub zog txiaj.
Ntxiv mus, thiamine hydrochloride koom nrog hauv kev sib txuas thiab kev ua haujlwm ntawm transketolase thiab transaldolase, enzymes tseem ceeb rau txoj kev pentose phosphate. Txoj hauv kev no tsis yog tsuas yog tsim NADPH, qhov tseem ceeb txo qis hauv cov tshuaj tiv thaiv anabolic, tab sis kuj tseem pab tswj cov redox tshuav nyiaj li cas hauv lub cell.
Neural Function thiab Kev Tiv Thaiv
Thiamine hydrochloride yog qhov tseem ceeb rau kev tswj hwm kev ua haujlwm ntawm lub paj hlwb. Nws yog ib qho tseem ceeb ntawm thiamine pyrophosphate (TPP), uas yog qhov tseem ceeb rau kev ua haujlwm ntawm acetylcholinesterase, ib qho enzyme uas rhuav tshem acetylcholine, neurotransmitter tseem ceeb rau kev sib kis.
Kev tshawb fawb tau pom tias thiamine hydrochloride tuaj yeem tiv thaiv cov hlwb neuronal los ntawm oxidative kev nyuaj siab thiab excitotoxicity. Tsiaj txhu thiab cellular thwmsim tau pom nws cov teebmeem neuroprotective, qhia txog cov kev siv tshuaj kho mob hauv cov kab mob neurodegenerative xws li Alzheimer's disease, Parkinson's disease, thiab mob stroke. Los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txo oxidative kev nyuaj siab, thiamine hydrochloride yuav pab txo tau neuronal puas thiab txhawb neuronal ciaj sia taus.
Kev siv tshuaj kho mob thiab kho muaj peev xwm
Clinically, thiamine hydrochloride feem ntau yog siv los kho thiamine deficiency, ib qho mob tshwm sim los ntawm qhov tsis muaj vitamin B1 hauv lub cev, uas tuaj yeem ua rau muaj teeb meem loj hauv lub paj hlwb. Qhov kev tsis txaus no tuaj yeem tshwm sim raws li beriberi, Wemicke's encephalopathy, peripheral neuritis, thiab plab zom mov. Kev tswj hwm ntawm thiamine hydrochloride tuaj yeem txo cov tsos mob no zoo los ntawm kev ntxiv cov qib thiamine hauv lub cev.
Ntxiv mus, thiamine hydrochloride pom daim ntawv thov nyob rau hauv ntau yam kev kho mob uas muaj thiamine xav tau los yog txo qhov nqus tau pom. Cov no suav nrog cov neeg raug mob kub hnyiab, cov neeg mob kub taub hau, cov neeg mob ntev ntev, cov kab mob malabsorption nrog rau cov kab mob siab lossis cov kab mob hauv plab, cov neeg mob hemodialysis, thiab cov poj niam cev xeeb tub lossis lactating. Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau cov neeg ua haujlwm hnyav thiab cov tib neeg uas muaj zaub mov tsis txaus vim kev noj zaub mov tsis txaus lossis cov khoom noj khoom haus parenteral.
Rau cov kab mob enzyme deficiency xws li Leigh's disease, maple syrup urine disease, lactic acidosis, thiab intermittent cerebellar ataxia, thiamine hydrochloride tuaj yeem kho cov tsos mob thaum noj tshuaj ntau.
Hauv kev lag luam khoom noj khoom haus, thiamine hydrochloride ua cov khoom noj khoom haus thiab cov khoom noj khoom haus, tshwj xeeb tshaj yog nyob rau hauv cov dej haus ua si kom ntxiv cov vitamin B1 hauv cov neeg ncaws pob. Nws kuj tseem muaj cov ntawv thov hauv cov tshuaj pleev ib ce ua cov tawv nqaij txias thiab hauv cov tshuaj lom neeg ua haujlwm rau kev sib xyaw amide compounds.
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Kev Tshawb Fawb Kev Ua Ntej thiab Cov Ntawv Thov Tshiab
Kev tshawb fawb tsis ntev los no tau nthuav dav kev nkag siab ntawm thiamine hydrochloride lub cev lub cev ua haujlwm tshaj li nws cov luag haujlwm hauv cov metabolism thiab kev tiv thaiv neural. Cov kev tshawb fawb tau tshawb xyuas nws lub peev xwm los hloov kho cov tshuaj insulin, txo qhov mob, thiab txhim kho cov hlab plawv.
Piv txwv li, kev tshawb fawb qhia tias thiamine hydrochloride tuaj yeem pab txo cov ntshav qab zib thiab cov cim tso zis ntawm insulin tsis kam, uas tuaj yeem pab tswj kev rog rog thiab ntshav qab zib hom 2. Los ntawm kev cuam tshuam ntau txoj hauv kev cuam tshuam txog kev laus, suav nrog kev txwv calorie, kev sib xyaw ntawm thiamine thiab lwm yam tshuaj tau pom tias txo qis kev noj zaub mov thiab qhov hnyav nce hauv cov qauv tsiaj.
Tsis tas li ntawd, thiamine hydrochloride tau cuam tshuam rau kev tswj hwm kev tiv thaiv kab mob. Nws tau raug pom tias yuav hloov kho cytokine ntau lawm thiab txo qhov mob, qhia txog cov kev siv hauv kev kho cov kab mob inflammatory xws li mob caj dab rheumatoid thiab kab mob plab hnyuv.
Kev nyab xeeb thiab kev mob tshwm sim
Thaum thiamine hydrochloride feem ntau suav hais tias muaj kev nyab xeeb thiab ua tau zoo, qee tus neeg yuav ntsib kev tsis zoo xws li tawv nqaij khaus, tawm hws, thiab ua xua. Cov kev mob tshwm sim no feem ntau yog mob me me thiab ntuav, daws teeb meem thaum txiav cov tshuaj ntxiv.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev noj ntau dhau ntawm thiamine hydrochloride, txawm hais tias tsis tshua muaj tshuaj lom, tuaj yeem ua rau mob plab hnyuv thiab lwm yam tsos mob uas tsis yog tshwj xeeb. Yog li, nws raug nquahu kom haus thiamine hydrochloride nyob rau hauv daim ntawv pom zoo noj zaub mov zoo (RDA) lossis raws li kws kho mob tau sau tseg.
Xaus
Thiamine hydrochloride yog ib qho tseem ceeb ntawm cov dej-soluble vitamin uas ua lub luag haujlwm tseem ceeb hauv cov piam thaj metabolism, kev ua haujlwm ntawm lub paj hlwb, thiab lwm yam txheej txheem physiological. Nws qhov tseem ceeb hauv kev tswj hwm lub zog ntawm tes, kev noj qab haus huv neuronal, thiab kev tiv thaiv kab mob tsis tuaj yeem ua rau muaj kev cuam tshuam ntau dhau.
Nrog rau kev tshawb fawb tsis tu ncua, cov kev siv peev xwm ntawm thiamine hydrochloride hauv kev kho mob thiab kev tiv thaiv kab mob txuas ntxiv nthuav dav. Los ntawm nws ib txwm siv los kho thiamine deficiency rau nws lub luag haujlwm tshiab hauv kev hloov kho cov tshuaj insulin, txo qhov mob, thiab txhim kho cov hlab plawv, thiamine hydrochloride tuav cov lus cog tseg ua tus neeg sawv cev kho mob hauv ntau yam kev kho mob.
Kev tshawb fawb yav tom ntej yuav tsum tsom mus rau kev nthuav qhia cov txheej txheem meej hauv qab ntawm thiamine hydrochloride lub cev ua haujlwm thiab tshawb nrhiav nws lub peev xwm hauv cov tswv yim kho tshiab. Raws li peb txoj kev nkag siab ntawm qhov sib xyaw no tob zuj zus, nws zoo li tias thiamine hydrochloride yuav ua lub luag haujlwm ntau dua hauv kev txhawb nqa tib neeg kev noj qab haus huv thiab kev noj qab haus huv.
Hauv kev xaus, thiamine hydrochloride yog cov khoom noj muaj txiaj ntsig zoo nrog kev cuam tshuam zoo rau tib neeg lub cev thiab tshuaj. Nws lub luag haujlwm sib txawv hauv cov metabolism, kev tiv thaiv neural, thiab kev tiv thaiv kab mob ua rau nws lub hom phiaj tseem ceeb rau kev tshawb fawb thiab kev loj hlob ntxiv. Nrog txuas ntxiv kev nce qib hauv kev nkag siab txog kev tshawb fawb thiab thev naus laus zis tshiab, lub peev xwm ntawm thiamine hydrochloride los txhim kho tib neeg kev noj qab haus huv thiab kho tus kab mob yuav tsis muaj tseeb yuav raug kaw ntxiv.