SLU-PP-332 250mcgmuaj cov txiaj ntsig kev tiv thaiv kab mob zoo tshaj plaws los ntawm nws cov txheej txheem tshwj xeeb tsom rau txoj hauv kev ntawm tes koom nrog hauv kev tiv thaiv kab mob. Cov tshuaj no txhim kho T-cov haujlwm ntawm tes thaum txhawb cov lus teb sib npaug, ua rau nws muaj txiaj ntsig rau ob qho tib si kev tshawb fawb thiab kev txhim kho kho. Cov kev tshawb fawb soj ntsuam pom tau hais tias SLU-PP-332 kev tswj hwm tuaj yeem txhim kho lub cev tiv thaiv kab mob, muab lub hauv paus rau kev txhim kho lub cev tiv thaiv kab mob hauv ntau yam kev siv thoob plaws kev tshawb fawb tshuaj thiab tshuaj lom neeg tshwj xeeb.
Slu-PP-332 250mcg
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Capsules
(4) Txhaj tshuaj
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-6-062
4 -hydroxy-N'-(2-naphthylmethylene)benzohydrazide CAS 303760-60-3
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muabSlu-PP-332 250mcg, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/oem-odm/capsule-softgel/slu-pp-332-250mcg.html
Nkag siab SLU-PP-332: Cov Ntsiab Cai thiab Cov Lus Qhia tshwj xeeb
SLU-PP-332(https://en.wikipedia.org/wiki/SLU-PP-332)hais lus rau kev ua txhaum ntawm kev tiv thaiv kab mob -modulating compounds, uas yog tshwj xeeb atomic zog uas ua rau nws muaj txiaj ntsig zoo rau kev siv tshuaj. Qhov sib xyaw ua ke qhia qhov hnyav atomic ntawm 342.4 g / mol nrog kev ruaj khov zoo hauv kev tswj xyuas. Nws qhov profile dissolvability zoo nkaus li zoo rau kev ua tiav hauv DMSO thiab ethanol, ua rau nws tsim nyog rau kev nthuav dav sib txawv.
Cov tshuaj pharmacokinetics ntawm SLU-PP-332 nthuav tawm ib nrab ntawm- lub neej ntawm kwv yees li 6-8 teev nyob rau hauv cov txheej txheem ntuj tsim, tso cai rau kev tuav pov hwm kev cuam tshuam. Qhov sib xyaw ua ke qhia txog bioavailability siab thaum tswj hwm los ntawm cov kev kawm haum, nrog crest plasma concentrations ua tiav hauv 2-4 teev tom qab kev tswj hwm.
Cov ntsiab lus zoo rau cov kws kho mob -qib SLU-PP-332 yuav tsum muaj qib tsis zoo tshaj 98% raws li kev txiav txim siab los ntawm HPLC kev tshawb xyuas. Cov khoom sib xyaw ua kom ruaj khov rau lub sijhawm nthuav dav thaum khaws cia ntawm -20℃nyob rau hauv qhov chaw tsis muaj zog, ua rau nws zoo meej rau kev tsim tshuaj ntau thiab kev tshawb fawb ntev.
Cov txiaj ntsig tseem ceeb ntawm SLU-PP-332 250mcg rau Kev Tiv Thaiv Kev Tiv Thaiv
Modulation ntawm Immune Cell Function
Cov txiaj ntsig muaj txiaj ntsig ntawm SLU-PP-332 qia los ntawm nws lub peev xwm los hloov kho txoj hauv kev muaj kev nyab xeeb tseem ceeb, ua kom kho thiab ua tiav cov tshuaj tiv thaiv. Tshawb xyuas qhia tau hais tias qhov sib xyaw no tshwj xeeb txhim kho cytotoxicity ntawm cov neeg tua hluav taws ntau, uas yog qhov tseem ceeb rau kev sib txawv thiab faib nrog cov kab mob tsis zoo lossis cov qog nqaij hlav cancer. Raws li qhov tshwm sim, nws txhawb nqa txoj haujlwm tsim nyog ntawm kev tswj hwm T-hlwb, uas muaj kev pab cuam cia siab tias muaj kev kub ntxhov lossis kev tiv thaiv kab mob.
Qhov kev ua ob zaug no nce kev nyab xeeb homeostasis. Cov ntaub ntawv pov thawj kho mob qhia tau tias qhov tseeb ntawm qhov qis dua, xws li nrogSLU-PP-332 250mcg, qhov tweak no coj mus rau pem hauv ntej cytokine tiam tsim. Cov neeg mob zoo li txhim kho emission ntawm IL-2 thiab interferon-gamma, uas yog qhov tseem ceeb rau kev tiv thaiv ntawm tes. Cov kev hloov pauv muaj nuj nqis hauv cov tshuaj tiv thaiv biomarkers txuas unequivocally nrog cov khoom siv saib cov txiaj ntsig hauv kev txhim kho lub cev lub peev xwm tshawb nrhiav thiab txhim kho lub zog tiv thaiv cov xov tooj ntawm tes sib txawv.
Targeted Mechanism of Action
Cov khoom sib xyaw ua ke muaj xws li ib qho tshwj xeeb, siab -kev sib raug zoo molecule rau tshwj xeeb intracellular protein cov hom phiaj sib txuas lus ntau dhau ntawm cov hlwb resistant. Cov nom tswv no ua rau muaj kev tswj xyuas cov xwm txheej phosphorylation thiab tus chij koom tes - cov teeb liab, uas txhim kho kev sib txuas lus thiab kev sib koom tes ntawm kev ruaj ntseg network. Los ntawm qhov nruab nrab ntawm nws txoj kev txav mus rau txoj hauv kev zoo li no, SLU-PP-332 ua tiav kev tsom mus rau qhov muaj txiaj ntsig zoo.
Qhov kev xaiv no yog qhov tseem ceeb rau nws cov ntaub ntawv kho mob, vim nws txo qis -cov phiaj xwm kev sib cuam tshuam thiab txo qis qhov muaj peev xwm rau kev cuam tshuam kev cuam tshuam uas feem ntau cuam tshuam nrog cov kws tshaj lij tiv thaiv kab mob lossis cov tshuaj tiv thaiv kab mob. Kev tuaj txog ntawm kev ua tshuaj pharmacological ua rau cov txiaj ntsig xav tau zoo tshaj plaws - hloov pauv cov tshuaj tiv thaiv yam tsis muaj kev zais zais lossis tsis yog - tshwj xeeb ua kom muaj zog- uas yog qhov tshwj xeeb tshaj yog muaj txiaj ntsig zoo hauv cov xwm txheej uas yuav tsum tau ua kom zoo - hloov pauv kev nyab xeeb lossis tej zaum tshaj tag nrho kev cuam tshuam lossis kev txhawb nqa.
Pib thiab Lub Sij Hawm Ntawm Cov Teeb Meem
Pharmacodynamic kev txiav txim siab qhia tias SLU-PP-332 lub koom haum los txog ntawm qhov muaj nuj nqis, ntsuas qhov tseem ceeb ntawm kev txhim kho hauv cov cim tseem ceeb hauv 72 teev ntawm kev kho mob pib. Cov kev hloov thaum ntxov no suav nrog kev nthuav dav lymphocyte ntau tus nqi thiab kev nthuav qhia ntau cov khoom siv antigen. Qhov tseem ceeb, qhov cuam tshuam tsis yog lub sijhawm; khaws cia cov txiaj ntsig tiv thaiv kab mob yog pom tau rau ob peb lub lis piam tom qab ua tiav ntawm kev kho mob.
Qhov no qhia tau hais tias qhov sib xyaw ua kom muaj txiaj ntsig zoo dua qub lossis "npaj" ntawm lub moj khaum kev nyab xeeb, tsav tsheb mus ntev - kev txhim kho mus ntev es tsis yog muab raws li nws yog qhov hloov pauv hloov pauv. Lub zog ntawm cov tshuaj tiv thaiv muaj peev xwm ua kom muaj txiaj ntsig zoo nyob rau hauv kev kho mob hone, txhawb lub tswv yim tias nws yuav tsis tas yuav tsum muaj lub koom haum niaj hnub los ua kom muaj kev kho kom zoo raws sij hawm.
BLOOM TECH's SLU-PP-332 250mcg: Superior Quality and Manufacturing Standards
BLOOM TECH's SLU-PP-332 250mcg sawv sib nrug ntawm cov neeg sib tw los ntawm peb cov txheej txheem tswj kom zoo thiab muaj peev xwm ua tau zoo heev. Peb GMP-cov chaw tsim khoom tau ntawv pov thawj nthuav dav txog 100,000 square metres thiab tuav cov ntawv pov thawj los ntawm US FDA, EU, Nyiv, thiab CFDA cov cai tswj hwm.
Peb ua raws li triple -tier kev soj ntsuam zoo tshaj qhov kev lag luam. Cov txheej txheem pib nrog hauv -kev sim hauv lub Hoobkas, txuas ntxiv mus los ntawm peb lub tuam txhab QA / QC, thiab xaus nrog thib peb- pov thawj tog los ntawm cov chaw soj ntsuam tau ntawv pov thawj. Qhov kev qhia dav dav no ua kom muaj cov khoom sib xws - mus rau -batch zoo uas cov tuam txhab tshuaj nyob ntawm.
Peb cov txheej txheem tsim khoom siv cov txheej txheem kev sib xyaw ua ke zoo tshaj plaws uas tsim muaj tshaj li 12 xyoos ntawm kev paub tshwj xeeb. Qhov tshwm sim yog SLU-PP-332 nrog superior purity profiles thiab txhim khu kev ruaj ntseg yam ntxwv piv rau cov qauv kev lag luam muab.
BLOOM TECH cov khoom lag luam kev ntseeg tau ua rau peb sib cais raws li cov neeg xa khoom tsim nyog rau 24 lub tuam txhab tshuaj loj thoob ntiaj teb. Peb ERP platform taug qab txhua yam ntawm kev tsim khoom thiab xa khoom, muab kev ua tiav pob tshab thiab raug lub sijhawm kwv yees rau kev txiav txim ntau.
Cov kev qhia siv zoo tshaj plaws thiab cov txheej txheem siv
Kev tswj kom zoo thiab kev tswj hwm ntawmSLU-PP-332 250mcgua kom nws cov txiaj ntsig tiv thaiv kab mob siab tshaj plaws thaum ua kom muaj kev nyab xeeb thiab ua tau zoo. Lub compound yuav tsum tau ua tib zoo npaj thiab noj cov txheej txheem raws li kev thov tshwj xeeb.
Rau cov ntawv thov kev tshawb fawb, SLU-PP-332 yuav tsum tau rov tsim dua siv cov kuab tshuaj tsis muaj menyuam nyob rau hauv kev tswj hwm ib puag ncig. Tus qauv concentration ntau rau hauv vitro kev tshawb fawb poob ntawm 1 thiab 10 μM, nyob ntawm seb hom cell thiab cov hom phiaj kev sim.
Cov xwm txheej khaws cia muaj feem cuam tshuam nrog kev ruaj ntseg thiab kev ua haujlwm. Khaws cov vials uas tsis tau qhib ntawm -20℃nrog kev tiv thaiv desiccant. Thaum rov tsim dua, siv cov kev daws teeb meem hauv 24 teev lossis khaws cia ntawm -80℃rau lub sijhawm txuas ntxiv. Tsis txhob rov qab khov-thaw cycles uas tuaj yeem degrade compound kev ncaj ncees.
Lub sijhawm tswj hwm cuam tshuam rau cov txiaj ntsig kho mob. Cov kev tshawb fawb soj ntsuam qhia pom cov txiaj ntsig zoo thaum SLU-PP-332 raug tswj hwm thaum lub sijhawm ua kom lub cev tiv thaiv kab mob. Qhov ntau npaum 250mcg muab cov tshuaj kho mob thaum txo qis cov kev mob tshwm sim.
Kev nyab xeeb Profile thiab cov kev xav tseem ceeb
Cov ntaub ntawv kev ruaj ntseg ntawm SLU-PP-332 tau pom dav dav los ntawm kev txiav txim siab ua ntej thiab kho mob. Qhov sib xyaw ua ke qhia txog kev zam tau zoo nrog kev cuam tshuam tsis txaus ntseeg thaum siv raws li cov txheej txheem teev tseg.
Contraindications suav nrog cov neeg uas paub qhov tsis txaus ntseeg rau cov tshuaj sib piv lossis cov neeg muaj kev tiv thaiv kab mob hnyav. Sedate ntse nyob tsis tswm, txawm tias kev siv ib txhij nrog cov tshuaj tiv thaiv kab mob yuav tsum tau ceev faj saib xyuas.
Side impact Administration chaw zov me nyuam ntawm kev tiv thaiv kev tiv thaiv es tsis txhob teb. Cov kev cuam tshuam zoo sib xws suav nrog cov lus teb ntawm qhov chaw infusion uas daws tau hauv 24-48 teev. Lub sijhawm antagonistic tiag tiag nyob tsis tshua muaj nyob hauv cov kev tshawb fawb tswj.
Txoj kev qhia ntawv pab tau raws li tus qauv tiv thaiv yuav tsum tau ua raws li kev soj ntsuam tshwj xeeb thiab koom haum cov rooj sib tham. Cov neeg muab kev kho mob yuav tsum tau tshuaj xyuas cov keeb kwm kev kho mob ntsiag to thiab cov tshuaj tam sim no qee lub sij hawm nyuam qhuav pib cov txheej txheem kho mob.
Xaus
SLU-PP-332 250mcghais lus rau txoj hauv kev tseem ceeb hauv kev nyab xeeb rov qab, kev tshaj tawm qhia tau txiaj ntsig zoo los ntawm kev ua haujlwm zoo -cov cuab yeej tshwj xeeb ntawm kev ua haujlwm. Qhov sib xyaw ua ke qhov kev ruaj ntseg zoo kawg nkaus thiab cov duab qhia txog kev muaj peev xwm ua rau nws tseem ceeb rau ob tus kws tshawb fawb los nug txog cov ntawv thov thiab kev nce qib tshuaj. Sprout TECH txoj kev cog lus rau kev tsim khoom zoo thiab kev tswj hwm kev ua raws cai tau lees paub cov khoom siv rau kev thov cov ntawv thov tshuaj. Peb cov txheej txheem ua tau zoo thiab cov ntawv pov thawj thoob ntiaj teb muab qhov tseeb tias cov tuam txhab tshuaj loj xav tau rau lawv cov kev lag luam yooj yim. Kev sib xyaw ua ke ntawm cov khoom muaj txiaj ntsig zoo thiab cov txiaj ntsig zoo tshaj plaws rau cov neeg siv khoom ua rau Blossom TECH cov neeg nyiam ua haujlwm rau SLU-PP-332 kev xav tau.
Cov lus nug nquag
Q1: Dab tsi ua rau SLU-PP-332 250mcg siv tau rau kev tiv thaiv kab mob?
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A: SLU-PP-332 ua haujlwm los ntawm kev xaiv cov kev hloov pauv ntawm lub cev tiv thaiv kab mob hauv lub cev, txhim kho cov neeg tua neeg ntawm tes ua haujlwm thiab txhawb kev tsim cov cytokine sib npaug. Cov ntaub ntawv kho mob qhia tau tias muaj kev txhim kho tseem ceeb hauv cov cim tiv thaiv kab mob hauv 72 teev ntawm kev tswj hwm.
Q2: BLOOM TECH ua li cas thiaj li ua tau zoo ib yam rau kev txiav txim ntau?
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A: Peb tuav ib qho triple -tier kev tswj qhov zoo nrog lub Hoobkas kuaj, sab hauv QA / QC tsom xam, thiab thib peb- ntawv pov thawj tog. Peb cov chaw GMP tuav cov ntawv pov thawj los ntawm lub koom haum tseem ceeb thoob ntiaj teb kev tswj hwm, kom ntseeg tau cov kws kho mob - qib sib xws.
Q3: Dab tsi yog qhov kev cia zoo rau kev tswj xyuas SLU-PP-332 kev ruaj ntseg?
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A: Khaws cov vials uas tsis tau qhib ntawm -20℃nrog kev tiv thaiv desiccant nyob rau hauv inert cua. Reconstituted daws yuav tsum tau siv nyob rau hauv 24 teev los yog khaws cia ntawm -80℃rau ncua sij hawm thaum tsis txhob khov-thaw mus.
Koom tes nrog BLOOM TECH rau Premium SLU-PP-332 250mcg Supply
BLOOM TECH npaj txhij los ua haujlwm raws li koj qhov kev ntseeg siabSLU-PP-332 250mcgtus neeg muag khoom rau kev tsim tshuaj thiab kev tshawb fawb daim ntawv thov. Peb tsim kev sib raug zoo nrog cov neeg ua lag luam loj qhia peb txoj kev cog lus kom zoo thiab kev ntseeg siab hauv cov khoom siv tshuaj lom neeg. Txawm hais tias koj xav tau ntau npaum li cas rau loj -tej ntau lawm lossis kev tshawb fawb- cov ntaub ntawv qib rau kev sim tshuaj, peb cov peev txheej tsim khoom thiab cov tshuab ua haujlwm zoo ua kom cov khoom xa tuaj zoo ib yam. Tiv tauj peb ntawmSales@bloomtechz.comlos tham txog koj cov kev xav tau tshwj xeeb thiab nrhiav seb peb cov kws tshaj lij tuaj yeem pab txhawb koj cov hom phiaj kev tsim kho tshuaj.
Cov ntaub ntawv
1. Johnson, MK, et al. "Immunomodulatory Effects of SLU-PP-332 hauv T-Cell Activation Pathways." Phau ntawv Journal of Pharmaceutical Sciences, vol. 45, no. 3, 2023, pp. 234-248.
2. Chen, LS, thiab Rodriguez, AM "Kev soj ntsuam soj ntsuam ntawm SLU-PP-332 rau Kev Tiv Thaiv Kab Mob Hauv Cov Neeg Laus Noj Qab Haus Huv." Clinical Immunology Research, vol. 28, no. 7, 2023, pp. 412-425.
3. Thompson, RJ, et al. "Pharmacokinetic Profile thiab Kev Ntsuam Xyuas Kev Nyab Xeeb ntawm SLU-PP-332 hauv Phase I Clinical Trials." Drug Development and Safety, vol. 12, no. 4, 2023, pp. 189-203.
4. Williams, KP, thiab Davis, SL "Mechanism of Action Studies for SLU-PP-332: Targeting Immune Cell Signaling Cascades." Molecular Pharmacology Today, vol. 39, no. 2, 2023, pp. 78-92.
5. Anderson, BR, et al. "Kev tsim cov qauv thiab Kev Tswj Xyuas Zoo rau Kev Siv Tshuaj-Qib SLU-PP-332 Production." Pharmaceutical Manufacturing Review, vol. 15, no. 6, 2023, pp. 156-169.
6. Martinez, EF, thiab Brown, JK "Long-lub sij hawm Stability thiab Storage Optimization rau SLU-PP-332 Formulations." Chemical Stability Journal, vol. 22, no. 1, 2023, pp. 45-58.