Fleas feem ntau yog thawj cov kab mob tiv thaiv ntawm tus tswv dev lub siab. Txawm li cas los xij, lub ntiaj teb ntawm cov kab mob cab no loj dua li qhov me me dhia. Mites, zuam, kab mob plawv thiab kab mob plab hnyuv yog qhov phom sij tiag tiag rau kev noj qab haus huv thiab kev nplij siab ntawm tus dev.Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajmuab ob qho kev tshawb fawb pov thawj cov khoom xyaw hauv ib lub hli qhov ncauj ntau npaum li cas uas cov kws kho tsiaj thiab cov tswv tsiaj tab tom nrhiav ntau thiab ntau dua. Daim ntawv no rhuav tshem qhov kev ua haujlwm ob zaug, vim li cas mites xav tau kev saib xyuas ntau dua li lawv feem ntau tau txais, thiab dab tsi ua rau qhov kev tsim no muaj peev xwm xaiv tau rau ntau -kab kab mob tswj.
Afoxolaner Thiab Milbemycin Oxime Chewable Tablets
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Ua Haujlwm Tiv Thaiv Hnyav, Ticks, thiab Mites?
Lub luag haujlwm ntawm Afoxolaner hauv Targeting External Parasites
Afoxolaner yog tshuaj tua kab thiab acaricide ntawm chav kawm isoxazoline. Nws lub hom phiaj tseem ceeb yog GABA-gated chloride channel, lub paj hlwb hloov pauv nyob rau hauv arthropods xws li fleas, zuam thiab mites. Afoxolaner thaiv kev txav ntawm chloride ions los ntawm cov channel no, ua rau cov kab mob cab cov hlab ntsha tuaj yeem tua tsis tau. Qhov tshwm sim yog sudden hyperexcitation, tuag tes tuag taw thiab tuag. Qhov tseem ceeb afoxolaner muaj kev sib raug zoo ntau dua rau arthropod GABA receptors dua li cov tsiaj txhu receptors uas suav rau nws qhov kev nyab xeeb zoo hauv dev. Cov kev tshawb fawb tau pom tias tom qab kev tswj hwm qhov ncauj, afoxolaner nce mus txog qhov siab tshaj plasma concentration (Cmax ntawm ~ 1,822 ± 165 ng / mL) hauv 2 mus rau 4 teev.
Nws muaj qhov bioavailability ntawm 88% thiab plasma ib nrab -lub neej ntawm ~ 2 lub lis piam - ntev txaus los muab tag nrho lub voj voog ntawm kev tiv thaiv txhua hli.
Yog vim li cas Fleas thiab zuam tsuas yog ib feem ntawm zaj dab neeg
Nyob rau hauv cov nqe lus ntawm kev tiv thaiv kab mob, feem ntau ntawm cov pej xeem mloog yog attracted los ntawm fleas thiab zuam, thiab yog vim li cas. Fleas ua rau khaus, kab mob thib ob ntawm daim tawv nqaij thiab cov kab mob dermatitis, thaum cov zuam nqa cov kab mob uas ua rau tus kab mob Lyme thiab ehrlichiosis. Tab sis mites (Demodex canis, Sarcoptes scabiei thiab Otodectes cynotis) kuj yog qhov chaw ntawm qhov mob zoo sib xws thiab cov teeb meem kho mob. Sarcoptes scabiei ua rau sarcoptic mange, uas kis tau ntawm cov tsiaj thiab tej zaum kuj yuav ua rau tib neeg daim tawv nqaij. Demodex mites nyob rau hauv cov hauv paus plaub hau thiab tej zaum yuav nce nyob rau hauv kev tiv thaiv kab mob, ua rau lub zos los yog generalized demodicosis.
Cov txheej txheem isoxazoline ntawm afoxolaner tau pom tias muaj txiaj ntsig zoo rau ntau hom kab tsuag hauv cov phooj ywg - tshuaj xyuas cov kws kho tsiaj, ua rau cov qauv tsim muaj txiaj ntsig zoo tshaj li tus qauv dev - thiab - zuam tshuaj.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets: Nkag siab txog Dual Mechanism for External Parasite Control
Milbemycin Oxime's Distinct Pathway
Milbemycin oxime ua los ntawm cov txheej txheem sib txawv ntawm afoxolaner. Nws yog ib qho tshuaj tiv thaiv kab mob macrolide uas khi rau glutamate -gated chloride channels hauv cov paj hlwb invertebrate thiab cov leeg nqaij. Qhov kev khi no nce permeability ntawm daim nyias nyias mus rau chloride ions thiab ua rau hyperpolarisation ntawm cell membrane. Cov kab mob neuromuscular tuag tes tuag taw yog li ua rau tuag taus rau cov kab mob hauv lub plawv xws li kab mob plawv, Dirofilaria immitis, thiab ntau lub plab hnyuv nematodes xws li hookworms, roundworms thiab whipworms. Milbemycin oxime yog sib xyaw ntawm ob yam khoom, A3 (kwv yees 20%) thiab A4 (kwv yees li 80%), muaj cov yam ntxwv sib txawv ntawm cov tshuaj pharmacokinetic.
A3 peaks ntawm 1-2 teev nrog ib nrab- lub neej ntawm 1.6 hnub thaum A4 muaj qhov sib piv ntawm qhov nqus nqus tab sis ib nrab hnub nyoog ntawm 3.3 hnub yog li ua kom lub qhov rais tiv thaiv ntev nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj.
Kev sib koom ua ke ntawm ob yam khoom xyaw nquag
Kev sib xyaw ntawm afoxolaner thiab milbemycin oxime tsis yog qhov yuam kev. Afoxolaner muaj txiaj ntsig zoo rau cov kab mob ectoparasites - cov neeg uas nyob ntawm lossis ze ntawm daim tawv nqaij - whereas milbemycin oxime ua haujlwm tawm tsam cov kab mob endoparasites, lossis cov neeg nyob hauv cov hlab ntsha thiab plab hnyuv. Txhua yam tshuaj ib leeg tsis them rau ob qho tib si ntawm cov tshuaj kho mob zoo. Raws li kws kho tsiaj, cov afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj ua hauj lwm ua ke los tsim ib daim ntaub thaiv npog thiab yog ib daim ntaub thaiv npog tiag tiag.
Lub hli qhov ncauj formulation sidesteps ua raws li cov teeb meem cuam tshuam nrog cov tshuaj pleev ib ce uas yuav ntxuav tawm, yuav tsum tau siv nyob rau hauv tej lub sij hawm, los yog ua rau lub cheeb tsam ntawm daim tawv nqaij khaus. Qhov kev sib koom ua ke no yog qhov tseeb ntawm cov txiaj ntsig siv tau rau cov tsev nrog ntau tus dev lossis dev nrog cov neeg nyob sab nraud.
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Target Mites Los Ntawm Kev Ua Haujlwm Zoo Tshaj Plaws
Mite Biology thiab yog vim li cas Standard Treatments feem ntau poob luv
Mites yog arachnids, tsis yog kab. Isoxazoline cov tshuaj tswj hwm kev ua tau zoo ntawm cov kab mob mites, vim tias lawv cov paj hlwb muaj txiaj ntsig zoo piv rau lwm cov arthropods. Cov mite Sarcoptes scabiei burrows rau hauv cov khaubncaws sab nraud povtseg ntawm daim tawv nqaij uas nws lays qe. Cov no hatch hauv peb mus rau kaum hnub. Demodex canis yog mite uas nyob hauv cov hauv paus plaub hau thiab qog sebaceous. Feem ntau cov neeg muaj tsawg heev uas tsis pom muaj kab mob tshwm sim kom txog thaum lub cev tsis muaj zog. Cov tshuaj acaricides ib txwm muaj teeb meem nrog kev nkag mus rau hauv cov chaw follicular lossis burrowed. Muaj kev ntseeg siab tshaj tawm mus rau cov microenvironments no yog cov tshuaj siv hauv qhov ncauj thiab xa tawm ntawm cov ntshav thiab cov ntaub so ntswg.
Cov kev sim tshuaj ntsuam xyuas tau pom tias afoxolaner muaj txiaj ntsig zoo hauv kev kho mob sarcoptic thiab demodectic mange, nrog rau kev txo qis hauv mite suav nrog hauv 28 hnub tom qab pib kho.
Otodectes thiab Broader Mite Spectrum
Otodectes cynotis (pob ntseg mite) ua rau mob khaus pob ntseg thiab tom qab kab mob los yog kab mob poov xab yog tias tsis kho. Cov kab mob hauv cheeb tsam txuas ntxiv tau tswj hwm kev kho mob nrog kev kho pob ntseg, tab sis kev tiv thaiv kab mob tiv thaiv kab mob tuaj yeem ua rau muaj txiaj ntsig zoo ntxiv ntawm kev tiv thaiv, tshwj xeeb tshaj yog nyob rau hauv cov tsiaj uas muaj kev sib kis ntawm pob ntseg kab mob los yog hauv tsev nrog ntau tus tsiaj.
Milbemycin oxime tau pom tias muaj zog tiv thaiv pob ntseg mite larvae thiab cov neeg laus hauv kev siv tshuaj kho mob. Cov tshuaj tiv thaiv kab mob muaj zog tshwj xeeb tshaj yog nyob rau hauv tag nrho cov spectrum ntawm mites, los ntawm nto -cov tsiaj nyob rau hauv burrow- yoog thiab follicle- cov neeg nyob txawv teb chaws, thaum ob qho tib si cov tshuaj nquag muaj nyob ua ke.
Afoxolaner thiab Milbemycin Oxime Chewable ntsiav tshuaj rau cov dev: Tshaj li Flea Control nyob rau hauv Kev Tswj Kab Tsuag
Kev tiv thaiv kab mob plawv raws li cov txiaj ntsig tseem ceeb
Kab mob plawv tseem yog ib qho tseem ceeb tshaj plaws ntawm cov kab mob kis kab mob ntawm cov dev hauv ntiaj teb uas yoov tshaj cum muaj ntau, suav nrog ntau thaj chaw ntawm North thiab South America, Southeast Asia thiab Southern Europe. Cov kev sim tswj tau pom tias kev tswj hwm txhua hli ntawm milbemycin oxime tiv thaiv Dirofilaria immitis L3 thiab L4 larvae. Cov dev nyob rau thaj tsam endemic muaj kev tiv thaiv zoo ib yam tiv thaiv kev tsim cov neeg laus lub plawv nrog kev noj txhua hli. Qhov kom zoo dua rau kev tiv thaiv ib leeg ua rau txhua lub hli muaj txiaj ntsig zoo rau ntau tus tswv tsiaj txawm tias nyob hauv thaj chaw thaj chaw nrog rau lub caij nyoog lwm tus cab cab.
Gastrointestinal Nematodes: Lub Hidden Burden
Ntau tus tswv tsev yuav tsis paub tias muaj kab mob plab hnyuv li cas xws li Toxocara canis, Ancylostoma caninum thiab Trichuris vulpis nyob hauv zej zog dev. Cov kab mob subclinical tuaj yeem ua rau malabsorption ntawm cov as-ham, poob phaus, anemia thiab protein- poob enteropathy yam tsis muaj kev kho mob tshwm sim. Txhua lub hlis, afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj hais txog tus nqi zais no los ntawm suav nrog cov pov thawj nematicidal kev txiav txim ntawm milbemycin oxime, xyuas kom muaj kev pab cuam txawm tias tus tswv lub hom phiaj tseem ceeb yog kev tswj hwm tus kab mob sab nraud.
Vim li cas thiaj xaiv Afoxolaner thiab Milbemycin Oxime Chewable Tablets rau Ntau -Kev Tiv Thaiv Kab Mob Hauv Cov dev?
Pharmacokinetic Reliability hla ib lub hlis twg
Ib qho ntawm cov laj thawj zoo tshaj plaws rau qhov muaj pes tsawg leeg yog nws cov tshuaj pharmacokinetic durability. Ob -plasma ib nrab ntawm lub lim tiam - lub neej ntawm afoxolaner ua rau cov ntshav plasma ntau ntxiv thaum lub sijhawm siv tshuaj, kom ntseeg tau tias muaj txiaj ntsig zoo rau cov yoov tshaj cum, zuam lossis mite uas tuaj yeem kov tus dev ntawm kev kho mob txhua hli. A4 feem ntawm milbemycin oxime nrog ib nrab - lub neej ntawm 3.3 hnub muab qhov pib tawg ntawm nematicidal kev ua kom tshem tawm cov larvae thaum ntxov ntawm lub voj voog. Qhov no staggered kinetic profile qhia tau hais tias cov formulation tsis tsuas yog ib tug taw tes - nyob rau hauv - lub sij hawm kho - nws ua raws li ib tug mus tas li pharmacological teeb meem nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj.
Dosing Flexibility hla qhov hnyav
Five unique weight-based specifications, for dogs from 2 kg to over 50 kg, provide precision dosage, minimising under treatment and excessive chemical exposure. Dogs weighing 2-3.5 kg get the 9.375 mg afoxolaner + 1.875 mg milbemycin oxime pill, while dogs 30-60 kg get the 150 mg + 30 mg tablet. Higher specification tablets may be compounded for dogs >50kg los muab cov tshuaj zoo rau ib kg. Cov qauv tsim qib no sawv cev rau qhov kev cog lus tseem ceeb rau kev ua tshuaj kho mob thoob plaws hauv spectrum ntawm hom dev lub cev pom hauv kev kho mob.
Xaus
Kev tswj cov kab mob hauv cov dev yuav tsum muaj kev pom dav dua li tsuas yog tiv thaiv hma. Txhua tus mites, ticks, heartworms thiab plab hnyuv nematodes muab lawv tus kheej kev nyab xeeb kev nyab xeeb thiab ib leeg, pharmacologically suab, txhua hli qhov ncauj formulation los kho lawv yog ib tug muaj tseeb kev txhim kho nyob rau hauv veterinary tiv thaiv kev kho mob. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj yog qhov tseeb lawv hais tias lawv yog - ob lub tshuab ua haujlwm sib txawv ua haujlwm hauv kev hais kwv txhiaj thoob plaws hauv cov kab mob cab sab hauv thiab sab nrauv. Txawm hais tias nws yog sarcoptic mange, pob ntseg mites, zuam - kis tau tus kab mob, los yog kab mob plawv, cov ntaub ntawv hauv paus tseem txhim kho nyob rau hauv kev pom zoo ntawm kev sib xyaw ua ke nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj.
FAQ
1.Can afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj kho demodectic mange hauv dev?
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Cov kev tshawb fawb soj ntsuam tau tshaj tawm qhov txo qis hauv Demodex canis mite suav tom qab kev kho mob nrog afoxolaner - muaj cov tshuaj isoxazoline. Kev faib tawm ntawm afoxolaner los ntawm plasma thiab cov ntaub so ntswg tso cai rau nws mus txog cov hauv paus plaub hau uas Demodex nyob - ib puag ncig uas cov tshuaj pleev ib ce feem ntau nkag mus tsis sib xws. Veterinary kev taw qhia yeej ib txwm pom zoo ua ntej pib kev kho mob rau demodicosis generalized.
2.Puas yog cov chewable ntsiav tshuaj muaj kev nyab xeeb rau txhua tus dev yug?
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Cov qauv tsim tau suav tias muaj kev nyab xeeb rau feem ntau ntawm cov dev yug tsiaj thaum noj ntawm qhov hnyav kom raug - raws li koob tshuaj. Cov dev nqa MDR1 (ABCB1) gene mutation - tshwj xeeb tshaj yog Collies thiab lwm yam herding breeds - tuaj yeem pom cov tshuaj hloov pauv cov metabolism. Milbemycin oxime yog P-glycoprotein substrate, thiab cov dev cuam tshuam tuaj yeem tsim cov ntshav plasma ntau dua. Kev ntsuam xyuas caj ces thiab kev sab laj kws kho tsiaj yog pom zoo ua ntej siv rau hauv cov tsiaj uas muaj feem cuam tshuam.
3.Cov ntsiav tshuaj pib ua haujlwm sai npaum li cas tom qab kev tswj hwm?
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Afoxolaner nce mus txog qhov siab tshaj plaws plasma concentration nyob rau hauv 2 mus rau 4 teev ntawm kev tswj qhov ncauj, txhais tau hais tias dev mub thiab zuam tua kev ua si pib nyob rau hauv cov sij hawm ntawm koob tshuaj. Milbemycin oxime A3 thiab A4 Cheebtsam ncav cuag qhov siab tshaj plaws hauv 1 mus rau 2 teev. Qhov kev nqus sai sai no txhais tau rau kev ua haujlwm tiv thaiv kab mob sai, nrog kev tiv thaiv kev ruaj ntseg thoob plaws lub hli tag nrho los ntawm cov khoom sib txuas ntawm ib nrab -lub neej.
Npaj rau Tau Txais Afoxolaner thiab Milbemycin Oxime Chewable Tablets? Koom tes nrog Bloomtechz
Bloomtechz tau tsim nws lub koob npe nrov tshaj li 15 xyoo dhau los ua tus neeg muag khoom ntseeg siab ntawm cov kws tshuaj nruab nrab thiab cov kws kho tsiaj ua haujlwm rau cov neeg siv khoom thoob plaws tebchaws Asmeskas, Lub Tebchaws Yelemees, Nyiv, Australia, thiab dhau mus. Peb GMP- ntawv pov thawj qhov chaw tsim khoom - hla 100,000 square meters thiab tuav US -FDA, EU-GMP, JP, thiab CFDA ntawv pov thawj - xyuas kom meej tias txhua batch ua tau raws li cov qauv zoo uas koj xav tau. Raws li kev tsim nyogafoxolaner thiab milbemycin oxime chewable ntsiav tshuajtus neeg muag khoom, Bloomtechz muab cov khoom lag luam hauv API hmoov thiab cov ntsiav tshuaj tiav cov qauv thoob plaws tsib qhov hnyav -raws li cov lus qhia tshwj xeeb, nrog OEM thiab ODM kev xaiv muaj rau cov haujlwm kev cai. Peb triple -txuas kev txheeb xyuas qhov zoo - Hoobkas tshuaj xyuas, hauv -lub tsev QA/QC, thiab thib peb-tso cai tswj xyuas - muab kev ntsuas ntsuas rau koj nyob rau txhua theem ntawm cov saw hlau. Hu rau peb pab neeg niaj hnub no thiab paub txog qhov tseeb thiab kev ntseeg siab uas 24 lub tuam txhab koom tes thoob ntiaj teb twb ntseeg lawm.
📧 Hu rau peb:Sales@bloomtechz.com
Cov ntaub ntawv
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2. Beugnet, F., Halos, L., Larsen, D., & de Vos, C. (2016). Kev ua tau zoo ntawm qhov ncauj afoxolaner rau kev kho mob ntawm canine generalized demodicosis. PIB, 23, 14.
3. Biswas, S., Chakraborty, S., & Bhattacharya, D. (2019). Pharmacokinetic thiab pharmacodynamic profiles ntawm milbemycin oxime A3 thiab A4 Cheebtsam hauv Beagle dev tom qab tswj qhov ncauj. Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, 42(3), 312–320.
4. Fourie, JJ, Liebenberg, JE, Horak, IG, Taenzler, J., Heckeroth, AR, & Frénais, R. (2015). Kev ua tau zoo ntawm kev hais lus afoxolaner (NexGard®) tawm tsam Otodectes cynotis kab mob ntawm cov dev. Parasites & Vectors, 8, 506.
5. Kaminsky, R., Gauvry, N., Schorderet Weber, S., Skripsky, T., Bouvier, J., Wenger, A., & Schroeder, F. (2008). Kev txheeb xyuas lub hom phiaj ntawm anthelmintic compound milbemycin oxime nyob rau hauv dawb -nyob nematodes. Parasitology Research, 103(5), 1135–1142.
6. McTier, TL, Kryda, K., Wachowski, M., Mahabir, SP, Woods, DJ, & Larsen, D. (2019). Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj rau dav -spectrum sab hauv thiab sab nraud parasite tswj nyob rau hauv dev: Cov ntsiab lus ntawm pharmacological thiab soj ntsuam pov thawj. Veterinary Parasitology, 273, 98–107.