Gs 441524 Hmoov, Kev cog lus tawm tsam, tau txais kev saib xyuas tseem ceeb rau cov neeg tshawb nrhiav thiab cov khoom siv ua me nyuam nrog rau ntau yam sib xyaw, ua rau muaj kev sib xyaw nrog kev ua haujlwm nyab xeeb, muaj peev xwm kev pheej hmoo, thiab kev cuam tshuam ntawm ph-al-alents cov neeg sawv cev ntawm nws cov kev ruaj khov .
GS 441524 Hmoov cas 1191237-69-0
1. General Specification (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30MG, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https: // www . . com / ntsiav tshuaj-ncej
2. Kev Customization:
Peb yuav sib tham ntawm ib leeg zuj zus, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm tsuas yog .
Intern Code: BM -2-1-049
Gs -441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC-MS, HNMR
Kev txhawb thev naus laus zis: R & Dept .-4
Peb muabGs 441524 Hmoov, thov saib mus rau lub vev xaib nram qab no kom cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv khoom lag luam .
Khoom:https: // www . bloomtechz. com / synthetic-inclediates / gs {}} HTML
Kev nyab xeeb kom ua ke nrog gs -441524 hmoov
Thaum xav txog cov qauv ntawmGs -441524 hmoov(https: // en . wikipedia . {/ gs -441524) Rau kev kho mob, nws yog qhov tseem ceeb heev kom paub cov khoom xyaw tshaj tawm uas tuaj yeem txhim kho lawv cov kev tswj hwm thiab txhim kho lawv cov chaw muag tshuaj thiab txhim kho lawv cov khoom siv pharmacological.
Solubility Enhancers
Ib qho ntawm thawj cov nyom hauv sau gs -441524}}}}}}} solubility enhance ua ke nrog cov compound:
Cyclodextrins: cov cyclic oligaccharides muaj ntawv suav nrog nrog gs -441524, txhim kho nws cov aquousous solubility thiab bioavailability {}}
Polyethylene Glycol (Peg): Qhov hnyav me me ntawm PEG tuaj yeem siv los txhim kho cov solubility ntawm gs {}} hmoov tsis muaj kev sib txawv.
Polysorbates: Nonionic Surfactants li Twubility Gs {}} Thiab txhim kho nws cov kev sib cais hauv cov kua formulion.
Stabilizers thiab cov tshuaj txuag
Txhawm rau kom muaj lub zog thiab txuas ntxiv lub txee lub neej ntawmGs 441524 HmoovKev tsim qauv, qee cov stabiilizers thiab cov tshuaj txuag tuaj yeem nyab xeeb kom ruaj ntseg:
Antioxidants: compounds xws li butylated hydroxyanisole (Bha) lossis ascorbic acid tuaj yeem tiv thaiv gs {}}}
Chelating cov neeg sawv cev: Edta lossis citric acid tuaj yeem ntxiv rau cov hluav taws xob ntxiv rau cov hlau uas tuaj yeem ntsuas qhov kev ua tsis zoo ntawm gs -441524.
Antimicrobial antervatives: benzyl cawv lossis cov parabens tuaj yeem siv tau ntau cov qauv kev tsim kho kom tiv thaiv microbial kev loj hlob {}}
Bulking tus neeg sawv cev thiab ua rau
Rau cov khoom siv tshuaj ntau ntau cov ntaub ntawv lossis lycophilized cov qauv ntawm gs -441524 hmoov} hmoov, cov nram qab no tuaj yeem siv tau kev nyab xeeb:
Mannitol: cov cawv no ua haujlwm ua tus sawv cev zoo heev thiab cryoprotreant rau khov-qhuav formululed.
Microcrystalline Cellulose tuaj yeem txhim kho cov khoom ntws thiab kev hloov kho tshiab ntawm gs {{nkaus} hmoov nyob rau hauv cov ntsiav tshuaj tsim.
Lactose lactose: ib qho kev ua tsis tau zoo uas tuaj yeem siv rau hauv ob qho ua kua thiab cov qauv tsim ntawm gs -441524.
Kev phom sij ntawm kev sib xyaw gs -441524 hmoov nrog cov tshuaj tsis sib xws
Thaum qee yam excipients tuaj yeem txhim kho cov khoom ntawm gs -441524 nws yog qhov tseem ceeb uas yuav tsum tau muaj kev nyab xeeb thiab ua kom muaj kev nyab xeeb los ntawm gs {2}.
Tshuaj Tsis Txaus Ntseeg
Qee qhov sib xyaw ua ke yuav hnov mob nrog gs -441524 hmoov, ua rau muaj kev txwv tsis pub tshuaj xyuas lossis tsim ntawm kev tsis xav tau los ntawm cov khoom lag luam:
Cov tshuaj oxidizing oxidizing: cov tshuaj zoo li hydrogen peroxide lossis poov tshuaj permanganate tuaj yeem oxidize gs {{0} {}}
Txo cov neeg sawv cev: cov tebchaw xws li ascorbic acid nyob rau hauv siab tej zaum yuav hloov cov qauv tshuaj lom neeg ntawm gs -441524.
Hlau ions: qee cov hlau ions, tuaj yeem ntsuas cov hlau, tuaj yeem ua kom pom qhov kev tsis zoo ntawm gs {}} {}.
Lub cev tsis haum
Qee yam tshuaj yuav tsis yog tshuaj lom tshwm sim nrog gs -441524 hmoov tab sis tseem tuaj yeem cuam tshuam nws lub cev lub cev:
Hygroscopic excipients: cov ntaub ntawv uas tau yooj yim nqus dej noo los ntawm cov chaw ib puag ncig tuaj yeem ua rau nws cov khoom ruaj khov hauv cov khoom siv tshuaj {}}
Cov polymers tsis sib xws: qee yam siv polymers siv tau nyob rau hauv kev tawm tswv yim-tso tawm yuav muaj kev sib cuam tshuam nrog gs-441524, hloov nws tso tawm profile lossis bioavailability.
Lipophilic tshuaj: sib xyaw gs -441524 hmoov nplej nrog theem sib cais los yog tsis sib xws hauv cov kua ua kua.
Kev Txheeb Xyuas Kev Ncaj Ncees Phom
Thaum xav txogFIP kev kho mob redditKev sib tham lossis lwm cov kev thov yuav, nws yog qhov tseem ceeb kom paub txog kev lom neeg muaj kuab lom uas tuaj yeem tshwm sim:
Enzyme inducers: tebchaw uas ntxias cov metabolic enzymes yuav ua kom nrawm dua ntawm gs-441524 Nyob rau hauv lub cev, txo nws tus kheej kho qhov ua tau zoo {}}
Protein-binding cov neeg sawv cev: cov tshuaj uas nthuav tawm cov protein ntau yuav sib tw nrog gs-441524} {.
PH-POJ NIAM ZIB: Qee cov roj ntsha buffers lossis ph-kho cov neeg sawv cev yuav tsim ib puag ncig uas muaj kev lom zem lossis kev ua si ntawm gs-441524.
PH-hloov cov neeg sawv cev thiab lawv cov nyhuv ntawm gs -441524 hmoov stability
Qhov ruaj khov ntawm gs -441524 Hmoov tau cuam tshuam nrog cov kev sib xyaw ua ke ntawm PHC-}} {1} .
Acidic Ph Modifiers
Acidic tej zaum yuav muaj sib txawv ntawm gs -441524 hmoov:
Cov kua qaub me me: cov organic accic zoo li citric acid lossis acetic acid, thaum siv nyob rau hauv qee hom formulations .
Cov kua qaub muaj zog: raug rau cov kua qaub muaj zog xws li cov kua qaub hydrochloric ntawm gs {{0} {.
Buffiner Systems: Phosphate lossis citrate tsis tuaj yeem siv los tswj cov kua qaub me ntsis, uas yuav yog qhov zoo tshaj plaws rau gs {0}.
Alkaline P Modifiers
Qhov ruaj khov ntawm gs -441524 Hmoov tau cuam tshuam tau ntau yam cuam tshuam los ntawm Alkaline Cov Mob:
Tej zaum cov tshuaj tsis muaj zog xws li cov tshuaj tsw qab me xws li sodium bicarbonate tuaj yeem zam rau hauv cov nyiaj me me tab sis yuav tsum tau siv ceev faj kom tsis txhob muaj pH-dog dig demradation.
Cov pob hluav taws xob muaj zog: raug rau cov kev sib txuas lus zoo xws li sodium hydroxide lossis potassium hydrocround tuaj yeem ua rau muaj kev tsis txaus siab ntawm gs -441524.
Amine-muaj expiPients: qee cov neeg ua haujlwm amine-based yuav sib cuam tshuam nrog gs-441524, muaj peev xwm ua cov tshuaj tsw qab lossis hloov kho cov tshuaj lom neeg.
Ph-Hawm Solubility thiab Ruaj Khwv
Nkag siab ph-desenty tus cwj pwm ntawm gs -441524 hmoov yog qhov tseem ceeb rau nws cov qauv:
Solubility nkhaus: Aqueous solubility ntawm gs -441524}} yuav txawv ntawm cov sib txawv ntawm PHO, cuam tshuam rau nws cov kev xaiv sib txawv thiab cov qauv kev xaiv.
Qhov rai Stability: Qhia qhov tseeb PHUG qhov twg gs -441524 Cov chaw ua pov thawj ntau qhov kev ruaj khov yog qhov tseem ceeb rau kev txhim kho cov qauv zoo.
Zwitterionic tus cwj pwm: gs -441524}} Thov ua kom muaj kev cuam tshuam nrog lwm cov ionic hom {}}
Thaum tshawb nrhiavFIP kev kho mob redditCov kev sib tham, nws yog ib qho tseem ceeb uas yuav tsum xav txog qhov kev ruaj ntseg ntawm pH ntau rau kev kho kom ruaj khov, yuav tsum ua tib zoo} Oplectionating freatulation tsim qauv.
Tag
Hauv kev xaus, qhov sib xyaw ntawm gs -441524 cov tshuaj tiv thaiv kev nyab xeeb uas yuav tsum muaj kev sib txuam ntawm cov tshuaj, thiab muaj peev xwm ua tau zoo tshaj plaws thiab muaj peev xwm loj dua gs -441524 kev formulion .
Rau cov tuam txhab ua lag luam, polymer thiab plasticics rau tshawb nrhiav cov peev txheej ntawm gs {}, tsim kev txawj ntse hauv xyoo 2009, muaj kev tshaj lij hauv kev siv tshuaj lom neeg thiab Cov txheej txheem kev lim dej, suav nrog Suzuki thiab Grignard Regonion, HIGHT}
Kom paub ntau ntxiv txogGs 441524 Hmoovthiab lwm yam tshuaj tshwj xeeb, lossis sib tham txog kev sib cog lus ntev rau kev yuav khoom ntev, thov hu rau peb ntawmSales@bloomtechz.com. Peb Pab Pawg ntawm cov kws tshaj lij yog npaj los pab koj cov tshuaj lom neeg, txawm yog kev kho mob, lossis roj thiab roj av}
Ntawv Sawv cev
1. Johnson, L . "} ."}} "journal ntawm Cov Tshuaj Tshawb Fawb, 110 (4), 1652-1665.
{{02. chen, y .} {} "}}"} {{{104786.
3. Smith, R}}}}}}} {} Cov ntaub ntawv xov xwm thoob ntiaj teb ntawm cov kws tshuaj, 615, 121514.
4.} Zhang, w . "}"} {} "} {}"} {} (7), 279.