Lub hauv paus rau phau ntawv
Artemisinin, cais los ntawm cov tshuaj HmoobArtemisia Annua, tau hloov kho cov kev kho mob ntawm Malaria, tus kab mob uas tuag taus cuam tshuam rau ntau lab thoob ntiaj teb. Kab lus no muab cov ntsiab lus tshawb fawb ntawm kev kuaj mob ntawm kev ua yeeb yam ntawm cov kws kho mob kws kho mob, tsom rau kev ua, kev ua tau zoo, kev nyab xeeb, thiab cov kev siv tau nyob rau hauv cov kab mob tsis muaj mis. Qhov tshawb nrhiav ntawm Artemisin cim tau ib qho kev sib tw tseem ceeb hauv kev tawm tsam Malaria, thiab kev tshawb nrhiav txuas ntxiv txuas ntxiv tshawb nws lub peev xwm.
Peb muab Artemisinin hmoov cas 63968-64-9, Thov saib mus rau lub vev xaib hauv qab no rau cov ncauj lus kom ntxaws ntxaws thiab cov ntaub ntawv.
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Malaria tseem yuav ua rau muaj kev hem thawj tseem ceeb rau kev noj qab haus huv thoob plaws ntiaj teb, ua rau muaj ntau lab tus kab mob thiab tuag ntau dua txhua xyoo. Ib qho kev txhawj xeeb tseem ceeb yog kev txhim kho ntawm kev tiv thaiv mus rau cov tshuaj tiv thaiv tshuaj tiv thaiv tshuaj tiv thaiv tshuaj tiv thaiv kab mob, uas tau ua rau qee cov kev kho mob tsis ua haujlwm. Hauv kev teb rau qhov kev sib tw no, lub zej zog tshawb fawb tau siv zog rau nws txoj kev tshawb nrhiav rau lwm txoj kev pabcuam, cov tswv yim kho kom zoo.
Artemisinin, ib qho compound teej tug rau lub sesquiterToDoDoDoD chav kawm thiab tau los ntawm cov nroj tsuag Artemisia Annua Annua tau txais txiaj ntsig zoo li cov tshuaj tiv thaiv kab mob antimalarial. Nws cov txiaj ntsig tseem ceeb rau ntawm cov yam ntxwv ntawm cov yam ntxwv sib txawv ntawm lwm cov neeg sawv cev antimalarial. Artemisinin lub tshuab ua haujlwm, raws li tau piav qhia yav tas los, tsim kev puas tsuaj rau Hemaria cov tshuaj tsw qab thiab cov protein, ua rau nws txoj kev tshem tawm sai sai los ntawm lub cev.
Muab cov dav dav tiv thaiv kom cov tshuaj tiv thaiv cov tshuaj uas muaj kev sib raug zoo nrog rau cov artistemisinin sawv cev rau kev tawm tsam cov kab mob no. Cov kev kho mob artemisinin muaj ua qhov tseem ceeb hauv kev tswj hwm ntawm Malaria, tshwj xeeb yog nyob rau hauv cov tshuaj uas tsis tshua muaj cov yeeb tshuaj.
Hauv cov ntsiab lus, Malaria tseem yog qhov teeb meem kev noj qab haus huv tseem ceeb, thiab cov tshuaj tiv thaiv kev noj qab haus huv tau ua rau cov kev tshawb nrhiav tshiab. Artemisinin, muab tau los ntawm Artemisia Annua Anentua, tau tawm los ntawm lub zog thiab cov tshuaj tua kab mob antimalarial tus neeg sawv cev, ua ib kab tshiab ntawm kev tiv thaiv kab mob tshiab.
Mechanism ntawm Kev Ua
Artemisinin, muaj cov tshuaj tiv thaiv muaj zog, ua haujlwm los ntawm kev sib tw tiv thaiv lub plab zom mov ntawm cov ntshav plab thaum nws nyob sab hauv cov ntshav liab. Daim ntawv ua haujlwm nquag ntawm Artemisinin, hu ua DihydroAncisinin, muaj kev cuam tshuam nrog HEME, ib qho tshuaj tsim tawm thaum cab tsoo hemoglobin los ntawm cov qe ntshav liab. Qhov kev sib cuam tshuam no tau tshwm sim hauv kev tsim cov dawb radicals, muaj cov molecules heev uas ua rau cov cab.
Qhov tsim ntawm cov dawb radicals cuam tshuam tus cab ib daim nyias nyias thiab cov protein, ua rau nws tsis muaj zog. Qhov kev cuam tshuam no ua rau muaj kev tshem tawm nrawm ntawm tus cab los ntawm lub cev thiab ib qho kev txo qis hauv nws cov pej xeem lossis biomass. Dab tsi ua rau Artemisinin tshwj xeeb tshwj xeeb piv rau lwm cov tshuaj tiv thaiv antimalarial yog nws cov tshuab kev ua. Tshuaj tiv thaiv cov tshuaj ib txwm ua rau qee cov txheej txheem tshwj xeeb lossis cov txheej txheem metabolic hauv cov cab. Hauv kev sib piv, Artemisinin txoj kev kom ncaj qha cuam tshuam nrog cov kab ke ntawm cov qauv kev ntseeg siab los ntawm kev sib tham thiab ua kom nws cov tshuaj pleev ib ce thiab cov protein los ntawm kev tsim dawb.
Secmical Efficacy
Kev kho mob Artemisinin-raws li kev kho mob (Cov Tub Txib) tau dhau los ua cov khoom lag luam thawj zaug, tshwj xeeb rau cov tshuaj tiv thaiv kab mob chloroquine thiab lwm yam tshuaj tiv thaiv cov tshuaj tiv thaiv kab mob. Cov kev tshawb fawb soj ntsuam tau pom kev ua yeeb yam ntawm kev ua yeeb yam ntawm kev tuag Malaria lub neej thiab morbidity. Nyob rau hauv ib qho kev kawm kev kawm nyob rau xyoo 1970, lub koom haum ntawm Suav merteria tshuaj tshuaj zoo li qub ntawm Artemisinin hauv kev kho mob malaria tshwm sim los ntawmPlasmodium VivaxthiabPlasmodium FalciparumCov. Kev tshawb fawb tom qab tau lees paub tias nws ua tau zoo rau kev kho chloroquine-resistantP. FalciparumMalaria thiab Cerebral Malaria. Lub sijhawm ua rau kev kub taub hau thiab cov pa cab yog qhov sib piv luv dua nrog kev kho mob artemisinin piv rau chloroquine lossis quinine.
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Kev Nyab Xeeb Profile
Artemisinin muaj cov tshuaj lom tsawg heev, nrog cov tsis zoo rau kev sib tw tsis zoo uas tau tshaj tawm hauv kev sim kuaj mob. Cov kev tawm tsam feem ntau muaj xws li cov kev ntxhov siab, xws li xeev siab, ntuav, thiab raws plab. Txawm li cas los xij, cov tsos mob no feem ntau yog hloov thiab daws qhov ntev tsis muaj qhov xav tau kev kho mob tshwj xeeb. Qhov tsawg toxicity ntawm Artemisin yog ntaus nqi rau nws hom tshwj xeeb hom kev nqis tes ua cov cab hauv cov ntshav liab, nrog kev cuam tshuam tsawg rau ntawm host hlwb. Cov kev tshawb fawb tau taug mus sij hawm ntev yuav tsis tau tshaj tawm tias muaj kev cuam tshuam loj uas cuam tshuam nrog kev siv artemisin.
Kuj thiab kev sib tw
Kev sib ntaus tawm tsam Malaria ntsib kev kub siab heev nrog qhov tshwm sim ntawm kev tiv thaiv mus rau Artemisinin. Lub Malaria Parasite tau yoog raws li kev puas tsuaj ntawm Artemisinin, tsim kev kho mob kom siv sijhawm ntev dua kom tshem cov cab no kom meej. Qhov kev tsis kam yog qhov kev txhawj xeeb loj vim nws yuav cuam tshuam rau kev nce qib ua rau muaj kev tswj hwm kev ua haujlwm nrog Armarisinin-raws li kev kho mob.
Nyob rau hauv teb rau qhov kev sib tw no, cov kws tshawb nrhiav tau ua haujlwm tshiab ntawm Artemisinin uas tuaj yeem tuav lossis tseem txhim kho nws cov tshuaj tiv thaiv kev tiv thaiv thaum tsis tshua muaj kev cuam tshuam rau kev tiv thaiv tsis taus. Ib qho ntxiv, kev kho kom zoo, hu ua artemisinin-based ua ke kho mob (ua), tau dhau los ua lub hauv paus ntawm malaria. Ua ke ua ke ua ke Artemisin nrog lwm cov tshuaj tiv thaiv, xws li Lumrealorial, lossis amodiaquine, txhua tus nrog cov qauv sib txawv ntawm cov cab.
Qhov kev nkag siab tom qab kev ua yog siv cov tshuaj nrog cov txheej txheem sib txawv ntawm kev nqis tes ua kom txo qis kev pheej hmoo ntawm kev tsim tawm. Los ntawm kev sib tw muaj ntau yam ntawm tus cab lub biology ib txhij, kev ua rau nws nyuaj rau cov cab no mus evolve mus rau tag nrho kev kho mob regimen. Txoj kev mus ze no tsis tsuas yog khaws cia kev ua tau zoo ntawm Artemisinin tab sis kuj ua kom muaj zog ntau dua thiab muaj txiaj ntsig zoo.
Cov ntawv thov nyob rau hauv cov kab mob uas tsis muaj malarial
Tshaj dhau nws cov peev txheej antimalarial, cov kev tshawb fawb tsis ntev los no tau pom zoo tias Artemisinin thiab nws cov kev ua yeeb yam muaj cov ntawv thov tsis muaj malarial. Tej zaum artemisinin yuav muaj cov kab mob tawm tsam, tshuaj tiv thaiv mob qog noj ntshav, thiab cov tshuaj tiv thaiv kab mob sib txawv. Hauv cov kev tshawb fawb vitro thiab tsiaj txhu tsiaj tau ua kom pom qhov kev ua tau zoo ntawm kev loj hlob ntawm ntau yam kab mob cancer ntawm cov kabmob, suav nrog tus mob qog noj ntshav, nyuv, thiab mob qog noj ntshav. Ib qho ntxiv, Artemisinin tau qhia cov kev cog lus hauv kev kho mob pib, xws li kev mob ntsws opthimmune, los ntawm kev hloov pauv ntawm lub cev tiv thaiv kab mob. Txawm li cas los xij, cov kev tshawb fawb soj ntsuam ntxiv kom paub meej tias yuav tsum tau lees paub cov kev tshawb pom no thiab teeb tsa lub peev xwm kho tau ntawm Artemisinin hauv cov kab mob tsis muaj malarial.
Cov Khoom Siv Hluav Taws Xob
Cov khoom siv tshuaj ntawm Artemisinin yog qhov tseem ceeb rau kev nkag siab txog kev kho mob thiab kev ua kom zoo siv cov regtimens. Artemisinin yog nrawm dhau los tom qab cov thawj coj ntawm qhov ncauj, nrog cov ntshav ntshav siab sib xyaw ua tiav tiav rau hauv 1-2 teev. Nws muaj luv luv ib nrab-lub neej, xws li los ntawm 1-2}}}}}}}} kev siv tshuaj los tswj ntau yam kev kho mob. Lub xyoob articailability ntawm Artemisin tau cuam tshuam los ntawm cov zaub mov noj, muaj ntau dua Plasma ntau heev pom thaum muab cov khoom noj muaj roj. Artemisinin tau muab faib rau dav thoob plaws lub cev, nrog cov siab ua tiav hauv cov nqaij xws li daim siab xws li lub siab, thiab raum. Nws yog Metabolized feem ntau los ntawm daim siab thiab tawm hauv cov kua tsib thiab cov zis.
Tag
Artemisinin yog cov tshuaj tiv thaiv zoo kawg uas muaj cov cim tshwj xeeb ntawm kev ua, muaj zog ua tau zoo, thiab cov tshuaj lom tsawg. Nws nrhiav tau tau hloov kho cov kev kho mob ntawm cov neeg tsis muaj txiaj ntsig thiab tau txais kev cawm dim nyob hauv lub neej. Txawm li cas los xij, qhov tshwm sim ntawm Artemisinin Kuj yuav tsum muaj cov kev tshawb fawb tsis tu ncua los tsim cov kev kho mob tshiab thiab kev kho kom zoo. Ib qho ntxiv, cov ntawv thov muaj peev xwm ntawm Artemisinin hauv kev kho cov kab mob uas tsis muaj malarial rau kev tshawb fawb yav tom ntej. Nrog txuas ntxiv kev nkag siab nws cov khoom siv tshuaj thiab ua kom zoo rau kev tawm tsam hauv kev tawm tsam Malaria thiab lwm yam kab mob tau ntau xyoo los.