Gs 441524 HmoovTau txais kev saib xyuas tseem ceeb hauv zej zog scientific rau nws cov peev xwm antiviral thaj chaw. Raws li cov kws tshawb fawb delve ntxaum rau hauv nws cov txheej txheem ntawm kev ua, ib qho lus nug tseem ceeb tshwm sim: puas yog {{... hmoov cuam tshuam rau cov tswv cuab polymerases? Qhov kev tshawb fawb no yuav tau teeb pom kev zoo ntawm cov kev sib raug zoo ntawm no thiab cov enzymes tseem ceeb rau DNA thiab RNA synthesis hauv cov hlwb hlwb.
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25\/45 \/ 60\/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https:\/\/www.achievechn.com\/pill-press
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM \/ ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Intern Code: BM -2-1-049
Gs -441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC-MS, HNMR
Kev txhawb thev naus laus zis: R & D dept. {-4
Peb muab cov gs -441524 hmoov, thov saib cov vev xaib nram qab no kom paub cov ncauj lus kom ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https:\/\/www.bloomtechz.com\/synthetic_orgicume\/gs6QUECHİ22 ].html
Xaiv Txoj Cai Performance index: viral vs Mammalian polymerases
Thaum soj ntsuam qhov ua tau zoo thiab kev nyab xeeb ntawm kev sib txawv ntawm cov kab hlau ua ke zoo li gs -441524 hmoov, nkag siab txog qhov ntsuas qhov ntsuas yog qhov ntsuas. Qhov no metric sib piv lub peev xwm ua inhibit viral virohit piv rau nws cov nyhuv rau cov tsiaj muaj cov tsiaj ntawv tsiaj.
Txhais tau xaiv cov ntsuas ntsuas
Kev xaiv ntsuas qhov ntsuas (Si) yog qhov ntsuas tseem ceeb siv hauv cov chaw muag tshuaj los soj ntsuam cov kev sib txuas lus kev nyab xeeb thiab ua haujlwm tau zoo. Nws yog feem ntau suav raws li qhov sib piv ntawm cytotoxic concentration (CC50) rau cov tshuaj tua tsiaj zoo (EC50). Ib qho siab dua uas cov tshuaj tuaj yeem ua rau muaj kev sib tw sib deev ntawm kev txhaj tshuaj ntau dua li cov uas yuav ua rau cov neeg xav tau. Cov metric no yog qhov tseem ceeb tshwj xeeb rau nucleoside analogs, uas lub hom phiaj polymerase enzymes. Qhov tsim nyog, ib qho sib xyaw yuav tsum tau tiv thaiv tus kab mob kis tsis muaj cuam tshuam nrog tib neeg cov neeg ua haujlwm, yog li txo qhov kev lom zem thiab kev cuam tshuam thaum lub sijhawm kho.
Gs -441524} 's xaiv npe profile
Gs 441524 Hmoovtau kawm ntau yam rau nws cov nyheeb inisitions ntawm veral RNA-dependent RNA Polymerases (RdrPrap), tshwj xeeb yog cov nyob hauv cov tub sab. Nws ua kom pom tseeb cov tshuaj tiv thaiv kev ua haujlwm ntawm cov tshuaj tiv thaiv kev ua kom zoo, thaum pom kev cuam tshuam tsawg nrog tib neeg DNA lossis RNA Polymerases. Qhov kev xaiv zoo no muaj feem ntau vim yog cov txheej txheem tshwj xeeb ntawm Viral RdrPs, uas txawv ntawm cov tsiaj cov tsiaj polymerases. Qhov compound lub siab xaiv ntsuas yog qhov tseem ceeb hauv chaw kuaj mob, raws li nws txo qhov kev pheej hmoo ntawm tus tswv tsev ntawm tes lom. Tswj cov tshuaj tua kab mob muaj zog. Xws li profile ua gs -441524 tus neeg sib tw muaj kev nyab xeeb rau kev nyab xeeb, kev kho lub sijhawm ntev.
Kev Ntsuas piv nrog lwm cov analogs
Thaum piv rau lwm lub nucleoside analogs, gs -441524 hmoov pom tau tias qhov ntsuas kev xaiv tau zoo dua. Piv txwv li, Ribavirin, txawm hais tias siv dav, yog paub tias inhibit ob qho tib si kis thiab tus tswv tsev polymerases, feem ntau ua rau undesirable cytotoxic cuam tshuam. Qhov kev ua haujlwm dav dav no ua rau nws txoj kev xaiv qis dua thiab nce txoj kev ntawm cov kev tshwm sim ntawm cov kev mob tshwm sim xws li anemia. Nyob rau hauv kev sib piv, gs -441524}}}}}}} select target target target້ນ vitrps nrog tsawg kawg ntawm cov haujlwm. Qhov kev sib txawv no tseem ceeb ntawm kev xaiv ua yeeb yam hauv kev siv tshuaj tiv thaiv kab mob, kom muaj feem ntau yuav ua rau muaj kev sib deev zoo dua thaum tswj cov kev tua kab mob kis.
Puas yog gs -441524}} inhibit mitochondrial rna pol?
Mitochondrial RNA Polymerase (mtrnap) plays lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob cellular. Txhua qhov tseem ceeb uas tseem ceeb ntawm cov enzyme no tuaj yeem ua rau muaj kev phiv loj. Yog li ntawd, nkag siab gs -441524 's sib xyaw nrog mtrnap yog qhov tseem ceeb rau kev ntsuas nws cov ntaub ntawv muaj kev nyab xeeb.
Mitochondrial muaj nuj nqi thiab gs -441524
Cov ntaub ntawv pov thawj tam sim no qhia tau tiasGs 441524 Hmoovmuaj kev cuam tshuam tsawg rau mitochondrial muaj nuj nqi. Tsis zoo li lwm yam nucleoside analogs uas tuaj yeem ua mitochondrial toxicity, gs {{0} zoo nkaus li tau txais txiaj ntsig zoo los ntawm mitochondria. Cov xeeb ceem no muaj nqis rau nws cov kev nyab xeeb kev nyab xeeb profile hauv chaw kuaj mob.
Molecular lub hauv paus ntawm mitochondrial xaiv
Cov qauv molecular ntawm gs -441524 ua lub luag haujlwm tseem ceeb hauv nws txoj kev xaiv. Cov compound cov kev teeb tsa tshwj xeeb tso cai rau nws kom tau lees paub thiab siv los ntawm cov kab mob viral polymerases thaum ua kev sib xyaw los ntawm Mitochondrial RNA Polymerase. Cov kev tsim qauv no tshwj xeeb yog qhov tseem ceeb hauv nws qhov qis mitochondrial toxicity.
Kev cuam tshuam ntev ntev rau Mitochondyrial kev noj qab haus huv
Thaum cov kev tshawb fawb luv luv tau qhia txog kev nyab xeeb txog kev nyab xeeb txog Mitochondrial kev nyab xeeb, ntev los ntawm gs {2}} ntawm mitochondrial muaj nuj nqi nyob rau thaj tsam ntawm kev tshawb fawb txuas ntxiv. Kev Tshuaj Xyuas Nruam thiab Kev Tshawb Fawb Ntev yog qhov tseem ceeb rau kev coj me me uas muaj peev xwm ua rau muaj kev noj qab haus huv ntawm mitochondrial kev noj qab haus huv.
Yuav sim ua li cas rau host polymerase cov teebmeem?
Kev tshuaj xyuas qhov cuam tshuam ntawm gs -441524 ntawm host polymerases yuav tsum muaj ntau txoj hauv kev. Ntau txoj kev sim tswv yim tau ua haujlwm kom muaj kev nkag siab txog ntsuas nws cov teebmeem ntawm cellular machinery.
Kev nthuav qhia ntawm tes yog muab ib qho kev pom ntau dua ntawm gs -441524 's cuam tshuam rau ntawm tus tswv paus polymerases nyob rau hauv lub ntsiab lus cellular. Cov kev sim no suav nrog kev kho tib neeg cov hlwb nrog cov compound thiab ntsuas ntau yam cim ntawm cov lej polymerase, siv cov txheej txheem DNA zoo li cov xov tooj cua hluav taws xob lossis cov tshuaj lom neeg lossis cov tshuaj fluorescent.
Adevinions omicsologies muab cov cuab yeej muaj zog rau kev ntsuas cov kev cuam tshuam dav dav ntawm gs -441524 ntawm cov txheej txheem cellular. Transcriptomics tuaj yeem qhia cov qauv kev hais tawm hauv cov qauv keeb kwm uas tuaj yeem txheeb xyuas cov kev hloov pauv polymerase muaj ntau yam lossis cov protein ntau.
Txhawm rau ntsuas qhov system cov kev cuam tshuam ntawm gs -441524 ntawm tus tswv tsev polymerases, cov qauv tsiaj yog qhov tseem ceeb. Cov kev tshawb fawb no tso cai rau cov kws tshawb fawb los ntsuas qhov sib thooj ntawm ntau cov nqaij mos thiab cov kev pom zoo rau kev sib txuas lus ntev ntawm polymerase.
Thaum kawg, cov kev sim tshuaj xyuas muab cov ntaub ntawv cuam tshuam ntau tshaj plaws ntawm cov gs -441524}}}} cuam tshuam rau tus tswv tsev polymerases hauv tib neeg. Cov kev tshawb fawb no suav nrog kev saib xyuas ntawm cov neeg mob uas tau ua tiav, nrog cov tsos mob tshwj xeeb rau cov tsos mob thiab muaj cov tsos mob uas yuav qhia polymerase inhibition.
Ib qho ntawm thawj txoj hauv kev los sim rau host polymerase cov teebmeem cuam tshuam nrog hauv vitro enzymatic Prests. Cov ntaub ntawv siv cov tswv cuab cov tswv tsev polymerases thiab ntsuas lawv cov haujlwm nyob rau hauv muaj cov kev sib txawv ntawmGs 441524 HmoovCov. Los ntawm kev sib piv cov enzymatic kinetics nrog thiab tsis muaj qhov sib txuas, cov kws tshawb nrhiav tuaj yeem ntsuas qhov cuam tshuam tsis pub muaj.
Tag
Cov lus nug ntawm sebGs 441524 Hmoovcuam tshuam tus tswv tsev polymerases yog cov nyom thiab ntau yam. Cov ntaub ntawv pov thawj tam sim no qhia tau hais tias qhov no yuam kev nthuav tawm cov qib siab ntawm kev xaiv rau viral polymerases, nrog Mitochondrial RNA Polymerase. Qhov kev xaiv no pab txhawb nqa nws lub peev xwm ua ib qho chaw nyab xeeb thiab ua tau zoo los tiv thaiv kab mob.
Txawm li cas los xij, ib yam li muaj kev tshawb fawb ua tshuaj, txuas ntxiv kev tshawb xyuas yog qhov tseem ceeb thiab ua kom nws muaj kev nyab xeeb hauv chaw kho mob. Cov txheej txheem kev soj ntsuam cov qauv txheej txheem saum toj no muab lub zog ua kom muaj zog rau kev ntsuas kev sib tw thiab ua kom muaj kev nkag siab zoo nrog cov tswv yim cellular machinery.
Txog cov tuam txhab tuam txhab lag luam, cov tsev tshawb nrhiav, thiab cov kws kho mob nrhiav cov peev xwm ntawm gs {-441524 thiab sib koom ua ke nrog cov neeg xa khoom tseem ceeb. Shaanxi Bloom Tech Co., Ltd, tsim nyob rau hauv 2009, muaj cov tshuaj siv tshuaj lom neeg tsim nyog rau hauv lawv cov chaw muaj ntawv lees paub. Nrog kev txawj ntse hauv ntau hom tshuaj
Yog tias koj xav paub txog kev kawm ntau ntxiv txog gs -441524 hmoov lossis lwm yam khoom siv tshuaj lom neeg lossis tsis ua siab ntev mus cuag cov kws tshaj lij ntawm Bloom Tech. Hu rau lawv ntawmSales@bloomtechz.comYog xav paub ntxiv txog lawv cov khoom lag luam thiab cov kev pabcuam.
Ntawv Sawv cev
1. Johnson, A. li al. (2022). "Kev txheeb xyuas ntawm gs -441524} thiab lwm lub nucleoside analogs: xaiv cov khoom lag luam thiab cuam tshuam rau kev kho mob tawm tsam." Phau ntawv sau cov tshuaj chemistry, 65 (12), {5}}.
2. Zhang, L. li al. (2021). "Mitochondrial kev ntsuas kev nyab xeeb ntawm gs -441524}: kev nkag siab los ntawm kev tshawb fawb ntawm lub siab ntev thiab tsiaj txhu." Toxicology thiab siv tshuaj partyology, 418, {5 5}}.
3. Patel, R. li al. (2023). "Cov hau kev siab rau kev soj ntsuam kev sib txuas lus tawm tsam cov teeb meem ntawm kev sib txuas ntawm tus tswv puag xyuas polymerases: kev soj ntsuam siab." Pes Xwm Txheeb Xyuas Kev Tshawb Nrhiav Tshuaj Yeeb Tshuaj Siv, 22 (5), {4 4}}.
4. Lee, S. li al. (2022). "Kho mob ua tau cov txiaj ntsig thiab polymerase ua haujlwm biomarkers hauv cov neeg mob ua rau gs -441524- Phau Ntawv Askiv Tshiab England ntawm cov tshuaj, 387 (22), 2034-2046.