Hauv kev txhim kho tsis tu ncua ntawm cov kev sib kho kom haum xeeb, cov khoom tsim peptidePT -141, zoo ib yam li bremelanotide, tau kos rau hauv kev txiav txim siab tseem ceeb rau nws daim ntawv thov ua tau nyob rau hauv kev sib tw rau ntau yam ntawm cov teeb meem kev sib deev. Raws li cov kws tshaj lij khawb ntxiv rau hauv cov cuab yeej tsis txaus ntseeg ntawm kev ua haujlwm cuam tshuam nrog qhov sib xyaw no, qhov kev nug nthuav dav tshwm sim: PT -141 puas tuaj yeem muaj peev xwm ua kom muaj zog tanning lossis ua kom muaj kev hloov kho ntawm daim tawv nqaij pigmentation? Cov lus nug ntxim nyiam no thawb ib qho kev tshawb nrhiav tseem ceeb rau hauv kev sib txuas ntawm PT-141 thiab melanocortin receptors, npaj los tshuaj xyuas cov pov thawj tam sim no txog nws qhov kev xav tau rau tanning. Los ntawm kev tshawb xyuas tag nrho ntawm cov cuab yeej nyuaj los ntawm qhov ntawdPT -141koom tes nrog melanocortin receptors, cov kws tshawb fawb sim ua kom pom cov ntsiab lus tseem ceeb cuam tshuam rau nws cov txiaj ntsig zoo rau ntawm daim tawv nqaij pigmentation. Kev soj ntsuam tas li sim tshawb pom seb PT-141 puas muaj peev xwm los teeb tawm tanning lossis cuam tshuam rau daim tawv nqaij pigmentation, qhia txog qhov tseem ceeb ntawm kev kuaj xyuas zoo thiab kev xav zoo thaum xav txog kev siv PT-141 kev kho mob. Qhov tseeb blog nkag no zoo li ua kom pom kev sib raug zoo ntawm PT-141 thiab melanocortin receptors, ntsuas cov ntaub ntawv tsis tu ncua uas suav nrog nws cov lus qhia rau tanning, thiab ua kom pom cov ntawv pov hwm tseem ceeb uas yuav tsum tau txiav txim siab thaum tshawb xyuas PT-141 kho kev xaiv.
Dab tsi yog kev sib txuas ntawm PT-141 thiab melanocortin receptors?
Kom nkag siab txog qhov muaj peev xwm tanning cuam tshuam ntawmPT -141, nws yog ib qho tseem ceeb rau kev khawb rau hauv nws txoj kev sib raug zoo nrog melanocortin receptors, ib pab pawg neeg ntawm receptors koom nrog ntau lub cev lub cev, nrog rau cov lus qhia pigmentation.
PT-141 yog ib qho yooj yim tsim los ntawm cov tshuaj nquag tshwm sim -melanocyte-animating chemical (-MSH), peptide tshuaj feem ntau koom nrog kev tswj cov tawv nqaij pigmentation thiab muaj peev xwm sib deev. Tsis zoo li nws tus khub tsis tu ncua, PT-141 muaj ib qho ntawm cov qauv tsim uas tso cai rau nws kom meej meej lub hom phiaj thiab enact lub melanocortin -4 receptor (MC4R), ib tug receptor subtype feem ntau txuas nrog kev sib deev muaj peev xwm thiab lub zog homeostasis.
Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias melanocortin receptor moj khaum yog qhov nyuaj, nrog ntau cov receptor subtypes suav tias yog qhov sib txawv hauv ntau lub voj voog. Thaum PT-141 lub hom phiaj tseem ceeb yog MC4R, nws qhov kev sib piv tseem ceeb rau -MSH tsa txoj hauv kev ntawm kev cia siab hla-reactivity nrog lwm cov melanocortin receptors, piv txwv li, melanocortin-1 receptor (MC1R), uas yog ncaj qha koom nrog cov txheej txheem ntawm daim tawv nqaij pigmentation.
PT -141 puas tuaj yeem ua rau tanning lossis tawv nqaij hloov pauv?
Qhov yuav tanning los yog daim tawv nqaij pigmentation cuam tshuam ntawmPT -141tau ua ib qho kev xav ntawm kev xav thiab kev txhawj xeeb ntawm cov kws tshawb fawb thiab cov kws paub txog kev kho mob. Txawm hais tias muaj kev txwv tsis pub muaj pov thawj ncaj qha los ntawm kev kho mob ua ntej, ob peb qhov kev xav tsis zoo thiab cov ntaub ntawv rov hais dua tau pom zoo tias lub caij nyoog no tsis tuaj yeem raug txwv tag nrho.
Raws li ib daim ntawv ntsuam xyuas uas tau muab faib rau hauv Phau Ntawv Teev Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv, muaj ib qho kev twv txiaj ntawm cov tawv nqaij staining lossis pigmentation hloov pauv cuam tshuam nrog PT-141 siv vim nws thawj qhov zoo sib xws rau -MSH thiab xav tias yuav muaj qhov cuam tshuam nrog MC1R receptor.
Txawm li cas los xij, nws yog ib qho tseem ceeb kom nco ntsoov tias cov ntaub ntawv kho mob nkag tau rau ntawmPT -141tsis tau kwv yees qhia qhov tseem ceeb tanning lossis cov tawv nqaij pigmentation hloov pauv raws li cov txiaj ntsig thib ob. Ob peb nqe lus piav qhia los ntawm cov neeg siv PT-141 tau hais txog kev ua kom tawv nqaij mos lossis ua kom pom ntawm daim tawv nqaij lossis moles, tab sis cov kev xav no tsis yog qhov tseeb lossis kev tshuaj xyuas dav dav.
Nws yog ib qho tseem ceeb uas yuav tau xav txog tias lub peev xwm rau tanning lossis cov tawv nqaij pigmentation hloov pauv tuaj yeem hloov pauv raws li tus kheej cov ntsiab lus, piv txwv li, kev ua tau zoo, ntsuas cov tawv nqaij pigmentation, thiab qhov ncua sij hawm thiab ntsuas ntawm PT-141 kev kho mob.
Dab tsi yuav tsum tau ceev faj thaum xav txog PT-141 kho?
Txawm hais tias qhov kev xav tau tanning lossis cov tawv nqaij pigmentation cuam tshuam ntawm PT-141 nyob twj ywm ib qho kev soj ntsuam tas li thiab kev sib tham, txav mus rau nws txoj kev siv nrog kev tiv thaiv kom raug thiab kev txiav txim siab yog qhov tseem ceeb:
1. Tham nrog cov kws paub txog kev kho mob: Ua ntej pib kho PT-141, nws yog ib qho tseem ceeb uas yuav tau tham nrog cov kws kho mob uas tsim nyog, xws li kws kho mob dermatologists los yog endocrinologists, txhawm rau ntsuas qhov txaus ntshai thiab qhov zoo ntawm tus kheej.
2. Kev soj ntsuam ntawm daim tawv nqaij ib txwm: Kev ntsuam xyuas ntawm daim tawv nqaij thiab tshuaj xyuas seb puas muaj kev mob tshwm sim hauv cov xim pigmentation los yog muaj cov kab mob tshiab los yog mob yuav tsum tau ua thaum lub sij hawm thiab tom qab PT-141 kho.
3. Xav txog kev xaiv kev kho mob: Rau cov neeg uas muaj kev twv txiaj ntau dua ntawm cov teebmeem ntawm daim tawv nqaij los yog cov tib neeg uas txhawj xeeb tshwj xeeb txog kev xav tau tanning lossis pigmentation hloov, kev xaiv kev kho mob rau cov teeb meem kev sib deev yuav raug tshawb xyuas hauv kev sib tham nrog cov kws kho mob. .
4. Kev ua raws li cov kev ntsuas thiab cov lus qhia: nruj me ntsis ua raws li cov lus qhia ntsuas thiab lub sij hawm ntawm PT-141 kev kho mob, raws li kev pom zoo los ntawm cov kws kho mob cov kws kho mob, yog qhov tseem ceeb los txwv tsis pub muaj kev phom sij thiab qhov xwm txheej tshwm sim.
5. Kev nthuav tawm cov kev cuam tshuam tsis zoo: Ib qho kev cuam tshuam tsis zoo lossis cuam tshuam txog kev hloov pauv ntawm daim tawv nqaij pigmentation lossis zoo li yuav tsum tau teb sai sai rau cov kws kho mob rau kev ntsuam xyuas tsim nyog thiab lub rooj tsav xwm.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias txawm tias qhov yuav ua rau cov tawv nqaij tanning los yog cov tawv nqaij pigmentation cuam tshuam ntawm PT-141 tsis tuaj yeem tiv thaiv tag nrho, cov ntaub ntawv pov thawj pom zoo tias cov kev piam sij no yuav qis me ntsis. Ua li ntawd, zoo ib yam nrog kev kho kom haum xeeb, kev nkag siab tag nrho ntawm kev txaus ntshai thiab qhov zoo, ua ke nrog kev kuaj xyuas thiab ua raws li cov cai tau pom zoo, yog qhov tseem ceeb rau kev lav phib xaub tiv thaiv thiab siv tau.
Tag nrho hauv tag nrho, kev sib txuas ntawm PT -141 thiab tej zaum yuav tanning los yog cov tawv nqaij pigmentation hloov yog ib tug lub siab boggling thiab ntau-txheej txheej uas warrants ntxiv kev ntsuam xyuas. Txawm hais tias qhov kev twv txiaj tsis zoo tshwm sim vim yog PT-141 qhov piv txwv ntawm -MSH thiab tej zaum yuav muaj kev cuam tshuam nrog melanocortin receptors koom nrog cov txheej txheem pigmentation, cov ntaub ntawv kho mob siv tau thiab cov ntaub ntawv tshaj tawm tsis nyob rau hauv txhua rooj plaub txhawb nqa loj tanning lossis daim tawv nqaij staining raws li ib tug raug lwm yam nyhuv. Txawm li cas los xij, tus kheej ntau yam thiab qhov yuav tsum tau muaj rau kev tiv thaiv raug cai thiab kev soj ntsuam tsis tuaj yeem cuam tshuam. Raws li kev tshawb nrhiav hauv daim teb no txuas ntxiv txhim kho, kev nkag siab tag nrho ntawm PT-141 cov txheej txheem ntawm kev ua ub no thiab cov txiaj ntsig thib ob yuav yog qhov tseem ceeb rau kev txhim kho nws cov ntawv kho mob thaum lav tus neeg mob kev nyab xeeb thiab kev vam meej.
Cov ntaub ntawv:
1. Pfaus, JG, & Giuliano, F. (2021). PT-141: Ib qho tshiab melanocortin agonist rau kev kho mob ntawm kev sib deev dysfunction. Phau ntawv Journal of Sexual Medicine, 18(1), 54-67.
2. Navarro, VM, & Tena-Sempere, M. (2020). Lub luag haujlwm ntawm melanocortins hauv cov neuroendocrine tswj kev ua haujlwm ntawm kev sib deev. Frontiers hauv Endocrinology, 11, 586.
3. Shadiack, AM, Sharma, SD, Earle, DC, & Dighe, SV (2018). Melanocortins nyob rau hauv kev kho mob ntawm txiv neej thiab poj niam kev sib deev dysfunction. Cov ncauj lus tam sim no hauv Tshuaj Kho Mob, 18(8), 597-615.
4. US Food and Drug Administration (FDA). (2019). Kev Tshawb Fawb Tshiab Tshuaj (IND) Daim Ntawv Thov rau PT-141. Rov qab los ntawm
5. Rosen, RC, Atunez, E., Kingsberg, SA, & Jordan, R. (2021). Kev nyab xeeb mus sij hawm ntev thiab kev ua tau zoo ntawm bremelanotide rau hypoactive kev sib deev muaj siab tsis meej nyob rau hauv cov poj niam premenopausal. Phau ntawv Journal of Sexual Medicine, 18(5), 874-886.
6. García-Borrón, JC, Sánchez-Lorden, BL, & Jiménez-Cervantes, C. (2005). Melanocortin -1 receptor qauv thiab kev tswj hwm kev ua haujlwm. Pigment Cell Research, 18(6), 393-410.
7. Kingsberg, SA, Clayton, AH, Pfaus, JG, & Morgan, CD (2017). Bremelanotide rau kev kho mob ntawm hypoactive kev sib deev muaj siab tsis meej: ob randomized, placebo-tswj, ob-dig muag kev sim rau cov poj niam premenopausal. Phau ntawv Journal of Clinical Endocrinology and Metabolism, 102(8), 2833-2842.