Kab mob parasite tseem yog ib qho kev sib tw tsis tu ncua hauv cov kws kho tsiaj, cuam tshuam rau kev noj qab haus huv ntawm canine thoob plaws ntau lub cev. Cov kab mob sab nraud xws li dev mub thiab zuam ua rau tawv nqaij khaus thiab kis kab mob - cov kab mob, thaum cov kab mob sab hauv xws li kab mob plawv thiab plab hnyuv nematodes cuam tshuam rau lub cev tseem ceeb. Kev siv tshuaj deworming feem ntau xav tau ntau yam tshuaj siv rau ntawm cov sij hawm sib txawv, tsim teeb meem rau cov tswv tsiaj. Kev tsim kho tshiab niaj hnub no tau hais txog qhov nyuaj no los ntawm cov qauv kev sib xyaw ua ke uas lub hom phiaj ntawm cov kab mob sab nraud thiab sab hauv ib txhij. CovAfoxolaner thiab Milbemycin Oxime Chewable Tabletssawv cev rau kev tshawb fawb txog kev daws teeb meem uas muab kev tiv thaiv zoo los ntawm kev sib txawv tsis tau ntxiv cov txheej txheem ntawm kev ua. Kev nkag siab txog yuav ua li cas ob cov khoom xyaw tshuaj nquag ua haujlwm ua ke muab kev pom zoo rau cov tswv yim tswj cov kab mob niaj hnub no.
Afoxolaner Thiab Milbemycin Oxime Chewable Tablets
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Ua Haujlwm Los Ntawm Cov Khoom Uas Muaj Dua?
Afoxolaner thiab Milbemycin Oxime Chewable Tablets ua haujlwm vim tias lawv muaj ob hom tshuaj sib txawv uas ua haujlwm ua ke los tua cov kab mob tshwj xeeb. Qhov ob - txoj kev muaj cov khoom xyaw no siv qhov zoo ntawm qhov sib txawv hauv cov kab mob ua haujlwm li cas thaum ua kom tsiaj muaj kev nyab xeeb.
Afoxolaner's Mechanism Tawm tsam Ectoparasites
Afoxolaner yog ib qho tshuaj tua kab isoxazoline thiab acaricide. Cov tshuaj no khi rau arthropod paj hlwb ligand-gated chloride ion channels. Nws tsom rau glutamate-gated chloride channels thiab GABA receptors. Afoxolaner khi rau cov chaw receptor no txhawm rau tiv thaiv chloride ion hla hla cov paj hlwb. Qhov teeb meem no tiv thaiv cov neurons los ntawm kev xa cov teeb liab kom tsim nyog, ua rau cov hlab ntsha tsis muaj zog thiab cov kab mob parasite hyperexcitation.
Kev ua haujlwm ntawm lub hlwb ntau dhau depletes cov khoom siv hluav taws xob, tuag tes tuag taw, zuam, thiab mites thiab tua lawv tsis pub dhau ob peb teev tom qab siv nws.Vim tias nws tsuas cuam tshuam rau cov kab mob hauv lub cev, Afoxolaner tsis muaj mob. Afoxolaner khi ntau zog rau arthropod GABA receptors dua li vertebrate receptors, raws li kev tshawb fawb. Cov kev kho mob kev txawj ntse ntawm cov dev yog txo los ntawm qhov kev khi zoo tshaj plaws.Pharmacokinetic kev tshawb fawb qhia tias afoxolaner ua tiav cov ntshav siab tom qab ob mus rau plaub teev ntawm kev tswj qhov ncauj.
Nws tshem tawm ib nrab -lub neej yog ob lub lis piam, yog li nws tiv thaiv ectoparasites rau ib hlis.
Milbemycin Oxime Kev Ua Haujlwm ntawm Endoparasites
Streptomyces hygroscopicus fermentation khoom tsim cov anthelmintic macrocyclic lactone milbemycin oxime. Milbemycin A3 (20%) thiab A4 (80%) yog qhov zoo sib xws.Cov tshuaj no ua rau cov paj hlwb thiab cov leeg glutamate-gated chloride channels los tua cov kab mob uas raug kab mob.
Thaum milbemycin oxime khi, chloride ions tuaj yeem ua rau cov membrane hyperpolarise. Heartworm larvae, roundworms, hookworms, thiab whipworms tuag ntawm hyperpolarisation, uas ua rau cov leeg nqaij leeg ua tsis taus pa thiab nres cov neurones los ntawm firing.Tsiaj CNSs tsis tuaj yeem tau txais milbemycin oxime vim cov ntshav - hlwb barrier.CNS thiab peripheral glutagmate invertebrate {4} pom parasites.Milbemycin tsis tuaj yeem hla tsiaj cov ntshav- lub hlwb thaiv vim tias cov channel no muaj ntau dua.
Milbemycin A3 thiab A4 ncov hauv cov ntshav tom qab 1-2 teev thiab ploj tom qab 1.6-3.3 hnub. Nyob rau hauv cov qauv pharmacokinetic no, cov tshuaj mus txog tag nrho cov ntaub so ntswg kom puas cov kab mob parasite thaum lawv loj hlob thiab tshem tawm lub cev sai sai los tiv thaiv tib neeg.
Complementary Pharmacological Profiles
Muab afoxolaner thiab milbemycin oxime ua ke rau hauv ib lub ntsiav tshuaj uas noj tau ua rau cov txiaj ntsig kho tau ntev dua thaum lub hom phiaj sib txawv ntawm cov kab mob.
Qhov ntev ib nrab- lub neej ntawm afoxolaner tua cov yoov thiab zuam uas tau txais tshiab txhua lub hlis, muab kev pabcuam ectoparasite tsis tu ncua. Milbemycin oxime muaj luv luv tab sis txaus ib nrab- lub neej uas tau tshem tawm cov kab mob endoparasite uas twb muaj lawm thiab tiv thaiv kab mob plawv los ntawm kev tso qe. Lub sijhawm sib koom ua ke no txo qis tag nrho cov kev tswj hwm uas yuav tsum tau ua, uas txhim kho kev kho mob thiab kev tiv thaiv tag nrho.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets Mechanism rau Sab Nraud thiab Internal Parasite Control
Qhov txiaj ntsig tiag tiag ntawm Afoxolaner thiab Milbemycin Oxime Chewable Tablets yog los ntawm lawv cov kev tawm tsam sai rau cov kab mob sab nraud thiab lawv lub peev xwm los tiv thaiv thiab kho cov kab mob sab hauv. Los ntawm kev sim tshuaj, cov sijhawm tshwj xeeb thiab cov nqi ntawm kev ua tau zoo rau cov kab mob sib txawv tau raug teeb tsa.
Kev tshem tawm sai Ectoparasite
Field studies suggest that afoxolaner kills fleas 30 minutes after application and is over 98% effective after 8 hours. Immediately stopping the flea's reproductive cycle before it lays eggs cleans the environment. Afoxolaner kills ticks like Ixodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus, and Amblyomma americanum (>95%). Kev tshem cov zuam sai npaum li cas yog qhov tseem ceeb rau kev tswj kab mob vim tias ntau tus zuam - kis tau tus kab mob yuav tsum tau 24 mus rau 48 teev ntawm adhesion.
Afoxolaner tua cov zuam hauv 6-12 teev, txo cov kab mob sib kis.Afoxolaner's pharmacokinetics tiv thaiv cov kab mob ectoparasites ntev thiab tswj cov qib ntshav plasma thoob plaws lub hli. Cov dev ib txwm coj cov kab mob tshiab los ntawm lawv ib puag ncig, tab sis cov tshuaj ua kom lawv puas tsuaj ua ntej lawv tuaj yeem noj lossis rov tsim dua. Cov kev kho mob ua haujlwm hauv lub cev cov ntaub so ntswg, tsis zoo li cov tshuaj pleev ib ce uas ntxuav tawm lossis ua kom puas.
Endoparasite Kev Tiv Thaiv thiab Kev Kho Mob
Tsis tas li ntawd, milbemycin oxime tuaj yeem siv los kho cov kab mob hauv plab hnyuv nematode thiab ua kom tsiaj tsis txhob kis kab mob plawv. Thaum muab ib hlis ib zaug, milbemycin oxime tua cov ntaub so ntswg -theem heartworm worms (Dirofilaria immitis) uas nkag mus rau hauv cov hlab ntsha thaum tus tsiaj raug yoov tshaj cum lub hli ua ntej. Qhov kev tshem tawm rov qab no txwv tsis pub cov kab mob hauv lub plawv los ntawm kev loj hlob mus rau cov neeg laus cov kab mob plawv uas yuav txwv tsis pub nkag mus rau hauv cov hlab ntsws ntsws thiab ua rau lub plawv mob.
Milbemycin oxime muaj qhov dav -spectrum kev ua haujlwm tawm tsam cov kab mob hauv plab. Cov kev tshawb fawb ntawm nws cov txiaj ntsig tau pom tias nws tua ntau dua 90% ntawm ascarid (Toxocara canis, Toxascaris leonina) qe, 95% ntawm cov kab nuv ntses (Ancylostoma caninum, Ancylostoma braziliense), thiab feem pua ntawm cov kab mob zoo sib xws (Trichuris vulpis). Txoj hnyuv nematode ua haujlwm tau tshem tawm cov kab mob laus uas twb muaj lawm hauv plab hnyuv, thaum kev tiv thaiv kab mob plawv tsuas ua haujlwm ntawm qee theem ntawm cov theem larval.
Qhov ob lub luag haujlwm no ua ob qho kev tiv thaiv thiab kev kho mob ua rau cov kab mob parasite tswj tau yooj yim dua los ntawm kev saib xyuas ob qho xwm txheej tam sim no thiab kev pheej hmoo kis mus ntxiv.
Hla -Spectrum Protection Advantages
Txoj kev sib xyaw ua ke coj mus rau hauv tus account qhov tseeb tseem ceeb hauv kev kho mob: dev feem ntau raug rau ntau tshaj ib hom kab mob parasite tib lub sijhawm. Kev tshawb fawb Vector ib txwm qhia tias qee tus dev muaj dev mub, zuam, thiab kab mob kab mob tib lub sijhawm.
Tib - cov tshuaj tso cai rau dev qhib rau cov kab mob cab uas tsis tau kho, yog li lawv yuav tsum tau noj ntau dua ib qho tshuaj thiab ua raws li cov phiaj xwm nyuaj rau muab rau lawv.Lub Afoxolaner thiab Milbemycin Oxime Chewable Tablets ua rau kev tiv thaiv yooj yim dua los ntawm kev sib xyaw cov kab mob sab nraud thiab sab hauv rau hauv ib lub hlis ib zaug. Txoj kev sib koom ua ke no ua rau nws yooj yim dua rau cov neeg siv khoom ua raws, ua rau muab cov tshuaj tsis muaj kev ntxhov siab rau ob tus tsiaj thiab lawv cov tswv, thiab ua kom paub tseeb tias tsis muaj qhov sib txawv.
Yuav Ua Li Cas Kev Sib Txuas Cov Qauv Txhim Kho Kev Tiv Thaiv Kab Mob Hauv Cov dev?
Kev sib xyaw ntawm cov tshuaj muaj txiaj ntsig uas dhau mus dhau qhov yooj yim ntxiv cov teebmeem thaum cov khoom muaj cov khoom ua haujlwm zoo ua ke. Txoj kev uas Afoxolaner thiab Milbemycin Oxime Chewable Tablets tau ua kom zoo rau ntau yam, xws li lawv saj zoo npaum li cas, lawv muaj bioavailable npaum li cas, lawv muaj kev nyab xeeb npaum li cas, thiab lawv siv yooj yim npaum li cas.
Palatability Engineering rau Txhim Kho Kev Ua Raws Cai
Kev ua raws li cov tshuaj noj yog qhov tseem ceeb hauv kev ua tiav ntawm kev tiv thaiv kev noj qab haus huv. Cov dev feem ntau tsis xav noj cov tshuaj hauv qhov ncauj vim tias lawv saj los yog hnov mob, uas tuaj yeem ua rau kev noj tshuaj tsis tiav lossis kev kho mob so. Muaj cov khoom noj qab haus huv hauv cov ntsiav tshuaj chewable mis uas ua rau nws nyiam noj ntau dua. Raws li kev tshawb fawb txog kev lees paub, ntau dua 90% ntawm cov dev zoo siab noj cov ntsiav tshuaj txawm hais tias lawv muab rau lawv los ntawm tes los yog tov nrog zaub mov.
Vim tias qhov kev lees txais siab no, tsis tas yuav muaj cov txheej txheem uas nyuaj rau cov tsiaj txhu thiab lawv cov tswv, xws li yuam lawv noj tshuaj.
Cov qauv chewable kuj ua rau nws yooj yim dua rau cov tshuaj tso tawm thiab absorbed tsis tu ncua. Nyob rau hauv sib piv rau cov tshuaj, uas yuav txav tau sai heev los ntawm lub digestive system, daim ntawv chewable so nyob rau hauv lub plab, cia cov active khoom xyaw maj mam nkag mus rau hauv lub cev. Txoj kev uas cov tshuaj no yaj ua rau lawv nqus tau zoo tshaj plaws, uas yog qhov zoo rau ob qho tib si afoxolaner thiab milbemycin oxime.
Qhov no yuav pab ua kom cov tshuaj pharmacokinetic pom hauv kev tshawb fawb bioavailability ntau dua.
Kev Nyab Xeeb Profile Los ntawm Kev Xaiv Lub Hom Phiaj
Thaum siv ntawm cov koob tshuaj pom zoo, cov tshuaj kho mob ntawm afoxolaner thiab milbemycin oxime muab cov npoo loj. Kev tshawb fawb txog kev nyab xeeb nrog koob tshuaj txog tsib npaug ntawm qib pom zoo tau muab rau lub sijhawm ntawm lub hlis qhia tias cov dev noj qab haus huv tsis muaj kev phiv loj heev.
Cov tsos mob me me, xws li ntuav ntuav lossis zawv plab hauv qee tus tsiaj kho, yog cov tshuaj tiv thaiv ntau tshaj plaws.Cov no feem ntau ploj mus ntawm lawv tus kheej.Qhov kev nyab xeeb zoo no yog vim qhov kev xaiv molecular uas peb tau tham txog ua ntej, uas txhais tau hais tias cov tshuaj khi ntau dua rau cov hom phiaj hauv lub paj hlwb ntawm invertebrates.
Cov lus qhia txog kev nyab xeeb kuj tseem txhim kho los ntawm kev coj mus rau hauv tus tsiaj ntawm tus tsiaj.Qee hom herding dev muaj kev hloov pauv hauv cov tshuaj tiv thaiv kab mob ntau yam (MDR1) uas ua rau lawv nkag siab ntau dua rau macrocyclic lactones.Txawm tias milbemycin oxime muaj kev nyab xeeb dua rau MDR1-mutant dev dua li lwm cov macrocyclic lactones zoo li lawv cov tsiaj txhu yuav tsum tau tham.
Simplified Administration thiab Compliance Benefits
Cov phiaj xwm kev tswj hwm txhua hli yog ib qho yooj yim rau kev ua hauj lwm rau kev tiv thaiv kev noj qab haus huv vim tias lawv ua raws li kev mus ntsib kws kho mob thiab kev saib xyuas tus tsiaj.Siv cov tshuaj sib txawv rau kev tiv thaiv kab mob plawv, kev tswj flea, tswj zuam, thiab kev kho kab mob hauv plab, tib txoj kev siv tshuaj - hloov. Qhov no ua rau nws yooj yim dua rau nco ntsoov thaum noj koj cov tshuaj, ua rau nws tsis tshua muaj qhov uas koj yuav tsis tau koob tshuaj, thiab txo qis tag nrho cov nqi ntawm koj cov tshuaj piv rau kev yuav ob peb lub hom phiaj cov khoom lag luam.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets Targeting Pathways tawm tsam ntau hom kab mob
Txoj hauv kev uas afoxolaner thiab milbemycin oxime ua haujlwm ntawm qib molecular los ua kom cov kab mob kis tau yooj yim qhia tau tias lub paj hlwb ntawm arthropods, worms, thiab tib neeg tau hloov pauv txawv li cas.
Neurotransmitter Receptor Sib txawv
Invertebrate paj hlwb tswj kev ua haujlwm ntawm lub cev muaj zog thiab kev hnov lus ua haujlwm siv inhibitory neurotransmission, feem ntau GABA thiab glutamate. Arthropods yog lub hom phiaj tshuaj tua kab vim tias lawv lub paj hlwb peripheral muaj ntau GABA receptors. Crustacean GABA receptors muaj cov subunits sib txawv thiab cov hnab ris ntau dua li tib neeg. Cov qauv kev hloov pauv no tso cai rau afoxolaner kom muaj txiaj ntsig zoo rau arthropod receptor zoo thaum khi.
Invertebrates muaj glutamate{0}}gated chloride channels, uas cov tsiaj tsis muaj. Glutamate excites tsiaj los ntawm ntau receptors. Nematodes thiab arthropods cuam tshuam neurotransmission siv glutamate-gated chloride channels. Milbemycin oxime activates invertebrate - cov channel tshwj xeeb, ua rau lawv tuag tes tuag taw nrog ntau cov cim thaiv. Qhov kev txhawj xeeb loj tshaj plaws txog kev toxicity ploj mus vim tsiaj tsis muaj cov kab no. Txawm li cas los xij, cov koob tshuaj supratherapeutic yuav tsum tau saib xyuas rau qhov tsis yog - cov teebmeem.
Kev nkag mus thiab kev faib tawm Barriers
Cov ntshav- lub hlwb thaiv yog ib qho tseem ceeb ntawm cov ntaub thaiv npog uas ua kom cov co toxins nkag mus rau hauv lub hauv paus paj hlwb ntawm cov tsiaj. Loj, lipophilic molecules tsis tuaj yeem dhau los ntawm qhov kev xaiv permeability bar yog tias lawv cuam tshuam nrog qee cov proteins thauj. Milbemycin oxime yog lipophilic, tab sis nws ua haujlwm raws li lub substrate rau P-glycoprotein efflux twj uas pom nyob rau hauv cov hlwb uas kab cov ntshav - hlwb barrier. Cov twj no txav milbemycin molecules rov qab mus rau hauv cov hlab ntsha, uas txwv tsis pub lawv los ntawm kev tsim nyob rau hauv lub hauv paus paj hlwb.
Parasites tsis muaj tib hom kev ruaj ntseg phab ntsa, yog li cov tshuaj tuaj yeem nkag mus rau hauv lawv lub paj hlwb.
Afoxolaner tau muab faib ua ib txoj hauv kev zoo sib xws, nrog cov qib siab pom hauv cov ntshav thiab cov khoom nruab nrog cev sab nraud ntawm lub cev, qhov twg ectoparasites noj. Hniav thiab zuam noj ntshav thiab noj hauv afoxolaner, uas tsim nyob rau hauv lawv lub paj hlwb thiab tua lawv. Cov kab mob kis tau txawv ntawm cov tshuaj pleev ectoparaiticides, uas nyob ntawm daim tawv nqaij thiab plaub hau thiab tiv thaiv sab hauv, txawm tias thaum tus dev ua luam dej lossis da dej.
Lub neej Cycle Interruption Strategies
Cov theem kev loj hlob ntawm cov kab mob rhiab heev yuav tsum tau tsom rau kev tswj hwm. Milbemycin oxime tsom cov ntaub so ntswg- theem larvae (L3 thiab L4) uas tsiv mus thoob plaws hauv cov nqaij mos thiab cov nqaij mos tom qab yoov tshaj cum tshem tawm cov kab mob plawv. Cov kab mob plawv loj tuaj yeem tiv taus macrocyclic lactones, thaum cov menyuam yaus muaj kev nkag siab ntau dua. Kev kho txhua hli yuav rhuav tshem cov larvae ua ntej lawv mus txog rau lub ntsws pulmonary, qhov twg cov neeg laus lub plawv nyob thiab ua rau muaj mob.Mibemycin oxime tuaj yeem tua cov kab mob plab hnyuv thiab cov laus, nyob ntawm hom thiab theem.
Roundworms thiab hookworms muaj kev cuam tshuam thoob plaws hauv lawv lub neej, whereas whipworms yuav xav tau ntau yam kev kho mob. Txoj kev npaj koob tshuaj txhua hli ua rau muaj kev cuam tshuam loj heev rau canines ntau txoj hauv kev los tua kab mob.
Afoxolaner tua cov neeg laus ua ntej lawv nteg qe, tiv thaiv ectoparasite reproduction. Tom qab noj cov ntshav, cov poj niam fleas nteg qe 24-48 teev tom qab, tab sis afoxolaner tua lawv hauv 8 teev. Qhov kev txiav txim ceev no tua cov qe qe thiab larvae, txo cov tsiaj txhu thiab ib puag ncig kab mob.
Nkag siab txog Dual -Kev Ua Haujlwm ntawm Afoxolaner thiab Milbemycin Oxime Chewable Tablets
Yuav kom tswj tau cov kab mob tag nrho, koj yuav tsum paub tsis tsuas yog yuav ua li cas txhua yam tshuaj ua haujlwm, tab sis kuj yuav ua li cas sib txawv ua ke nrog cov txheej txheem ntawm -lub neej veterinary.
Cov ntaub ntawv pov thawj-Raws li kev siv tau zoo
Cov tshuaj noj tsiaj yuav tsum tau mus rau ntau qhov kev sim teb kom paub meej tias lawv muaj kev nyab xeeb thiab ua tau zoo ua ntej cov tub ceev xwm pom zoo rau lawv. Afoxolaner thiab Milbemycin Oxime Chewable Tablets tau sau npe tom qab ntau qhov kev sim hauv ntau qhov kev nyab xeeb thiab qhov chaw. Cov kev tshawb fawb no siv ntau hom tsiaj, qhov ntau thiab tsawg, thiab kev noj qab haus huv ntawm cov dev. Lawv raug kho raws li qhia ntawm daim ntawv lo thiab muaj cov kab mob cab uas tau sim siv cov kev kuaj mob ib txwm muaj.
Nws feem ntau kis tus kab mob thiab tshuaj xyuas cov dev mub ntawm lub sijhawm teem tseg los ntsuas lawv cov kev ua tau zoo.Qhov kev kho thawj zaug txo cov dev mub suav yuav luag 95% hauv 24 teev, thiab qhov kev poob qis txuas ntxiv txhua hli. Kev ntsuas kev ua tau zoo ntawm zuam qhia tau hais tias ntau hom zuam raug tshem tawm sai siv cov tswv yim zoo sib xws. Qhov kev sim tiv thaiv kab mob plawv txuas ntxiv tau nthuav tawm cov dev kho rau yoov tshaj cum kab mob thiab tom qab ntawd kuaj lawv lub cev ntau lub hlis tom qab rau cov kab mob plawv. Kev tiv thaiv tau ua tiav vim cov pab pawg kho mob tsis muaj lossis ob peb kab mob plawv.
Kev koom ua ke rau hauv Kev Tiv Thaiv Kev Noj Qab Haus Huv
Hauv cov kws kho tsiaj niaj hnub no, kev saib xyuas kev tiv thaiv tau hais txog kom cov tsiaj noj qab haus huv thiab zam kom tsis txhob muaj tus nqi siab ntawm kev kho cov kab mob parasitic uas twb muaj lawm. Xyoo-kev zam dhau ntawm cov kab mob parasite tam sim no yog cov qauv hauv feem ntau ntawm lub ntiaj teb. Qhov no yog vim kev hloov pauv huab cua thiab ntau yam tsiaj mus ncig ua rau cov kab mob kis mus rau thaj chaw tshiab. Afoxolaner thiab Milbemycin Oxime Chewable Tablets ua haujlwm zoo nrog cov phiaj xwm no vim tias lawv tau noj txhua lub hlis, txawm tias lub sijhawm twg los xij ntawm lub xyoo.
Qhov dav -spectrum kev pab them nqi muab kev ntseeg siab rau cov kws kho tsiaj, vim lawv paub tias cov neeg siv tshuaj ib leeg tiv thaiv ntau yam kab mob. Qhov no tag nrho - ib puag ncig cov txheej txheem yog qhov tshwj xeeb tshaj yog nyob rau hauv cov chaw uas muaj kab mob hauv lub plawv thiab cov kev tiv thaiv tsis ua haujlwm, ua rau kim thiab txaus ntshai kev kho mob rau cov neeg laus. Ib yam li ntawd, kev tua cov zuam sai sai txo qhov kev pheej hmoo ntawm cov kab mob sib kis, uas pab kom tsis txhob muaj kab mob xws li Lyme kab mob, ehrlichiosis, thiab anaplasmosis.
Qhov Zoo ntawm Kev Tsim Khoom thiab Kev Pabcuam Chain Considerations
Pharmaceutical zoo kev ruaj ntseg ua kom paub tseeb tias tag nrho cov khoom tsim muaj tib theem ntawm lub zog, kev nyab xeeb, thiab kev ua haujlwm. BLOOM TECH khaws cov chaw tsim khoom uas yog GMP- tau ntawv pov thawj thiab ua tau raws li cov qauv txawv teb chaws tsim los ntawm US FDA, EU, thiab PMDA. Cov ntawv pov thawj no qhia tau tias kev tswj xyuas nruj nruj tau ua raws. Cov no suav nrog kev sim cov khoom siv raw, ua kom lub ntsej muag ntawm cov txheej txheem tsim khoom, tshuaj xyuas cov khoom tiav, thiab kawm lawv cov kev ruaj ntseg.
Kev tswj xyuas kom zoo yog xav tau nyob rau hauv cov khoom siv rau cov khoom siv tshuaj nquag thiab cov qauv ua tiav kom lawv tsis txhob tawg thaum khaws lossis xa khoom. Kev nyab xeeb-tswj cia khaws cov khoom kom nyab xeeb los ntawm kev ua kom lawv tsis txhob raug kub thiab av noo uas tuaj yeem ua rau lawv ruaj khov. Cov ntaub ntawv kaw lus khaws cia ntawm txhua pawg los ntawm lub sijhawm nws tau ua kom txog thaum nws xa tawm mus rau cov neeg siv khoom. Qhov no cia txhua qhov teeb meem zoo tau kho sai thiab ua kom cov kev cai ua raws.
Xaus
Qhov kev tsim tawm dual - kev ua haujlwm uas ua ke nrog afoxolaner thiab milbemycin oxime yog ib kauj ruam loj rau kev tswj cov kab mob hauv cov tsiaj. Qhov kev sib xyaw ua ke no tiv thaiv ntau yam kab mob los ntawm kev ua haujlwm ua ke hauv kev sib ntxiv. Afoxolaner ua haujlwm tawm tsam ectoparasites los ntawm thaiv GABA receptors, thiab milbemycin oxime ua haujlwm tawm tsam endoparasites los ntawm kev ua kom glutamate -gated chloride channels. Cov ntsiav tshuaj yog ib qho yooj yim noj ib hlis ib zaug. Lub laj thawj kev tshawb fawb tom qab txoj kev no yog los ntawm kev paub tob ntawm cov kab mob hauv lub paj hlwb ntawm cov kab mob parasites, pharmacology ntawm cov tsiaj nyeg, thiab cov kev xav tau ntawm cov kws kho tsiaj. Kev nyab xeeb thiab kev ua tau zoo ntawm Afoxolaner thiab Milbemycin Oxime Chewable Tablets tau raug pov thawj los ntawm kev tswj xyuas kev ua tau zoo thiab kev siv dav hauv kev kho mob. Qhov no txhawb nqa lawv lub luag haujlwm ua ib feem tseem ceeb ntawm kev tiv thaiv kab mob niaj hnub no.
FAQ
1. Dab tsi ua rau ob qho - cov khoom tsim muaj txiaj ntsig zoo dua li ib qho - cov khoom lag luam?
Qhov sib tov tau tshem tawm ntawm ob qho tib si kab mob sab nraud, xws li yoov thiab zuam, thiab cov kab mob sab hauv, xws li kab mob plawv thiab plab hnyuv nematodes. Ib leeg- cov khoom lag luam feem ntau tsuas yog ua haujlwm ntawm ib hom kab mob cab, uas txhais tau tias ntau dua ib qho tshuaj yuav tsum tau noj nyob rau lub sijhawm sib txawv. Afoxolaner thiab Milbemycin Oxime Chewable Tablets ua haujlwm nyob rau hauv ob txoj hauv kev uas sib ntxiv thiab ua haujlwm tib lub sijhawm. Qhov no ua rau cov ntsiav tshuaj siv tau yooj yim dua thiab ua kom paub tseeb tias tsis muaj qhov sib txawv hauv kev tiv thaiv ntawm kev siv tshuaj.
2. Kev kho mob sai npaum li cas pib tshem tawm cov kab mob tom qab kev tswj hwm?
Afoxolaner pib tua fleas hauv 30 feeb thiab tshem tawm ntau dua 98% ntawm lawv hauv 8 teev. Ticks tau ploj mus hauv 6 mus rau 12 teev, raws li hom. Milbemycin oxime pib ua haujlwm tam sim ntawd ntawm cov ntaub so ntswg-theem heartworm larvae thiab plab hnyuv cab. Txawm li cas los xij, nws yuav siv sij hawm li ob peb hnub rau qee lub plab hnyuv nematodes kom tshem tawm tag nrho vim tias cov kab mob laus tau raug tshem tawm thiab dhau los ntawm kev zom zaub mov.
3. Puas muaj cov dev tshwj xeeb uas xav tau kev saib xyuas tshwj xeeb ua ntej siv cov tshuaj no?
Collies, Australian Shepherds, thiab lwm yam tsiaj yug tsiaj uas muaj MDR1 cov noob hloov pauv ntau dua rau macrocyclic lactones. Milbemycin oxime muaj kev nyab xeeb dua rau cov tsiaj no dua li lwm cov macrocyclic lactones, tab sis tus kws kho tsiaj tuaj yeem pab koj txheeb xyuas seb koj tus tsiaj muaj kev pheej hmoo dab tsi. Tsis tas li ntawd, cov menyuam dev hnub nyoog qis dua 8 lub lis piam los yog dev sib dua 2 kg yuav tsum tsis txhob noj cov tshuaj no kom txog thaum lawv muaj hnub nyoog thiab qhov hnyav.
Koom tes nrog BLOOM TECH raws li koj qhov kev ntseeg siab Afoxolaner thiab Milbemycin Oxime Chewable Tablets Supplier
BLOOM TECH yog ib lub chaw tsim khoom tsim nyog uas tau ua cov tshuaj organic thiab tshuaj intermediates rau ntau tshaj 12 xyoo. Peb 100,000-square-meter GMP-certified chaw tau raug tshuaj xyuas thiab dhau los ntawm US FDA, EU cov neeg ua haujlwm, PMDA, thiab MFDS, ua kom lawv ua tau raws li cov qauv zoo txawv teb chaws. Peb yog ib lub tuam txhab muaj kev ntseeg siab uas muag Afoxolaner thiab Milbemycin Oxime Chewable Tablets. Peb muab ob qho API ntshiab hmoov thiab cov ntsiav tshuaj tiav hauv ntau qhov ntau thiab tsawg kom haum rau dev ntawm 2 kg txog 60 kg. Peb qhov kev tswj xyuas nruj nruj suav nrog peb theem kev kuaj xyuas: kuaj hauv cov nroj tsuag, tshuaj xyuas los ntawm QA / QC chav haujlwm tshwj xeeb, thiab kev tshuaj xyuas los ntawm cov cai sab nraud. Peb qhov kev kuaj xyuas no ua kom muaj kev ncaj ncees ntawm cov khoom ntawm txhua theem.
Peb ua haujlwm nrog cov tuam txhab kws tshuaj, pab pawg tshawb fawb biotech, cov tuam txhab cog lus cog lus, cov chaw muag tshuaj, thiab cov chaw muag khoom hauv Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada, thiab lwm qhov chaw. Peb cov qauv tsim nqi meej, cov lus cog tseg rau lub sijhawm ua haujlwm raug, thiab kev txhawb nqa cov ntaub ntawv tag nrho yuav ua rau koj cov saw hlau ua haujlwm zoo dua thaum tseem ua tau raws li tsoomfwv cov qauv. Txawm hais tias koj xav tau kev tshawb fawb- cov ntaub ntawv qib nrog cov ntaub ntawv qhia ntxaws ntxaws, GMP ntau- cov khoom siv ua raws nrog DMF kev txhawb nqa, lossis OEM / ODM cov qauv tsim los rau koj, peb pab neeg tshaj lij tuaj yeem ua tau raws li koj xav tau hauv ib qho chaw.
Hu rau peb cov neeg ua haujlwm paub txog ntawmSales@bloomtechz.comtam sim ntawd los tham txog koj cov kev xav tau rau Afoxolaner thiab Milbemycin Oxime Chewable Tablets thiab nrhiav seb BLOOM TECH tuaj yeem pab koj txoj kev lag luam loj hlob los ntawm kev muab cov khoom zoo, tus nqi qis, thiab kev pabcuam zoo.
Cov ntaub ntawv
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