Los ntawm Kev Sib cuag rau Kev Tswj: Yuav Ua Li Cas Compound Fipronil Drops Act

Thaum koj siv ib qho chaw- ntawm kev kho mob rau koj tus tsiaj, tej zaum koj yuav pom cov txiaj ntsig tsis pub dhau ob teev - dev mub qeeb, ces nres tag nrho. Tab sis dab tsi tshwm sim ntawm lub sijhawm uas cov kua kov ntawm daim tawv nqaij thiab lub sijhawm uas cov dev mub poob tswj nws lub cev? Txoj kev taug ntawmcompound fipronil pooblos ntawm daim ntawv thov chaw mus rau flea paj hlwb yog ib tug meej, kauj ruam - los ntawm - cov txheej txheem hauv paus hauv cov khoom biochemistry. Kev nkag siab nws pab koj txaus siab vim li cas cov khoom xyaw nquag no tseem yog lub hauv paus ntawm veterinary parasitology rau xyoo lawm.

Compound Fipronil Thiab Praziquantel Spot On Solution

1. General Specification (hauv Tshuag)
(1) Kev daws teeb meem
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-9-022
Compound Fipronil thiab Praziquantel Spot On Solution
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Lub luag haujlwm ntawm Sebaceous Gland Network

Compound fipronil tee tsis yog nyob ntawm daim tawv nqaij tom qab muab tso rau. Fipronil yog cov khoom tseem ceeb uas ua haujlwm. Nws txav mus los ntawm cov qog sebaceous, uas yog tib lub cev uas kis tau cov roj ntuj thoob plaws hauv daim tawv nqaij thiab lub tsho. Raws li kev tshawb fawb tso tawm nyob rau hauv cov ntaub ntawv kws tshuaj kws kho tsiaj, fipronil kis thoob plaws lub cev tag nrho ntawm cov tsiaj nyob hauv 24 teev tom qab siv tshuaj pleev. Nws ua qhov no los ntawm lipid- txoj kev nplua nuj es tsis txhob nqus mus rau hauv cov hlab ntsha.

Qhov no yog qhov sib txawv tseem ceeb heev.

Cov tshuaj nkag mus los ntawm txheej lipid txheej ntawm daim tawv nqaij es tsis txhob ntawm cov hlab ntsha. Qhov no txhais tau hais tias nws tsim raws nraim qhov twg fleas thiab zuam kov ntawm daim tawv nqaij, ntawm qhov chaw thiab hauv cov hauv paus plaub hau.

Kev khaws cia hauv Sebum thiab Cov Plaub Hau

Fipronil txuas mus rau sebum thiab tsim nyob rau hauv cov plaub hau shafts thaum nws nkag mus rau hauv lub sebaceous network. Cov nyhuv cia no yog dab tsi ua rau cov tshuaj fipronil tee ua haujlwm ntev dua, feem ntau yog plaub lub lis piam lossis ntau dua kom tshem tawm cov dev mub. Sebum zoo li qeeb - tso tawm cov ntaub ntawv uas ua rau muab cov khoom muaj txiaj ntsig rov qab rau ntawm lub tsho tiv no txawm tias tom qab ntxuav lossis tawm hauv tshav ntuj.Vim tias fipronil yog lipophilic, uas txhais tau hais tias nws ruaj khov rau cov rog- cov chaw soluble, qhov kev khi no muaj zog heev thiab nyob ruaj khov nyob rau hauv ib txwm muaj.

Translocation hla Lipid Barrier

Lub stratum corneum yog txheej saum toj kawg nkaus ntawm daim tawv nqaij ntawm cov tsiaj. Nws feem ntau yog ua los ntawm lipid bilayers. Vim tias fipronil yog lipophilic heev (log P tus nqi ntawm 4.0), nws tuaj yeem yooj yim tawg mus rau hauv ib puag ncig no thiab txav mus thoob plaws ntawm daim tawv nqaij. Cov kev tshawb fawb uas saib yuav ua li cas cov residues kis tawm tom qab qhov chaw- ntawm kev kho mob qhia tau hais tias nyob rau hauv 24 mus rau 48 teev, cov nyiaj fipronil tuaj yeem pom nyob rau hauv lwm qhov chaw uas tsis yog qhov uas nws tau thov. Qhov kev hloov mus rau sab nraud ua kom paub tseeb tias cov khoom siv npog tag nrho lub cev yam tsis tas yuav nkag mus rau hauv lub cev.

Yog vim li cas Topical Distribution Matters for Efficacy

Ntev npaum licompound fipronil poobnyob rau sab nraud, lawv tuaj yeem nres cov kab mob uas lawv kov tus tswv tsev. Thaum tus dev dhia mus rau ntawm tus tsiaj kho, nws tuaj yeem tiv nrog fipronil ua ntej nws tuaj yeem txuas thiab pub. Nto- cov tshuaj nquag sib txawv ntawm cov txheej txheem sib txawv vim tias lawv muaj qhov kev sib cuag no -tua tshuab. Cov txiaj ntsig tau tshwm sim yog kev tuag sai-fleas raug fipronil feem ntau pom cov tsos mob ntawm neuromuscular cuam tshuam nyob rau hauv feeb ntawm kev sib cuag, thiab tuag ua ntej lawv tuaj yeem noj cov ntshav tiav.

Absorption Los ntawm Flea Cuticle

Fleas tuaj yeem noj fipronil los ntawm lawv cov tawv nqaij, uas yog hu ua cuticle, thaum lawv taug kev ntawm cov plaub uas muaj nws. Lub cuticles ntawm kab muaj waxy lipid txheej uas yog structurally zoo li cov nyob rau hauv mammalian daim tawv nqaij. Fipronil tuaj yeem nkag mus sai vim tias nws yog lipophilic. Thaum fipronil nkag mus rau hauv lub cev hma, nws nkag mus rau hauv hemolymph (cov kua uas txav los ntawm kab) thiab tom qab ntawd mus rau cov ntaub so ntswg hlwb. Cov txheej txheem ntawm kev nqus dej no ua haujlwm zoo txaus kom xa cov nyiaj tuag mus rau lub paj hlwb tom qab tsuas yog luv luv ntawm qhov chaw.

Selective Affinity rau Kab Neural Tissue

Ib yam uas ua rau fipronil tshwj xeeb yog tias nws xaiv. Nws yooj yim dua rau fipronil los khi rau GABA-gated chloride channels hauv kab ntau dua li nws yog khi rau tib receptors hauv cov tsiaj. Qhov kev xaiv no los ntawm qhov tseeb tias cov qauv pleev xim ntawm cov receptor subunits hauv arthropods thiab vertebrates txawv. Nyob rau hauv lub neej tiag tiag, qhov no txhais tau hais tias compound fipronil tee zoo nkauj heev tsuas yog ua mob rau cov cab uas lawv txhais tau tias yuav tua, tawm hauv tus tswv tsiaj kom nyab xeeb ntev npaum li lawv tau siv raws li qhia.

Lub Mechanism ntawm Chloride Channel Inhibition

Gamma-aminobutyric acid (GABA) yog cov tshuaj tseem ceeb uas ua rau lub paj hlwb qeeb qeeb hauv ob qho tib si vertebrates thiab kab. Hauv kab, GABA txuas mus rau ligand-gated chloride channels ntawm neuron daim nyias nyias. Qhov no cia chloride ions ntws mus rau hauv thiab nres cov neurons los ntawm kev tua. Fipronil thaiv qhov ntws ntawm ions los ntawm kev tuav cov chloride channel qhov ntawm picrotoxin khi qhov chaw. Txij li thaum cov tshuaj chloride ntws raug tso tseg, lub teeb liab inhibiting tsis tuaj yeem dhau los, thiab lub hlwb kev ua haujlwm tsis raug tswj xyuas lawm.

Qhov tshwm sim ntawm Uncontrolled Neural Excitation

Lub cev muaj zog neurons hluav taws tsis raug nres ib zaug GABA-kev tswj hwm kev sib haum xeeb ploj lawm.

Qhov no lub xeev ntawm kev zoo siab heev sai sai kis tau los ntawm cov flea lub paj hlwb. Kev soj ntsuam ntawm tus cwj pwm yog txuas ncaj qha rau qhov no neurochemistry: fleas uas tau nthuav tawm qhia kev ua siab loj, tsis xis nyob, thiab cov leeg tshee ua ntej lawv tuag tes tuag taw. Vim hais tias fipronil binding yog irreversible ntawm qhov tuag ntau npaum li cas, cov dev mub yuav tsis tau zoo dua ib zaug txaus ntawm cov tshuaj nkag mus rau nws lub hlwb.Compound fipronil poobsiv cov txheej txheem no los ua haujlwm ib yam nkaus txhua lub sijhawm ntawm fleas ntawm txhua theem ntawm kev loj hlob uas tuaj rau hauv kev sib cuag ncaj qha nrog tus tswv tsev kho mob.

Los ntawm Neurochemical Blockade mus rau lub cev sib tsoo

Muaj qhov kev txiav txim siab neurophysiological meej txog yuav ua li cas cov khoom mus los ntawm GABA channel thaiv mus rau tag nrho lub cev tsis ua haujlwm. Thaum lub cev muaj zog neurons nyob depolarized ntev, cov leeg cog lus tsis tu ncua thiab tsis muaj kev sib koom tes. Lub flea txoj kev txav mus los, uas yog txhais tau tias pab nws dhia thiab rub nrog qhov tseeb, tsis ua haujlwm txhua. Cov kab mob parasites pib cog lus randomly, nws lub cev txoj hauj lwm ntog, thiab nws poob lub peev xwm txav los yog lo rau nws tus tswv lub pluab. Qhov kev puas tsuaj ntawm lub cev no tuaj yeem pom tsuas yog feeb tom qab kev sib cuag thiab yog kauj ruam kawg hauv cov tshuaj tiv thaiv kab mob neurochemical uas sib xyaw fipronil poob pib.

Systemic Shutdown thiab Mortality

Raws li lub cev muaj zog tsis ua hauj lwm zuj zus lawm, cov dev mub cov kab mob metabolic kuj raug mob los ntawm lub hlwb hyperactivation uas kav ntev. Thaum cov leeg mob tas li, lawv cov khw muag khoom hluav taws xob khiav tawm sai heev. Nrog rau kev poob ntawm locomotion, kev ua pa ua pa kuj txo qis, uas yog ib feem tswj los ntawm lub paj hlwb. Thaum lub zog poob qis, ua pa tsis ua haujlwm, thiab cov nqaij ntshiv txuas ntxiv mus ntev; kev tuag tshwm sim. Tag nrho cov txheej txheem, los ntawm cov cuticle raug absorbed mus rau kev tuag, tuaj yeem tshwm sim hauv 30 feeb yog tias cov txheej txheem kho tau ncaj qha thiab hnyav heev los ntawm cov khoom seem ntawm fipronil.

Compound fipronil poobua hauj lwm nyob rau hauv ib tug zoo-txhais txoj kev lom, uas muaj xws li mus tom qab los ntawm sebaceous channels, raug absorbed los ntawm cov dev mub cuticle, thiab xaiv khi ntawm kab GABA-gated chloride channels. Qhov no tso tawm cov tshuaj tiv thaiv kab mob uas tsis muaj kev tswj hwm neural excitation uas ua rau lub cev tsis ua haujlwm thiab kev tuag. Nyob rau hauv txhua kauj ruam ntawm cov txheej txheem no, cov compound ua tib zoo kawm txog kev lom neeg thiab lub cev zoo. Kev nkag siab txog cov txheej txheem no pab cov neeg xa khoom thiab cov kws tsim khoom hauv cov kws kho tsiaj lossis cov kws kho tsiaj ua liaj ua teb xaiv kev xaiv zoo dua txog qhov twg yuav tau txais cov khoom xyaw, yuav ua li cas tshuaj, thiab ua pov thawj tias lawv ua haujlwm li cas.

Yog tias koj tab tom nrhiav rau qhov chaw ntseeg tau ntawmcompound fipronil poob, Bloomtechz muaj kev tsim khoom thiab kev tsim kho vaj tsev zoo ua rau cov neeg siv tshuaj thiab cov tshuaj tshwj xeeb uas xav tau qhov tseeb ntawm qhov loj. Bloomtechz tau ua lag luam txij li xyoo 2008 thiab muaj GMP- ntawv pov thawj qhov chaw tsim khoom uas yog 100,000 square meters thiab muaj ntawv pov thawj los ntawm US FDA, EU, Nyiv, thiab CFDA. Peb cov txheej txheem kev lees paub zoo muaj peb yam kev kuaj xyuas: Hoobkas- theem, hauv-QC tsev, thiab tshuaj xyuas los ntawm tus thib peb- txoj cai. Txoj kev no, peb tuaj yeem paub tseeb tias txhua batch koj tau txais raws li cov nqe lus ntawm koj daim ntawv cog lus, lossis koj tau txais koj cov nyiaj rov qab tag nrho. Bloomtechz tau ua cov organic synthesis rau ntau tshaj 12 xyoo thiab muaj 24 lub tuam txhab lees paub thoob ntiaj teb raws li cov neeg siv khoom hauv cov chaw muag tshuaj, cov ntaub ntawv tshiab, thiab cov khoom siv tshuaj tshwj xeeb. Lawv muab cov nqi meej meej, lub sij hawm ua cov khoom raug, thiab cov ntaub ntawv tshawb xyuas tau los pab koj nrog koj cov kev yuav khoom, los ntawm kev sim - ntsuas R & D mus rau kev tsim khoom ntau.

Hu rau pab pawg Bloomtechz ntawmSales@bloomtechz.comlos tham txog koj cov kev xav tau sib txuas, tau txais ib qho kev tsocai, lossis nrhiav paub ntau ntxiv txog peb cov ntaub ntawv GMP.

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