Thaum cov tswv tsiaj xav txog kev tiv thaiv lawv cov dev thiab miv los ntawm cov kab mob cab, cov kab mob plawv feem ntau tuaj rau hauv siab ua ntej. Tab sis qhov kev hem thawj mus tob dua qhov ntawd. Cov plab hnyuv nematodes, daim tawv nqaij -cov kab mob burrowing, thiab cov ntaub so ntswg-cov larvae hauv tsev tuaj yeem cuam tshuam tus tsiaj txoj kev noj qab haus huv nyob ntsiag to thaum lub sijhawm.Milbemycin Oxime hmoov hais txog qhov kev hem thawj tag nrho no - thiab nkag siab tias nws ua haujlwm li cas tuaj yeem pab cov kws kho tsiaj, cov kws tsim qauv, thiab cov tuam txhab noj qab haus huv tsiaj ua kev txiav txim siab zoo dua.
Kab lus no rhuav tshem cov kev tshawb fawb tom qab milbemycin oxime, nws ncav cuag thoob plaws nematode lub neej theem, thiab yog vim li cas nws tseem ua hauj lwm raws li lub hauv paus pob zeb muaj nyob rau hauv niaj hnub veterinary antiparasitic khoom.
Milbemycin Oxime hmoov
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-1-112
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Milbemycin Oxime Powder cuam tshuam li cas Nematode Life Stages?
Larvicidal Activity: Tuav cov kab mob ua ntej lawv tsim
Thaum siv los ua tshuaj, milbemycin oxime hmoov yog qhov tseem ceeb heev vim tias nws tuaj yeem tua cov qe qe ua ntej lawv loj hlob mus rau cov neeg laus. Tom qab tus dev noj txhua hli, cov tshuaj nquag txav los ntawm nws lub cev thiab mus txog cov ntaub so ntswg -cov larvae nyob rau theem siab txaus ua rau nws nyuaj rau lawv txav thiab ciaj sia. Heartworm larvae feem ntau yuav mob thaum lawv nyob rau theem L3 thiab L4 ntawm kev loj hlob. Qhov no yog vim li cas thiaj muab koob tshuaj ib hlis ib zaug ua rau lub qhov rais zoo rau kev tiv thaiv.
Cov kws tshawb fawb hauv thaj chaw kws kho tsiaj tau hais tias milbemycin oxime tuaj yeem tua ntau dua 99% ntawm cov kab mob plawv yog tias nws muab rau hauv 30 hnub ntawm kev sib cuag.
Adulticidal thiab Persistent Effects ntawm plab hnyuv kab mob
Lub qhov rais larvicidal no yog siv los ntawm cov kws kho tsiaj thoob plaws ntiaj teb los txiav txim siab npaum li cas los muab txhua lub hlis.
Toxocara canis, Ancylostoma caninum, thiab Trichuris vulpis yog cov neeg laus kab mob khaub thuas, kab nuv ntses, thiab nplawm uas nyob hauv plab. Cov tshuaj milbemycin oxime zoo heev los tua cov kab mob no. Kev kuaj tsiaj tau pom tias cov tshuaj no ua haujlwm ntau dua 90% ntawm lub sijhawm los kho tus neeg laus Toxocara canis mob hauv dev. Vim li no, nws yog ib qho zoo active ingredient rau compound deworming ntsiav tshuaj.
Milbemycin Oxime Powder thiab Neuromuscular Pathway ntawm Nematodes
Glutamate-Gated Chloride Channels: Lub Hom Phiaj Tseem Ceeb
Milbemycin Oxime hmoovnres GluCl channels, uas yog glutamate -gated chloride ion channels. Muaj qee qhov ntawm lub paj hlwb ntawm nematodes thiab arthropods uas zoo li cov no uas tsis pom nyob rau hauv vertebrates. Tsis muaj txoj hauv kev los kaw cov channel no tom qab milbemycin oxime txuas rau lawv. Qhov no xa ntau cov chloride ions mus rau cov kab mob hauv cov hlab ntsha thiab cov leeg hlwb. Lub cell membrane tau them dhau lawm, uas ua rau tus kab mob tuag tes tuag taw thiab ua rau nws txav tsis tau dua.
Qhov kev xaiv no tsis yog ib qho coincidence xwb. Nws muaj kev nyab xeeb rau cov dev, miv, thiab txawm tias cov tsiaj rhiab nrog MDR1 (ABCB1) gene variation vim tsiaj tsis muaj GluCl raws.
Thaum muab milbemycin oxime ntau npaum li cas, cov dev zoo li Collies muaj kev nyab xeeb vim lawv tsis muaj P-glycoprotein ua haujlwm ntawm cov ntshav- lub hlwb thaiv. Qhov no yog qhov ua rau nws txawv ntawm cov tshuaj yav dhau los hauv tib chav kawm li avermectin.
Vim Li Cas Xaiv Qhov Tseem Ceeb rau Mammalian Kev Nyab Xeeb
Cov tshuaj chloride hauv cov tsiaj nyeg yog GABA-gated, thiab thaum muaj ntau ntawm lawv, qee cov macrocyclic lactones tuaj yeem txuas nrog lawv. Milbemycin oxime tuaj yeem pab nrog ntau yam mob ntxiv vim tias nws khi rau GluCl raws ntau dua li GABA receptors. Cov kev tshawb fawb uas muab tib neeg rau 3 mg / kg / hnub rau lub sijhawm ntev thiab nrhiav kev mob toxicity tsis pom muaj teeb meem neurological. Nws tuaj yeem siv tau ntev - tiv thaiv txhua hli vim qhov no.
Qhov no precision nyob rau hauv yuav ua li cas tej yam ua hauj lwm kuj tseem ceeb nyob rau hauv lub formulation theem. Cov neeg uas ua tshuaj, zom zom, lossis txhaj tshuaj tuaj yeem siv cov tshuaj uas muaj cov tshuaj tiv thaiv kab mob tsis tu ncua thiab tsis tas yuav ua raws li cov lus qhia nruj heev. Qhov no ua rau nws yooj yim dua los npaj thiab xa lawv mus rau tsoomfwv.
Yuav Ua Li Cas Qhov Kev Ua ntawm Milbemycin Oxime Powder Extends Los ntawm Heartworms rau Roundworms
Kev Tiv Thaiv Heartworm Larvae
Kev ua tau zoo ntawm Milbemycin oxime hmoov tiv thaiv cov menyuam yaus theem ntawm Dirofilaria immitis, cov kab mob uas ua rau cov kab mob plawv hauv cov dev, tau tshawb fawb ntau. Milbemycin oxime feem ntau cuam tshuam rau cov theem tsis zoo ntawm cov menyuam yaus uas muaj nyob hauv tus tswv tsev ntau dua li cov neeg laus lub plawv. Nws ua haujlwm los ntawm kev cuam tshuam cov paj hlwb thiab cov leeg nqaij ua haujlwm ntawm cov kab mob cab thiab tuaj yeem tiv thaiv cov larvae loj hlob ntxiv. Cov tshuaj yog ib qho tseem ceeb active caij rau txoj kev tshawb no ntawm kev tiv thaiv kab mob plawv thiab rau veterinary formulations. Kev paub txog nws theem- tshwj xeeb kev txiav txim kuj tseem ceeb thaum txiav txim siab txog nws kev koom ua ke rau hauv kev tswj hwm tus kab mob loj dua.
Cov teebmeem ntawm Roundworms thiab lwm yam nematodes
Milbemycin Oxime hmoovyog nquag tawm tsam ntau tshaj li tsuas yog heartworm larvae. Nws kuj tseem muaj zog tiv thaiv ntau lub plab hnyuv nematodes, suav nrog cov kab mob sib kis xws li Toxocara canis thiab Toxascaris leonina. Hloov chaw, cov kab mob no nyob hauv plab hnyuv tsis zoo rau kev ncig. Txawm li cas los xij, milbemycin oxime tseem cuam tshuam rau lub paj hlwb thiab cov leeg nqaij ntawm cov kab mob no. Thiab yog vim li cas cov tshuaj tau raug tshuaj xyuas rau lwm yam kev siv tshaj li kev tiv thaiv kab mob plawv. Cov kws tshawb fawb tuaj yeem soj ntsuam qhov tsis zoo, theem kev loj hlob thiab cov lus teb lom neeg thiab tseem saib qhov cuam tshuam rau ntau hom kab mob parasite.
Sib piv Parasite Targets thiab Kev Tshawb Fawb Cov Ntawv Thov
Qhov sib txawv tseem ceeb ntawm cov kab mob plawv thiab cov kab mob plab hnyuv loj tuaj nyob rau hauv qhov chaw ntawm cov kab mob thiab qhov twg ntawm cov theem kev loj hlob raug tawm tsam. Rau kev tshawb nrhiav kab mob plawv, qhov tseem ceeb tshaj plaws yog nyob rau theem tsis muaj zog larval . Roundworm kev tshawb fawb muaj feem cuam tshuam ncaj qha rau cov hnyuv nematodes. Milbemycin oxime hmoov yog cov qauv zoo rau kev kawm thiab nws cov haujlwm tau tshawb xyuas hauv cov kab mob sib txawv no. Cov kev sib piv no muaj txiaj ntsig zoo rau cov kws tshawb fawb kom nkag siab txog cov txiaj ntsig ntawm ib qho tshuaj ntawm lwm cov nematodes thiab txhawb cov kws tshawb fawb los tshawb xyuas ntxiv txog kev siv cov tshuaj sib xyaw hauv cov tshuaj kws kho tsiaj rau kev tswj cov kab mob cab.
Cov kab mob nematode twg tuaj yeem Milbemycin Oxime Powder Target?
Milbemycin oxime yog ib qho macrocyclic lactone siv nyob rau hauv veterinary parasitology thiab tau pom tias muaj txiaj ntsig zoo tiv thaiv ntau tus kab mob nematode loj. Lub hom phiaj tiag tiag yuav txawv raws li hom tsiaj thiab cov khoom tsim. Milbemycin oxime muaj ntawv tso cai nyob rau hauv cov dev rau cov neeg laus hookworm, roundworm thiab whipworm thiab tej yam kev npaj nyob rau hauv miv rau gastrointestinal roundworm thiab hookworm.
Cov neeg laus Hookworms hauv dev thiab miv
Milbemycin oxime yog ib qho tseem ceeb los tiv thaiv -tus kab mob plab hnyuv nematode tawm tsam hookworms. Ancylostoma caninum yog lub hom phiaj paub hauv cov dev thaum feline formulations tuaj yeem tsom Acylostoma tubaeforme . Cov kab mob no nyob hauv lub plab zom mov thiab yuav ua rau muaj teeb meem xws li ntshav poob hauv txoj hnyuv thiab kev noj qab haus huv tsis zoo. Ib qho kev lees paub ntau dua ntawm kev siv milbemycin oxime raws li tau txheeb xyuas ntawm cov kws kho tsiaj ntawv yog kev tswj lossis kev kho mob ntawm cov neeg laus kab mob hookworm.
Roundworms thiab Whipworms hauv dev
Milbemycin oxime kuj tau pom tias muaj txiaj ntsig zoo tiv thaiv kab mob loj, xws li Toxocara canis thiab Toxascaris leonina.
Pom zoo cov khoom lag luam dev tswj thiab tshem tawm cov paub tab Trichuris vulpis, tus kab mob canine whipworm. Raws li cov kab mob no muaj lub neej sib txawv thiab cuam tshuam rau cov ntaub so ntswg, kev txheeb xyuas cov hom kev koom tes tseem yog qhov tseem ceeb hauv kev tsim cov kws kho tsiaj kho tsiaj lossis cov txheej txheem kawm.
Hom -Tshwj xeeb Nematode Coverage
Lub nematode spectrum tsis zoo ib yam rau txhua tus tsiaj los yog tag nrho cov formulations. Piv txwv li, Tebchaws Asmeskas cov ntawv sau npe suav nrog cov kab nuv ntses, kab kab kab thiab kab nplawm, thaum lub sijhawm tam sim no UK cov khoom lag luam muaj Ancylostoma tubaeforme thiab Toxocara cati ntawm nws cov kab mob hauv plab. Yog li, cov kws tshawb fawb thiab kws kho tsiaj uas xav txog milbemycin oxime hmoov yuav tsum sib txheeb cov qauv thiab cov hom phiaj nrog cov kab mob hauv qab kev kawm es tsis xav ua ntau yam tawm tsam txhua tus nematodes.
Milbemycin Oxime Powder ua Broad -Spectrum Nematode Control Cov khoom xyaw
Combination Formulations thiab Expanded Label Claims
Ib feem tseem ceeb ntawm kev ua tshuaj yog milbemycin oxime. Tab sis nws yeej ci thaum sib xyaw nrog lwm cov khoom xyaw uas ua haujlwm zoo nrog nws. Nws tuaj yeem tua cov kab mob hauv plab, cov kab nuv ntses, cov kab nplawm, thiab cov kab mob tapeworms hauv ib lub hlis twg thaum sib xyaw nrog praziquantel. Qhov no ua rau koj tsis txhob mob plawv. Daim duab no, nrog ntau dua ib qho kev siv, ua rau nws yooj yim dua rau cov tswv tsiaj kom taug qab txhua yam sib txawv uas lawv cov tsiaj xav tau.
Kev lag luam-rau- cov neeg yuav khoom lag luam yuav tsum nrhiav cov hmoov milbemycin oxime uas yog GMP- tau ntawv pov thawj thiab tau sim nrog HPLC thiab LC-MS. Qhov no muaj tseeb rau cov tuam txhab uas tsim tshuaj, cov khoom lag luam rau tsiaj, thiab cov tshuaj tshwj xeeb.
Hauv Teb Chaws Asmeskas, EU, Nyiv, thiab Australia, kev tswj hwm kev xa khoom xav tau cov ntaub ntawv pov thawj tias cov khoom yog ntshiab, ruaj khov, thiab muaj peev xwm nrhiav tau qhov twg nws tau tsim.
Scalable Supply rau Ntiaj Teb Veterinary Markets
Ntau tus neeg nyob rau sab hnub tuaj Asia, Latin America, thiab Middle East tau txais tsiaj, yog li muaj ntau qhov kev thov rau cov tshuaj tua kab mob thoob plaws ntiaj teb. Milbemycin oxime hmoov yog ib feem loj ntawm qhov kev loj hlob no vim tias nws yog cov khoom xyaw nquag uas tau sim thiab pom zoo los ntawm cov tub ceev xwm. Nrog rau US -FDA, EU-GMP, thiab PMDA kev pom zoo, ib qhov chaw tsim khoom tuaj yeem muag rau cov lag luam sab nraud ntawm Teb Chaws Asmeskas yam tsis tas yuav mus dhau cov kauj ruam ntxiv kom tau txais kev tsim nyog. Cov khoom tshiab tuaj yeem nkag mus rau hauv kev lag luam sai heev tam sim no.
Xaus
Milbemycin Oxime hmoovkhwv tau nws qhov chaw raws li qhov dav -spectrum antiparasitic nquag los ntawm kev sib xyaw ua ke ntawm cov hom phiaj molecular, kev nyab xeeb ntawm cov tsiaj nyeg, thiab ntau yam kev sib xyaw ua ke. Los ntawm kev thaiv cov kab mob plawv larval mus rau kev tshem tawm cov kab mob hauv plab hnyuv thiab nkag mus rau cov kab mob follicular mite, nws ncav cuag cov kab mob cab ua rau nws yog ib qho tseem ceeb tshaj plaws ntawm cov khoom xyaw hauv cov kws kho tsiaj niaj hnub no. Rau cov tuam txhab tsim lossis nthuav lawv cov khoom lag luam kws kho tsiaj, nws sawv cev rau kev ntseeg siab, zoo -tus yam ntxwv, thiab thoob ntiaj teb lees txais cov khoom siv tshuaj.
Cov lus nug nquag
Q: Dab tsi yog tus qauv purity specification rau milbemycin oxime hmoov siv nyob rau hauv veterinary ntsiav tshuaj formulations?
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Feem ntau, HPLC tsom xam yog siv los ua pov thawj tias qib purity raws li API cov cai. Tus lej CAS yog 129496-10-2, uas yog siv rau hauv tsoomfwv daim ntawv thov. Cov neeg yuav khoom yuav tsum nug lawv cov neeg muag khoom rau HPLC, LC-MS, thiab HNMR daim ntawv pov thawj ntawm kev tshuaj xyuas ua ntej lawv pib ua cov qauv.
Q: Puas yog milbemycin oxime hmoov zoo rau miv thiab dev?
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A: Yog. Milbemycin oxime tuaj yeem muab rau cov miv thiab dev hauv cov nqi uas nyob ntawm seb lawv hnyav npaum li cas. Ntau tus miv noj cov ntsiav tshuaj uas muaj 5.75 mg, 11.5 mg, lossis 23.0 mg. Nws muaj kev nyab xeeb rau cov tsiaj nyeg thiab kab vim tias nws tsuas yog khi rau GluCl cov kab hauv kab thiab tsis muaj txoj hauv kev zoo kom nkag mus rau hauv cov tsiaj lub hlwb.
Q: Cov ntawv pov thawj dab tsi yuav tsum muaj milbemycin oxime hmoov cov khoom lag luam tuav rau kev xa tawm mus rau kev lag luam tswj hwm?
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A: Tus neeg muag khoom yuav tsum muaj tsawg kawg yog US -FDA EIR tsab ntawv, EU- daim ntawv pov thawj GMP, thiab cov ntaub ntawv pom zoo PMDA yog tias lawv xav muag rau Asmeskas, EU, Nyiv, lossis Australia. Muaj cov pov thawj ntxiv tias cov txheej txheem tsim khoom yog qhov zoo thiab cov khoom siv khoom lag luam muaj kev ntseeg siab ua tsaug rau GMP cov ntaub ntawv tshuaj xyuas los ntawm cov neeg paub zoo -paub thoob ntiaj teb.
Koom Tes Nrog Bloomtechz - Koj Trusted Milbemycin Oxime Powder Supplier
Bloomtechz npaj txhij los pab koj txhim kho koj cov khoom kho tsiaj yog tias koj xav tau ib tus neeg muag khoom txhim khu kev qha ntawm milbemycin oxime hmoov uas muaj cai ua li ntawd thiab muaj peev xwm ua tau. FDA hauv Teb Chaws Asmeskas, GMP hauv EU, PMDA, MFDS, thiab BGV hauv Hamburg, Lub teb chaws Yelemees tau pom zoo rau peb cov nroj tsuag Xi'an. Ua li no, koj tuaj yeem paub tseeb tias txhua pawg ntawmmilbemycin oxime hmoovua tau raws li cov qauv rau kev ua tau zoo thiab cov ntaub ntawv uas koj pawg neeg tswj hwm xav tau.
Peb tuaj yeem pab koj nrog ntau yam, xws li API ntshiab hmoov, npaj tau- cov ntsiav tshuaj (nrog 2.3 mg rau 23.0 mg ntawm API ib ntsiav tshuaj rau dev thiab miv), tag nrho cov ntaub ntawv txheeb xyuas (HPLC, LC-MS, thiab HNMR), thiab OEM/ODM customization. Peb tau ua hauj lwm nrog cov organic synthesis thiab triple - txuas kev txheeb xyuas qhov zoo rau ntau tshaj 12 xyoo. Qhov no suav nrog lub Hoobkas, hauv-tsev QA/QC, thiab kev sim los ntawm tus thib peb- txoj cai. Peb cog lus tias yuav muab tag nrho cov nyiaj rov qab rau koj yog tias cov khoom tsis ua raws li peb cov qauv. Qhov kev cog lus no sawv tom qab txhua qhov khoom xa tuaj.
Hu rau peb pab neeg tam sim ntawd los tham txog koj cov kev xav tau, tau txais cov qauv, lossis tau txais cov nqi raws sijhawm thiab cov ntaub ntawv coj mus kuaj. Xa email rau peb ntawmSales@bloomtechz.com.
Cov ntaub ntawv
1. Prichard, RK, & Geary, TG (2019). Kev pom ntawm kev siv hluav taws xob ntawm moxidectin rau kev tswj cov kab mob parasitic nematodes nyob rau hauv lub ntsej muag ntawm kev txhim kho anthelmintic tsis kam. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, 10, 69–83.
2. Bowman, DD, & Atkins, CE (2009). Heartworm biology, kho, thiab tswj. Veterinary Clinics of North America: Small Animal Practice, 39(6), 1127–1158.
3. Sasaki, T., Ishikawa, H., & Yamamoto, S. (1992). Milbemycin oxime: Pharmacological profile thiab kev kho mob hauv cov tshuaj kho tsiaj. Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, 15(4), 332–344.
4. Shoop, WL, Mrozik, H., & Fisher, MH (1995). Cov qauv thiab kev ua haujlwm ntawm avermectins thiab milbemycins hauv tsiaj noj qab haus huv. Veterinary Parasitology, 59(2), 139–156.
5. Blagburn, BL, & Dryden, MW (2009). Biology, kev kho mob, thiab tswj cov kab mob yoov thiab zuam. Veterinary Clinics of North America: Small Animal Practice, 39(6), 1173–1200.
6. Paul, AJ, Tranquilli, WJ, & Seward, RL (1987). Kev soj ntsuam kev soj ntsuam hauv collies muab ivermectin qhov ncauj piv rau milbemycin oxime. American Journal of Veterinary Research, 48(4), 684–685.