Thaum cov kab mob nkag mus rau hauv cov hlwb, lawv siv cov cuab yeej hauv lub hlwb los luam lawv tus kheej DNA. Txhawm rau ua cov kev kho mob uas ua haujlwm, nws tau dhau los ua qhov tseem ceeb dua kom nkag siab tias cov tshuaj tiv thaiv kab mob tiv thaiv cov txheej txheem no li cas. GS-441524 hmoov yog ib kauj ruam loj rau kev kawm txog cov kab mob vim tias nws tuaj yeem txwv tsis pub tsim cov kab mob RNA ntawm qib molecular. Qhov no nucleoside analogue tau pom ntau qhov kev cog lus tawm tsam cov kab mob RNA sib txawv los ntawm kev thaiv cov txheej txheem tseem ceeb.
Cov kws tshawb fawb thiab chemists thoob plaws ntiaj teb tab tom saib yuav ua li cas cov tshuaj no txwv tsis pub tsim cov kab mob cov khoom siv caj ces. Vim li casGS-441524 hmoovua haujlwm raws li nws muab cov ntaub ntawv tseem ceeb rau peb ua cov tshuaj tiv thaiv kab mob zoo dua. Cov tshuaj no ua rau pom cov lus cog tseg hauv kev sib ntaus sib tua kab mob uas xav tau RNA- nyob ntawm RNA polymerase kom rov ua dua, ob qho tib si hauv cov kws kho tsiaj thiab hauv kev tshawb fawb biomedical feem ntau.
GS-441524 Fp
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-1-001
GS-441524 CAS Nr .: 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-4
GS-441524 Powder Inhibit Viral RNA Synthesis li cas hauv Cells?
Txoj kev GS-441524 hmoov tua kab mob yog raws li txoj kev nws cov molecules zoo li ntuj nucleosides. Thaum cov tshuaj no tau muab rau cov kab mob uas muaj kab mob, nws hloov pauv metabolically rau hauv nws daim ntawv active triphosphate. Daim ntawv nquag no ua haujlwm nrog cov tshuab uas cov kab mob siv los luam lawv cov genomes. Nws tsom rau RNA-dependent RNA polymerase (RdRp) enzyme uas cov kab mob xav tau rau qhov no.
Cellular Uptake thiab Metabolic Activation
Thaum GS-441524 hmoov nkag mus rau hauv cov hlwb, nws dhau los ntawm cov txheej txheem enzymatic uas ua rau phosphorylation. Cov molecule hloov mus rau hauv triphosphate nucleotide analogue thaum phosphate pawg tau ntxiv los ntawm tus tswv tsev cell kinases. Qhov kev ua kom metabolic no yog qhov tsim nyog vim tias tsuas yog daim ntawv triphosphate tuaj yeem sib tw nrog cov nucleotides ntuj thaum tus kab mob RNA raug tsim.
Cov txheej txheem ntawm kev hloov dua siab tshiab feem ntau tshwm sim nyob rau hauv cov sij hawm ntawm cov hlwb raug nthuav tawm, muab cov khoom sib xyaw ua ke rau hauv txoj haujlwm kom tsis txhob kis kab mob sib kis uas twb tau mus lawm.
Kev sib tw nrog Natural Nucleotides
Daim ntawv nquag ntawm GS-441524 hmoov muaj cov qauv zoo ib yam li adenosine triphosphate, uas yog lub tsev thaiv kev ua rau RNA.
Vim li no, cov molecule tuaj yeem ncaj qha sib tw nrog cov nucleotides ib txwm muaj los ntxiv rau cov kab mob RNA uas loj hlob tuaj.Tus kab mob RdRp enzyme tsis tuaj yeem qhia qhov txawv ntawm qhov nucleoside analogue thiab ntuj substrate, yog li nws tau ntxiv thaum lub sij hawm elongation theem ntawm viral genome replication. Qhov kev sib tw inhibition no yog ib txoj hauv kev tseem ceeb tshaj plaws los tiv thaiv kev kis tus kab mob.
Mechanism ntawm Chain Termination
Thaum kis kab mob polymerase ntxiv GS-441524 derivative rau RNA strand tshiab, cov qauv molecular txwv txoj hlua ntawm kev loj hlob ntxiv lawm. Lub compound muaj qhov hloov pauv ribose uas nres qhov tsim ntawm cov phosphodiester ntxiv tom qab ntawd. Txawm hais tias nws tsis xaus cov saw tam sim ntawd, raws li qee qhov nucleoside analogues ua, txuas ntxiv ua rau cov saw hlau xaus tom qab.
Qhov kev ncua sij hawm no ua rau kev tsim cov kab mob RNA uas tsis puv thiab tsis tuaj yeem ua lawv txoj haujlwm kom zoo hauv cov kab mob sib kis lossis kev txhais cov protein.
Kev cuam tshuam rau Viral Polymerase Fidelity
Ntxiv rau kev ntxiv nws tus kheej ncaj qha, GS-441524 hmoov hloov pauv tus kab mob RNA polymerase ua haujlwm zoo npaum li cas.
Qhov no nucleoside analogue hloov pauv qhov enzyme ua haujlwm tau zoo thiab raug thaum nws nyob hauv qhov chaw nquag. Kev tshawb fawb ntawm cov qauv polymerase tau pom tias nws hloov pauv thaum nws ua haujlwm nrog cov tshuaj no, uas ua rau muaj kev ua yuam kev ntau dua thaum ntxiv nucleotides tom qab. Cov kev tsim no - hloov pauv ua rau tus kab mob txawm tias tsis haum thiab tsis tuaj yeem rov ua dua, tsim ob txoj hauv kev los txwv nws.
GS-441524 Hmoov thiab RNA Transcription Blockage Mechanism
Cov txheej txheem ntawm tus kab mob RNA transcription tseem ceeb heev vim nws hloov cov ntaub ntawv genomic rau hauv RNA molecules ua haujlwm. GS-441524 hmoov tiv thaiv cov txheej txheem no los ntawm kev cuam tshuam nrog ntau cov molecules hauv ntau txoj kev. Cov tshuaj tuaj yeem txwv tsis pub hloov pauv ntau dua li ib qho, suav nrog los ntawm kev sib tw nrog thiab cuam tshuam nrog cov kab mob rov ua dua tshiab.
Kev sib tham nrog Replication Complex Cheebtsam
Replication-cov ntaub ntawv hloov pauv yog cov pab pawg nyuaj ntawm cov molecules uas cov kab mob siv los luam lawv tus kheej. RNA synthesis, proofreading, thiab ua yog tag nrho cov kev sib koom tes los ntawm cov kab mob proteins uas muaj nyob rau hauv cov qauv no. GS-441524 hmoov hloov tsis tsuas yog lub polymerase enzyme tab sis kuj muaj kev ruaj ntseg thiab kev ua haujlwm ntawm cov proteins uas txuas nrog rau hauv cov complexes.
Raws li kev tshawb fawb, ntxiv cov nucleoside analogue no tuaj yeem ua rau muaj kev hloov pauv hauv cov qauv ntawm cov tshuab replication uas ua rau nws ua haujlwm tsis zoo tag nrho.
Kev cuam tshuam ntawm Template Recognition
Txhawm rau pib transcription, tus kab mob polymerase yuav tsum raug nrhiav thiab txuas mus rau tus kab mob RNA lub hom phiaj. Cov kev tshawb fawb tau pom tias ntxiv GS-441524 hmoov rau cov qauv strands tuaj yeem cuam tshuam tom qab hloov pauv.
Polymerase enzymes uas sim siv cov strands raws li cov qauv muaj teeb meem pom lawv vim hais tias cov nucleotides hauv cov qauv tau hloov pauv. Qhov no pib muaj cov tshuaj tiv thaiv kab mob uas qhov pib inhibition tsim los ntawm ntau lub voj voog rov ua dua, txo qis kev tsim cov kab mob RNA dhau sijhawm.
Qhov cuam tshuam rau Subgenomic RNA Synthesis
Ntau tus kab mob RNA ua rau subgenomic RNAs uas xav tau los ua qee cov kab mob sib kis. Cov hmoov GS-441524 tso siab rau cov txheej txheem ntawm kev sib txuas. Thaum cov khoom sib xyaw muaj nyob rau hauv cov ntawv sau luv luv ntawm RNA ntu, nws zoo li ua rau muaj teeb meem ntau tshaj plaws, tej zaum vim tias cov molecules no tau hloov kho nucleotides ntau dua.
Qhov kev xaiv inhibition no tuaj yeem cuam tshuam loj rau kev tsim cov kab mob kis kab mob, txawm tias nws tsuas yog muaj kev cuam tshuam me me rau kev tsim cov genomic RNA.
Temporal Dynamics ntawm Inhibition
Lub sij hawm sib txawv muaj qhov sib txawv ntawm txoj kev GS-441524 hmoov nres transcription.
Tsis pub dhau ob peb teev ntawm kev sib cuag thawj zaug, muaj qhov poob qis hauv cov kab mob RNA ntau lawm, thiab qib ntawm kev tawm tsam yog siab tshaj tom qab lub sijhawm ntev ntawm tes. Cov qauv no nyob rau lub sijhawm qhia tau hais tias cov tshuaj no puas nyob hauv cov hlwb thiab ua li cas nws maj mam dhau los ua ib feem ntawm tus kab mob RNA molecules. Tshawb nrhiav seb cov kev hloov pauv no ua haujlwm li cas pab ua kom cov phiaj xwm noj tshuaj zoo dua rau kev siv kho mob.
Dab tsi Nres Viral Genetic Materials Ntau Lawm Nrog GS-441524 hmoov?
Ntau qhov xwm txheej molecular raug teeb tsa thaum GS-441524 hmoov ntxiv, uas txwv kev tsim cov khoom siv tshuaj tua kab mob. Ua ke, cov txheej txheem no tso tseg kev tsim cov kab mob genomes uas tuaj yeem ua lawv txoj haujlwm. Kev sib xyaw ua haujlwm vim tias nws tuaj yeem cuam tshuam cov tshuab uas cov kab mob siv los luam lawv tus kheej hauv txoj hauv kev uas kho tsis tau.
Steric Hindrance ntawm qhov chaw nquag
Cov qauv molecular ntawm GS-441524 derivatives uas ntxiv txwv qhov chaw uas siv tau los ntawm polymerase. Cov piam thaj hloov pauv mus rau hauv cov cheeb tsam uas feem ntau tau txais cov nucleotides tshiab, tso tseg qhov sib ntxiv ntawm ntau lub tsev thaiv.
Nws tau muaj zog dua li qhov hloov pauv nucleotides ntxiv rau cov saw loj hlob, uas yog hu ua steric cuam tshuam. Lub polymerase enzyme txoj haujlwm catalytic poob qis, thiab nws tsis ua haujlwm tag nrho thaum cov kev txwv tseem ceeb hloov mus txog.
Induction ntawm Polymerase Dissociation
Muaj pov thawj los ntawm kev sim uas ntxiv GS-441524 hmoov tuaj yeem ua rau cov kab mob polymerase cais tawm sai dhau los ntawm nws cov qauv RNA. Qhov hloov pauv ntawm RNA-polymerase complex ua rau nws tsis tshua koom nrog, uas cia cov enzyme cais ua ntej tag nrho-ntev genome synthesis tiav.
Thaum qhov no tshwm sim sai dhau lawm, nws tawm tom qab ib feem RNA cov khoom uas ploj lawm cov cheeb tsam tseem ceeb. Yog tsis muaj tag nrho cov genomes, cov kab mob tsis tuaj yeem tso ua ke cov kab mob sib kis, uas nres lub voj voog ntawm kev rov ua dua.
Tsim cov khoom tsis yog-RNA ua haujlwm
GS-441524 hmoov-hloov RNA molecules feem ntau tsis muaj lub luag haujlwm lom neeg, txawm tias thaum txiav cov saw hlau tsis tshwm sim tam sim ntawd.
Cov analogues ntxiv tuaj yeem txwv tsis pub RNA los ntawm folding kom raug, uas txwv tsis pub tsim cov txheej txheem tseem ceeb theem nrab thiab qib theem uas xav tau rau tus kab mob ua haujlwm. Cov misfolded RNAs tsis tuaj yeem ua haujlwm raws li cov lus qhia zoo rau kev txhais cov proteins lossis ntim cov genomes. Kev tsim kho ntawm RNA molecules puas siv cov peev txheej hauv cov hlwb yam tsis tau pab tus kab mob kis.
Intracellular RNA Synthesis Suppression ntawm GS-441524 Hmoov
Nyob rau hauv ib puag ncig nyuaj hauv hlwb, GS-441524 hmoov muaj ntau yam cuam tshuam rau kev tsim cov kab mob RNA. Qhov sib xyaw ua ke muaj peev xwm los tsom cov kab mob polymerases thaum tawm hauv lub cell enzymes ib leeg yog ib qho txiaj ntsig zoo tshuaj. Qhov kev xaiv no los ntawm qhov tseeb tias cov kab mob thiab tib neeg cov polymerases tsis zoo ib yam.
Xaiv Lub Hom Phiaj ntawm Viral Enzymes
Cov qauv thiab substrate tshwj xeeb ntawm tus kab mob RNA- nyob ntawm RNA polymerases txawv heev ntawm cov tib neeg DNA polymerases. GS-441524 hmoov siv qhov zoo ntawm qhov sib txawv no los ntawm kev tso cai rau cov kab mob enzymes kom paub nws yooj yim dua. Daim ntawv triphosphate ntawm cov tshuaj tiv thaiv kab mob RdRp cov chaw ua haujlwm zoo dua li tib neeg polymerases.
Qhov kev khi tshwj xeeb no txo qis qhov kev sib koom ua ke rau hauv cov cell nucleic acids. Qhov no txo qis txoj kev pheej hmoo ntawm cell puas thaum ua kom muaj zog tiv thaiv kab mob.
Concentration-Txoj kev cuam tshuam
Tus nqi ntawm RNA synthesis inhibition yog ncaj qha ntsig txog tus nqi ntawm cov nquag GS-441524 molecules hauv hlwb.
Cov nqi qis dua ua rau muaj kev cuam tshuam ib nrab, uas ua rau qeeb ntawm kev loj hlob ntawm cov kab mob tab sis tsis txwv lawv tag nrho. Ntawm cov nyiaj ntau dua, kev tsim cov kab mob RNA yuav luag tag. Qhov kev sib haum xeeb no- teb kev sib raug zoo cia cov kws kho mob txiav txim siab qhov zoo tshaj plaws rau kev kho mob, sib piv nws ua haujlwm zoo npaum li cas nrog cov kev mob tshwm sim.
Compartmentalization thiab Localization
Tus kab mob replication feem ntau tshwm sim nyob rau hauv ib feem ntawm cov hlwb, xws li replication organelles los yog daim nyias nyias - khi vesicles. Yuav ua li cas cov hmoov GS-441524 faib nyob rau hauv cov compartments no cuam tshuam zoo npaum li cas nws thaiv cov enzyme. Cov tshuaj zoo nkag mus rau cov chaw replication no, mus txog qib siab txaus hauv zos kom tsis txhob muaj cov haujlwm polymerase, raws li kev tshawb fawb.
Qhov sib xyaw ua ke muaj peev xwm nkag mus rau hauv cov chaw zais no yog qhov tseem ceeb rau nws txoj haujlwm tiv thaiv kab mob tag nrho.
Duration ntawm Inhibitory Effect
Ntev npaum li cas RNA synthesis raug tso tseg nyob ntawm seb qhov sib txuas ruaj khov npaum li cas thiab lub xov tooj ntawm tes siv zog li cas.GS-441524 hmoov metabolites muaj ib nrab-lub neej nyob hauv hlwb, yog li inhibitory concentrations nyob rau lub sijhawm ntev.
Qhov no ntev - cov nyhuv kav ntev yuav txo cov sij hawm uas yuav tsum tau muab tshuaj kom tus kab mob tswj tau. Ua rau daim ntawv triphosphate los ntawm niam txiv molecule ib zaug ntxiv muab cov nyhuv reservoir uas ua rau cov tshuaj ua haujlwm ntev dua tom qab thawj koob tshuaj.
GS-441524 Powder thiab Viral Genome Formation cuam tshuam
Rau cov kab mob genome kom tsim tau tag nrho, ntau cov txheej txheem biochemical yuav tsum ua haujlwm ua ke zoo kawg nkaus. GS-441524 hmoov messes qhov kev sib koom tes ntawm ib tug xov tooj ntawm cov ntsiab lus tseem ceeb, uas nres lub rooj sib txoos ntawm kev ua haujlwm ntawm cov kab mob genomes. Lub compound cov nyhuv mus tag nrho txoj kev los ntawm tus txheej txheem ntawm ua ib tug genome.
Kev cuam tshuam ntawm Genome Circularization
Rau ntau tus kab mob RNA kom rov ua dua kom zoo, cov genome yuav tsum tau nthuav dav. Qhov no yog ua los ntawm cov kws kho mob cov protein cuam tshuam nrog 5' thiab 3' kawg ntawm tus kab mob RNA. Yog tias koj ntxiv GS-441524 hmoov ze rau qhov kawg no, nws tuaj yeem cuam tshuam cov tshuaj tiv thaiv uas xav tau rau kev ncig. Yog tias tsis muaj kev sib kis zoo, cov tshuab rau kev rov ua dua tsis tuaj yeem ua cov hlua sib txuas kom sai thiab ua tau zoo, uas ua rau qeeb ntawm tag nrho cov genome.
Cov kab mob nrog cov txheej txheem rov ua dua tshiab tshwj xeeb yog cuam tshuam los ntawm qhov teeb meem no.
Kev Tiv Thaiv Kev Ua Haujlwm Zoo Zoo
Cov kab mob genomes feem ntau hloov tom qab lawv tau tsim, xws li los ntawm capping, polyadenylation, thiab cleavage rau hauv cov ntaub ntawv paub tab. Txoj kev ua cov enzymes no teb nrog GS-441524 hmoov-hloov RNA molecules txawv.
Nucleoside analogues tuaj yeem ua rau nws nyuaj rau kev ua cov enzymes kom pom qhov chaw zoo lossis ua rau cov qauv txawv txawv. Thaum cov genomes ua tiav tsis raug, lawv tsis ua haujlwm zoo thaum lub sij hawm kis kab mob tom ntej, txawm tias lawv tau ntim zoo rau hauv cov kab mob.
Kev cuam tshuam nrog ntim cov teeb liab
Qee qhov RNA ntu thiab cov qauv, hu ua cov cim ntim, pab cov kab mob kis tau mus rau hauv capsids. Ntxiv GS-441524 derivatives tuaj yeem hloov cov cim no los ntawm kev hloov pauv RNA folds li cas lossis los ntawm kev cuam tshuam ncaj qha rau kev paub ua ntu zus. Thaum ntim cov cim tsis ua haujlwm zoo, cov kab mob sib kis tsis tuaj yeem thaiv DNA kom zoo.
Qhov no ua rau cov kab mob sib kis uas tsis muaj dab tsi thiab tsis muaj cov khoom siv caj ces lossis cov khoom uas tsis tiav cov genomes uas tsis tuaj yeem kis tus kabmob tshiab.
Txo ntawm Genome Stability
RNA molecules nrog GS-441524 derivatives tsis ruaj khov dua li cov kab mob genomes uas tsis tau hloov pauv. Kev hloov pauv rau cov nucleotides tuaj yeem ua rau lawv tsis tshua muaj kev cuam tshuam rau cov cellular ribonucleases, uas qee zaum tuaj yeem ua kom nrawm ntawm cov kab mob tshiab RNA.
Qhov no ua rau nws kom tsawg dua cov noob kab mob ruaj khov muaj rau kev txhais lus thiab rov ua dua. Thaum ua ke nrog kev sib txuas qeeb qeeb, qhov kev poob qis hauv kev ruaj ntseg ua rau nws nyuaj rau cov kab mob sib kis.
Xaus
Txoj kev uas GS-441524 hmoov nres kev tsim cov kab mob RNA yog ib qho nyuaj ntawm kev tsom mus rau cov tshuaj tiv thaiv kab mob. Qhov nucleoside analogue no txwv tsis pub tsim cov khoom siv tshuaj tua kab mob los ntawm kev sib tw sib txuas, sib txuas sib txuas, thiab cuam tshuam nrog kev ua haujlwm ntawm polymerase. Vim hais tias cov molecule tsuas yog tsom rau cov kab mob enzymes thiab tsis yog cov cell cell polymerases, nws muaj lub qhov rais kho tau zoo thiab tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob.
Kev nkag siab txog cov txheej txheem molecular no tseem yuav pab tsim cov tshuaj tshiab thiab txhim kho cov phiaj xwm kho mob. Lub peev xwm ntawm GS-441524 hmoov ua haujlwm tiv thaiv ntau theem ntawm cov kab mob RNA synthesis qhia tau hais tias nucleoside analogues tuaj yeem siv los tua cov kab mob RNA. Raws li txoj kev tshawb fawb mus tom ntej, cov tswv yim tshiab no yuav pab cov kws tshawb fawb ua cov tshuaj tiv thaiv kab mob zoo dua uas ua haujlwm zoo dua thiab muaj kev nyab xeeb dua.
Cov kws tshawb fawb thiab cov neeg ua haujlwm hauv kev lag luam tshuaj uas ua haujlwm nrog cov kab mob RNA tuaj yeem siv GS-441524 hmoov kom paub ntau ntxiv txog yuav ua li cas cov kab mob rov ua dua thiab tuaj nrog txoj hauv kev tshiab los kho lawv. Lub compound yog ib feem tseem ceeb ntawm kev tshawb fawb tshuaj tua kab mob vim tias nws txoj kev ua haujlwm tau nkag siab zoo, thiab nws tau pom tias ua haujlwm.
FAQ
Tsis pub dhau ob peb teev tom qab tau txais, cov khoom sib xyaw yog coj los ntawm cov hlwb, thiab nws cov metabolism pib ua haujlwm. Nws feem ntau yuav siv li 4 mus rau 8 teev rau daim ntawv triphosphate los tsim kom tau txais txiaj ntsig zoo, thaum lub sijhawm nws nres qhov tsim cov kab mob RNA. Nyob ntawm qhov koob tshuaj thiab tus nqi ntawm cov hlwb siv lub zog, cov teebmeem inhibitory feem ntau yog lawv qhov muaj zog tshaj plaws nyob rau hauv 24 mus rau 48 teev ntawm lub sijhawm ntev - raug.
Cov tshuaj ua haujlwm zoo heev nrog tus kab mob RNA- nyob ntawm RNA polymerases thiab tsis nrog DNA lossis RNA polymerases los ntawm cov tsiaj nyeg. Qhov kev ntxub ntxaug no los ntawm qhov tseeb tias tus kab mob thiab tus tswv tsev enzymes muaj cov qauv sib txawv. Cov nyiaj ntau heev tuaj yeem ua rau qee qhov kev koom ua ke rau hauv cov tswv tsev cell nucleic acids, tab sis cov tshuaj kho mob feem ntau tsis muaj kev cuam tshuam rau kev sib txuas ntawm cellular RNA li niaj zaus. Qhov no yuav pab tau lub compound qhov kev ruaj ntseg profile.
Cov kev hloov pauv hauv RdRp noob tuaj yeem ua rau muaj kab mob tiv thaiv los ntawm kev hloov pauv ntawm qhov chaw ua haujlwm polymerase thiab ua rau nws nyuaj rau cov khoom sib txuas los yog sib koom ua ke. Feem ntau, nws yuav siv ntau tshaj ib qho kev hloov pauv rau kev tiv thaiv rau daim ntawv, thiab nws tshwm sim qeeb dua nrog lwm cov tshuaj tiv thaiv kab mob. Ntau qhov cuam tshuam ntawm cov tshuaj ua rau nws nyuaj rau cov noob los ua resistant piv rau cov tshuaj tiv thaiv kab mob uas tsuas yog tsom rau ib lub noob.
Koom Tes Nrog BLOOM TECH raws li Koj Trusted GS-441524 Powder Supplier
Tau GS-441524 hmoov los ntawm tus neeg muag khoom zoo yog qhov tseem ceeb heev yog tias koj xav mus tom ntej nrog koj cov kev tshawb fawb tshuaj tua kab mob lossis tsim kho kev siv. BLOOM TECH tau ua cov organic synthesis rau ntau tshaj 12 xyoo thiab muaj GMP- cov chaw tsim khoom tau lees paub raws li cov qauv hauv Asmeskas, EU, Nyiv, thiab CFDA. Peb qhov kev lees paub zoo siv peb theem ntawm kev soj ntsuam: kev sim hauv lub Hoobkas, kev pov thawj los ntawm QA / QC department, thiab thib peb- ntawv pov thawj tog los ntawm cov chaw tso cai. Qhov no ua kom koj tau txais cov tshuaj-qib cov tshuaj uas ua tau raws li cov qauv nruj tshaj plaws.
Peb paub tias hnub kawg ntawm kev kawm tseem ceeb heev. Peb lub platform ERP muab sijhawm rau koj raug coj mus kuaj, tus nqi meej nrog cov nyiaj tau los ruaj khov, thiab tag nrho cov ntaub ntawv koj xav tau kom yooj yim tshem tawm kev lis kev cai. Peb muab kev cia siab, kev txhawb nqa, thiab kev tswj hwm kev ua raws li koj cov haujlwm xav tau vim peb tau txais kev pom zoo rau 24 ntawm lub ntiaj teb cov tuam txhab tshuaj thiab biotechnology loj tshaj plaws. Peb ib qho -stop service model ua rau nws yooj yim mus nrhiav tau siab - purity chemicals, txawm koj xav tau kev tshawb fawb -qib npaum li cas nrog meej analytical cov ntaub ntawv los yog loj -scale ntau lawm nrog scalable mov chains.
Koj puas tau npaj los nrhiav qhov chaw ntseeg siab rau koj qhov kev tshawb fawb txog kab mob? Hu rau peb cov neeg ua haujlwm paub txog ntawmSales@bloomtechz.comlos tham txog koj cov kev xav tau tshwj xeeb thiab paub txog BLOOM TECH qhov sib txawv ntawm cov khoom siv tshuaj lom neeg zoo.
Cov ntaub ntawv
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2. Agostini ML, Andres EL, Sims AC, et al. Coronavirus cuam tshuam rau cov tshuaj tiv thaiv kab mob remdesivir (GS-5734) yog kho los ntawm tus kab mob polymerase thiab cov ntawv pov thawj exoribonuclease. mBio. 2018;9(2):e00221-18.
3. Gordon CJ, Tchesnokov EP, Woolner E, et al. Remdesivir yog ib qho ncaj qha - ua yeeb yam tshuaj tiv thaiv kab mob uas inhibits RNA- nyob ntawm RNA polymerase los ntawm tus mob ua pa nyuaj rau tus mob coronavirus 2 nrog lub zog siab. Phau ntawv Journal of Biological Chemistry. 2020;295(20):6785-6797.
4. Murphy BG, Lawrence M, Murakami E, et al. Cov nucleoside analog GS-441524 muaj zog tiv thaiv kab mob feline infectious peritonitis (FIP) hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
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