Lub zej zog Veterinary tau sau tsegFluralaner poob, muaj peev xwm cable, vim nws qhov tsis ruaj khov thiab muaj kuab. Nws ib qho - ntawm- {} Yam khoom atomic yog ze rau nws cov nyhuv thev. Hauv qhov no hauv - ntsuas qhov tob, peb yuav tshuaj xyuas cov kev kawmfluralaner's(https://en.wikipedia.org/wiki/Fridalaner) Ntev dua -} Term kev ua los ntawm dhia rau hauv cov qauv sib xyaw ntawm nws cov qauv atomic thiab nws txoj kev mob siab.
Fluralaner poob
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) daws
(2) Ntsiav tshuaj
(3) kev txhaj tshuaj
(4) txau
(5) poob
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Code sab hauv: BM-9-007
Fluralaner CASE 864731-61-3
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH XI'AN HOOBKAS
Kev tsom xam: HPLC, LC - ms, hnmr
Kev Txhawb Nqa Tshuab: R & Dept.-4
Peb muabFluralaner poob, thov saib mus rau lub vev xaib txuas ntxiv no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomteechz.com/Oemixat622 }oadm/liquid/Fridaner_TML
Tus qauv - kev sib raug zoo hauv parasiticides
Nkag siab txog cov qauv - kev sib txuas sib txuas (SARS) hauv parasiticides yog qhov tseem ceeb rau kev tsim tau thiab ntev}}}}}}}}}}} {}}}}}}}}}}}}}}}}}}}}}}}} {}}}} {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} {}-}} kav cov tshuaj. Cov kev sib txuas no muab cov khoom siv ntawm kev paub txog li cas cov qauv atomic ntawm ib qho kev cuam tshuam nrog nws cov kev ua haujlwm thiab kev pheej hmoo.
Qhov tseem ceeb ntawm SARS hauv Tshuaj Tsim
Tus qauv - Kev ua haujlwm sib txuas nrog lub hauv paus ntawm lub hom phiaj ntawm rooj plaub. Los ntawm kev xav txog kev sib raug zoo ntawm ib tus qauv molecule thiab nws cov kev cuam tshuam zoo, tuaj yeem ua kom zoo rau kev ua tau zoo, kev nyab xeeb, thiab ntev ntawm kev ua si. Nyob rau hauv cov ntaub ntawv ntawm Parasiticides xws li fluralaner, SARS muab kev pab hauv kev piav qhia tshwj xeeb cov kev ua kom pom tseeb uas ua rau nws lub cev ua haujlwm tiv thaiv kev ua ub no.
Cov txheej txheem tseem ceeb ntawm Fluralaner
Floraneaner belongs rau isoxhazoline chav kawm ntawm parasiticides. Nws cov qauv molecular yog tus yam ntxwv los ntawm ntau cov ntsiab lus tseem ceeb:
Lub nplhaib nruab nrab isoxzoline
Ib lub trifluorostomethyl pab pawg
Cov neeg muaj ntxhiab tsw
Ib qho chaw nyob
Cov qauv txheej txheem no ua haujlwm Synergistically rau Sib ThamFluralaner poobCov khoom lag luam zoo nkauj, suav nrog nws cov potency muaj nuj nqis thiab txuas ntxiv ntev ntawm kev nqis tes ua.
Floraner Tshuaj Txom Loj Cov Ntaw
Qhov zoo kawg yog kev nyob zoo ntawm Fluralaner feem ntau tau qhab nia rau nws cov tshuaj ruaj khov. Ob peb lub ntsiab lus tseem ceeb ntawm nws cov qauv atomic ua rau cov kev ua tau zoo no, tso cai rau cov compound kom nyob twj ywm dynamic hauv tus tsiaj lub cev rau lub sijhawm nthuav dav.
Isoxazoline Cov Tub Ntxhais Txiaj Ntsig
Nyob rau hauv lub siab ntawm Fluralaner tus qauv nyob rau isoxzzoline nplhaib. Qhov no herocyclico yog intrinsically khov kho vim nws tus cwj pwm ntxhiab thiab hluav taws xob xaav. Lub chaw nyob Isoxzoline sawv los ntawm cov kev rho tawm metabolic, ua rau muaj kev sib tw tseem ceeb rau Fluralaner lub ntev- kav cov teebmeem.
Cawv ntawm lub Trifluorostomethyl pab pawg
Qhov ze ntawm ib lub trifluoromethyl (CF3) sib sau ua ke hauv Fluralaner tus qauv ua si ib feem tseem ceeb hauv nws qhov ruaj khov. Qhov no profound electroneGative pawg txhim kho cov kab ke lipophilicity, yooj yim rau nws cov kev tshaj tawm thiab txij nkawm hauv cov nqaij rog. Dhau li, CF3 pab pawg lub teeb thiab hluav taws xob cuam tshuam xyuas kom lub atom ntawm cov enzymatic degradation.
Stereochemistry thiab kev ruaj khov
Fluralaner muaj lub chaw chairal, ua rau muaj ob lub tsev khaws khoom. Qhov tshwj xeeb stereochemistry ntawm active omer ua rau nws txoj kev ua tau zoo tshaj plaws rau lub hom phiaj thiab cuam tshuam tag nrho cov ruaj khov hauv kev siv hluav taws xob.
Molecular kev hloov kho rau lub caij nyoog ntev
Kev txhim kho ntawm Fluralaner koom nrog kev hloov kho cov tswv yim molecular los txhim kho nws txoj kev mob siab. Cov kev hloov kho no tau tsim los txhawm rau ua kom zoo dua cov compound cov khoom siv hluav taws xob thiab tiv thaiv metabolic tsis saib xyuas.
Lipophilicity optimization
Ib qho tseem ceeb saib ntawm Fluralaner lub tswv yim Atomic yog nws qhov kev ua tau zoo lipophilicity. Kev ceev faj kev hloov kho ntawm hydrophilic Cheebtsam hauv nws cov qauv tso cai rau kev ua kom tau txais txiaj ntsig zoo, kev tshaj tawm, thiab saib xyuas hauv lub cev. Cov cim lipophilic no yog khaub ncaws dawb hauv qab zib kom sau hauv cov nqaij goley cov nqaij, ua cov kev cuam tshuam hauv khw uas tau ua nws cov haujlwm.
Metabolic ruaj khov kev txhim kho
Fluralaner tus qauv ntsiab lus hais tias nws txhim kho nws txoj kev tiv thaiv tsis taus rau cov metabolic tawg. Qhov chaw seem ntawm fluorine ions thiab lwm yam chaw hloov ua rau muaj cov xwm txheej sib txawv
Metabolic tsis kam mechanisms
Nkag siab txog cov metabolic resistance kho tshuab ntawmFluralaner poobyog qhov tseem ceeb rau kev piav qhia nws cov haujlwm ntev. Cov txheej txheem no suav nrog ob cov compound cov kev ntsuas thiab nws kev sib cuam tshuam nrog tus tsiaj cov tsiaj metabolism.
Cytochrome P450 Kuj
Fluralaner pom pom zoo heev rau cov metabolism hauv Cytochrome P450 enzymes, uas yog lub luag haujlwm rau kev sib tawg thiab xenobiotics. Qhov sib xyaw ua qauv tshwj xeeb, tshwj xeeb yog lub xub ntiag ntawm lub trifluoromethyl pab pawg, ua rau nws ua tsis tau zoo rau cov enzymes no.
Ntshav cov protein khi
Lwm qhov kev pab txhawb rau Fluralaner's Areitance yog nws cov ntshav siab ntawm Plasma Protein khi. Cov cuab yeej no pab tiv thaiv qhov sib txuas los ntawm kev tshem tawm sai sai thiab tswj hwm qhov kev cuam tshuam khov kho hauv cov ntshav, ua kom nws cov teebmeem antiparasitic.
Tsim Qauv Cai rau Long -} Kawg ua tau zoo
Kev txhim kho ntawm Fluralaner piv txwv ntau tus qauv tsim tseem ceeb rau kev tsim ntev {}} kav cov patasiticides. Cov ntsiab cai no tuaj yeem siv rau kev txhim kho ntawm lwm cov tebchaw yav tom ntej.
Kev Ntsuas Cov Potency thiab Kev Ua Phem
Ua tiav qhov kev hloov kho lub zog ntawm lub zog thiab kev ceeb toom yog lub hauv paus ntawm Fluralaner, lav tau tias cov compound conventic thiab ntev {}}}}}}}}}}}}}}}}}} lub sij hawm tiv thaiv parasites. Lub zog siab txhawb nqa kev siv tshuaj me me thaum ua kom muaj kev ua tau zoo me me thaum ua kom muaj cov tshuaj thauj khoom ntawm cov tsiaj. Nyob rau tib lub sijhawm, Floraneaner qhov kev txiav txim siab tso cai nws txhawm rau ua kom muaj kev pab cuam yam yuav tsum tau ua tiav, ua kom txav mus los ntawm kev ua haujlwm tom qab ib qho kev tswj hwm. Qhov kev sib raug zoo no tau ua tiav los ntawm lub tsev ua haujlwm hauv nruab nrab, ua kom zoo li lipophilicity, suab, thiab lub zog ua kom ruaj khov. Cov kws tshuaj ntsuam ua tib zoo zoo zoo-}} Cov cim kev ntseeg siab thiab lav cov cim kev sib tw thiab kev lag luam antiparasitic sedate tsim.
Hom phiaj tshwj xeeb cov receptors
Qhov kos duab -}}}}} Kev cuam tshuam nrog kev cuam tshuam tshwj xeeb, lub gaba- gi} gated chloride charawlies thiab acarines. Los ntawm cov nom kev tshwj xeeb rau cov neeg ua haujlwm hauv nroog no tshwj xeeb, Floraneaner ntse ua tiav kev tawm tsam thiab kev txuag lub moj khaum Qhov tseeb tiag tiag tsom rau kev txo qis kev phom sij ntawm kev phom sij ntawm - hom phiaj cuam tshuam thiab txhim kho los ntawm kev ruaj ntseg thiab kev nyab xeeb loj rau cov tsiaj kho. Ntxiv mus, xws li tau txais kev tshwj xeeb ua kom muaj peev xwm tswj tau kom muaj kev tswj hwm kom nruj, lav tus kheej qhov chaw nyob tsis tas li, kev pom zoo ua kom tsis muaj kev cuam tshuam nrog Parasite. Cov txheej txheem npaj no sawv cev rau li cas receptor- ua kev xaiv ntev dua thaum {{}} tiam patasiticides.
Kev siv tus physicochemical cov khoom
Kev tsim qauv ntawm fluralaner kev sib tw tshwj xeeb cov khoom siv dag ntxias kom txhim kho nws txoj kev mob siab. Cov no suav nrog:
High lipophilicity rau cov ntaub so ntswg faib thiab ua haujlwm sib tuav
Kev ua siab zoo molecular hnyav rau kev ntsuas kev nqus thiab tshem tawm
Tswj solubility kom tswj ruaj khov -} lub xeev ntau heev
Los ntawm nplua - tuning cov khoom no, cov kws tshawb nrhiav tau tsim cov compound nrog ib qho kev ncua ntev ntev ntawm kev nqis tes ua.
Tag
Qhov xav tsis thoob ntawm Fluralaner yog kev lees paub ntawm kev tswj hwm lub suab Medate Medical Plan thiab qhov kev sib raug zoo ntawm cov qauv omicic thiab organic. Los ntawm kev ceev faj kev hloov, ua kom zoo ntawm cov khoom siv dag ntxias ntawm cov khoom siv ntawm cov haujlwm uas tau sib cais ua ntu zus uas tau sib cais hauv thaj teb ntawm cov kab mob passiticides. Raws li kev tsav tshebFloraner Snit Chaw tsim tshuaj paus, cov txheej txheem txheej txheem ntawm cov ntsiab lus ntawd cuam tshuam tsis yog tias kev cog lus los txhim kho kev ruaj ntseg, muaj peev xwm, thiab kev nplij siab rau cov tswv cuab tus tsiaj. Los ntawm kev ua kom zoo rau cov lus qhia thiab lav tau cov kws tshuaj paus {{}}}}} Ua si Fluralaner ntev heev hauv cov tshuaj kho tsiaj.
Raws li peb mus rau unwind cov nyom ntawm cov qauv - kev ua tsis ncaj ncees lawm clotinate qhov kev vam meej ntawm lub neej yav tom ntej- kav teb chaws. Qhov kev ua tau zoo no tsis tau tshawb xyuas tsis yog tias peb nkag siab txog cov phiaj xwm atomic tab sis dhau txoj hauv kev kom muaj kev vam meej thiab pab tau kev kho mob antiparasitic.
Cov FAQ
1. Ntev npaum li cas Fluralaner nyob twj ywm hauv tus tsiaj lub cev?
Fluralaner feem ntau tseem nyob rau 12 lub lis piam hauv dev thiab miv tom qab ib koob. Qhov txuas ntxiv mus txuas ntxiv no yog vim nws cov qauv molecular thiab cov chaw muag tshuaj.
2. Yog fluralaner muaj kev nyab xeeb rau ntev-} kev siv nyob rau hauv cov tsiaj?
Cov kev tshawb fawb tau tshwm sim tias Fluralaner yog los ntawm thiab kev nyab xeeb loj rau ntev {{}} siv siv thaum tswj hwm kev tswj hwm. Nyob rau hauv txhua rooj plaub, raws li nrog ib tug kws qhia ntawv, nws yog ib tus kws kho tsiaj los saib xyuas kev kho mob, tshwj xeeb rau cov tsiaj ua ntej- txoj kev noj qab haus huv.
3. Cov cab puas tuaj yeem tsim kev tawm tsam rau Fluralaner?
Thaum lub peev xwm rau kev tawm tsam nrog txhua tus antiparasitic compound, facuralaner hom kev ua haujlwm tshwj xeeb ntawm kev ua ub no ua rau txhim kho cov kev txhim kho tsawg dua. Nyob rau hauv txhua rooj plaub, raws li kev siv thiab kev hloov kho ntawm cov neeg ua haujlwm ua haujlwm tiv thaiv antiparasitic ua rau txo qis kev phom sij.
Tus khub nrog Bloom Tech rau koj cov kev xav tau hauv Fluralaner xav tau
Raws li ib tug cojFloraner Snit Chaw tsim tshuaj paus, Bloom Tech tau cog lus los xa cov siab - yeej tsis muaj kev daws teeb meem. Peb cov kws tshaj lij hauv synthic thiab cov kws tshaj tshuaj hauv kev ua kom ntseeg tau tias koj tau txais cov khoom lag luam sab nrauv rau koj cov kws kho tsiaj. Nrog peb lub xeev - ntawm -}}}}}}}}}}}}}}}}}}}}}}}}} Cov txheej txheem tswj hwm zoo, peb tuaj yeem lav cov kev coj dawb huv thiab kev ua tau zoo ntawm peb cov khaub ncaws fluralaner.
Muaj kev paub txog lub Bloom Tech txawv txawv hauv Fluralaner poob ntau lawm. Peb pab neeg ntawm cov kws tshaj lij yog npaj los pab koj nrog cov kev cai tsim qauv, cov kev txiav txim siab ntau, thiab kev txhawb nqa. Tsis txhob ua kom muaj kev cuam tshuam rau qhov zoo thaum nws los txog rau Parasite Tswj - Xaiv cov Tech Tech - Xaiv cov tech tech ua koj tus khub uas ntseeg siab nyob hauv Fluralaner chaw tsim khoom.
Npaj txhij los txhawb koj cov parasiticide rau koj? Hu rau peb cov pab pawg muag hnub no ntawmSales@bloomtechz.comTxhawm rau tham txog koj cov kev xav tau facuralaner thiab nrhiav tau Yuav ua li cas Bloom Tech tuaj yeem txhawb koj cov hom phiaj ua lag luam.
Ntawv Sawv cev
1. Gassel, M., li al. (2014). Tus tshiab Isoxzoline ectoparasitebe facuralaner: xaiv inhibrecition {}} glutamate { Kab biochemistry thiab molecular biology, 45, 111-124.
2. Walther, FM, li al. (2014). Kev nyab xeeb thiab ua tau zoo ntawm kev sib tham saib xyuas ntawm Fluralaner thiab Milbemycin Oxime - ib qho chaw kho mob hauv chaw kho mob hauv cov dev uas muaj kev sib xyaw ntawm Nematodes thiab dev mub. Parasites & Vectors, 7, 525.
3. Taenzer, J., li al. (2014). Pharmaconinetics ntawm Fluralaner hauv cov dev tom qab ib qho kev tswj hwm ntawm qhov ncauj lossis lub luag haujlwm. Parasites & Vectors, 7, 85.
4. Klip, FL, EAT. (2016). Floraner Pharconinetics hauv cov dev beagle hauv qab ntawm ib leeg ntawm kev coj noj coj ua lossis kev tswj hwm. Parasites & Vectors, 9, 168.