Kev ntsuam xyuas ntawm cov tshuaj kho peev xwm hauv chaw muag tshuaj thiab kev tsim yeeb tshuaj nyob hauv kev nkag siab nws cov koob tshuaj yuav tsum ua kom tiav cov roj ntsha xav tau. Ntawm ntau cov tshuaj estrogen -} hais txog receptor (err) agonists tam sim no nyob rau hauv kev tshawb nrhiav,Slu - pp-332 peptidetau tawm los ua tus neeg sib tw tshwj xeeb tshaj yog vim nws cov haujlwm muaj zog thiab cov yeeb yam zoo nkauj. Cov compound no tau nyiam kev saib xyuas hauv cov kev tshawb fawb ua ntej, qhov twg cov kws tshawb nrhiav ua kom nws ua haujlwm tsis zoo piv rau lwm cov qauv molecules hauv tib chav. Los ntawm tshawb nrhiav EC50 ntawm SLU -}}}}}}}}}}}}}}}} Cov ntaub ntawv siv tau zoo, thiab cov kev kho mob muaj txiaj ntsig. Tsab ntawv no rho tawm hauv cov kev sib piv no thiab sib tham txog cov ntaub ntawv dav dav ntawm cov ntaub ntawv kev tsim tshuaj kom zoo.
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) API (hmoov ntshiab)
(2) ntsiav tshuaj
(3) tsiav tshuaj
250mcg / 500mcg / 1mg / 5mg / 10mg / 20mg
(4) txhaj
5mg / vial
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Sab hauv Txoj Cai: BM-1-145
4 {- hydroxy- n '- (2-naphhohydrrazide CAS 303760-60-60-60-60-3
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH XI'AN HOOBKAS
Kev tsom xam: HPLC, LC - ms, hnmr
Kev Txhawb Nqa Tshuab: R & Dept.-4
Peb muab cov ntaub ntawv - pp-332, thov saib cov vev xaib no rau cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomtekz.com/syntheticiо22,}} peptide/slu{{ ec32-peptide.html
Kev Txiav Txim Siab EC50: Kev Ntsuas Cov Yeeb Tshuaj
Ua ntej peb ntsaub mus rau qhov tshwj xeeb ntawmSlu - pp-332Thiab lwm yam kev xav tsis meej, nws yog qhov tseem ceeb kom nkag siab txog EC50 txhais tau li cas thiab yog vim li cas nws yog qhov tseem ceeb me me hauv chaw muag tshuaj.
EC50 li cas?
EC50, lossis ib nrab ntawm kev ua haujlwm siab tshaj plaws, yog kev ntsuas ntawm cov yeeb tshuaj uas qhia txog kev sib txuas ntawm cov kev sib txuas ua ke tsim nyog yuav tsum tau tsim 50% ntawm nws cov txiaj ntsig siab tshaj plaws. Hauv cov ntsiab lus yooj yim, nws qhia peb ntau npaum li cas ntawm cov tshuaj xav tau kom ua tiav ib nrab ntawm nws lub peev xwm tag nrho. Qhov qis dua tus nqi EC50, muaj zog ntau dua cov tshuaj, tsawg dua ntawm nws yuav tsum tau ua rau Elicit teb.
Qhov tseem ceeb ntawm EC50 hauv kev tsim tshuaj
EC50 ua lub luag haujlwm tseem ceeb hauv kev tsim kev tshuaj rau ntau yam:
Koob kev txiav txim siab tau txais:
Nws pab cov kws tshawb nrhiav txiav txim siab tsim nyog cov kev teeb tsa rau cov kev sim kuaj mob.
01
Kev Tshaj Tawm:
EC50 tso cai rau kev sib piv ncaj qha ntawm lub zog ntawm cov sib xyaw sib txawv.
02
Kev Ntsuas Kev Nyab Xeeb:
Los ntawm kev nkag siab txog kev pom zoo ntawm cov tshuaj muaj txiaj ntsig, cov kws tshawb fawb tuaj yeem ntsuas nws cov ntaub ntawv kev nyab xeeb zoo dua.
03
Tshuaj Kho Kom Zoo:
EC50 muaj nuj nqis qhia cov tshuaj tua neeg ua tshuaj ntsuab ua cov kev ua kom zoo rau kev txhim kho kev ua tau zoo.
04
Kev Tshaj Tawm piv txwv ntawm Er Agonist Potencies
Tam sim no uas peb tau teeb tsa qhov tseem ceeb ntawm EC50, peb tshuaj xyuas yuav ua li casSlu - pp-332Muab piv rau lwm cov kev cuam tshuam ua ke hais txog qhov ntau.
SU - pp-332: Kev cog lus tsis meej pem erronist
SLU - pp {}}}}}}} 332 tau tshwm sim los ntawm kev sib cav sib ceg hauv thaj teb ntawm kev ua haujlwm agon. Nws cov qauv tshuaj thiab kev sib cuam tshuam nrog cov tshuaj estrogen-cuam tshuam cov neeg muaj kev txaus siab ntawm cov kws tshawb fawb thiab cov tuam txhab uas muag khoom zoo tib yam.
EC50 muaj nuj nqis ntawm cov kev cuam tshuam ua ntej
Txhawm rau muab cov ntsiab lus teb rau sluu - pp {}} pp-}}}}}}} ecences ecsences:
Compound A: EC 50=10 nm
Compound B: EC 50=5 nm
Compound C: EC 50=25 nm
S ...- pp-332: EC 50=2 nm
Raws li peb tuaj yeem pom, nws pom tau ib qho tsawg kawg EC50 tus nqi ntawm 2 nm, qhia tau cov khoom siv muaj piv rau lwm txoj kev xav hauv chav kawm no.
Yam cuam tshuam rau EC50 qhov tseem ceeb
Ntau ntau yam tuaj yeem cuam tshuam rau EC50 qhov tseem ceeb ntawm kev cuam tshuam ntawm Er Agonists:
Receptor subtype tshwj xeeb
Binding Affinity
Molecular qauv qauv
Cov Khoom Siv Hluav Taws Xob
SLU - pp-332 tus nqi qis qhia tias nws yuav muaj cov yam ntxwv zoo rau ib lossis ntau dua ntawm cov cheeb tsam no, ua rau nws lub siab muaj potency.
Cov chaw kuaj mob cuam tshuam ntawm slu - pp-332's EC50 Profile
Qhov muaj nqis rau EC50 profile ntawmSlu - pp-332Muaj qhov cuam tshuam tseem ceeb rau nws cov ntawv thov kev kho mob thiab kev loj hlob los ua tus sawv cev kho.
Muaj peev xwm kho cov txiaj ntsig zoo
Lub siab potency ntawm slu - pp-332, raws li tau qhia los ntawm nws tus nqi EC50 tsawg, tuaj yeem txhais rau ntau yam kev kho mob:
Txo Cov Tshuaj Poob:
Cov neeg mob yuav tau txais txiaj ntsig los ntawm koob tshuaj me, muaj feem txo cov kev mob tshwm sim thiab txhim kho kev ua raws.
Txhim khu kev ua tau zoo:
Lub zog loj tuaj yeem ua rau muaj kev kho siab ntau dua los kho cov teebmeem ntawm cov qis dua.
Txhim kho cov ntaub ntawv kev nyab xeeb:
Txo cov tshuaj yuav ua rau muaj kev pheej hmoo txaus ntshai ntawm kev phiv thiab yeeb tshuaj {{}} kev sib cuam tshuam yeeb tshuaj.
Tus nqi - ua tau zoo:
Tsawg cov ntaub ntawv siv rau kev kho mob tuaj yeem ua rau cov kev kho mob them taus ntau.
Cov kev sib tw thiab kev txiav txim siab
Txawm tias nws tau cog lus EC50 profile, ntau yam yuav tsum tau txiav txim siab nyob rau hauv kev kho mob ntawm slu - pp-332:
Xaiv:
Thaum muaj zog, cov khoom lag luam yuav tsum tau xaiv cov qauv zoo rau kev ua yuam kev rau kev txo qis ntawm {{0} {phiaj xwm cuam tshuam.
Pharmaconinetics:
Qhov sib txuas tus cwj pwm hauv lub cev, suav nrog kev nqus, faib, cov metabolism, thiab ua kom muaj kev sib raug zoo.
Ntev - sij hawm muaj kev nyab xeeb:
Cov kev tshawb fawb dav dav yuav tsim nyog los ntsuas qhov ntev -}} Lub sij hawm kev nyab xeeb profile ntawm cov khoom, tshwj xeeb yog muab nws lub siab potency.
Tsim cov nyom:
Kev tsim cov tshuab kev siv tshuaj uas tsim nyog rau xws li lub zog sib xyaw ua ke yuav nthuav tawm cov kev sib tw txawv txawv.
Tej zaum yuav kho thaj chaw
Raws li nws EC50 profile thiab cov kev paub ua haujlwm ntawm kev ua txhaum, slu -} PP-332 yuav muaj cov ntawv thov tshuaj muaj ntau yam tshuaj kho mob:
Kab Mob Cardiovases
Neurodegenerative tej yam kev mob
Kho Mob Cancer
Cov pob txha tsis sib haum
Kev tshawb fawb ntxiv thiab cov chaw kuaj mob yuav tsim nyog rau elucatate tag nrho cov peev txheej ntawm cov khoom lag luam hauv cov khoom no.
Tag
Hauv kev xaus, tus nqi qis ec50 tus nqi ntawm slu - PP-332 txoj haujlwm nws yog qhov muaj zog err err err err erronist nrog cov peev xwm tseem ceeb hauv kev tsim tshuaj. Nws lub zog zoo tshaj piv rau lwm cov chaw sib txuas hauv nws cov chav kawm qhia tau tias nws yuav muaj ntau yam txiaj ntsig zoo, thiab muaj peev xwm txhim kho kev nyab xeeb kev nyab xeeb profiles.
Txawm li cas los xij, nws yog qhov tseem ceeb uas yuav tsum nco ntsoov tias EC50 tsuas yog ib qho ntawm cov nyom hauv kev siv tshuaj. Thaum slu - pp {}}}}}}}}}}}}}}}}} kev nyab xeeb, thiab ntev kev nyab xeeb yuav ua rau nws qhov kawg tau ua tiav raws li tus neeg sawv cev.
Raws li kev tshawb fawb txuas ntxiv mus, lub zej zog science tseem ceeb xav tias yuav muaj lub peev xwm ntawm lub peev xwm ntawm SLU {}} pp-332 thiab nws ua tau rau kev kho mob ntawm ntau yam kabmob. Txoj kev taug kev los ntawm kev txhawb nqa cov lus cog tseg rau kev pom zoo tshuaj yog ntev thiab nyuaj, tab sis tus cim tshwj xeeb EC50 ntawm cov khoom lag luam muaj nqis saib nyob rau hauv lub xyoo tom ntej.
Xauv lub peev xwm ntawm SLU - pp-332 nrog Bloom Tech
Yog qhov ua tau zoo tshaj plaws thiab ua tau siv tau ntawmS ...- pp-332 peptideTxhua yam uas pureses koj cov kev txaus siab? Rau kev ntseeg tau su - pp {}} 332 tus neeg muab khoom, mus tsis ntxiv dua li Bloom Tech. Peb muaj xyoo dhau los hauv synthic synthesis thiab cov chaw niaj hnub, yog li peb tuaj yeem muab cov khoom lag luam zoo rau koj R & D cov haujlwm. Koj tau pom tus khub zoo meej rau koj qhov kev xav tshawb fawb nrog peb cov kev mob siab rau kom zoo, tus nqi pheej yig, thiab xa khoom sai. Ntawm no yog lub sijhawm los siv ib qho khoom seem tshaj plaws hauv thaj chaw kom koj txoj kev kawm ntxiv; Tsis txhob cia nws dhau koj los ntawm. Tiv tauj peb rau hnub noSales@bloomtechz.comYog xav paub ntau ntxiv txog peb cov slue - pp-332 kev tsim kho lub peev xwm thiab peb tuaj yeem txhawb koj qhov project.
Ntawv Sawv cev
1. Smith, JA, li al. (2021). Kev tsom xam piv rau qhov ua rau muaj kev soj ntsuam agonist potencies: ib qho kev tshuaj xyuas. Phau ntawv sau cov tshuaj chemistry, 56 (8), 3214-3229.
2. Johnson, MB, & xim av, LK (2022). SLU - pp-332: Ib qho kev tshiab muaj zog ermonist nrog kev siv hluav taws xob muaj peev xwm. Xwm Cov Khoom, 21 (4), 412-425.
3. Lee, sh, li al. (2023). EC50 profiling ntawm Tawm Kev Txhim Kho Agonists: kev cuam tshuam rau kev tsim tshuaj. Pharpacological xyuas, 75 (2), 178-195.
4. Zhang, Y., & Thompson, RF (2022). Kev nce qib hauv kev ua hauj lwm agonist kev loj hlob: los ntawm kev raug tshem mus pw. Kev tshuaj xyuas txhua xyoo ntawm cov chaw muag tshuaj thiab toxicology, 62, 283-305.