Trilostane Capsule ua haujlwm li cas hauv dev?

Yog tias koj tus kws kho tsiaj tau hais rau koj tias koj tus dev muaj hyperadrenocorticism, feem ntau hu ua Cushing's syndrome, trilostane ntsiav tshuajtuaj yeem muab tau raws li kev xaiv kho mob. Tab sis nws ua haujlwm li cas hauv koj tus dev lub cev? Kev nkag siab tias cov tshuaj no ua haujlwm li cas tuaj yeem ua rau koj xis nyob nrog koj tus tsiaj txoj kev npaj kho mob thiab pab koj nug cov lus nug zoo dua thaum koj mus ntsib kws kho mob.

Cov lus qhia no piav qhia txog kev tshawb fawb hauv cov lus yooj yim, yooj yim -- nkag siab cov lus kom koj tuaj yeem kawm tau dab tsi tshwm sim ntawm qib hormonal thaum koj tus dev noj tshuaj trilostane.

Trilostane Capsule

1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
Customizable
(2) Tablet
Customizable
(3) API (Ntshiab hmoov)
PE / Al foil hnab / ntawv lub thawv rau cov hmoov ntshiab
HPLC Ntau dua lossis sib npaug rau 99.0%
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-6-010
Trilostane CAS 13647-35-3

Adrenal caj pas thiab nws lub luag haujlwm hauv Steroid Production

Hauv cov dev, cov qog adrenal zaum saum lub raum thiab muaj txoj haujlwm tseem ceeb: lawv tsim cov tshuaj steroid uas cuam tshuam rau cov metabolism, tiv thaiv kab mob thiab kev cuam tshuam rau kev ntxhov siab. Cov txheej txheem no yog flawless nyob rau hauv ib tug noj qab nyob zoo dev. Hauv cov dev nrog Cushing's syndrome, cov qog adrenal tsim cov cortisol ntau dhau. Cortisol yog ib qho tshuaj hormones glucocorticoid thiab ua rau qhov hnyav nce, nqhis dej ntau ntxiv, plaub hau poob, thiab lub lauj kaub -zoo li plab .

Steroidogenesis yog kev hloov pauv hloov pauv hloov pauv hloov pauv ntawm cov roj cholesterol mus rau hauv cov tshuaj hormones steroid. Txhua qhov kev hloov pauv no yog catalysed los ntawm ib qho enzyme tshwj xeeb. Thaiv ib qho enzyme thiab tag nrho cov kab hauv qab ntawm cov khoom tsim tshuaj hormones.

Qhov twg Trilostane kauj ruam hauv

Trilostane ntsiav tshuajua haujlwm los ntawm ncaj qha inhibiting lub qog adrenal sib tw. Qhov no tsis ua mob rau cov ntaub so ntswg adrenal tab sis nyob ib ntus thiab nres ib qho tseem ceeb enzyme, tiv thaiv cov txheej txheem tsis tu ncua ntawm steroid synthesis. Yog li no kev xaiv inhibition yog dab tsi ua rau trilostane ib qho kev pom zoo kho txij li nws txo qis cov tshuaj hormones ntau dhau yam tsis ua mob rau lub caj pas.

Kev tshawb fawb hauv cov ntaub ntawv kws kho tsiaj endocrinology tau qhia tias trilostane cuam tshuam nrog qhov chaw nquag ntawm 3 -hydroxysteroid dehydrogenase (3 -HSD), ib qho tseem ceeb enzyme hauv kev tsim cov tshuaj steroid thaum ntxov. Trilostane tsuas yog zaum ntawm qhov chaw no thiab, ua li ntawd, thaiv lub substrate los ntawm kev khi. Qhov no tseem ceeb tso tus brakes rau tag nrho cov txheej txheem steroidogenesis.

Dab tsi yog 3 -HSD Enzyme?

Txoj kev biosynthesis ntawm adrenal steroids yog tswj los ntawm 3 -hydroxysteroid dehydrogenase (3 -HSD rau luv) enzyme. Nws catalyses conversion ntawm pregnenolone rau progesterone thiab dehydroepiandrosterone (DHEA) rau androstenedione. Cov kev hloov pauv no yog thawj kauj ruam uas thaum kawg tsim cortisol, aldosterone thiab cov tshuaj hormones poj niam txiv neej. Thaum 3 -HSD ua haujlwm tsis raug, adrenal cortex tsis tuaj yeem ua tiav cov tshuaj hormones.

Hom kab mob Cushing feem ntau hauv cov dev yog pituitary -dependent hyperadrenocorticism. Nyob rau hauv daim ntawv no, lub caj pas pituitary generates ntau heev ntawm adrenocorticotropic hormone (ACTH), uas overstimulates lub qog adrenal.

Qhov kawg tshwm sim yog kev khiav tawm ntawm cov tshuaj steroids.

Yuav ua li cas Trilostane cuam tshuam txoj kev

Lub active ingredient nyob rau hauv ib ntsiav tshuaj ntawm trilostane yog absorbed los ntawm lub plab hnyuv kab mob ntawm tus aub thiab xa mus rau lub adrenal cortex los ntawm kev ncig. Tom qab ntawd nws sib tw nrog enzyme 3 -HSD. Lo lus "kev sib tw" tseem ceeb ntawm no - trilostane tsis mus tas li inhibit enzyme. Es tsis txhob, nws yuav daig nyob rau hauv lub hnab tshos khi thiab tiv thaiv tej yam ntuj tso substrates los ntawm tag nrho cov kev hloov dua siab tshiab.

Kev tshawb fawb hauv cov kws kho tsiaj tau pom tias qhov kev kho mob ntawm qhov ncauj trilostane ua rau txo qis hauv adrenal steroid excretion hauv cov sij hawm kho.

Qhov kev txwv no yog kev sib tw; Yog li, qhov ntau npaum li cas yuav raug titrated los hloov cov qib ntawm kev tawm tsam, tso cai rau cov kws kho tsiaj kom kho tus kheej mus rau qib tshuaj hormones ntawm txhua tus dev.

Thaum atrilostane ntsiav tshuajthaiv cov 3 -HSD txoj hauv kev, cortisol tso tawm los ntawm adrenal cortex txo qis heev. Tus dev lub cev pib muaj cov tshuaj hormones ntau dua, thiab cov ntaub ntawv kho mob ntawm Cushing's syndrome maj mam txhim kho ntau hnub mus rau lub lis piam.

Hauv cov dev, kev kho mob nrog trilostane tau pom nyob rau hauv kev tshawb fawb soj ntsuam kom ua rau muaj qhov txo qis hauv cov zis cortisol- mus rau -creatinine ratios thiab post-ACTH stimulation cortisol concentrations. Lawv yog cov cim qhia txog kev kuaj mob uas siv los ntawm kws kho tsiaj los saib xyuas cov lus teb rau kev kho.

Cortisol tsis yog tib yam tshuaj hormones cuam tshuam

Cortisol tsis cuam tshuam tshwj xeeb los ntawm trilostane, vim tias 3 -HSD koom nrog hauv kev tsim ntau cov tshuaj steroid. Aldosterone yog ib qho mineralocorticoid, thiab nws tswj sodium thiab potassium. Nws kuj yuav raug inhibited. Cov kws kho tsiaj yuav kuaj xyuas electrolyte panels thoob plaws hauv kev kho kom tsis txhob muaj kev phom sij tsawg ntawm aldosterone, ib qho mob hu ua hypoadrenocorticism (Addison's disease).

Lub adrenal cortex tau muab faib ua peb thaj tsam, zona glomerulosa (aldosterone), zona fasciculata (cortisol), thiab zona reticularis (androgens). Trilostane inhibits 3 -HSD nyob rau hauv peb thaj tsam ntawm adrenal cortex, qhia txog qhov yuav tsum tau ceev faj npaum li cas thiab saib xyuas hauv qhov chaw kho mob.

Kev Kho Kom Zoo Dua Lub Sijhawm

Cov dev ntawm trilostane capsule therapy feem ntau muaj ACTH stimulation test plaub mus rau rau lub lis piam tom qab pib noj tshuaj, thiab qee zaus tom qab ntawd. Qhov kev ntsuas no ntsuas ntau npaum li cas cortisol koj lub qog adrenal tseem tuaj yeem ua tau thaum nws txhawb nqa. Cov kws kho tsiaj tom qab ntawd siv cov ntaub ntawv los hloov cov koob tshuaj kom tsim nyog. Qee tus dev xav tau koob tshuaj ntau ntxiv rau lub sijhawm raws li cov qog adrenal hloov qee yam. Lwm tus ua tau zoo ntawm cov tshuaj tsis tu ncua rau lub hlis lossis xyoo.

Daim duab tag nrho hauv cov ntsiab lus yooj yim

Nov yog qhov yooj yim version ntawm tag nrho cov txheej txheem: Hauv ib tus dev uas muaj tus kab mob Cushing, cov qog adrenal muaj zog heev thiab tsim cortisol ntau dhau. Lub Trilostane capsule yog absorbed rau hauv cov hlab ntsha thiab mus rau cov qog adrenal, qhov twg nws khi rau 3β-HSD enzyme - enzyme uas yuav tsum tau rau zus tau tej cov cortisol thiab lwm yam tshuaj hormones. Qhov no thaiv cov enzyme, thiab cortisol ntau lawm qeeb rau qib noj qab haus huv, thiab tus dev zoo dua.

Cov txheej txheem ntawm kev ua haujlwm no tau piav qhia meej hauv cov phooj ywg- tshuaj xyuas cov ntaub ntawv kws kho tsiaj thiab tau txhawb nqa daim ntawv tso cai ntawm trilostane rau kev siv dev hauv ntau lub tebchaws, suav nrog Tebchaws Meskas thiab thoob plaws Tebchaws Europe.

Vim li cas qhov txheej txheem no tseem ceeb rau koj tus dev lub neej zoo

Cov dev uas tsis kho Cushing's kab mob feem ntau yog plagued los ntawm kev qaug zog tsis tu ncua, rov ua dua ntawm daim tawv nqaij, cov leeg tsis muaj zog, thiab tso zis ntau dhau. Trilostane ntsiav tshuaj ua haujlwm ntawm lub hauv paus ntawm qhov teeb meem, inhibiting steroidogenesis ntawm qib enzymatic es tsis yog tsuas yog zais cov tsos mob. Cov dev feem ntau yuav pib pom kev txhim kho (xws li lub zog ntau dua, kev siv dej tsawg dua, thiab kev loj hlob ntawm lawv lub tsho loj) thaum thawj ib mus rau ob lub hlis ntawm kev kho mob tas li.

Covtrilostane ntsiav tshuajyog ib qho kev sib tw inhibitor ntawm adrenal cortex enzyme 3 -HSD uas cuam tshuam cov cascade ntawm steroidogenesis thiab txo qis ntau tshaj cortisol. Cov txheej txheem yog ob qho tib si lub hom phiaj thiab thim rov qab, ua rau nws zoo tagnrho rau lub sijhawm ntev - kho tus kab mob canine Cushing's. Cov dev feem ntau lees txais cov tshuaj no zoo thiab muaj kev txhim kho zoo hauv lawv lub neej txhua hnub nrog kev siv tshuaj txaus thiab ua tib zoo saib xyuas cov kws kho tsiaj.

Ntawm Bloomtechz, peb nkag siab tias kev nkag mus rau cov kws kho mob muaj txiaj ntsig zoo - cov khoom xyaw qib tseem ceeb heev - rau koj cov qauv, koj cov neeg siv khoom, thiab thaum kawg cov tsiaj hauv lawv txoj kev saib xyuas. Peb GMP- qhov chaw tsim khoom tau lees paub npog 100,000 square metres thiab tuav cov ntawv pov thawj los ntawm US FDA, EU, JP, thiab CFDA cov cai tswj hwm. Peb xa cov tshuaj trilostane capsule thiab nws cov khoom siv tshuaj muaj txiaj ntsig (API) nrog HPLC purity Ntau dua lossis sib npaug li 99.0%, txhawb nqa los ntawm triple-txuas kev soj ntsuam zoo ntawm qib Hoobkas, peb lub tuam tsev QA / QC sab hauv, thiab ib qho kev lees paub thib peb- tog koom haum. Txawm hais tias koj xav tau OEM / ODM formulations, bulk API hmoov, los yog customized dosage forms, peb cov kev paub R & D pab neeg txhawb nqa koj los ntawm lab scale mus rau tag nrho cov tsim. Raws li tus kws tshaj lijtrilostane ntsiav tshuajtus neeg muag khoom, peb ua haujlwm nrog 24 tus neeg koom tes tsim nyog thoob ntiaj teb thoob plaws kev lag luam tshuaj, kev tshawb fawb, thiab kev lag luam tshuaj tshwj xeeb.

Npaj los tham txog koj cov kev xav tau kev pab? Hu rau peb pab neeg hnub no ntawmSales@bloomtechz.com- peb teb tam sim ntawd thiab muab tus nqi raug, lub sij hawm coj mus kuaj, thiab cov ntaub ntawv tag nrho rau kev lis kev cai.

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2. Neiger R., Ramsey I., O'Connor J., Hurley KJ, Mooney CT. - Trilostane kho 78 tus dev nrog pituitary-dependent hyperadrenocorticism. Veterinary Record, 2002.

3. Vaughan MA, Forward ZA, Padgett SL. - Siv trilostane rau kev kho mob pituitary-nyob ntawm hyperadrenocorticism hauv dev. Phau ntawv Journal ntawm American Animal Hospital Association, 2008.

4. Feldman EC, Nelson RW, Feldman MS. - Kev siv qis- thiab siab -dose dexamethasone kuaj rau qhov txawv ntawm pituitary- nyob ntawm cov qog adrenal hyperadrenocorticism hauv dev. Phau ntawv Journal ntawm American Veterinary Medical Association, 1996.

5. Lien YH, Huang HP. - Kev siv ketoconazole thiab trilostane rau kev tswj hwm ntawm ib txwm tshwm sim hyperadrenocorticism hauv dev hauv Taiwan. Phau ntawv Journal of Veterinary Internal Medicine, 2008.

6. Burkhardt WA, Boretti FS, Reusch CE, Sieber-Ruckstuhl NS. - Kev ntsuam xyuas ntawm lub hauv paus cortisol, endogenous ACTH, thiab cortisol/ACTH piv los saib xyuas cov dev nrog hyperadrenocorticism kho nrog trilostane. Phau ntawv Journal of Veterinary Internal Medicine, 2013.